BRPI0607053A2 - produção de proteìnas heterooligoméricas em plantas - Google Patents
produção de proteìnas heterooligoméricas em plantasInfo
- Publication number
- BRPI0607053A2 BRPI0607053A2 BRPI0607053-1A BRPI0607053A BRPI0607053A2 BR PI0607053 A2 BRPI0607053 A2 BR PI0607053A2 BR PI0607053 A BRPI0607053 A BR PI0607053A BR PI0607053 A2 BRPI0607053 A2 BR PI0607053A2
- Authority
- BR
- Brazil
- Prior art keywords
- plant
- viral vector
- protein subunit
- plants
- production
- Prior art date
Links
- 102000004169 proteins and genes Human genes 0.000 title abstract 2
- 108090000623 proteins and genes Proteins 0.000 title abstract 2
- 239000013603 viral vector Substances 0.000 abstract 7
- 102000002067 Protein Subunits Human genes 0.000 abstract 5
- 108010001267 Protein Subunits Proteins 0.000 abstract 5
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
- C12N15/8243—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
- C12N15/8251—Amino acid content, e.g. synthetic storage proteins, altering amino acid biosynthesis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/59—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g.hCG [human chorionic gonadotropin]; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/67—General methods for enhancing the expression
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8201—Methods for introducing genetic material into plant cells, e.g. DNA, RNA, stable or transient incorporation, tissue culture methods adapted for transformation
- C12N15/8202—Methods for introducing genetic material into plant cells, e.g. DNA, RNA, stable or transient incorporation, tissue culture methods adapted for transformation by biological means, e.g. cell mediated or natural vector
- C12N15/8203—Virus mediated transformation
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
- C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
- C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
- C12N15/8258—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon for the production of oral vaccines (antigens) or immunoglobulins
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Endocrinology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Reproductive Health (AREA)
- Gastroenterology & Hepatology (AREA)
- Virology (AREA)
- Immunology (AREA)
- Nutrition Science (AREA)
- Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
Abstract
PRODUçãO DE PROTEìNAS HETEROOLIGOMéRICAS EM PLANTAS. A presente invenção refere-se a um processo para produzir em uma planta, em um tecido da planta, ou em células da planta, uma proteína heterooligomérica que compreende pelo menos uma primeira e uma segunda subunidade da proteína, sendo que o dito processo compreende expressar em células da planta pelo menos a dita primeira e a dita segunda subunidade da proteína, (i) disponibilizar para a dita planta, o dito tecido da planta ou as ditas células da planta, um vetor viral de RNA de fita simples, sentido positivo, que codifica pelo menos a dita primeira e a dita segunda subunidade da proteína, ou (ii) disponibilizar para a dita planta, o dito tecido da planta ou as ditas células da planta, um primeiro e um segundo vetor viral de RNA de fita simples, sentido positivo, sendo que o dito primeiro vetor viral codifica pelo menos a dita primeira subunidade da proteína, o dito segundo vetor viral codifica pelo menos a dita segunda subunidade da proteína, com o que pelo menos o dito primeiro vetor viral e o dito segundo vetor viral são vetores virais não-competitivos.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US59360605P | 2005-01-28 | 2005-01-28 | |
US60/593.606 | 2005-01-28 | ||
EP05001819.1 | 2005-01-28 | ||
EP05001819A EP1686176A1 (en) | 2005-01-28 | 2005-01-28 | Production of antibodies in plants with plus-sense single-stranded viral RNA vectors |
PCT/EP2006/000721 WO2006079546A2 (en) | 2005-01-28 | 2006-01-27 | Production of antibodies in plants with plus -sense single -stranded viral rna vectors |
Publications (2)
Publication Number | Publication Date |
---|---|
BRPI0607053A2 true BRPI0607053A2 (pt) | 2009-08-04 |
BRPI0607053B1 BRPI0607053B1 (pt) | 2018-02-06 |
Family
ID=34933496
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0607053-1A BRPI0607053B1 (pt) | 2005-01-28 | 2006-01-27 | Processo para produzir em uma planta, tecido vegetal, ou em células vegetais, um anticorpo como uma proteína hetero-oligomérica que compreende pelo menos uma primeira e uma segunda subunidade proteica |
Country Status (14)
Country | Link |
---|---|
US (2) | US8940963B2 (pt) |
EP (2) | EP1686176A1 (pt) |
JP (1) | JP5015012B2 (pt) |
KR (1) | KR101293218B1 (pt) |
CN (1) | CN101115842B (pt) |
AT (1) | ATE547429T1 (pt) |
AU (1) | AU2006208631B2 (pt) |
BR (1) | BRPI0607053B1 (pt) |
CA (1) | CA2595328C (pt) |
DK (1) | DK1844152T3 (pt) |
ES (1) | ES2383670T3 (pt) |
IL (1) | IL184574A (pt) |
MX (1) | MX2007008993A (pt) |
WO (1) | WO2006079546A2 (pt) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1764414A1 (en) | 2005-09-17 | 2007-03-21 | Icon Genetics AG | Plant viral particles comprising a plurality of fusion proteins consisting of a plant viral coat protein, a peptide linker and a recombinant protein and use of such plant viral particles for protein purification |
EP1897953A1 (en) * | 2006-09-06 | 2008-03-12 | Icon Genetics GmbH | Potexvirus-derived replicon |
WO2008094512A2 (en) | 2007-01-29 | 2008-08-07 | The Ohio Sate University Research Foundation | System for expression of genes in plants from a virus-based expression vector |
JP5925677B2 (ja) | 2009-06-15 | 2016-06-01 | アイコン・ジェネティクス・ゲーエムベーハー | キシロシルトランスフェラーゼ活性の欠損したベンサミアナタバコ(Nicotianabenthamiana)植物 |
SI23374A (sl) | 2010-05-24 | 2011-11-30 | Nacionalni@inštitut@za@biologijo | Uporaba glikozidaz in glikoziltransferaz za povečano proizvodnjo proteinov |
EP2625276B1 (en) * | 2010-10-08 | 2018-03-28 | Fraunhofer USA Inc. | Closterovirus-based nucleic acid molecules and uses thereof |
EP2655626B1 (en) * | 2010-12-22 | 2018-04-11 | Philip Morris Products S.a.s. | Method and system for the vacuum infiltration of plants |
EP2500035A1 (en) | 2011-03-15 | 2012-09-19 | Icon Genetics GmbH | Pharmaceutical formulation containing immunglobulin |
EP2551348B1 (en) | 2011-07-29 | 2014-09-24 | Icon Genetics GmbH | Production of galactosylated N-glycans in plants |
AU2012320847B2 (en) | 2011-10-04 | 2018-03-08 | Icon Genetics Gmbh | Nicotiana benthamiana plants deficient in fucosyltransferase activity |
US20160002654A1 (en) | 2013-02-20 | 2016-01-07 | National Institute Of Advanced Industrial Science And Technology | Nucleic acid molecule for expressing foreign gene in plant and method therefor |
EP2777711A1 (en) | 2013-03-11 | 2014-09-17 | Icon Genetics GmbH | Her2/Neu cancer vaccine |
WO2014147235A1 (en) | 2013-03-22 | 2014-09-25 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Kits comprising plus-sense single stranded rna viral vectors and methods for producing polypeptides using the kits |
GB201617109D0 (en) * | 2016-10-07 | 2016-11-23 | Rothamsted Res Ltd | Vectors and methods for protein expression in plants |
US20190359993A1 (en) * | 2017-02-15 | 2019-11-28 | National Agriculture And Food Research Organization | Method for producing genome-edited plant utilizing plant virus vectors |
CN107372609A (zh) * | 2017-07-27 | 2017-11-24 | 河南柏裕植物免疫科技有限公司 | 苹果病毒病疫苗 |
EP3456829A1 (en) | 2017-09-18 | 2019-03-20 | Nomad Bioscience GmbH | Method of improving potexviral vector stability |
BR112021009192A2 (pt) * | 2018-11-13 | 2021-09-14 | University Of Maryland, College Park | Vetor de ácido ribonucleico (rna) de fita simples e senso positivo, planta hospedeira, composição, método para introduzir um segmento heterólogo (ou segmentos heterólogos) em uma planta hospedeira, processo para produzir, em uma planta, um órgão de planta, um tecido de planta ou uma célula de planta, um segmento heterólogo (ou segmentos heterólogos), kit, uso do vetor de rna, uso da planta hospedeira, método de produção de um vetor para uso com uma planta, vetor, uso de um rna como um vetor, uso de um rna, e rna para uso como um medicamento ou no tratamento de uma doença ou afecção de um planta |
JPWO2020226176A1 (pt) * | 2019-05-09 | 2020-11-12 | ||
BR112022009127A2 (pt) * | 2019-11-12 | 2022-08-16 | Univ Maryland | Vetor de ácido ribonucleico, planta compreendendo um porta-enxerto de laranja azeda e um vetor baseado em irna, método para introdução de um segmento heterólogo em uma planta hospedeira, método de fabricação de um vetor de ácido ribonucleico, e vetor baseado em irna |
WO2021193870A1 (ja) | 2020-03-26 | 2021-09-30 | デンカ株式会社 | Fc領域の一部を欠損した抗体を含む試薬 |
EP4261221A1 (en) | 2020-12-25 | 2023-10-18 | Denka Company Limited | Method for measuring target antigen, and insoluble particles and kit for target antigen measurement used therein |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2329074A1 (en) * | 1998-10-30 | 2000-05-11 | Thomas Jefferson University | Production of biomedical peptides and proteins in plants using plant virus vectors |
WO2002008221A2 (en) | 2000-07-20 | 2002-01-31 | Neurogen Corporation | Capsaicin receptor ligands |
DE10121283B4 (de) * | 2001-04-30 | 2011-08-11 | Icon Genetics GmbH, 80333 | Verfahren und Vektoren zur Amplifikation oder Expression von gewünschten Nucleinsäuresequenzen in Pflanzen |
US20030084482A1 (en) * | 2001-06-08 | 2003-05-01 | Gerald Hall | Production of proteins in plants |
GB0221940D0 (en) * | 2002-09-20 | 2002-10-30 | Athena Biodetection Aps | Antibody and screening method |
US8148608B2 (en) * | 2004-02-20 | 2012-04-03 | Fraunhofer Usa, Inc | Systems and methods for clonal expression in plants |
US7763430B2 (en) | 2003-04-22 | 2010-07-27 | Baxter International Inc. | Diagnostic assay for anti-von Willebrand Factor cleaving protease (ADAMTS13) antibodies |
-
2005
- 2005-01-28 EP EP05001819A patent/EP1686176A1/en not_active Withdrawn
-
2006
- 2006-01-27 BR BRPI0607053-1A patent/BRPI0607053B1/pt active IP Right Grant
- 2006-01-27 JP JP2007552582A patent/JP5015012B2/ja active Active
- 2006-01-27 MX MX2007008993A patent/MX2007008993A/es active IP Right Grant
- 2006-01-27 US US11/814,931 patent/US8940963B2/en active Active
- 2006-01-27 KR KR1020077019434A patent/KR101293218B1/ko active IP Right Grant
- 2006-01-27 CA CA2595328A patent/CA2595328C/en active Active
- 2006-01-27 CN CN2006800032646A patent/CN101115842B/zh active Active
- 2006-01-27 EP EP06704266A patent/EP1844152B1/en active Active
- 2006-01-27 DK DK06704266.3T patent/DK1844152T3/da active
- 2006-01-27 AU AU2006208631A patent/AU2006208631B2/en active Active
- 2006-01-27 AT AT06704266T patent/ATE547429T1/de active
- 2006-01-27 ES ES06704266T patent/ES2383670T3/es active Active
- 2006-01-27 WO PCT/EP2006/000721 patent/WO2006079546A2/en active Application Filing
-
2007
- 2007-07-12 IL IL184574A patent/IL184574A/en active IP Right Grant
-
2014
- 2014-11-24 US US14/551,570 patent/US20150315604A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
DK1844152T3 (da) | 2012-04-30 |
US8940963B2 (en) | 2015-01-27 |
BRPI0607053B1 (pt) | 2018-02-06 |
US20150315604A1 (en) | 2015-11-05 |
AU2006208631B2 (en) | 2011-09-22 |
KR20070102570A (ko) | 2007-10-18 |
JP2008535473A (ja) | 2008-09-04 |
IL184574A (en) | 2013-05-30 |
JP5015012B2 (ja) | 2012-08-29 |
CN101115842B (zh) | 2012-10-03 |
CA2595328C (en) | 2015-03-24 |
EP1844152A2 (en) | 2007-10-17 |
IL184574A0 (en) | 2007-10-31 |
US20090111145A1 (en) | 2009-04-30 |
CN101115842A (zh) | 2008-01-30 |
EP1844152B1 (en) | 2012-02-29 |
WO2006079546A3 (en) | 2006-10-05 |
EP1686176A1 (en) | 2006-08-02 |
WO2006079546A2 (en) | 2006-08-03 |
CA2595328A1 (en) | 2006-08-03 |
ATE547429T1 (de) | 2012-03-15 |
AU2006208631A1 (en) | 2006-08-03 |
ES2383670T3 (es) | 2012-06-25 |
KR101293218B1 (ko) | 2013-08-05 |
MX2007008993A (es) | 2007-12-07 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
B06H | Technical and formal requirements: requirement cancelled [chapter 6.8 patent gazette] |
Free format text: ANULACAO DA EXIGENCIA 6.6 POR TER SIDO INDEVIDA REFERENTE A RPI NO 2199 DE 26/02/2013. |
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B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
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