BRPI0517818A2 - método de tratamento do rubor quente com um medicamento relacionado com a mirtazapina, e, uso de s-mirtazapina - Google Patents
método de tratamento do rubor quente com um medicamento relacionado com a mirtazapina, e, uso de s-mirtazapina Download PDFInfo
- Publication number
- BRPI0517818A2 BRPI0517818A2 BRPI0517818-5A BRPI0517818A BRPI0517818A2 BR PI0517818 A2 BRPI0517818 A2 BR PI0517818A2 BR PI0517818 A BRPI0517818 A BR PI0517818A BR PI0517818 A2 BRPI0517818 A2 BR PI0517818A2
- Authority
- BR
- Brazil
- Prior art keywords
- mirtazapine
- treatment
- week
- rats
- hot
- Prior art date
Links
- RONZAEMNMFQXRA-MRXNPFEDSA-N esmirtazapine Chemical compound C1C2=CC=CN=C2N2CCN(C)C[C@@H]2C2=CC=CC=C21 RONZAEMNMFQXRA-MRXNPFEDSA-N 0.000 title claims abstract description 40
- 239000003814 drug Substances 0.000 title claims abstract description 23
- 229960001785 mirtazapine Drugs 0.000 title claims abstract description 17
- 238000000034 method Methods 0.000 title claims abstract description 15
- RONZAEMNMFQXRA-UHFFFAOYSA-N mirtazapine Chemical compound C1C2=CC=CN=C2N2CCN(C)CC2C2=CC=CC=C21 RONZAEMNMFQXRA-UHFFFAOYSA-N 0.000 title claims description 16
- 238000011010 flushing procedure Methods 0.000 title claims description 12
- 229940079593 drug Drugs 0.000 title description 11
- 238000011282 treatment Methods 0.000 claims abstract description 65
- 238000004519 manufacturing process Methods 0.000 claims abstract description 4
- 239000004480 active ingredient Substances 0.000 claims description 8
- 206010060800 Hot flush Diseases 0.000 abstract description 26
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- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 description 1
- WSVLPVUVIUVCRA-KPKNDVKVSA-N Alpha-lactose monohydrate Chemical compound O.O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O WSVLPVUVIUVCRA-KPKNDVKVSA-N 0.000 description 1
- 206010002091 Anaesthesia Diseases 0.000 description 1
- LZZYPRNAOMGNLH-UHFFFAOYSA-M Cetrimonium bromide Chemical compound [Br-].CCCCCCCCCCCCCCCC[N+](C)(C)C LZZYPRNAOMGNLH-UHFFFAOYSA-M 0.000 description 1
- 229920002261 Corn starch Polymers 0.000 description 1
- SXRSQZLOMIGNAQ-UHFFFAOYSA-N Glutaraldehyde Chemical compound O=CCCCC=O SXRSQZLOMIGNAQ-UHFFFAOYSA-N 0.000 description 1
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- 206010019233 Headaches Diseases 0.000 description 1
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- RONZAEMNMFQXRA-INIZCTEOSA-N LSM-5894 Chemical compound C1C2=CC=CN=C2N2CCN(C)C[C@H]2C2=CC=CC=C21 RONZAEMNMFQXRA-INIZCTEOSA-N 0.000 description 1
- 229920004011 Macrolon® Polymers 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Cardiology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Dermatology (AREA)
- Diabetes (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP04105778.7 | 2004-11-15 | ||
| EP04105778 | 2004-11-15 | ||
| PCT/EP2005/055947 WO2006051111A1 (en) | 2004-11-15 | 2005-11-14 | S-mirtazapine for the treatment of hot flush |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0517818A2 true BRPI0517818A2 (pt) | 2010-03-16 |
Family
ID=34929859
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0517818-5A BRPI0517818A2 (pt) | 2004-11-15 | 2005-11-14 | método de tratamento do rubor quente com um medicamento relacionado com a mirtazapina, e, uso de s-mirtazapina |
Country Status (30)
| Country | Link |
|---|---|
| US (4) | US20070265245A1 (enExample) |
| EP (1) | EP1814555B1 (enExample) |
| JP (1) | JP2008519810A (enExample) |
| KR (1) | KR20070085470A (enExample) |
| CN (2) | CN101056641A (enExample) |
| AR (1) | AR053780A1 (enExample) |
| AT (1) | ATE439843T1 (enExample) |
| AU (1) | AU2005303778B2 (enExample) |
| BR (1) | BRPI0517818A2 (enExample) |
| CA (1) | CA2587283C (enExample) |
| CY (1) | CY1110538T1 (enExample) |
| DE (1) | DE602005016141D1 (enExample) |
| DK (1) | DK1814555T3 (enExample) |
| ES (1) | ES2329815T3 (enExample) |
| HR (1) | HRP20090513T1 (enExample) |
| IL (1) | IL182767A (enExample) |
| MX (1) | MX2007005827A (enExample) |
| MY (1) | MY144089A (enExample) |
| NO (1) | NO20072285L (enExample) |
| NZ (1) | NZ554858A (enExample) |
| PE (1) | PE20061051A1 (enExample) |
| PL (1) | PL1814555T3 (enExample) |
| PT (1) | PT1814555E (enExample) |
| RS (1) | RS51138B (enExample) |
| RU (1) | RU2396957C2 (enExample) |
| SI (1) | SI1814555T1 (enExample) |
| TW (1) | TW200631584A (enExample) |
| UA (1) | UA88655C2 (enExample) |
| WO (1) | WO2006051111A1 (enExample) |
| ZA (1) | ZA200703884B (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007002174A2 (en) * | 2005-06-27 | 2007-01-04 | N.V. Organon. | A method of treatment of hormone depletion induced vasomotor symptoms |
| US20070129611A1 (en) * | 2005-12-06 | 2007-06-07 | University Of North Texas Health Science Center At Fort Worth | System, Method and Apparatus for Assessing Menopausal or Post-Hysterectomy Symptoms |
| EP1993556A1 (en) * | 2006-03-06 | 2008-11-26 | N.V. Organon | An improved method of weaning from hormonal treatment of hormone depletion induced vasomotor symptoms |
| AU2007324467A1 (en) * | 2006-11-22 | 2008-05-29 | N.V. Organon | Vaginal delivery system for mirtazapine |
| US7645750B2 (en) * | 2006-12-13 | 2010-01-12 | Yung Shin Pharmaceutical Ind. Co., Ltd. | Method of treating symptoms of hormonal variations |
| JP2009018992A (ja) | 2007-07-10 | 2009-01-29 | Sumitomo Chemical Co Ltd | 光学活性ミルタザピンの製造方法 |
| US8420624B2 (en) | 2007-12-04 | 2013-04-16 | Yung Shin Pharm. Ind. Co., Ltd. | Methods for treating or preventing symptoms of hormonal variations |
| JP6876003B2 (ja) | 2015-02-27 | 2021-05-26 | デクラ リミテッド | イヌ及びネコにおける、食欲の刺激、体重減少の管理、及び拒食症の処置 |
| KR102608479B1 (ko) * | 2017-05-25 | 2023-12-01 | 글리테크 엘엘씨. | Nmdar 길항제-반응성 신경정신 질환을 위한 병용 요법 |
| WO2021167579A1 (ru) | 2020-02-19 | 2021-08-26 | Иван УЛИНИЧ | Универсальное устройство для тепловой обработки пищевых продуктов |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL189199C (nl) * | 1975-04-05 | 1993-02-01 | Akzo Nv | Werkwijze ter bereiding van farmaceutische preparaten met werking op het centraal zenuwstelsel op basis van benz(aryl)azepinederivaten, de verkregen gevormde farmaceutische preparaten, alsmede werkwijze ter bereiding van de toe te passen benz(aryl)azepinederivaten. |
| US4515792A (en) * | 1982-09-30 | 1985-05-07 | Ciba-Geigy Corporation | Tetracyclic heterocycles and antidepressant compositions thereof |
| JPH1187727A (ja) * | 1997-09-12 | 1999-03-30 | Mitsubishi Electric Corp | 半導体装置 |
| ES2212550T3 (es) * | 1998-04-02 | 2004-07-16 | Akzo Nobel N.V. | Solucion oral liquida que comprende el antidepresor mirtazapina. |
| RU2195951C1 (ru) * | 2001-08-20 | 2003-01-10 | Общество с ограниченной ответственностью "Лаборатория "Ирис" | Средство для лечения климактерических расстройств |
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2005
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- 2005-11-14 EP EP05808013A patent/EP1814555B1/en not_active Expired - Lifetime
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- 2005-11-14 AT AT05808013T patent/ATE439843T1/de active
- 2005-11-14 WO PCT/EP2005/055947 patent/WO2006051111A1/en not_active Ceased
- 2005-11-14 KR KR1020077011981A patent/KR20070085470A/ko not_active Ceased
- 2005-11-14 CN CNA200580038949XA patent/CN101056641A/zh active Pending
- 2005-11-14 CN CN2012102639294A patent/CN102772414A/zh active Pending
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- 2005-11-14 SI SI200530802T patent/SI1814555T1/sl unknown
- 2005-11-14 HR HR20090513T patent/HRP20090513T1/xx unknown
- 2005-11-14 US US11/667,579 patent/US20070265245A1/en not_active Abandoned
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2007
- 2007-04-23 IL IL182767A patent/IL182767A/en not_active IP Right Cessation
- 2007-04-30 NO NO20072285A patent/NO20072285L/no not_active Application Discontinuation
- 2007-05-14 ZA ZA200703884A patent/ZA200703884B/xx unknown
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2009
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2010
- 2010-07-01 US US12/828,720 patent/US20100267694A1/en not_active Abandoned
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2012
- 2012-08-09 US US13/570,481 patent/US20120302552A1/en not_active Abandoned
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2013
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