BRPI0517555A - n-alquilpirimidinonas substituìdas - Google Patents

n-alquilpirimidinonas substituìdas

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Publication number
BRPI0517555A
BRPI0517555A BRPI0517555-0A BRPI0517555A BRPI0517555A BR PI0517555 A BRPI0517555 A BR PI0517555A BR PI0517555 A BRPI0517555 A BR PI0517555A BR PI0517555 A BRPI0517555 A BR PI0517555A
Authority
BR
Brazil
Prior art keywords
substituted
activity
pyrimidinones
substituted pyrimidinones
cyclooxygenase
Prior art date
Application number
BRPI0517555-0A
Other languages
English (en)
Inventor
Terri Lee Boehm
Lance Christopher Christie
Balekudru Devadas
Heather Margaret Madsen
Laura Marrufo
Shaun Selness
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of BRPI0517555A publication Critical patent/BRPI0517555A/pt

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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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Abstract

N-ALQUILPIRIMIDINONAS SUBSTITUIDAS. A presente invenção é voltada em linhas gerais a compostos de pirimidinona substituida que geralmente inibem a atividade de p38 quinase, de TNF e/ou de ciclooxigenase. Tais pirimidinonas substituidas incluem compostos correspondendo em linhas gerais em estrutura à seguinte fórmula (I) em que R˜ , R� , R� , R¬ 4A¬ , R¬ 4B¬ , R¬ 4C¬ , R¬ 4D¬ e R¬ 4E¬ são conforme definido neste relatório. A presente invenção também é voltada a composições de tais pirimidinonas substituidas (especialmente a composições farmacêuticas) , a intermediários para a síntese de tais pirimidinonas substituidas, a métodos para a preparação de tais pirimidinonas substituidas e a métodos para o tratamento (inclusive a prevenção) de condições (tipicamente de condições patológicas) associadas com a atividade de p38 quinase, a atividade de TNF, e/ou a atividade de ciclooxigenase-2.
BRPI0517555-0A 2004-10-13 2005-10-03 n-alquilpirimidinonas substituìdas BRPI0517555A (pt)

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US61885604P 2004-10-13 2004-10-13
US63794904P 2004-12-21 2004-12-21
PCT/IB2005/003063 WO2006040666A1 (en) 2004-10-13 2005-10-03 Substituted n-alkylpyrimidinones

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WO (1) WO2006040666A1 (pt)

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EP1987022A1 (en) * 2006-02-10 2008-11-05 Pfizer Products Inc. Pyridinone pyrazole urea and pyrimidinone pyrazole urea derivatives
EP1992344A1 (en) 2007-05-18 2008-11-19 Institut Curie P38 alpha as a therapeutic target in pathologies linked to FGFR3 mutation
US9056110B2 (en) * 2011-12-06 2015-06-16 Confluence Life Sciences, Inc. Substituted pyrimidinone-phenyl-pyrimidinyl compounds
CN108503568A (zh) * 2017-02-27 2018-09-07 无锡杰西医药股份有限公司 一种适用于工业化生产的高纯度异硫氰酸酯类化合物制备方法

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JPS63112566A (ja) * 1986-10-28 1988-05-17 Nissan Chem Ind Ltd ピリミジノン誘導体、その製法および殺虫・殺ダニ・殺菌剤
JPH01190670A (ja) * 1988-01-22 1989-07-31 Nissan Chem Ind Ltd ピリミジノン誘導体、その製法および殺虫・殺ダニ・殺菌剤
EP1470112A1 (en) * 2002-01-18 2004-10-27 Pharmacia Corporation Substituted pyridazinones as inhibitors of p38
GEP20063937B (en) * 2002-02-14 2006-10-10 Pharmacia Corp Substituted pyridinones as modulators of p38 map kinase
US7183287B2 (en) * 2003-04-03 2007-02-27 Pharmacia Corporation Substituted pyrimidinones
JP2007500128A (ja) * 2003-07-25 2007-01-11 アムジエン・インコーポレーテツド 置換複素環式化合物及び使用方法

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JP2008515964A (ja) 2008-05-15
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WO2006040666A1 (en) 2006-04-20
CA2580497A1 (en) 2006-04-20

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