BRPI0517555A - n-alquilpirimidinonas substituìdas - Google Patents

n-alquilpirimidinonas substituìdas

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Publication number
BRPI0517555A
BRPI0517555A BRPI0517555-0A BRPI0517555A BRPI0517555A BR PI0517555 A BRPI0517555 A BR PI0517555A BR PI0517555 A BRPI0517555 A BR PI0517555A BR PI0517555 A BRPI0517555 A BR PI0517555A
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BR
Brazil
Prior art keywords
substituted
activity
pyrimidinones
substituted pyrimidinones
cyclooxygenase
Prior art date
Application number
BRPI0517555-0A
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English (en)
Inventor
Terri Lee Boehm
Lance Christopher Christie
Balekudru Devadas
Heather Margaret Madsen
Laura Marrufo
Shaun Selness
Original Assignee
Upjohn Co
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Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of BRPI0517555A publication Critical patent/BRPI0517555A/pt

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    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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Abstract

N-ALQUILPIRIMIDINONAS SUBSTITUIDAS. A presente invenção é voltada em linhas gerais a compostos de pirimidinona substituida que geralmente inibem a atividade de p38 quinase, de TNF e/ou de ciclooxigenase. Tais pirimidinonas substituidas incluem compostos correspondendo em linhas gerais em estrutura à seguinte fórmula (I) em que R˜ , R� , R� , R¬ 4A¬ , R¬ 4B¬ , R¬ 4C¬ , R¬ 4D¬ e R¬ 4E¬ são conforme definido neste relatório. A presente invenção também é voltada a composições de tais pirimidinonas substituidas (especialmente a composições farmacêuticas) , a intermediários para a síntese de tais pirimidinonas substituidas, a métodos para a preparação de tais pirimidinonas substituidas e a métodos para o tratamento (inclusive a prevenção) de condições (tipicamente de condições patológicas) associadas com a atividade de p38 quinase, a atividade de TNF, e/ou a atividade de ciclooxigenase-2.
BRPI0517555-0A 2004-10-13 2005-10-03 n-alquilpirimidinonas substituìdas BRPI0517555A (pt)

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WO2013086208A1 (en) * 2011-12-06 2013-06-13 Confluence Life Sciences, Inc. Substituted pyrimidinone-phenyl-pyrimidinyl compounds
CN108503568A (zh) * 2017-02-27 2018-09-07 无锡杰西医药股份有限公司 一种适用于工业化生产的高纯度异硫氰酸酯类化合物制备方法

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AU2003209321A1 (en) * 2002-01-18 2003-07-30 Pharmacia Corporation Substituted pyridazinones as inhibitors of p38
ES2334990T3 (es) * 2002-02-14 2010-03-18 Pharmacia Corporation Piridinonas sustituidas como moduladores de p38 map quinasa.
US7183287B2 (en) * 2003-04-03 2007-02-27 Pharmacia Corporation Substituted pyrimidinones
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