BRPI0516233A - complexo compreendendo a mequitazina, uma ciclodextrina, e um agente de interação, processo de preparação do mesmo, e, composição farmacêutica destinada a ser administrada por via oral - Google Patents
complexo compreendendo a mequitazina, uma ciclodextrina, e um agente de interação, processo de preparação do mesmo, e, composição farmacêutica destinada a ser administrada por via oralInfo
- Publication number
- BRPI0516233A BRPI0516233A BRPI0516233-5A BRPI0516233A BRPI0516233A BR PI0516233 A BRPI0516233 A BR PI0516233A BR PI0516233 A BRPI0516233 A BR PI0516233A BR PI0516233 A BRPI0516233 A BR PI0516233A
- Authority
- BR
- Brazil
- Prior art keywords
- mequitazine
- complex
- cyclodextrin
- pharmaceutical composition
- preparing
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/5415—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
- A61K47/6951—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes using cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Nanotechnology (AREA)
- Pulmonology (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- General Engineering & Computer Science (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Immunology (AREA)
- Ophthalmology & Optometry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Abstract
COMPLEXO COMPREENDENDO A MEQUITAZINA, UMA CICLODEXTRINA, E UM AGENTE DE INTERACãO, PROCESSO DE PREPARAçãO DO MESMO, E, COMPOSIçãO FARMACêUTICA DESTINADA A SER ADMINISTRADA POR VIA ORAL. A presente invenção refere-se a um complexo compreendendo a mequitazina, uma ciclodextrina e um agente de interação caracterizado em que a taxa de solubilização na água da mequitazina complexada, medida para uma misturas a 2 g/1 de mequitazina em água a 35 °C, após 15 minutos de agitação, é superior a 50% a pH 9. Ela refere-se igualmente a um processo de preparação deste complexo e uma composição farmacêutica compreendendo o mesmo.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0411202A FR2876910B1 (fr) | 2004-10-21 | 2004-10-21 | Complexe comprenant la mequitazine, une cyclodextrine et un agent d'interaction |
PCT/EP2005/055388 WO2006042857A2 (fr) | 2004-10-21 | 2005-10-19 | Complexe comprenant la mequitazine, une cyclodextrine et un agent d'interaction |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0516233A true BRPI0516233A (pt) | 2008-08-26 |
Family
ID=34949969
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0516233-5A BRPI0516233A (pt) | 2004-10-21 | 2005-10-19 | complexo compreendendo a mequitazina, uma ciclodextrina, e um agente de interação, processo de preparação do mesmo, e, composição farmacêutica destinada a ser administrada por via oral |
Country Status (18)
Country | Link |
---|---|
US (1) | US7749982B2 (pt) |
EP (1) | EP1802348A2 (pt) |
JP (1) | JP5157447B2 (pt) |
KR (1) | KR101273840B1 (pt) |
CN (1) | CN101043908B (pt) |
AR (1) | AR051593A1 (pt) |
AU (1) | AU2005296875B2 (pt) |
BR (1) | BRPI0516233A (pt) |
CA (1) | CA2583783C (pt) |
FR (1) | FR2876910B1 (pt) |
IL (1) | IL182412A (pt) |
MX (1) | MX2007004787A (pt) |
NO (1) | NO20072433L (pt) |
NZ (1) | NZ555238A (pt) |
RU (1) | RU2389491C2 (pt) |
TW (1) | TWI372759B (pt) |
WO (1) | WO2006042857A2 (pt) |
ZA (1) | ZA200703080B (pt) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2914187B1 (fr) * | 2007-03-28 | 2011-01-21 | Pf Medicament | Complexes d'ibuprofene, de cyclodextrines et d'agents ternaires, et leurs utilisations en pharmaceutique. |
JP7029886B2 (ja) * | 2017-04-28 | 2022-03-04 | ロート製薬株式会社 | 医薬組成物及びその製造方法 |
KR20220085094A (ko) | 2020-12-14 | 2022-06-22 | 메디케어제약 주식회사 | 알레르기성 결막염을 동반한 만성 비염을 치료하는 약제학적 복합제제 |
Family Cites Families (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1250534A (pt) | 1969-03-03 | 1971-10-20 | ||
FR2522660A1 (fr) * | 1982-03-05 | 1983-09-09 | Pharmuka Lab | Isomere levogyre de la mequitazine, son procede de preparation et medicaments le contenant |
IT1196033B (it) | 1984-02-22 | 1988-11-10 | Chiesi Farma Spa | Composto ad attivita' antiinfiammatoria ottenuto per complessazione con beta-ciclodestrina e relative formulazioni farmaceutiche |
US4975426A (en) * | 1987-06-08 | 1990-12-04 | Analgesic Associates | Cough/cold mixtures comprising non-sedating antihistamine drugs |
JP2735122B2 (ja) | 1988-06-13 | 1998-04-02 | 旭化成工業株式会社 | メキタジンの液状シロップ製剤 |
FR2647343B1 (fr) * | 1989-05-24 | 1994-05-06 | Rhone Poulenc Sante | Nouvelle forme pharmaceutique poreuse et sa preparation |
KR920006911B1 (ko) * | 1989-06-14 | 1992-08-22 | 신풍제약 주식회사 | 안정한 피록시캄 주사액 조성물 및 그의 제조방법 |
TW262497B (en) | 1994-06-29 | 1995-11-11 | Toshiba Co Ltd | Washing machine |
FR2742053B1 (fr) | 1995-12-06 | 1998-03-06 | Chauvin Lab Sa | Compositions pharmaceutiques a base de mequitazine |
WO1998002187A1 (en) * | 1996-07-11 | 1998-01-22 | Farmarc Nederland B.V. | Pharmaceutical composition containing acid addition salt of basic drug |
JPH10167954A (ja) * | 1996-12-05 | 1998-06-23 | Takada Seiyaku Kk | メキタジン製剤 |
GB9800936D0 (en) | 1997-05-10 | 1998-03-11 | Univ Nottingham | Biofunctional polymers |
ES2149750T3 (es) * | 1999-01-06 | 2004-06-01 | Tecnimede-Sociedade Tecnico-Medicinal, S.A. | Complejos de inclusion de sales de aminoacidos de derivados de bencimidazol con ciclodextrinas, su preparacion y formulaciones farmaceuticas que contienen tales complejos. |
FR2788436A1 (fr) * | 1999-01-14 | 2000-07-21 | Pf Medicament | Composition d'un derive de phenothiazine |
FR2815540B1 (fr) * | 2000-10-19 | 2005-06-10 | Separex Sa | Procede de fabrication de tres fines particules constituees d'un principe insere dans une molecule hote |
WO2002089851A1 (fr) | 2001-03-06 | 2002-11-14 | Separex (Societe Anonyme) | Procede de fabrication de complexes hote-client |
FR2830761B1 (fr) | 2001-10-12 | 2003-12-12 | Pf Medicament | Procede de preparation d'un compose d'interaction d'un derive anilide avec un support poreux par fluide supercritique |
FR2830760B1 (fr) | 2001-10-12 | 2004-06-04 | Pf Medicament | Procede de preparation d'un compose d'interaction de substances actives avec un support poreux par fluide supercritique |
FR2854079B1 (fr) | 2003-04-25 | 2007-11-30 | Pf Medicament | Procede de preparation de complexes moleculaires |
SI2260871T1 (sl) | 2004-04-01 | 2013-09-30 | Pierre Fabre Medicament | Kompleksi sestavin, ki vključujejo piroksikam, ciklodekstrin in arginin |
-
2004
- 2004-10-21 FR FR0411202A patent/FR2876910B1/fr not_active Expired - Fee Related
-
2005
- 2005-10-19 MX MX2007004787A patent/MX2007004787A/es active IP Right Grant
- 2005-10-19 EP EP05801647A patent/EP1802348A2/fr not_active Withdrawn
- 2005-10-19 BR BRPI0516233-5A patent/BRPI0516233A/pt not_active IP Right Cessation
- 2005-10-19 CA CA2583783A patent/CA2583783C/fr not_active Expired - Fee Related
- 2005-10-19 RU RU2007118640/15A patent/RU2389491C2/ru not_active IP Right Cessation
- 2005-10-19 CN CN2005800358701A patent/CN101043908B/zh not_active Expired - Fee Related
- 2005-10-19 KR KR1020077010998A patent/KR101273840B1/ko active IP Right Grant
- 2005-10-19 US US11/665,839 patent/US7749982B2/en not_active Expired - Fee Related
- 2005-10-19 WO PCT/EP2005/055388 patent/WO2006042857A2/fr active Application Filing
- 2005-10-19 JP JP2007537271A patent/JP5157447B2/ja not_active Expired - Fee Related
- 2005-10-19 NZ NZ555238A patent/NZ555238A/en not_active IP Right Cessation
- 2005-10-19 AU AU2005296875A patent/AU2005296875B2/en not_active Ceased
- 2005-10-20 TW TW094136627A patent/TWI372759B/zh not_active IP Right Cessation
- 2005-10-21 AR ARP050104407A patent/AR051593A1/es unknown
-
2007
- 2007-04-10 IL IL182412A patent/IL182412A/en not_active IP Right Cessation
- 2007-04-16 ZA ZA200703080A patent/ZA200703080B/en unknown
- 2007-05-11 NO NO20072433A patent/NO20072433L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
CN101043908A (zh) | 2007-09-26 |
RU2389491C2 (ru) | 2010-05-20 |
NO20072433L (no) | 2007-05-11 |
US20070293454A1 (en) | 2007-12-20 |
IL182412A (en) | 2015-02-26 |
TWI372759B (en) | 2012-09-21 |
RU2007118640A (ru) | 2008-11-27 |
EP1802348A2 (fr) | 2007-07-04 |
US7749982B2 (en) | 2010-07-06 |
FR2876910B1 (fr) | 2007-04-13 |
WO2006042857A2 (fr) | 2006-04-27 |
NZ555238A (en) | 2010-04-30 |
KR20070084223A (ko) | 2007-08-24 |
KR101273840B1 (ko) | 2013-06-11 |
ZA200703080B (en) | 2008-05-28 |
CA2583783A1 (fr) | 2006-04-27 |
JP5157447B2 (ja) | 2013-03-06 |
JP2008517035A (ja) | 2008-05-22 |
WO2006042857A3 (fr) | 2006-07-27 |
IL182412A0 (en) | 2007-07-24 |
TW200621770A (en) | 2006-07-01 |
AU2005296875A1 (en) | 2006-04-27 |
CA2583783C (fr) | 2013-05-21 |
AR051593A1 (es) | 2007-01-24 |
AU2005296875B2 (en) | 2011-03-31 |
MX2007004787A (es) | 2007-05-15 |
FR2876910A1 (fr) | 2006-04-28 |
CN101043908B (zh) | 2011-11-16 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] | ||
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2433 DE 22-08-2017 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |
|
B15K | Others concerning applications: alteration of classification |
Ipc: B82Y 5/00 (2011.01), A61K 47/69 (2017.01) |