BRPI0512933A - gránulos compreendendo antibiótico de (beta)-lactama - Google Patents

gránulos compreendendo antibiótico de (beta)-lactama

Info

Publication number
BRPI0512933A
BRPI0512933A BRPI0512933-8A BRPI0512933A BRPI0512933A BR PI0512933 A BRPI0512933 A BR PI0512933A BR PI0512933 A BRPI0512933 A BR PI0512933A BR PI0512933 A BRPI0512933 A BR PI0512933A
Authority
BR
Brazil
Prior art keywords
granules
lactam antibiotic
volume
gas
per
Prior art date
Application number
BRPI0512933-8A
Other languages
English (en)
Inventor
Marinus Petrus Wilhelm Rijkers
Alexander Lucia Leon Duchateau
Johannes Helena Michae Mommers
Jozef Maria Mathias Boesten
Original Assignee
Dsm Ip Assets Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dsm Ip Assets Bv filed Critical Dsm Ip Assets Bv
Publication of BRPI0512933A publication Critical patent/BRPI0512933A/pt
Publication of BRPI0512933B1 publication Critical patent/BRPI0512933B1/pt
Publication of BRPI0512933B8 publication Critical patent/BRPI0512933B8/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
    • B01J2/22—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by pressing in moulds or between rollers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

GRáNULOS COMPREENDENDO UM ANTIBIóTICO DE ß-LACTAMA A presente invenção refere-se a grânulos contendo um antibiótico de ß-lactama, onde C~H2S(72h)~ <50 Ál de gás H~2~S por kg de antibiótico de ß-lactama, onde C~H2S(72h)~ é o volume de gás H~2~S sobre os grânulos por kg do antibiótico de ß-lactama, quando uma amostra dente 3,5 e 4,5 dos grânulos é mantida em um recipiente fechado com um volume de 20 ml a uma temperatura de 22 C durante 72 horas a pressão atmosférica (1 bar) A invenção também se refere a um processo para a preparação de grânulos contendo um antibiótico de ß-lactama, com este processo compreendendo a alimentação do antibiótico de ß-lactama a um compactador de rolo para compactar, reduzir o tamanho, por exemplo,fresagem, para produzir grânulos, onde a temperatura do antibiótico de ß-lactama que é alimentado ao compactador de rolo é suficientemente baixa para que C~H2S(72h)~ < 50 Ál de gás H~2~S por kg de antibiótico de ß-lactama, onde C~H2S(72h)~é o volume de gás H~2~S sobre os grânulos por kg do antibiótico de ß-lactama, quando uma amostra dente 3,5 e 4,5 dos grânulos é mantida em um recipiente fechado com um volume de 20 ml a uma temperatura de 22 C durante 72 horas a pressão atmosférica (100 kPa).
BRPI0512933A 2004-06-30 2005-06-28 grânulos compactados por rolo compreendendo antibiótico de (beta) - lactama e processo para preparação dos ditos grânulos BRPI0512933B8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP04076894 2004-06-30
PCT/EP2005/053036 WO2006003152A1 (en) 2004-06-30 2005-06-28 GRANULES COMPRISING A ß-LACTAM ANTIBIOTIC

Publications (3)

Publication Number Publication Date
BRPI0512933A true BRPI0512933A (pt) 2008-04-15
BRPI0512933B1 BRPI0512933B1 (pt) 2018-11-21
BRPI0512933B8 BRPI0512933B8 (pt) 2021-05-25

Family

ID=34928321

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0512933A BRPI0512933B8 (pt) 2004-06-30 2005-06-28 grânulos compactados por rolo compreendendo antibiótico de (beta) - lactama e processo para preparação dos ditos grânulos

Country Status (7)

Country Link
US (2) US20070248666A1 (pt)
EP (1) EP1786548B1 (pt)
KR (1) KR20070028469A (pt)
CN (1) CN100528318C (pt)
BR (1) BRPI0512933B8 (pt)
ES (1) ES2531598T3 (pt)
WO (1) WO2006003152A1 (pt)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10248293B2 (en) * 2011-09-30 2019-04-02 Nokia Technologies Oy Method, apparatus, computer program and user interface
CN103028346A (zh) * 2012-12-27 2013-04-10 内蒙古沃德生物质科技有限公司 内齿式生物质燃料压粒机
US10318318B2 (en) * 2016-02-26 2019-06-11 Red Hat, Inc. Extending user interface of a web console

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3843639A (en) * 1973-02-08 1974-10-22 Bristol Myers Co Production of cephalexin via methoxymethyl ester
DE2556561C2 (de) * 1975-12-16 1983-04-14 Boehringer Mannheim Gmbh, 6800 Mannheim Verfahren zur Herstellung von porösen Tabletten
TWI225402B (en) * 1996-03-13 2004-12-21 Biochemie Gmbh Auxiliary-free agglomerates
WO1999011261A1 (en) * 1997-08-29 1999-03-11 Dsm N.V. Granules free of excipients
US6358526B1 (en) * 2000-08-16 2002-03-19 Rexall Sundown Method of making tablets and tablet compositions produced therefrom
AR046755A1 (es) * 2003-12-10 2005-12-21 Shell Int Research Pellet de azufre que incluye un supresor h2s

Also Published As

Publication number Publication date
CN100528318C (zh) 2009-08-19
EP1786548A1 (en) 2007-05-23
US20070248666A1 (en) 2007-10-25
KR20070028469A (ko) 2007-03-12
CN1976748A (zh) 2007-06-06
EP1786548B1 (en) 2014-12-24
BRPI0512933B8 (pt) 2021-05-25
WO2006003152A1 (en) 2006-01-12
ES2531598T3 (es) 2015-03-17
US20110011961A1 (en) 2011-01-20
BRPI0512933B1 (pt) 2018-11-21

Similar Documents

Publication Publication Date Title
PH12015502824A1 (en) Crystals
AU2003260822A1 (en) Translation lookaside buffer with partial tag hashed according to page size indicator
MXPA05013734A (es) Hexahidropiroisoquinolinas como inhibidores de dpp-iv.
DE60301491D1 (en) Acc-hemmer
JO2650B1 (en) Solid product
IL187005A0 (en) Diacylglycerol acyltransferase inhibitors
TW200505919A (en) DPP-IV inhibitors
RS20050532A (en) 1,2,3-trisubstituted aryl and heteroaryl derivatives as modulators of metabolism and the prpphylaxis and treatment of disorders related thereto such as diabetes and hyperglycemia
HK1077305A1 (en) Phenyl- and pyridylpipereidinye-derivatives as modulators of glucose metabolism
MY149622A (en) Pyrazoles as 11-beta-hsd-1
WO2007031858A3 (en) An improved process for the preparation of beta-lactam antibiotic
WO2007128480A3 (en) Thioglycosides as pharmaceutically active agents
MY153985A (en) Aminotriazole derivatives as alx agonists
JO2681B1 (en) Indole derivatives
BRPI0512933A (pt) gránulos compreendendo antibiótico de (beta)-lactama
MX2007007174A (es) Derivados de cicloalquilamina.
MX2008009705A (es) Composiciones farmaceuticas que contienen docetaxel, un inhibidor de degradacion y un proceso para obtener el mismo.
CO5070574A1 (es) Derivado del acido fenoxiacetico y composicion farmaceutica que lo contiene
MX2009010567A (es) Derivados de imidazolidinona.
WO2007060448A3 (en) Chemical process for the preparation of an amido-phenoxybenzoic acid compound
MX2008001560A (es) Nuevos compuestos analogos de la camptotecina, un procedimiento para su preparacion y composiciones farmaceuticas que los contienen.
BRPI0410701A (pt) produto farmacêutico estabilizado
ZA200604410B (en) Imidazole derivatives, processes for preparing them and their uses
AR034120A1 (es) Compuesto derivado halogenado del acido 2-amino-4,5 heptenoico, composicion farmaceutica que lo comprende y el uso de dicho compuesto y dicha composicion en la fabricacion de un medicamento para inhibir o modular la sintesis de acido nitrico
UY31223A1 (es) Nueva formula cristalina de 3-(difluorometil)-1-metil-n-(3&#39;,4&#39;,5&#39;-trifluoro[1,1&#39;-bifenil]-2-il)-1h-pirazol-4-carboxamida

Legal Events

Date Code Title Description
B25A Requested transfer of rights approved

Owner name: DSM SINOCHEM PHARMACEUTICALS NETHERLANDS B.V. (NL)

B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 21/11/2018, OBSERVADAS AS CONDICOES LEGAIS.

B16C Correction of notification of the grant [chapter 16.3 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 28/06/2005 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF

B25D Requested change of name of applicant approved

Owner name: CENTRIENT PHARMACEUTICALS NETHERLANDS B.V. (NL)

B25K Entry of change of name and/or headquarter and transfer of application, patent and certificate of addition of invention: republication

Owner name: CENTRIENT PHARMACEUTICALS NETHERLANDS B.V. (NL)

Free format text: RETIFICACAO DO DESPACHO (25.4) ? ALTERACAO DE NOME PUBLICADO NA RPI NO 2636, DE 13/07/2021, QUANTO AO NOME DO DEPOSITANTE NA AVERBACAO.ONDE SE LE: CENTRIENT PHARMACEUTICALS NETHERLANS B.VLEIA-SE: CENTRIENT PHARMACEUTICALS NETHERLANDS B.V.