BRPI0512699A - compostos, processo para a fabricação de compostos, composições farmacêuticas, método para tratamento terapêutico e/ou profilático de doenças que são moduladas por agonistas lxr alfa e/ou lxr beta e uso de tais compostos - Google Patents
compostos, processo para a fabricação de compostos, composições farmacêuticas, método para tratamento terapêutico e/ou profilático de doenças que são moduladas por agonistas lxr alfa e/ou lxr beta e uso de tais compostosInfo
- Publication number
- BRPI0512699A BRPI0512699A BRPI0512699-1A BRPI0512699A BRPI0512699A BR PI0512699 A BRPI0512699 A BR PI0512699A BR PI0512699 A BRPI0512699 A BR PI0512699A BR PI0512699 A BRPI0512699 A BR PI0512699A
- Authority
- BR
- Brazil
- Prior art keywords
- compounds
- lxr
- modulated
- therapeutic
- manufacture
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- C07C215/68—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings and hydroxy groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/38—Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/32—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D277/28—Radicals substituted by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D333/58—Radicals substituted by nitrogen atoms
Abstract
COMPOSTOS, PROCESSO PAPA A FABRICAçãO DE COMPOSTOS, COMPOSIçõES FARMACêUTICAS, MéTODO PARA TRATAMENTO TERAPêUTICO E/OU PROFILáTICO DE DOENçAS QUE SãO MODULADAS POR AGONISTAS LXR ALFA E/OU LXR BETA E USO DE TAIS COMPOSTOS Trata-se de novos derivados de hexafluoroisopropanol de fórmula (I), onde R¬ 1¬ a R¬ 6¬, m e n são definidos na descrição e nas reivindicações bem como sais e ésteres fisiologicamente aceitáveis destes. Estes compostos ligam-se a LXR alfa e LXR beta e podem ser usados com medicamentos.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP04103006 | 2004-06-28 | ||
PCT/EP2005/006397 WO2006000323A1 (en) | 2004-06-28 | 2005-06-15 | Novel hexafluoroisopropanol derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0512699A true BRPI0512699A (pt) | 2008-04-01 |
Family
ID=34970254
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0512699-1A BRPI0512699A (pt) | 2004-06-28 | 2005-06-15 | compostos, processo para a fabricação de compostos, composições farmacêuticas, método para tratamento terapêutico e/ou profilático de doenças que são moduladas por agonistas lxr alfa e/ou lxr beta e uso de tais compostos |
Country Status (12)
Country | Link |
---|---|
US (4) | US7259178B2 (pt) |
EP (1) | EP1763502A1 (pt) |
JP (1) | JP4809338B2 (pt) |
CN (1) | CN1972897A (pt) |
AR (1) | AR049941A1 (pt) |
AU (1) | AU2005256394B2 (pt) |
BR (1) | BRPI0512699A (pt) |
CA (1) | CA2571356A1 (pt) |
MX (1) | MXPA06014807A (pt) |
RU (1) | RU2389718C2 (pt) |
TW (1) | TW200626527A (pt) |
WO (1) | WO2006000323A1 (pt) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1763502A1 (en) * | 2004-06-28 | 2007-03-21 | F.Hoffmann-La Roche Ag | Novel hexafluoroisopropanol derivatives |
CN101087754B (zh) * | 2004-12-22 | 2012-01-18 | 霍夫曼-拉罗奇有限公司 | 环己烷衍生物 |
US7928160B2 (en) * | 2005-08-25 | 2011-04-19 | Ppg Industries Ohio, Inc. | Coating composition of polyurea, polyurethane and flame retardant |
MX2009010567A (es) * | 2007-03-30 | 2009-10-22 | Hoffmann La Roche | Derivados de imidazolidinona. |
WO2009115212A1 (en) * | 2008-03-17 | 2009-09-24 | F. Hoffmann-La Roche Ag | Lxr ligand binding domain (lxr lbd) crystals |
TW201006816A (en) * | 2008-05-15 | 2010-02-16 | Organon Nv | Hexafluoroisopropanol derivatives |
FR2935380B1 (fr) * | 2008-08-29 | 2010-09-10 | Galderma Res & Dev | Nouveaux composes hexafluoro-2-biphenyl-isopropanol, modulateurs des recepteurs de type lxrs, leur procede de preparation et leur application comme medicaments en medecine humaine ou veterinaire ainsi qu'en cosmetique. |
JP5902619B2 (ja) * | 2009-07-10 | 2016-04-13 | ケース ウェスタン リザーブ ユニバーシティCase Western Reserve University | Rxrアゴニスト化合物および方法 |
EP3091970B1 (en) | 2014-01-10 | 2020-10-28 | Rgenix, Inc. | Lxr agonists and uses thereof |
EP3402477A4 (en) | 2016-01-11 | 2019-08-21 | The Rockefeller University | METHODS FOR THE TREATMENT OF DISORDERS ASSOCIATED WITH SUPPRESSIVE CELLS DERIVED FROM MYELOID CELLS |
CN109789129B (zh) * | 2016-07-12 | 2022-04-29 | 延世大学校产学协力团 | 自噬改良材料及其用途 |
CA3078981A1 (en) | 2017-11-21 | 2019-05-31 | Rgenix, Inc. | Polymorphs and uses thereof |
US20220257596A1 (en) | 2019-07-15 | 2022-08-18 | Novartis Ag | Methods for treating meibomian gland dysfunction with liver x receptor agonists |
WO2021119397A1 (en) | 2019-12-13 | 2021-06-17 | Rgenix, Inc. | Metal salts and uses thereof |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5075339A (en) * | 1989-07-28 | 1991-12-24 | Du Pont Merck Pharmaceutical Company | Benzylketone phospholipase A2 inhibitors |
US6316503B1 (en) * | 1999-03-15 | 2001-11-13 | Tularik Inc. | LXR modulators |
AU2003223684A1 (en) * | 2002-04-23 | 2003-11-10 | Chugai Seiyaku Kabushiki Kaisha | Lxr modulators for the treatment of cardiovascular diseases |
AU2003228614A1 (en) * | 2002-04-23 | 2003-11-10 | Chugai Seiyaku Kabushiki Kaisha | Lxr modulators |
US6900244B2 (en) * | 2002-05-24 | 2005-05-31 | Pharmacia Corporation | Anilino liver X-receptor modulators |
EP1763502A1 (en) * | 2004-06-28 | 2007-03-21 | F.Hoffmann-La Roche Ag | Novel hexafluoroisopropanol derivatives |
-
2005
- 2005-06-15 EP EP05750668A patent/EP1763502A1/en not_active Withdrawn
- 2005-06-15 RU RU2007103304/04A patent/RU2389718C2/ru not_active IP Right Cessation
- 2005-06-15 MX MXPA06014807A patent/MXPA06014807A/es active IP Right Grant
- 2005-06-15 AU AU2005256394A patent/AU2005256394B2/en not_active Ceased
- 2005-06-15 CN CNA200580020453XA patent/CN1972897A/zh active Pending
- 2005-06-15 WO PCT/EP2005/006397 patent/WO2006000323A1/en active Application Filing
- 2005-06-15 JP JP2007518482A patent/JP4809338B2/ja not_active Expired - Fee Related
- 2005-06-15 BR BRPI0512699-1A patent/BRPI0512699A/pt not_active IP Right Cessation
- 2005-06-15 CA CA002571356A patent/CA2571356A1/en not_active Abandoned
- 2005-06-24 TW TW094121308A patent/TW200626527A/zh unknown
- 2005-06-24 AR ARP050102607A patent/AR049941A1/es not_active Application Discontinuation
- 2005-06-27 US US11/168,622 patent/US7259178B2/en not_active Expired - Fee Related
-
2007
- 2007-05-08 US US11/801,067 patent/US7608721B2/en not_active Expired - Fee Related
- 2007-06-20 US US11/821,067 patent/US20080096937A1/en not_active Abandoned
-
2009
- 2009-09-10 US US12/556,598 patent/US7897815B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
RU2007103304A (ru) | 2008-08-10 |
WO2006000323A1 (en) | 2006-01-05 |
CA2571356A1 (en) | 2006-01-05 |
US20060004068A1 (en) | 2006-01-05 |
JP2008504313A (ja) | 2008-02-14 |
TW200626527A (en) | 2006-08-01 |
CN1972897A (zh) | 2007-05-30 |
US7897815B2 (en) | 2011-03-01 |
JP4809338B2 (ja) | 2011-11-09 |
US20080096937A1 (en) | 2008-04-24 |
AU2005256394A1 (en) | 2006-01-05 |
US7259178B2 (en) | 2007-08-21 |
AR049941A1 (es) | 2006-09-13 |
US7608721B2 (en) | 2009-10-27 |
MXPA06014807A (es) | 2007-02-12 |
RU2389718C2 (ru) | 2010-05-20 |
AU2005256394B2 (en) | 2008-07-17 |
EP1763502A1 (en) | 2007-03-21 |
US20070213377A1 (en) | 2007-09-13 |
US20100004297A1 (en) | 2010-01-07 |
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Legal Events
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B08L | Patent application lapsed because of non payment of annual fee [chapter 8.12 patent gazette] |
Free format text: REFERENTE AO NAO RECOLHIMENTO DAS 8A E 9A ANUIDADES. |
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B08I | Publication cancelled [chapter 8.9 patent gazette] |
Free format text: ANULADA A PUBLICACAO CODIGO 8.12 NA RPI NO 2260 DE 29/04/2014 POR TER SIDO INDEVIDA. |
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B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE AS 8A, 9A, 10A, 11A, 12A, 13A, 14A E 15A ANUIDADES. |
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B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2602 DE 17-11-2020 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |