BRPI0509543A - derivados de tiazolopiridina, condições farmacêuticas que contêm os mesmos e métodos para tratar condições mediadas por glucocinase - Google Patents
derivados de tiazolopiridina, condições farmacêuticas que contêm os mesmos e métodos para tratar condições mediadas por glucocinaseInfo
- Publication number
- BRPI0509543A BRPI0509543A BRPI0509543-3A BRPI0509543A BRPI0509543A BR PI0509543 A BRPI0509543 A BR PI0509543A BR PI0509543 A BRPI0509543 A BR PI0509543A BR PI0509543 A BRPI0509543 A BR PI0509543A
- Authority
- BR
- Brazil
- Prior art keywords
- conditions
- methods
- pharmaceutical
- glucokinase
- mediated
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4743—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having sulfur as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Abstract
DERIVADOS DE TIAZOLOPIRIDINA, CONDIçõES FARMACêUTICAS QUE CONTêM OS MESMOS E MéTODOS PARA TRATAR CONDIçõES MEDIADAS POR GLUCOCINASE. A presente invenção refere-se a compostos da fórmula (1) que são ativadores de atividade de glucocinase e, da mesma maneira, podem ser empregados como agentes terapêuticos para o tratamento de condições mediadas por glucocinase. Conseqüentemente, os compostos da fórmula (1) podem ser empregados para a prevenção e o tratamento de tolerância á glucose comprometida, diabetes Tipo 2 e obesidade.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US55915104P | 2004-04-02 | 2004-04-02 | |
PCT/EP2005/003454 WO2005095417A1 (en) | 2004-04-02 | 2005-04-01 | Thiazolopyridine derivates, pharmaceutical conditions containing them and methods of treating glucokinase mediated conditions |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0509543A true BRPI0509543A (pt) | 2007-09-18 |
Family
ID=34966970
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0509543-3A BRPI0509543A (pt) | 2004-04-02 | 2005-04-01 | derivados de tiazolopiridina, condições farmacêuticas que contêm os mesmos e métodos para tratar condições mediadas por glucocinase |
Country Status (11)
Country | Link |
---|---|
US (1) | US7781451B2 (pt) |
EP (1) | EP1737870A1 (pt) |
JP (1) | JP2007530631A (pt) |
KR (1) | KR20070006816A (pt) |
CN (1) | CN101098876A (pt) |
AU (1) | AU2005229415B2 (pt) |
BR (1) | BRPI0509543A (pt) |
CA (1) | CA2561157A1 (pt) |
MX (1) | MXPA06011365A (pt) |
RU (1) | RU2006138426A (pt) |
WO (1) | WO2005095417A1 (pt) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE0102299D0 (sv) | 2001-06-26 | 2001-06-26 | Astrazeneca Ab | Compounds |
CA2498089A1 (en) | 2002-10-03 | 2004-06-17 | Novartis Ag | Substituted (thiazol-2-yl) -amide or sulfonamide as glycokinase activators useful in the treatment of type 2 diabetes |
GB0226931D0 (en) | 2002-11-19 | 2002-12-24 | Astrazeneca Ab | Chemical compounds |
CA2560689C (en) * | 2004-04-02 | 2011-03-01 | Novartis Ag | Sulfonamide-thiazolpyridine derivatives as glucokinase activators useful in the treatment of type 2 diabetes |
GT200600429A (es) * | 2005-09-30 | 2007-04-30 | Compuestos organicos | |
GT200600428A (es) * | 2005-09-30 | 2007-05-21 | Compuestos organicos | |
PE20080251A1 (es) | 2006-05-04 | 2008-04-25 | Boehringer Ingelheim Int | Usos de inhibidores de dpp iv |
US7910747B2 (en) * | 2006-07-06 | 2011-03-22 | Bristol-Myers Squibb Company | Phosphonate and phosphinate pyrazolylamide glucokinase activators |
AU2007278261A1 (en) | 2006-07-24 | 2008-01-31 | F. Hoffmann-La Roche Ag | Pyrazoles as glucokinase activators |
TW200831081A (en) * | 2006-12-25 | 2008-08-01 | Kyorin Seiyaku Kk | Glucokinase activator |
KR20090121376A (ko) * | 2007-03-07 | 2009-11-25 | 교린 세이야꾸 가부시키 가이샤 | 글루코키나아제 활성화 물질 |
EP2203448B1 (de) * | 2007-09-21 | 2011-06-22 | Sanofi-Aventis | Phenothiazin-derivate mit doppelbindung, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
MX2010002772A (es) * | 2007-09-21 | 2010-03-31 | Array Biopharma Inc | Derivados de piridin-2-il-amino-1,2,4-tiadiazol como activadores de glucocinasa para el tratamiento de diabetes mellitus. |
MX2010007853A (es) | 2008-01-18 | 2010-10-06 | Astellas Pharma Inc | Derivado de fenilacetamida. |
US7741327B2 (en) | 2008-04-16 | 2010-06-22 | Hoffmann-La Roche Inc. | Pyrrolidinone glucokinase activators |
NZ588462A (en) | 2008-04-28 | 2012-07-27 | Kyorin Seiyaku Kk | Cyclopentylacrylic acid amide derivative |
US8222416B2 (en) | 2009-12-14 | 2012-07-17 | Hoffmann-La Roche Inc. | Azaindole glucokinase activators |
Family Cites Families (40)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6706406B1 (en) * | 1996-11-13 | 2004-03-16 | Fern Investments Limited | Composite steel structural plastic sandwich plate systems |
US6610846B1 (en) | 1999-03-29 | 2003-08-26 | Hoffman-La Roche Inc. | Heteroaromatic glucokinase activators |
RU2242469C2 (ru) | 1999-03-29 | 2004-12-20 | Ф.Хоффманн-Ля Рош Аг | Активаторы глюкокиназы |
US6320050B1 (en) | 1999-03-29 | 2001-11-20 | Hoffmann-La Roche Inc. | Heteroaromatic glucokinase activators |
MXPA01009814A (es) | 1999-03-29 | 2002-04-24 | Hoffmann La Roche | Activadores de la glucoquinasa. |
US6353111B1 (en) | 1999-12-15 | 2002-03-05 | Hoffmann-La Roche Inc. | Trans olefinic glucokinase activators |
ES2248309T3 (es) | 2000-05-03 | 2006-03-16 | F. Hoffmann-La Roche Ag | Activadores de glucoquinasa conteniendo hidantoina. |
CA2407416C (en) | 2000-05-03 | 2006-07-18 | Paige Erin Mahaney | Alkynyl phenyl heteroaromatic glucokinase activators |
US6489485B2 (en) | 2000-05-08 | 2002-12-03 | Hoffmann-La Roche Inc. | Para-amine substituted phenylamide glucokinase activators |
ES2230309T3 (es) * | 2000-05-08 | 2005-05-01 | F. Hoffmann-La Roche Ag | Fenilacetamidas sustituidas y su empleo con ativadores de qucokinasa. |
AU6591401A (en) | 2000-05-08 | 2001-11-20 | Hoffmann La Roche | Para-amine substituted phenylamide glucokinase activators |
ES2243547T3 (es) | 2000-07-20 | 2005-12-01 | F. Hoffmann-La Roche Ag | Bencenacetamida sustituida para alfa-acilo y alfa heteroatomos como activador de glucokinasa. |
US6369232B1 (en) | 2000-08-15 | 2002-04-09 | Hoffmann-La Roche Inc. | Tetrazolyl-phenyl acetamide glucokinase activators |
FR2816509B1 (fr) * | 2000-11-15 | 2004-02-06 | Sod Conseils Rech Applic | Association d'inhibiteurs de calpaine et de piegeurs des formes reactives de l'oxygene |
US6433188B1 (en) | 2000-12-06 | 2002-08-13 | Wendy Lea Corbett | Fused heteroaromatic glucokinase activators |
KR100545431B1 (ko) | 2000-12-06 | 2006-01-24 | 에프. 호프만-라 로슈 아게 | 축합된 이종방향족 글루코키나제 활성화제 |
US6482951B2 (en) | 2000-12-13 | 2002-11-19 | Hoffmann-La Roche Inc. | Isoindolin-1-one glucokinase activators |
SE0102764D0 (sv) | 2001-08-17 | 2001-08-17 | Astrazeneca Ab | Compounds |
US6911545B2 (en) | 2001-12-19 | 2005-06-28 | Hoffman-La Roche Inc. | Crystals of glucokinase and methods of growing them |
CZ2004747A3 (cs) | 2001-12-21 | 2004-11-10 | Novo Nordisk A/S | Deriváty amidů jako GK aktivátory |
EP1496052B1 (en) | 2002-03-26 | 2009-08-05 | Banyu Pharmaceutical Co., Ltd. | Novel aminobenzamide derivative |
CA2482346C (en) | 2002-04-26 | 2010-03-09 | F. Hoffmann-La Roche Ag | Substituted phenylacetamides and their use as glucokinase activators |
AU2003235307A1 (en) | 2002-05-16 | 2003-12-02 | Banyu Pharmaceutical Co., Ltd. | Crystal of glucokinase protein, and method for drug design using the crystal |
JP4881559B2 (ja) | 2002-06-27 | 2012-02-22 | ノボ・ノルデイスク・エー/エス | 治療薬としてのアリールカルボニル誘導体 |
CA2498089A1 (en) | 2002-10-03 | 2004-06-17 | Novartis Ag | Substituted (thiazol-2-yl) -amide or sulfonamide as glycokinase activators useful in the treatment of type 2 diabetes |
AU2003270285B2 (en) | 2002-10-03 | 2007-04-26 | F. Hoffmann-La Roche Ag | Indole-3-carboxamides as glucokinase (GK) activators |
MY141521A (en) | 2002-12-12 | 2010-05-14 | Hoffmann La Roche | 5-substituted-six-membered heteroaromatic glucokinase activators |
DK1585739T3 (da) | 2003-01-06 | 2011-06-20 | Lilly Co Eli | Substituerede arylcyclopropylacetamider som glucokinaseaktivatorer |
WO2004063194A1 (en) | 2003-01-06 | 2004-07-29 | Eli Lilly And Company | Heteroaryl compounds |
JP4621198B2 (ja) | 2003-02-11 | 2011-01-26 | プロシディオン・リミテッド | トリ(シクロ)置換アミドグルコキナーゼ活性化化合物 |
PL378117A1 (pl) * | 2003-02-11 | 2006-03-06 | Prosidion Limited | Tricyklopodstawione związki amidowe |
AU2004220234C1 (en) | 2003-02-13 | 2013-01-17 | Msd K.K. | Novel 2-pyridinecarboxamide derivatives |
EP1600442B1 (en) | 2003-02-26 | 2018-01-17 | Msd K.K. | Heteroarylcarbamoylbenzene derivative |
JP2005190248A (ja) * | 2003-12-26 | 2005-07-14 | Toudai Tlo Ltd | 配列探索システムおよび探索プログラム |
CA2560689C (en) | 2004-04-02 | 2011-03-01 | Novartis Ag | Sulfonamide-thiazolpyridine derivatives as glucokinase activators useful in the treatment of type 2 diabetes |
MXPA06012008A (es) | 2004-04-21 | 2007-01-25 | Prosidion Ltd | Compuestos de amida tri(ciclo) sustituidos. |
JP2008509898A (ja) | 2004-08-12 | 2008-04-03 | プロシディオン・リミテッド | 置換されたフェニルアセトアミドおよびグルコキナーゼ活性化剤としてのこれらの使用 |
JP2008521864A (ja) | 2004-12-03 | 2008-06-26 | トランステック・ファーマ、インコーポレイテッド | ヘテロ芳香族グルコキナーゼ活性化剤 |
GT200600428A (es) | 2005-09-30 | 2007-05-21 | Compuestos organicos | |
GT200600429A (es) | 2005-09-30 | 2007-04-30 | Compuestos organicos |
-
2005
- 2005-04-01 CA CA002561157A patent/CA2561157A1/en not_active Abandoned
- 2005-04-01 BR BRPI0509543-3A patent/BRPI0509543A/pt not_active IP Right Cessation
- 2005-04-01 KR KR1020067020379A patent/KR20070006816A/ko not_active Application Discontinuation
- 2005-04-01 AU AU2005229415A patent/AU2005229415B2/en not_active Ceased
- 2005-04-01 RU RU2006138426/04A patent/RU2006138426A/ru not_active Application Discontinuation
- 2005-04-01 EP EP05739675A patent/EP1737870A1/en not_active Withdrawn
- 2005-04-01 CN CNA2005800161799A patent/CN101098876A/zh active Pending
- 2005-04-01 WO PCT/EP2005/003454 patent/WO2005095417A1/en active Application Filing
- 2005-04-01 JP JP2007505511A patent/JP2007530631A/ja active Pending
- 2005-04-01 MX MXPA06011365A patent/MXPA06011365A/es not_active Application Discontinuation
- 2005-04-01 US US11/547,227 patent/US7781451B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
JP2007530631A (ja) | 2007-11-01 |
KR20070006816A (ko) | 2007-01-11 |
US20070265297A1 (en) | 2007-11-15 |
CA2561157A1 (en) | 2005-10-13 |
US7781451B2 (en) | 2010-08-24 |
WO2005095417A1 (en) | 2005-10-13 |
MXPA06011365A (es) | 2006-12-15 |
AU2005229415B2 (en) | 2009-05-14 |
CN101098876A (zh) | 2008-01-02 |
EP1737870A1 (en) | 2007-01-03 |
AU2005229415A1 (en) | 2005-10-13 |
RU2006138426A (ru) | 2008-05-10 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE AS 6A E 7A ANUIDADES. |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2158 DE 15/05/2012. |