BRPI0507366A - novas piperidinas como moduladores de quimiocima (ccr) - Google Patents

novas piperidinas como moduladores de quimiocima (ccr)

Info

Publication number
BRPI0507366A
BRPI0507366A BRPI0507366-9A BRPI0507366A BRPI0507366A BR PI0507366 A BRPI0507366 A BR PI0507366A BR PI0507366 A BRPI0507366 A BR PI0507366A BR PI0507366 A BRPI0507366 A BR PI0507366A
Authority
BR
Brazil
Prior art keywords
modulators
ccr
chemokine
piperidines
new piperidines
Prior art date
Application number
BRPI0507366-9A
Other languages
English (en)
Inventor
Alcaraz Lilian
Cage Peter
Furber Mark
Kinchin Elizabeth
Luckhurst Christopher
Rigby Aaron
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of BRPI0507366A publication Critical patent/BRPI0507366A/pt

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    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
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    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/52—Oxygen atoms attached in position 4 having an aryl radical as the second substituent in position 4
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
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    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
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Abstract

NOVAS PIPERIDINAS COMO MODULADORES DE QUIMIOCIMA (CCR) A presente invenção refere-se a compostos de fórmula (I) como moduladores da atividade de quimiocina (por exemplo, de CCR3) (para uso, por exemplo, no tratamento de asma).
BRPI0507366-9A 2004-02-02 2005-01-31 novas piperidinas como moduladores de quimiocima (ccr) BRPI0507366A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE0400208A SE0400208D0 (sv) 2004-02-02 2004-02-02 Chemical compounds
PCT/SE2005/000110 WO2005073192A1 (en) 2004-02-02 2005-01-31 Novel piperidines as chemokine modulators (ccr)

Publications (1)

Publication Number Publication Date
BRPI0507366A true BRPI0507366A (pt) 2007-07-03

Family

ID=31713276

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0507366-9A BRPI0507366A (pt) 2004-02-02 2005-01-31 novas piperidinas como moduladores de quimiocima (ccr)

Country Status (19)

Country Link
US (1) US7956070B2 (pt)
EP (1) EP1713772A1 (pt)
JP (2) JP4814109B2 (pt)
KR (1) KR20060128992A (pt)
CN (1) CN1938274A (pt)
AR (1) AR049770A1 (pt)
AU (2) AU2005207817B2 (pt)
BR (1) BRPI0507366A (pt)
CA (1) CA2553089A1 (pt)
CO (1) CO5700747A2 (pt)
IL (1) IL176992A0 (pt)
NO (1) NO20063921L (pt)
NZ (1) NZ548781A (pt)
RU (2) RU2348616C2 (pt)
SE (1) SE0400208D0 (pt)
TW (1) TW200529843A (pt)
UY (1) UY28731A1 (pt)
WO (1) WO2005073192A1 (pt)
ZA (1) ZA200606199B (pt)

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US7897621B2 (en) 2008-03-31 2011-03-01 Hoffmann-La Roche Inc. 2-trifluoromethylnicotinamide derivatives as HDL-cholesterol raising agents
TWI433838B (zh) * 2008-06-25 2014-04-11 必治妥美雅史谷比公司 作為趨化因子受體活性調節劑之六氫吡啶衍生物
US8410107B2 (en) 2010-10-15 2013-04-02 Hoffmann-La Roche Inc. N-pyridin-3-yl or N-pyrazin-2-yl carboxamides
US8669254B2 (en) 2010-12-15 2014-03-11 Hoffman-La Roche Inc. Pyridine, pyridazine, pyrimidine or pyrazine carboxamides as HDL-cholesterol raising agents
TW201418242A (zh) 2012-10-26 2014-05-16 Du Pont 作為除草劑之經取代的三唑
PL3164394T3 (pl) 2014-07-03 2020-09-07 Board Of Regents, The University Of Texas System Inhibitory GLS1 do leczenia chorób
US20160002204A1 (en) * 2014-07-03 2016-01-07 Board Of Regents, The University Of Texas System Gls1 inhibitors for treating disease
CN107921044B (zh) 2015-06-30 2022-01-21 德州大学系统董事会 用于治疗疾病的gls1抑制剂
CA3009355A1 (en) 2015-12-22 2017-06-29 Board Of Regents, The University Of Texas System Salt forms and polymorphs of (r)-1-(4-(6-(2-(4-(3,3-difluorocyclobutoxy)-6-methylpyridin-2-yl) acetamido) pyridazin-3-yl)-2-fluorobutyl)-n-methyl-1h-1,2,3-triazole-4-carboxamide
WO2019079632A1 (en) 2017-10-18 2019-04-25 Board Of Regents, The University Of Texas System GLUTAMINASE INHIBITOR THERAPY
WO2020025574A1 (en) 2018-08-03 2020-02-06 Bayer Aktiengesellschaft Process for the preparation of 6-(haloalkyl)-2-halo-5-acylpyridines and intermediates for this process
CN113121417A (zh) * 2019-12-30 2021-07-16 苏州盛迪亚生物医药有限公司 一种新型哌啶衍生物及其药物用途

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EP1713772A1 (en) 2006-10-25
KR20060128992A (ko) 2006-12-14
NZ548781A (en) 2008-11-28
JP2007519717A (ja) 2007-07-19
AU2005207817B2 (en) 2008-07-24
CN1938274A (zh) 2007-03-28
AU2005207817A1 (en) 2005-08-11
ZA200606199B (en) 2008-04-30
TW200529843A (en) 2005-09-16
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AU2008229856A1 (en) 2008-11-06
US7956070B2 (en) 2011-06-07
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US20070054924A1 (en) 2007-03-08
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