BRPI0506919A - composto ou um sal deste farmaceuticamente aceitável, composição farmacêutica, e, uso de um composto ou de um sal deste farmaceuticamente aceitável - Google Patents

composto ou um sal deste farmaceuticamente aceitável, composição farmacêutica, e, uso de um composto ou de um sal deste farmaceuticamente aceitável

Info

Publication number
BRPI0506919A
BRPI0506919A BRPI0506919-0A BRPI0506919A BRPI0506919A BR PI0506919 A BRPI0506919 A BR PI0506919A BR PI0506919 A BRPI0506919 A BR PI0506919A BR PI0506919 A BRPI0506919 A BR PI0506919A
Authority
BR
Brazil
Prior art keywords
pharmaceutically acceptable
compound
acceptable salt
pharmaceutical composition
diabetes
Prior art date
Application number
BRPI0506919-0A
Other languages
English (en)
Inventor
Guo Q Shi
Peter T Meinke
James F Dropinski
Yong Zhang
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of BRPI0506919A publication Critical patent/BRPI0506919A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/44—Two oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/26—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/62—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems having two or more ring systems containing condensed 1,3-oxazole rings
    • C07D263/64—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems having two or more ring systems containing condensed 1,3-oxazole rings linked in positions 2 and 2' by chains containing six-membered aromatic rings or ring systems containing such rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/34—Oxygen atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Child & Adolescent Psychology (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

COMPOSTO OU UM SAL DESTE FARMACEUTICAMENTE ACEITáVEL, COMPOSIçãO FARMACêUTICA E, USO DE UM COMPOSTO OU DE UM SAL DESTE FARMACEUTICAMENTE ACEITáVEL Fenoxifenil e fenoxibenzil oxazolidino-2,4-dionas e tiazolidino-2,4-dionas da fórmula (I) são agonistas ou agonistas parciais de PPAR gama e são úteis no tratamento e controle da hiperglicemia que é sintomática do diabete tipo II, tal como dislipidemia, hiperlipidemia, hipercolesterolemia, hipertrigliceridemia e obsidade que são freqüentemente associados com diabete tipo 2.
BRPI0506919-0A 2004-01-20 2005-01-18 composto ou um sal deste farmaceuticamente aceitável, composição farmacêutica, e, uso de um composto ou de um sal deste farmaceuticamente aceitável BRPI0506919A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US53763004P 2004-01-20 2004-01-20
PCT/US2005/001344 WO2005070905A1 (en) 2004-01-20 2005-01-18 Antidiabetic oxazolidinediones and thiazolidinediones

Publications (1)

Publication Number Publication Date
BRPI0506919A true BRPI0506919A (pt) 2007-06-05

Family

ID=34807112

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0506919-0A BRPI0506919A (pt) 2004-01-20 2005-01-18 composto ou um sal deste farmaceuticamente aceitável, composição farmacêutica, e, uso de um composto ou de um sal deste farmaceuticamente aceitável

Country Status (22)

Country Link
US (1) US20070173434A1 (pt)
EP (1) EP1709014B1 (pt)
JP (1) JP2007518803A (pt)
KR (1) KR20060128921A (pt)
CN (1) CN100451008C (pt)
AT (1) ATE363475T1 (pt)
AU (1) AU2005206540B2 (pt)
BR (1) BRPI0506919A (pt)
CA (1) CA2553405A1 (pt)
CY (1) CY1106757T1 (pt)
DE (1) DE602005001265T2 (pt)
DK (1) DK1709014T3 (pt)
ES (1) ES2287908T3 (pt)
IL (1) IL176878A0 (pt)
MX (1) MXPA06008190A (pt)
NO (1) NO20063720L (pt)
NZ (1) NZ548556A (pt)
PL (1) PL1709014T3 (pt)
PT (1) PT1709014E (pt)
RU (1) RU2355682C2 (pt)
WO (1) WO2005070905A1 (pt)
ZA (1) ZA200605512B (pt)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006138328A1 (en) * 2005-06-14 2006-12-28 Merck & Co., Inc. Process for the production of antidiabetic oxazolidinediones
AU2006269503A1 (en) 2005-07-06 2007-01-18 Merck & Co., Inc. Antidiabetic oxazolidinediones and thiazolidinediones
CA2612984A1 (en) * 2005-07-20 2007-02-15 Merck & Co., Inc. Antidiabetic oxazolidinediones and thiazolidinediones
WO2008096769A1 (ja) * 2007-02-08 2008-08-14 Daiichi Sankyo Company, Limited 置換されたセルコスポラミド誘導体を含有する医薬
US11241420B2 (en) 2007-04-11 2022-02-08 Omeros Corporation Compositions and methods for prophylaxis and treatment of addictions
US20160331729A9 (en) 2007-04-11 2016-11-17 Omeros Corporation Compositions and methods for prophylaxis and treatment of addictions
AU2019282727A1 (en) 2018-06-06 2020-11-26 Metavant Sciences Gmbh Methods of treating subjects having diabetes with chronic kidney disease
MX2020013567A (es) 2018-06-14 2021-05-27 Poxel Tableta recubierta con pelicula que comprende un derivado de triazina para su uso en el tratamiento de la diabetes.
CN111892569A (zh) * 2019-05-05 2020-11-06 石家庄圣泰化工有限公司 4,4’-联-1,3-二氧戊环-2,2’-二酮的合成方法
CN112898265A (zh) * 2019-11-18 2021-06-04 石家庄圣泰化工有限公司 4,4’-联-1,3-二氧戊环-2,2’-二酮的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH07138258A (ja) * 1993-11-16 1995-05-30 Taiho Yakuhin Kogyo Kk チアゾリジンジオン誘導体又はその塩
US6114526A (en) * 1996-07-01 2000-09-05 Dr. Reddy's Research Foundation Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases
WO1999032465A1 (en) * 1997-12-19 1999-07-01 Merck & Co., Inc. Arylthiazolidinedione derivatives
WO2003018135A1 (en) * 2001-08-24 2003-03-06 Wyeth Holdings Corporation Method of using 5-(arylsulfonyl)-,5-(arylsulfinyl), and 5-(arylsulfanyl)-thiazolidine-2,4-diones for inhibition of farnesyl-protein transferase

Also Published As

Publication number Publication date
IL176878A0 (en) 2006-10-31
RU2355682C2 (ru) 2009-05-20
PT1709014E (pt) 2007-08-13
DK1709014T3 (da) 2007-09-10
AU2005206540B2 (en) 2009-01-08
KR20060128921A (ko) 2006-12-14
US20070173434A1 (en) 2007-07-26
PL1709014T3 (pl) 2007-10-31
ES2287908T3 (es) 2007-12-16
NZ548556A (en) 2009-03-31
JP2007518803A (ja) 2007-07-12
WO2005070905A1 (en) 2005-08-04
MXPA06008190A (es) 2006-08-31
DE602005001265D1 (de) 2007-07-12
EP1709014A1 (en) 2006-10-11
AU2005206540A1 (en) 2005-08-04
RU2006129930A (ru) 2008-02-27
CA2553405A1 (en) 2005-08-04
ZA200605512B (en) 2007-11-28
CN100451008C (zh) 2009-01-14
CN1910163A (zh) 2007-02-07
NO20063720L (no) 2006-10-09
ATE363475T1 (de) 2007-06-15
EP1709014B1 (en) 2007-05-30
DE602005001265T2 (de) 2008-01-31
CY1106757T1 (el) 2012-05-23

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 6A ANUIDADES

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2099 DE 29/03/2011.