BRPI0506548A - métodos para produzir compostos de 4-tetrazolil-4-fenilpiperidina - Google Patents

métodos para produzir compostos de 4-tetrazolil-4-fenilpiperidina

Info

Publication number
BRPI0506548A
BRPI0506548A BRPI0506548-8A BRPI0506548A BRPI0506548A BR PI0506548 A BRPI0506548 A BR PI0506548A BR PI0506548 A BRPI0506548 A BR PI0506548A BR PI0506548 A BRPI0506548 A BR PI0506548A
Authority
BR
Brazil
Prior art keywords
tetrazolyl
methods
phenylpiperidine compounds
alkyl
groups
Prior art date
Application number
BRPI0506548-8A
Other languages
English (en)
Inventor
Kevin Brown
Timothy J Doyle
John W F Whitehead
Original Assignee
Euro Celtique Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Euro Celtique Sa filed Critical Euro Celtique Sa
Publication of BRPI0506548A publication Critical patent/BRPI0506548A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
    • C07D211/64—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4 having an aryl radical as the second substituent in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/22—Nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

MéTODOS PARA PRODUZIR COMPOSTOS DE 4-TETRAZOLIL-FENILPIPERIDINA São apresentados métodos,composição e intermediários,os quais são úteis para produzir compostos de 4-tetrazolil-4-fenilpiperidina de acordo com Fórmula (I), onde Ar¬ 1¬ é - cicloalquila C~ 3~-C~ 8~, fenila,naftila,antrila,fenantrila ou substituída com um ou mais grupos R¬ 2: Ar¬ 2 é fenila, naftila, antrila,fenantrila ou - heteroarila (5 a 7 membros), cada uma sendo não substituída ou substituída com um ou mais grupos R¬ 2¬; Z¬ 1¬ e Z¬ 2¬ são cada um, independentemente , um grupo - (alquila C~ 1~-C~ 3~), -NH-(alquila C~ 1~-C~ 3~) ou -N (alquila C~ 1~-C~ 3~)~2~;n é um número inteiro variando de 1 a 4, m é um número inteiro variando de 0 a 4; e, em certas configurações , a porção fenila anexada á posição 4 do anel de piperidina de um composto de acordo com a Fórmula (I) pode ser opcionalmente substituído com um ou mais grupos R¬ 2¬.
BRPI0506548-8A 2004-01-30 2005-01-31 métodos para produzir compostos de 4-tetrazolil-4-fenilpiperidina BRPI0506548A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US54083904P 2004-01-30 2004-01-30
US55298204P 2004-03-11 2004-03-11
PCT/US2005/003170 WO2005075455A2 (en) 2004-01-30 2005-01-31 Methods for making 4-tetrazolyl-4-phenylpiperidine compounds

Publications (1)

Publication Number Publication Date
BRPI0506548A true BRPI0506548A (pt) 2007-05-02

Family

ID=34841112

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0506548-8A BRPI0506548A (pt) 2004-01-30 2005-01-31 métodos para produzir compostos de 4-tetrazolil-4-fenilpiperidina

Country Status (9)

Country Link
US (2) US7557219B2 (pt)
EP (2) EP1709029A2 (pt)
JP (1) JP4634401B2 (pt)
KR (1) KR100886002B1 (pt)
AU (1) AU2005210496B2 (pt)
BR (1) BRPI0506548A (pt)
CA (2) CA2552087C (pt)
IL (2) IL177038A0 (pt)
WO (1) WO2005075455A2 (pt)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7202259B2 (en) * 2002-11-18 2007-04-10 Euro-Celtique S.A. Therapeutic agents useful for treating pain
CA2552087C (en) 2004-01-30 2011-01-25 Euro-Celtique S.A. Methods for making 4-tetrazolyl-4-phenylpiperidine compounds
FR2891149B1 (fr) 2005-09-26 2007-11-30 Biodex Sarl Composition pharmaceutique a action cicatrisante comprenant un derive de dextrane soluble et un facteur de croissance derive des plaquettes.
WO2017165558A1 (en) 2016-03-22 2017-09-28 Regents Of The University Of Minnesota Combination for treating pain

Family Cites Families (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2425721A (en) * 1945-08-06 1947-08-19 Univ Michigan Thiophene compounds and methods of obtaining the same
BE775611A (fr) 1970-11-24 1972-03-16 Synthelabo Derives de la (diphenyl-3,3 propyl-1)-1 piperidine, leur preparation etles medicaments qui en contiennent
US4695575A (en) * 1984-11-13 1987-09-22 Janssen Pharmaceutica, N.V. 4-[(bicycle heterocyclyl)-methyl and -hetero]-piperidines
US5366987A (en) * 1991-08-22 1994-11-22 Warner-Lambert Company Isoxazolyl-substituted alkyl amide ACAT inhibitors
JPH05297544A (ja) 1992-04-22 1993-11-12 Fuji Photo Film Co Ltd カラー拡散転写写真フィルムユニット
US5606037A (en) * 1992-11-09 1997-02-25 Biochem Pharma Inc. Processes antineoplastic heteronaphthoquinones
US5736523A (en) * 1992-11-09 1998-04-07 Biochem Pharma Inc. Antineoplastic heteronapthoquinones
US5635510A (en) 1993-05-06 1997-06-03 Merrell Pharmaceuticals Inc. Substituted pyrrolidin-3-yl-alkyl-piperidines
US5824690A (en) * 1993-05-06 1998-10-20 Hoechst Marion Roussel Inc. Substituted pyrrolidin-3-yl-alkyl-piperidines
US5502191A (en) * 1993-07-01 1996-03-26 American Cyanamid Company Method of synthesizing sterically hindered 5-substituted-1H-tetrazoles from nitriles using a lewis acid and an azide
US5412102A (en) 1994-05-27 1995-05-02 Syntex (U.S.A.) Inc. Processes for preparing 1-butyl-2-[2'-(2H-tetrazol-5-yl) biphenyl-4-ylmethyl]-1H-indole-3-carboxylic acid
EP0790826A4 (en) * 1994-11-16 1998-11-11 Synaptic Pharma Corp DYHYDROPYRIMIDINE AND THEIR USE
US6268369B1 (en) 1994-11-16 2001-07-31 Synaptic Pharmaceutical Corporation 5-(heterocyclic alkyl)-6-aryl-dihydropyrimidines
US5849737A (en) * 1995-04-14 1998-12-15 The Regents Of The University Of California Compositions and methods for treating pain
US6166085A (en) * 1995-04-14 2000-12-26 The Regents Of The University Of California Method of producing analgesia
JPH08325248A (ja) * 1995-05-26 1996-12-10 Chugoku Kayaku Kk テトラゾール類の新規な合成試薬及びそれを用いたテトラゾール類の製造方法
US5849761A (en) * 1995-09-12 1998-12-15 Regents Of The University Of California Peripherally active anti-hyperalgesic opiates
US6573282B1 (en) 1995-09-12 2003-06-03 Adolor Corporation Peripherally active anti-hyperalgesic opiates
CA2205664C (en) * 1995-09-26 2008-05-20 Toray Industries, Inc. Indole derivatives and medicinal use thereof
WO1997024325A1 (en) 1995-12-28 1997-07-10 Takeda Chemical Industries, Ltd. DIPHENYLMETHANE DERIVATIVES AS MIP-1α/RANTES RECEPTOR ANTAGONISTS
US6221888B1 (en) * 1997-05-29 2001-04-24 Merck & Co., Inc. Sulfonamides as cell adhesion inhibitors
DE59808753D1 (de) * 1997-12-17 2003-07-24 Aventis Pharma Gmbh Verfahren zur Alkylierung von Alkyl- oder Benzylcyanderivaten in Gegenwart von Trialkylaminen oder -phosphinen
TR200002570T2 (tr) * 1998-03-06 2000-12-21 Janssen Pharmaceutica N.V. Glisin naklini önleyiciler
US6308694B1 (en) * 1999-01-11 2001-10-30 Ford Global Technologies, Inc. Flow measurement and control
US6423519B1 (en) * 1998-07-15 2002-07-23 Gpc Biotech Inc. Compositions and methods for inhibiting fungal growth
PE20001420A1 (es) * 1998-12-23 2000-12-18 Pfizer Moduladores de ccr5
US7217714B1 (en) 1998-12-23 2007-05-15 Agouron Pharmaceuticals, Inc. CCR5 modulators
CA2362003C (en) * 1999-03-12 2009-04-21 Boehringer Ingelheim Pharmaceuticals, Inc. Heterocyclic urea and related compounds useful as anti-inflammatory agents
WO2001021169A1 (fr) 1999-09-20 2001-03-29 Takeda Chemical Industries, Ltd. Antagonistes de l'hormone de concentration de la melanine
CA2324330A1 (en) * 1999-11-08 2001-05-08 Ssp Co., Ltd. 4-hydroxy-4-phenylpiperidine derivatives and pharmaceuticals containing the same
US7456198B2 (en) 1999-12-06 2008-11-25 Purdue Pharma L.P. Benzimidazole compounds having nociceptin receptor affinity
JP2003518130A (ja) * 1999-12-22 2003-06-03 メルク フロスト カナダ アンド カンパニー 蛋白チロシンホスファターゼ１ｂ（ｐｔｐ−１ｂ）阻害薬としてのホスホン酸誘導体
WO2001056989A2 (en) 2000-02-01 2001-08-09 Cor Therapeutics, Inc. Inhibitors of factor xa
US6703525B2 (en) * 2000-02-16 2004-03-09 Boehringer Ingelheim Pharmaceuticals, Inc. Sulfonamide intermediates and methods of producing same
US6608052B2 (en) * 2000-02-16 2003-08-19 Boehringer Ingelheim Pharmaceuticals, Inc. Compounds useful as anti-inflammatory agents
EP1277737A4 (en) 2000-03-24 2003-05-07 Meiji Seika Kaisha DIPHENYLALKYLAMINE DERIVATIVES AS AGONISTS OF THE OPIOID -g (d) RECEPTOR
US6544981B2 (en) * 2000-06-09 2003-04-08 Bristol-Myers Squibb Company Lactam inhibitors of factor Xa and method
JPWO2002030896A1 (ja) * 2000-10-12 2004-02-19 エスエス製薬株式会社 ２，２−ジフェニルブタンアミド誘導体及びこれを含有する医薬
EP1373247A2 (en) 2001-03-29 2004-01-02 Tanabe Seiyaku Co., Ltd. Spiroisoquinoline compounds, methods for their preparation and intermediates thereof
TW200403058A (en) * 2002-04-19 2004-03-01 Bristol Myers Squibb Co Heterocyclo inhibitors of potassium channel function
US7202259B2 (en) 2002-11-18 2007-04-10 Euro-Celtique S.A. Therapeutic agents useful for treating pain
CA2552087C (en) 2004-01-30 2011-01-25 Euro-Celtique S.A. Methods for making 4-tetrazolyl-4-phenylpiperidine compounds

Also Published As

Publication number Publication date
US7557219B2 (en) 2009-07-07
AU2005210496A1 (en) 2005-08-18
KR100886002B1 (ko) 2009-03-03
IL208214A0 (en) 2010-12-30
EP1709029A2 (en) 2006-10-11
WO2005075455A3 (en) 2005-12-15
JP2007519749A (ja) 2007-07-19
US20070072909A1 (en) 2007-03-29
CA2552087C (en) 2011-01-25
EP2277875A2 (en) 2011-01-26
CA2720312A1 (en) 2005-08-18
US20090240056A1 (en) 2009-09-24
CA2552087A1 (en) 2005-08-18
EP2277875A3 (en) 2011-04-20
US8039636B2 (en) 2011-10-18
KR20070026397A (ko) 2007-03-08
AU2005210496B2 (en) 2009-04-23
WO2005075455A2 (en) 2005-08-18
IL177038A0 (en) 2006-12-10
JP4634401B2 (ja) 2011-02-16

Similar Documents

Publication Publication Date Title
CR8530A (es) Intermediarios de quinolona como inhibidores de receptores de tirosina quinasas y la sintesis de los mismos
EA200701176A1 (ru) Новые соединения нафталина, способ их получения и фармацевтические композиции, содержащие их
BRPI0601282A (pt) composição, e método de modificar a formação de hidrato de gás
DK1474406T3 (da) Disubstituerede thiazolylcarboxanilider samt deres anvendelse som mikrobicider
BRPI0510260A (pt) método para purificar um composto, e, kit farmacêutico
AR064561A1 (es) Derivados de 2-aza-biciclo[3.1.0]hexano y su uso en la preparacion de un medicamento para el tratamiento de enfermedades relacionadas con disfunciones generales del sistema de la orexina.
NO20063928L (no) Substituerte kinolinforbindelser
NO20071593L (no) Pyrimidinderivater
UY30498A1 (es) Nueva clase de compuestos de benzimidazolilo, sus sales, composiciones farmacéuticas conteniéndolos y aplicaciones
CR10381A (es) Uso de bifenilamidas de acido arilcarboxilico para el tratamiento de semillas
NO20082243L (no) Fremgangsmater og forbindelser for fremstiliing av CC-1065 analoger
ATE389635T1 (de) Pharmazeutisch wirksame piperidinderivate
AR031597A1 (es) Compuestos piperidinos,un proceso para su preparacion, composiciones farmaceuticas,y el uso de dichos compuestos para la fabricacion de un medicamento para uso como inhibidores ccr-3
BR0313686A (pt) Compostos quìmicos
CO6150038A1 (es) Nuevos derivados de diosmetina su procedimiento de preparacion y las composiciones farmaceuticas que los contienen
BRPI0510940A (pt) 1-aza-biciclo-3.1.1-nonanos
UY29892A1 (es) Nuevos derivados de cromano, composiciones farmaceuticas conteniendolos, procesos de preparacion y aplicaciones
DK1893589T3 (da) Substituerede N-benzo[d]isoxazol-3-yl-amin-derivater som inhibitorer af mGluR5-, serotonin-(5-HT) og noradrenalinreceptorer og deres anvendelse til fremstilling af lægemidler
CY1105786T1 (el) Εκδοχα φλαβονων η διαδικασια παρασκευης τους, η εφαρμογη τους ως φαρμακα
DK1644389T3 (da) Pyrinidinforbindelser med phosphonatgrupper som antivirale nukleotidanaloger
BRPI0506548A (pt) métodos para produzir compostos de 4-tetrazolil-4-fenilpiperidina
EA200970497A1 (ru) Производные пиррола, их получение и их применение в терапии
DE602006014001D1 (de) Herstellung von 2-aminothiazol-5-carbonsäurederivaten
EP1650200A4 (en) SULPHONATE COMPOUND AND FLUORESCENCE ENCODER USING THIS
BRPI0510397A (pt) compostos, composições farmacêuticas contendo os mesmos, e métodos de uso dos mesmos

Legal Events

Date Code Title Description
B15K Others concerning applications: alteration of classification

Free format text: ALTERADA DA INT. CL. C07D 401/04, C07D 211/64, C07D 257/04, C07D 307/22, C07C 237/20.

Ipc: C07D 211/64 (2006.01), C07D 257/04 (2006.01), C07D

B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B11E Dismissal acc. art. 34 of ipl - requirements for examination incomplete
B11T Dismissal of application maintained [chapter 11.20 patent gazette]