BRPI0503183A - procedimento para a preparação de um concentrado do fator von willebrand (fvw) por cromatografia e concentrado de fvw suscetìvel de ser assim obtido - Google Patents
procedimento para a preparação de um concentrado do fator von willebrand (fvw) por cromatografia e concentrado de fvw suscetìvel de ser assim obtidoInfo
- Publication number
- BRPI0503183A BRPI0503183A BRPI0503183-4A BRPI0503183A BRPI0503183A BR PI0503183 A BRPI0503183 A BR PI0503183A BR PI0503183 A BRPI0503183 A BR PI0503183A BR PI0503183 A BRPI0503183 A BR PI0503183A
- Authority
- BR
- Brazil
- Prior art keywords
- von willebrand
- concentrate
- fvw
- willebrand factor
- flow rate
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Diabetes (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
"PROCEDIMENTO PARA A PREPARAçãO DE UM CONCENTRADO DO FATOR VON WILLEBRAND (FvW) POR CROMATOGRAFIA E CONCENTRADO DE FvW SUSCETìVEL DE SER ASSIM OBTIDO". A invenção refere-se a um procedimento de preparação de um concentrado do fator von Willebrand de alta pureza de uma fração biológica contendo o fator von Willebrand, incluindo uma separação por cromatografia de troca aniónica empregando como suporte um polímero vinílico, tipo base fraca, a dita separação compreende as etapas de carregamento do suporte cromatográfico com a fração contendo o fator von Willebrand, previamente equilibrado com um tampão apropriado, com uma taxa de fluxo pré-determinada permitindo a retenção do fator von Willebrand, de lavagem do suporte com um tampão ácido, com a taxa de fluxo maior que a taxa de fluxo da etapa a) até que as proteínas não retidas e os contaminantes sejam removidos, de lavagem e equilíbrio do suporte cromatográfico com o tampão e usando a taxa de fluxo da etapa a), e eluição do fator von Willebrand pelo aumento da força iónica da etapa c). A invenção se refere também a um concentrado do fator von Willebrand para uso terapêutico susceptível de ser obtido pela implementação do processo cuja taxa do Fator VIII:C/FvW:RCo é menor que 0,06%.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0408897A FR2874216B1 (fr) | 2004-08-16 | 2004-08-16 | Procede de preparation d'un concentre de facteur von willebrand (fvw) par voie chromatographique et concentre de fvw susceptible d'etre ainsi obtenu |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0503183A true BRPI0503183A (pt) | 2006-05-16 |
Family
ID=34948021
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0503183-4A BRPI0503183A (pt) | 2004-08-16 | 2005-08-10 | procedimento para a preparação de um concentrado do fator von willebrand (fvw) por cromatografia e concentrado de fvw suscetìvel de ser assim obtido |
Country Status (10)
Country | Link |
---|---|
US (1) | US7888476B2 (pt) |
EP (2) | EP1632501B1 (pt) |
JP (1) | JP4822765B2 (pt) |
AU (1) | AU2005203243A1 (pt) |
BR (1) | BRPI0503183A (pt) |
CA (1) | CA2514438A1 (pt) |
DK (2) | DK2292656T3 (pt) |
ES (2) | ES2450967T3 (pt) |
FR (1) | FR2874216B1 (pt) |
PL (2) | PL1632501T3 (pt) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2920429B1 (fr) * | 2007-08-30 | 2012-10-05 | Lfb Biotechnologies | Procede de purification du facteur viii et du facteur von willebrand |
CN105816858A (zh) * | 2007-12-28 | 2016-08-03 | 巴克斯特国际公司 | 重组vwf配方 |
US11197916B2 (en) | 2007-12-28 | 2021-12-14 | Takeda Pharmaceutical Company Limited | Lyophilized recombinant VWF formulations |
ES2298096B1 (es) * | 2008-01-08 | 2009-01-01 | Grifols, S.A. | Procedimiento para la obtencion de un concentrado de factor von willebrand o del complejo de factor viii/factor von willebrand y utilizacionde los mismos. |
EP2326658A4 (en) * | 2008-09-12 | 2013-04-10 | Ge Healthcare Bio Sciences Ab | IMPROVED PROTEIN-AGGREGATE SEPARATION WITH MULTIMODAL ANION EXCHANGERS IN THE PRESENCE OF ZWITTERIONS EXCLUDED FROM THE PROTEIN |
CN102387784B (zh) * | 2008-10-21 | 2014-04-02 | 巴克斯特国际公司 | 冻干的重组vwf配方 |
IT1396528B1 (it) | 2009-01-19 | 2012-12-14 | Kedrion Spa | Nuovo processo di purificazione altamente selettivo di due proteine plasmatiche: von willebrand factor (vwf) e fibronectina (fn). |
WO2012082933A1 (en) | 2010-12-15 | 2012-06-21 | Baxter International, Inc. | Eluate collection using conductivity gradient |
WO2019038350A1 (en) | 2017-08-23 | 2019-02-28 | Csl Behring Gmbh | PROCESS FOR VIRAL FILTERING OF VON WILLEBRAND FACTOR |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4342748A (en) * | 1980-07-08 | 1982-08-03 | President And Fellows Of Harvard College | Sleep-promoting factor |
FR2632309B1 (fr) | 1988-06-07 | 1990-08-24 | Lille Transfusion Sanguine | Procede de purification par voie chromatographique de proteines, notamment de facteur viii, et les produits obtenus |
DE3904354A1 (de) | 1989-02-14 | 1990-08-16 | Behringwerke Ag | Pasteurisiertes, gereinigtes von willebrand-faktor-konzentrat und verfahren zu seiner herstellung |
FR2665449B1 (fr) * | 1990-08-02 | 1995-04-14 | Aquitaine Developp Transf Sang | Procede de fabrication de facteur von willebrand ayant une tres haute purete, depourvu en majeure partie de facteur antihemophilique (fviiic), et facteur von willebrand ainsi obtenu, ainsi qu'une composition pharmaceutique le contenant. |
FR2651437A1 (fr) * | 1989-09-05 | 1991-03-08 | Lille Transfusion Sanguine | Procede de preparation de concentre du complexe facteur viii-facteur von willebrand de la coagulation sanguine a partir de plasma total. |
FR2673632A1 (fr) * | 1991-03-08 | 1992-09-11 | Lille Transfusion Sanguine | Procede de preparation de concentre de facteur von willebrand humain de tres haute purete, approprie a un usage therapeutique. |
DE4204694C3 (de) * | 1992-02-01 | 1995-10-12 | Octapharma Ag | Verfahren zur Gewinnung von hochreinem, virusinaktiviertem Faktor VIII mittels Anionenaustauscher-Chromatographie |
US6518482B2 (en) | 1994-09-13 | 2003-02-11 | American National Red Cross | Transgenic non-human mammals expressing human coagulation factor VIII and von Willebrand factor |
DE4435485C1 (de) * | 1994-10-04 | 1996-03-21 | Immuno Ag | Verfahren zur Gewinnung von hochreinem von Willebrand-Faktor |
AT406867B (de) | 1997-02-27 | 2000-10-25 | Immuno Ag | Verfahren zur gewinnung von hochreinem vwf oder faktor viii/vwf-komplex |
AT405403B (de) * | 1997-02-27 | 1999-08-25 | Immuno Ag | Reinigung von von willebrand-faktor durch kationenaustauscherchromatographie |
US6531577B1 (en) | 1997-12-15 | 2003-03-11 | Hemasure Denmark A/S | von Willebrand factor (vWF)-containing preparation, process for preparing vWF-containing preparations, and use of such preparations |
FR2857267B1 (fr) | 2003-07-09 | 2006-03-10 | Lab Francais Du Fractionnement | Formulation stabilisante et solubilisante pour les proteines cryoprecipitables. |
-
2004
- 2004-08-16 FR FR0408897A patent/FR2874216B1/fr not_active Expired - Fee Related
-
2005
- 2005-07-20 ES ES05291553.5T patent/ES2450967T3/es active Active
- 2005-07-20 EP EP05291553.5A patent/EP1632501B1/fr not_active Not-in-force
- 2005-07-20 EP EP10186193.8A patent/EP2292656B1/fr not_active Not-in-force
- 2005-07-20 DK DK10186193.8T patent/DK2292656T3/da active
- 2005-07-20 PL PL05291553T patent/PL1632501T3/pl unknown
- 2005-07-20 ES ES10186193.8T patent/ES2483151T3/es active Active
- 2005-07-20 PL PL10186193T patent/PL2292656T3/pl unknown
- 2005-07-20 DK DK05291553.5T patent/DK1632501T3/en active
- 2005-07-25 AU AU2005203243A patent/AU2005203243A1/en not_active Abandoned
- 2005-08-03 CA CA002514438A patent/CA2514438A1/fr not_active Abandoned
- 2005-08-10 BR BRPI0503183-4A patent/BRPI0503183A/pt not_active IP Right Cessation
- 2005-08-12 US US11/203,655 patent/US7888476B2/en not_active Expired - Fee Related
- 2005-08-12 JP JP2005234830A patent/JP4822765B2/ja not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
EP2292656B1 (fr) | 2014-05-21 |
CA2514438A1 (fr) | 2006-02-16 |
US20060036081A1 (en) | 2006-02-16 |
PL2292656T3 (pl) | 2014-09-30 |
ES2450967T3 (es) | 2014-03-25 |
FR2874216B1 (fr) | 2006-11-03 |
EP2292656A2 (fr) | 2011-03-09 |
EP1632501A1 (fr) | 2006-03-08 |
DK1632501T3 (en) | 2014-03-03 |
JP4822765B2 (ja) | 2011-11-24 |
PL1632501T3 (pl) | 2014-05-30 |
DK2292656T3 (da) | 2014-07-28 |
AU2005203243A1 (en) | 2006-03-02 |
EP2292656A3 (fr) | 2012-01-25 |
FR2874216A1 (fr) | 2006-02-17 |
US7888476B2 (en) | 2011-02-15 |
JP2006058298A (ja) | 2006-03-02 |
ES2483151T3 (es) | 2014-08-05 |
EP1632501B1 (fr) | 2013-12-25 |
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B08F | Application fees: application dismissed [chapter 8.6 patent gazette] |
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B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2259 DE 22/04/2014. |