BRPI0417517A - método para melhorar eficácia de drogas radiorrotuladas terapêuticas - Google Patents

método para melhorar eficácia de drogas radiorrotuladas terapêuticas

Info

Publication number
BRPI0417517A
BRPI0417517A BRPI0417517-4A BRPI0417517A BRPI0417517A BR PI0417517 A BRPI0417517 A BR PI0417517A BR PI0417517 A BRPI0417517 A BR PI0417517A BR PI0417517 A BRPI0417517 A BR PI0417517A
Authority
BR
Brazil
Prior art keywords
drug
radiolabelled
therapeutic
radiosensitizer
drugs
Prior art date
Application number
BRPI0417517-4A
Other languages
English (en)
Inventor
Werner Krause
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Publication of BRPI0417517A publication Critical patent/BRPI0417517A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0038—Radiosensitizing, i.e. administration of pharmaceutical agents that enhance the effect of radiotherapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1027—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against receptors, cell-surface antigens or cell-surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1045—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against animal or human tumor cells or tumor cell determinants
    • A61K51/1069—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against animal or human tumor cells or tumor cell determinants the tumor cell being from blood cells, e.g. the cancer being a myeloma
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

"MéTODO PARA MELHORAR EFICáCIA DE DROGAS RADIORROTULADAS TERAPêUTICAS". A presente invenção refere-se a drogas radiorrotuladas e métodos para melhorar sua eficácia empregando-se um radiossensibilizador tal que o radiossensibilizador seja ou parte da droga radiorrotulada diretamente ligando-se o radiossensiibilizador à droga radiorrotulada ou produzindo-se uma mistura da droga radiorrotulada e um análogo da droga com o radiossensibilizador ligado à droga ao invés do radiorrótulo.
BRPI0417517-4A 2003-12-11 2004-12-13 método para melhorar eficácia de drogas radiorrotuladas terapêuticas BRPI0417517A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US52847303P 2003-12-11 2003-12-11
PCT/IB2004/004428 WO2005056058A2 (en) 2003-12-11 2004-12-13 Radiosensitizer conjugate to improve the efficacy of radiolabeled drugs

Publications (1)

Publication Number Publication Date
BRPI0417517A true BRPI0417517A (pt) 2007-03-06

Family

ID=34676848

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0417517-4A BRPI0417517A (pt) 2003-12-11 2004-12-13 método para melhorar eficácia de drogas radiorrotuladas terapêuticas

Country Status (14)

Country Link
EP (1) EP1691838A2 (pt)
JP (1) JP2007528874A (pt)
KR (1) KR20060118542A (pt)
CN (1) CN101031319A (pt)
AU (1) AU2004296621A1 (pt)
BR (1) BRPI0417517A (pt)
CA (1) CA2546057A1 (pt)
CR (1) CR8439A (pt)
EC (1) ECSP066618A (pt)
IL (1) IL175674A0 (pt)
MX (1) MXPA06006683A (pt)
NO (1) NO20063207L (pt)
RU (1) RU2006124510A (pt)
WO (1) WO2005056058A2 (pt)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI568453B (zh) * 2011-11-22 2017-02-01 原創生醫股份有限公司 具有螯合型複合微胞之藥物載體及其應用
CN106975078B (zh) * 2017-03-31 2020-11-10 国家纳米科学中心 一种包含多钨酸钆的纳米材料作为增敏剂的用途
WO2024013272A1 (en) * 2022-07-13 2024-01-18 Universite De Montpellier Combined therapy with nanoparticles and radiopharmaceuticals

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR022404A1 (es) * 1999-01-25 2002-09-04 Photogen Inc Metodo y agentes para la terapia de radiacion mejorada
AU2001249608A1 (en) * 2000-03-28 2001-10-08 Beth Israel Deaconess Medical Center Bladder cancer-specific peptides for diagnosis and therapy
CA2436092A1 (en) * 2001-01-29 2002-08-08 Idec Pharmaceutical Corporation Modified antibodies and methods of use
EP1534336A4 (en) * 2002-08-15 2005-12-14 Human Genome Sciences Inc ANTIBODIES IMMUNOSPECIFICALLY FIXING TO TRAIL RECEPTORS

Also Published As

Publication number Publication date
IL175674A0 (en) 2006-09-05
JP2007528874A (ja) 2007-10-18
CR8439A (es) 2006-12-07
RU2006124510A (ru) 2008-01-20
WO2005056058A3 (en) 2006-04-13
ECSP066618A (es) 2006-10-25
EP1691838A2 (en) 2006-08-23
CA2546057A1 (en) 2005-06-23
KR20060118542A (ko) 2006-11-23
MXPA06006683A (es) 2006-08-11
AU2004296621A1 (en) 2005-06-23
WO2005056058A2 (en) 2005-06-23
NO20063207L (no) 2006-07-10
CN101031319A (zh) 2007-09-05

Similar Documents

Publication Publication Date Title
BR0316906A (pt) administração do capsaicinoides
MXPA02012434A (es) Anticuerpos que se unen inmunoespecificamente a estimulador de linfocitos ii.
BR9914051A (pt) Métodos para administração de antibióticos
BR0207883A (pt) Composições de medicamentos à base de anticolenérgicos e inibidores de pde-iv
BR0310092A (pt) Combinação de compostos orgânicos
WO2003055979A3 (en) ANTIBODIES THAT IMMUNOSPECIFICALLY BIND TO BLyS
BRPI0410129A (pt) uso terapêutico de anticorpos anti-cs1
CY1112738T1 (el) Μια συνδυασμενη συνθεση που περιεχει ιβουπροφαινη και παρακεταμολη
TW200510349A (en) Combination of an allosteric inhibitor of matrix metalloproteinase-13 and a ligand to an alpha-2-delta receptor
EP1390491A4 (en) METHOD OF TREATING NEURODEGENERATIVE, PSYCHIATRIC AND OTHER DISEASES WITH DEACETYLASE INHIBITORS
AR077474A2 (es) El uso de un anticuerpo anti tnf alfa neutralizador de alta afinidad, en la fabricacion de un medicamento y conjunto de elementos
DK1534335T3 (da) FcgammaRIIB-specifikke antistoffer og fremgangsmåder til anvendelse deraf
BR0318269A (pt) composições, alvos, métodos e dispositivos para a terapia de distúrbios oculares e perioculares
BR0307998A (pt) Hidroxietilaminas substituìdas
BRPI0411451A (pt) formas de dosagens orais de memantina
BR0215148A (pt) Composições farmacêuticas de agonista parcial 5ht4
BR0211336A (pt) Métodos para o tratamento da fibrose do fìgado
BR0014946A (pt) Uso de dipiridamol ou mopidamol na fabricação de um medicamento para o tratamento e prevenção de distúrbios da microcirculação dependentes da fibrina
BR0313413A (pt) Uso da vacinação beta amilóide juntamente com um inibidor da cox-2 seletivo para o tratamento da doença de alzheimer
BRPI0411176A (pt) combinação farmacêutica consistindo de modafinil e outra droga
BRPI0417517A (pt) método para melhorar eficácia de drogas radiorrotuladas terapêuticas
BR0315659A (pt) Composição farmacêutica oral para administração uma vez ao dia para a liberação controlada de tramadol ou um sal do mesmo
BRPI0407438A (pt) Sistema terapêutico compreendendo amoxicilina e ácido clavulânico
BR0012058A (pt) Combinação sinérgica: gabapentina e pregabalina
BR0204889A (pt) Kit para a redução de dor

Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE AS 3A, 5A, 6A E 7A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2158 DE 15/05/2012.