BRPI0416596A - dispersões amorfas sólidas de um inibidor da mtp para tratamento da obesidade - Google Patents
dispersões amorfas sólidas de um inibidor da mtp para tratamento da obesidadeInfo
- Publication number
- BRPI0416596A BRPI0416596A BRPI0416596-9A BRPI0416596A BRPI0416596A BR PI0416596 A BRPI0416596 A BR PI0416596A BR PI0416596 A BRPI0416596 A BR PI0416596A BR PI0416596 A BRPI0416596 A BR PI0416596A
- Authority
- BR
- Brazil
- Prior art keywords
- mtp inhibitor
- solid amorphous
- obesity treatment
- amorphous dispersions
- solid
- Prior art date
Links
- 239000007787 solid Substances 0.000 title abstract 3
- 208000008589 Obesity Diseases 0.000 title abstract 2
- 239000006185 dispersion Substances 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 235000020824 obesity Nutrition 0.000 title abstract 2
- -1 2-benzyl (methyl) amino-2-oxo-1-phenylethyl Chemical group 0.000 abstract 1
- 239000004305 biphenyl Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 229920000642 polymer Polymers 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Obesity (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Child & Adolescent Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Plant Substances (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US51993103P | 2003-11-14 | 2003-11-14 | |
| PCT/IB2004/003581 WO2005046644A1 (en) | 2003-11-14 | 2004-11-01 | Solid amorphous dispersions of an mtp inhibitor for treatment of obesity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0416596A true BRPI0416596A (pt) | 2007-01-30 |
Family
ID=34590458
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0416596-9A BRPI0416596A (pt) | 2003-11-14 | 2004-11-01 | dispersões amorfas sólidas de um inibidor da mtp para tratamento da obesidade |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US20080293801A1 (https=) |
| EP (1) | EP1696887A1 (https=) |
| JP (1) | JP2007511500A (https=) |
| KR (1) | KR20060096076A (https=) |
| CN (1) | CN1878538A (https=) |
| AR (1) | AR048206A1 (https=) |
| AU (1) | AU2004289110A1 (https=) |
| BR (1) | BRPI0416596A (https=) |
| CA (1) | CA2545443A1 (https=) |
| CO (1) | CO5690536A2 (https=) |
| IL (1) | IL175372A0 (https=) |
| MX (1) | MXPA06005489A (https=) |
| NO (1) | NO20062778L (https=) |
| NZ (1) | NZ546677A (https=) |
| TW (1) | TW200515909A (https=) |
| WO (1) | WO2005046644A1 (https=) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20080068127A (ko) * | 2005-12-15 | 2008-07-22 | 에프. 호프만-라 로슈 아게 | 피롤로[2,3-ｃ]피리딘 유도체 |
| WO2008090198A1 (en) * | 2007-01-25 | 2008-07-31 | Janssen Pharmaceutica Nv | Use of mtp inhibitors for increasing levels of satiety hormones |
| EP2522657B1 (en) | 2010-01-06 | 2016-08-03 | Takeda Pharmaceutical Company Limited | Indole derivative |
| US8313774B1 (en) | 2012-06-26 | 2012-11-20 | Magnifica Inc. | Oral solid composition |
| EP3861989A1 (en) * | 2020-02-07 | 2021-08-11 | Bayer Aktiengesellschaft | Pharmaceutical composition containing regorafenib and a stabilizing agent |
| US12453728B1 (en) | 2024-08-08 | 2025-10-28 | Redux Therapeutics, Llc | Compositions comprising inhibitors of microsomal triglyceride transfer protein and Apo-B secretion |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1146866A (en) * | 1979-07-05 | 1983-05-24 | Yamanouchi Pharmaceutical Co. Ltd. | Process for the production of sustained release pharmaceutical composition of solid medical material |
| US4884235A (en) * | 1988-07-19 | 1989-11-28 | Thiele Alfred A | Micromagnetic memory package |
| WO1992018106A1 (fr) * | 1991-04-16 | 1992-10-29 | Nippon Shinyaku Co., Ltd. | Procede de production d'une dispersion solide |
| US5340591A (en) * | 1992-01-24 | 1994-08-23 | Fujisawa Pharmaceutical Co., Ltd. | Method of producing a solid dispersion of the sparingly water-soluble drug, nilvadipine |
| JP3265680B2 (ja) * | 1992-03-12 | 2002-03-11 | 大正製薬株式会社 | 経口製剤用組成物 |
| DE19504832A1 (de) * | 1995-02-14 | 1996-08-22 | Basf Ag | Feste Wirkstoff-Zubereitungen |
| ES2287971T3 (es) * | 1997-08-11 | 2007-12-16 | Pfizer Products Inc. | Dispersiones farmaceuticas solidas con biodisponibilidad incrementada. |
| KR100575944B1 (ko) * | 2001-06-28 | 2006-05-02 | 화이자 프로덕츠 인코포레이티드 | 미소체 트리글리세라이드 전달 단백질(ｍｔｐ) 및/또는아포지방단백질 ｂ(ａｐｏ ｂ)분비의 억제제로서의트리아미드-치환된 인돌, 벤조푸란 및 벤조티오펜 |
| AR038375A1 (es) * | 2002-02-01 | 2005-01-12 | Pfizer Prod Inc | Composiciones farmaceuticas de inhibidores de la proteina de transferencia de esteres de colesterilo |
-
2004
- 2004-11-01 NZ NZ546677A patent/NZ546677A/en unknown
- 2004-11-01 CN CNA2004800334168A patent/CN1878538A/zh active Pending
- 2004-11-01 MX MXPA06005489A patent/MXPA06005489A/es unknown
- 2004-11-01 WO PCT/IB2004/003581 patent/WO2005046644A1/en not_active Ceased
- 2004-11-01 US US10/595,732 patent/US20080293801A1/en not_active Abandoned
- 2004-11-01 KR KR1020067009334A patent/KR20060096076A/ko not_active Ceased
- 2004-11-01 EP EP04798760A patent/EP1696887A1/en not_active Withdrawn
- 2004-11-01 JP JP2006538977A patent/JP2007511500A/ja not_active Abandoned
- 2004-11-01 CA CA002545443A patent/CA2545443A1/en not_active Abandoned
- 2004-11-01 AU AU2004289110A patent/AU2004289110A1/en not_active Abandoned
- 2004-11-01 BR BRPI0416596-9A patent/BRPI0416596A/pt not_active IP Right Cessation
- 2004-11-12 TW TW093134701A patent/TW200515909A/zh unknown
- 2004-11-12 AR ARP040104185A patent/AR048206A1/es unknown
-
2006
- 2006-05-01 IL IL175372A patent/IL175372A0/en unknown
- 2006-05-12 CO CO06045059A patent/CO5690536A2/es unknown
- 2006-06-14 NO NO20062778A patent/NO20062778L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| CN1878538A (zh) | 2006-12-13 |
| AU2004289110A1 (en) | 2005-05-26 |
| IL175372A0 (en) | 2006-09-05 |
| CO5690536A2 (es) | 2006-10-31 |
| TW200515909A (en) | 2005-05-16 |
| AR048206A1 (es) | 2006-04-12 |
| US20080293801A1 (en) | 2008-11-27 |
| JP2007511500A (ja) | 2007-05-10 |
| KR20060096076A (ko) | 2006-09-05 |
| NZ546677A (en) | 2008-11-28 |
| WO2005046644A1 (en) | 2005-05-26 |
| NO20062778L (no) | 2006-08-14 |
| MXPA06005489A (es) | 2006-08-11 |
| EP1696887A1 (en) | 2006-09-06 |
| CA2545443A1 (en) | 2005-05-26 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| BR0307277A (pt) | Composições farmacêuticas de inibidores da proteìna de transferencia do éster de colesterilo | |
| PL1861365T3 (pl) | N-sulfonylopirole i ich zastosowanie jako inhibitorów deacetylazy histonów | |
| PT1328269E (pt) | Associacao de um antagonista do receptor cb1 e de sibutramina composicoes farmaceuticas que os contem e sua utilizacao para o tratamento da obesidade | |
| BR0205612A (pt) | Componentes e catalisadores para a (co) polimerização de olefinas | |
| DE60317677D1 (de) | Ox40 (=cd134) rezeptor agonisten und therapeutische verwendung | |
| BRPI0602379A (pt) | prótese para anastomose | |
| EA200300073A1 (ru) | Фармацевтические композиции ингибиторов белка переноса холестериловых эфиров | |
| CY1114284T1 (el) | Σουλφονυλοπυρρολες ως hdac αναστολεις | |
| MX2010001657A (es) | Reguladores de mmp-9 y usos de los mismos. | |
| AR038207A1 (es) | Composicion farmaceutica dispersable oralmente de agomelatina | |
| DE60334379D1 (de) | Copolymerverbindung, diese enthaltende polymerzusammensetzung, bilderzeugungsverfahren und dieselbe benutzende bilderzeugungsvorrichtung | |
| BRPI0416596A (pt) | dispersões amorfas sólidas de um inibidor da mtp para tratamento da obesidade | |
| ATE516052T1 (de) | Zusammensetzungen für knochenzemente enthaltend eine nichtpolymerisierbare organoiodverbindung | |
| WO2004024009A8 (en) | Bone plates | |
| BR0315554A (pt) | Dispersões poliméricas com alta estabilidade e processos para sua preparação | |
| BRPI0515776A (pt) | auxiliares de retenção e drenagem | |
| DK1969111T3 (da) | Sammensætninger og fremgangsmåder til at reducere dårlig lugt | |
| ATE503774T1 (de) | Photohärtbare michaeladditionspolymere | |
| BRPI0404824A (pt) | Processos para preparar uma composição de polìmero, um polìmero multifuncional, e uma composição multifuncional para modificação de cabelos | |
| ATE299703T1 (de) | Mmp-hemmer bei bindegewebserweichung | |
| CR9008A (es) | Nuevo procedimiento y compuestos intermedios de preparacion de derivados de n-(1-benzhidril-azetidin-3-il)-n-fenilmetilsulfonamida | |
| BRPI0416482A (pt) | componente sólido de catalisador para a (co) polimerização de etileno, processo para a preparação de um componente sólido, e, catalisador e processo para a (co) polimerização de etileno | |
| AU2003264131A1 (en) | Polarization-optimized axicon system, and an illuminating system for microlithographic projection system having such an axicon system | |
| EP1961295A3 (en) | Elastic bandage for horses' legs and relative method of realisation | |
| DK1580201T3 (da) | Vandig behandlingssammensætning og polymerer til brug heri |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 5A,6A E 7A ANUIDADE(S) |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2129 DE 25/10/2011. |