BRPI0416596A - dispersões amorfas sólidas de um inibidor da mtp para tratamento da obesidade - Google Patents
dispersões amorfas sólidas de um inibidor da mtp para tratamento da obesidadeInfo
- Publication number
- BRPI0416596A BRPI0416596A BRPI0416596-9A BRPI0416596A BRPI0416596A BR PI0416596 A BRPI0416596 A BR PI0416596A BR PI0416596 A BRPI0416596 A BR PI0416596A BR PI0416596 A BRPI0416596 A BR PI0416596A
- Authority
- BR
- Brazil
- Prior art keywords
- mtp inhibitor
- solid amorphous
- obesity treatment
- amorphous dispersions
- solid
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Obesity (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Child & Adolescent Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Indole Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
"DISPERSõES AMORFAS SóLIDAS DE UM INIBIDOR DA MTP PARA TRATAMENTO DA OBESIDADE". Uma composição compreende uma dispersão amorfa sólida compreendendo (S)-N-(2-¢benzil(metil)amino!-2-oxo-1-feniletil)-1-metil-5-¢4<39>-(trifluor ometil)-¢1,1<39>-bifenil!-2-carboxamido!-1H-indol-2-carboxamida e um polímero.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US51993103P | 2003-11-14 | 2003-11-14 | |
PCT/IB2004/003581 WO2005046644A1 (en) | 2003-11-14 | 2004-11-01 | Solid amorphous dispersions of an mtp inhibitor for treatment of obesity |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0416596A true BRPI0416596A (pt) | 2007-01-30 |
Family
ID=34590458
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0416596-9A BRPI0416596A (pt) | 2003-11-14 | 2004-11-01 | dispersões amorfas sólidas de um inibidor da mtp para tratamento da obesidade |
Country Status (16)
Country | Link |
---|---|
US (1) | US20080293801A1 (pt) |
EP (1) | EP1696887A1 (pt) |
JP (1) | JP2007511500A (pt) |
KR (1) | KR20060096076A (pt) |
CN (1) | CN1878538A (pt) |
AR (1) | AR048206A1 (pt) |
AU (1) | AU2004289110A1 (pt) |
BR (1) | BRPI0416596A (pt) |
CA (1) | CA2545443A1 (pt) |
CO (1) | CO5690536A2 (pt) |
IL (1) | IL175372A0 (pt) |
MX (1) | MXPA06005489A (pt) |
NO (1) | NO20062778L (pt) |
NZ (1) | NZ546677A (pt) |
TW (1) | TW200515909A (pt) |
WO (1) | WO2005046644A1 (pt) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE449776T1 (de) * | 2005-12-15 | 2009-12-15 | Hoffmann La Roche | Pyrroloä2,3-cüpyridinderivate |
WO2008090198A1 (en) * | 2007-01-25 | 2008-07-31 | Janssen Pharmaceutica Nv | Use of mtp inhibitors for increasing levels of satiety hormones |
EP2522657B1 (en) * | 2010-01-06 | 2016-08-03 | Takeda Pharmaceutical Company Limited | Indole derivative |
US8313774B1 (en) | 2012-06-26 | 2012-11-20 | Magnifica Inc. | Oral solid composition |
EP3861989A1 (en) * | 2020-02-07 | 2021-08-11 | Bayer Aktiengesellschaft | Pharmaceutical composition containing regorafenib and a stabilizing agent |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1146866A (en) * | 1979-07-05 | 1983-05-24 | Yamanouchi Pharmaceutical Co. Ltd. | Process for the production of sustained release pharmaceutical composition of solid medical material |
US4884235A (en) * | 1988-07-19 | 1989-11-28 | Thiele Alfred A | Micromagnetic memory package |
KR0182801B1 (ko) * | 1991-04-16 | 1999-05-01 | 아만 히데아키 | 고체 분산체의 제조방법 |
US5340591A (en) * | 1992-01-24 | 1994-08-23 | Fujisawa Pharmaceutical Co., Ltd. | Method of producing a solid dispersion of the sparingly water-soluble drug, nilvadipine |
JP3265680B2 (ja) * | 1992-03-12 | 2002-03-11 | 大正製薬株式会社 | 経口製剤用組成物 |
DE19504832A1 (de) * | 1995-02-14 | 1996-08-22 | Basf Ag | Feste Wirkstoff-Zubereitungen |
DE69837903T2 (de) * | 1997-08-11 | 2008-02-14 | Pfizer Products Inc., Groton | Feste pharmazeutische Dispersionen mit erhöhter Bioverfügbarkeit |
SK287806B6 (sk) * | 2001-06-28 | 2011-10-04 | Pfizer Products Inc. | Triamid-substituované indoly, benzofurány a benzotiofény ako inhibítory mikrozómového proteínu prenášajúceho triglyceridu (MTP) a/alebo sekrécie apolipoproteínu B (Apo B) |
AR038375A1 (es) * | 2002-02-01 | 2005-01-12 | Pfizer Prod Inc | Composiciones farmaceuticas de inhibidores de la proteina de transferencia de esteres de colesterilo |
-
2004
- 2004-11-01 NZ NZ546677A patent/NZ546677A/en unknown
- 2004-11-01 BR BRPI0416596-9A patent/BRPI0416596A/pt not_active IP Right Cessation
- 2004-11-01 WO PCT/IB2004/003581 patent/WO2005046644A1/en active Application Filing
- 2004-11-01 CN CNA2004800334168A patent/CN1878538A/zh active Pending
- 2004-11-01 KR KR1020067009334A patent/KR20060096076A/ko not_active Application Discontinuation
- 2004-11-01 JP JP2006538977A patent/JP2007511500A/ja not_active Abandoned
- 2004-11-01 US US10/595,732 patent/US20080293801A1/en not_active Abandoned
- 2004-11-01 AU AU2004289110A patent/AU2004289110A1/en not_active Abandoned
- 2004-11-01 MX MXPA06005489A patent/MXPA06005489A/es unknown
- 2004-11-01 CA CA002545443A patent/CA2545443A1/en not_active Abandoned
- 2004-11-01 EP EP04798760A patent/EP1696887A1/en not_active Withdrawn
- 2004-11-12 TW TW093134701A patent/TW200515909A/zh unknown
- 2004-11-12 AR ARP040104185A patent/AR048206A1/es unknown
-
2006
- 2006-05-01 IL IL175372A patent/IL175372A0/en unknown
- 2006-05-12 CO CO06045059A patent/CO5690536A2/es unknown
- 2006-06-14 NO NO20062778A patent/NO20062778L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
AU2004289110A1 (en) | 2005-05-26 |
NO20062778L (no) | 2006-08-14 |
IL175372A0 (en) | 2006-09-05 |
CO5690536A2 (es) | 2006-10-31 |
TW200515909A (en) | 2005-05-16 |
US20080293801A1 (en) | 2008-11-27 |
NZ546677A (en) | 2008-11-28 |
WO2005046644A1 (en) | 2005-05-26 |
KR20060096076A (ko) | 2006-09-05 |
MXPA06005489A (es) | 2006-08-11 |
CA2545443A1 (en) | 2005-05-26 |
JP2007511500A (ja) | 2007-05-10 |
CN1878538A (zh) | 2006-12-13 |
EP1696887A1 (en) | 2006-09-06 |
AR048206A1 (es) | 2006-04-12 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 5A,6A E 7A ANUIDADE(S) |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2129 DE 25/10/2011. |