BRPI0416123B8 - composição antiinflamatória e composição antiinfecciosa para uso oftálmico ou otolaringológico e método para tratar a dita inflamação e infecção - Google Patents

composição antiinflamatória e composição antiinfecciosa para uso oftálmico ou otolaringológico e método para tratar a dita inflamação e infecção

Info

Publication number
BRPI0416123B8
BRPI0416123B8 BRPI0416123A BRPI0416123A BRPI0416123B8 BR PI0416123 B8 BRPI0416123 B8 BR PI0416123B8 BR PI0416123 A BRPI0416123 A BR PI0416123A BR PI0416123 A BRPI0416123 A BR PI0416123A BR PI0416123 B8 BRPI0416123 B8 BR PI0416123B8
Authority
BR
Brazil
Prior art keywords
composition
ophthalmic
treating
inflammation
infection
Prior art date
Application number
BRPI0416123A
Other languages
English (en)
Inventor
Krishnamoorthy Ramesh
Original Assignee
Bausch & Lomb
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bausch & Lomb filed Critical Bausch & Lomb
Publication of BRPI0416123A publication Critical patent/BRPI0416123A/pt
Publication of BRPI0416123B1 publication Critical patent/BRPI0416123B1/pt
Publication of BRPI0416123B8 publication Critical patent/BRPI0416123B8/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0043—Nose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/7036—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin having at least one amino group directly attached to the carbocyclic ring, e.g. streptomycin, gentamycin, amikacin, validamycin, fortimicins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Ophthalmology & Optometry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Otolaryngology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

"composição antiinflamatória e composição antiinfecciosa para uso oftálmico ou otolaringológico e método para tratar a dita inflamação e infecção". a presente invenção refere-se a formulações para uso tópico, compreendendo antibióticos em combinação com esteróides antiinflamatórios para o tratamento de infecções oftálmicas e inflamação contínua. mais especificamente, a presente invenção refere-se à formulações farmacêuticas oftálmicas compreendendo uma quantidade estabilizadora de ph, constituída de tobramicina e esteróide brando de etabonato de loteprednol.
BRPI0416123A 2003-10-31 2004-10-27 composição antiinflamatória e composição antiinfecciosa para uso oftálmico ou otolaringológico e método para tratar a dita inflamação e infecção BRPI0416123B8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/698,322 US20050095205A1 (en) 2003-10-31 2003-10-31 Combination of loteprednol etabonate and tobramycin for topical ophthalmic use
PCT/US2004/035562 WO2005044231A1 (en) 2003-10-31 2004-10-27 Suspension of loteprednol etabonate and tobramycin for topical ophthalmic use

Publications (3)

Publication Number Publication Date
BRPI0416123A BRPI0416123A (pt) 2007-01-02
BRPI0416123B1 BRPI0416123B1 (pt) 2018-11-21
BRPI0416123B8 true BRPI0416123B8 (pt) 2021-05-25

Family

ID=34550614

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0416123A BRPI0416123B8 (pt) 2003-10-31 2004-10-27 composição antiinflamatória e composição antiinfecciosa para uso oftálmico ou otolaringológico e método para tratar a dita inflamação e infecção

Country Status (14)

Country Link
US (2) US20050095205A1 (pt)
EP (1) EP1677761B1 (pt)
JP (2) JP2007509952A (pt)
KR (1) KR101086990B1 (pt)
CN (1) CN1897917A (pt)
AT (1) ATE391493T1 (pt)
AU (1) AU2004287443B2 (pt)
BR (1) BRPI0416123B8 (pt)
CA (1) CA2544139C (pt)
DE (1) DE602004013035T2 (pt)
ES (1) ES2303967T3 (pt)
HK (1) HK1092354A1 (pt)
TW (1) TWI359022B (pt)
WO (1) WO2005044231A1 (pt)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050197303A1 (en) * 2003-10-31 2005-09-08 Bausch & Lomb Incorporated Combination of loteprednol etabonate and tobramycin for topical ophthalmic use
US20050095205A1 (en) * 2003-10-31 2005-05-05 Ramesh Krishnamoorthy Combination of loteprednol etabonate and tobramycin for topical ophthalmic use
WO2007032997A1 (en) * 2005-09-13 2007-03-22 Bausch & Lomb Incorporated Ophthalmic formulation containing loteprednol etabonate for treatment of dry eye
US20070093461A1 (en) * 2005-10-26 2007-04-26 Bausch & Lomb Incorporated Effect of Loteprednol etabonate on vascular dysfunction
US7767217B2 (en) * 2006-03-14 2010-08-03 Foresight Biotherapeutics Ophthalmic compositions comprising povidone-iodine
KR20160033796A (ko) * 2006-03-28 2016-03-28 자블린 파머슈티칼스 인코포레이티드 저 복용량의 디클로페낙 및 베타-사이클로덱스트린 제형
KR20090010953A (ko) * 2006-03-28 2009-01-30 자블린 파머슈티칼스 인코포레이티드 저 복용량의 비-스테로이드성 항염증성 약물 및 베타-사이클로덱스트린 제형
WO2008085913A1 (en) * 2007-01-04 2008-07-17 Rib-X Pharmaceuticals, Inc. Methods for treating, preventing, or reducing the risk of opthalmic, otic, and nasal infections
CN101317847B (zh) * 2007-06-06 2010-10-13 深圳市瑞谷医药技术有限公司 一种眼用或耳鼻用药物组合物及其用途
US20090239836A1 (en) * 2008-03-24 2009-09-24 Mary Lee Ciolkowski Multifunctional Ophthalmic Compositions
EP2291081B1 (en) * 2008-06-12 2020-06-03 Foresight Biotherapeutics, Inc. Povidone iodine, a novel alternative preservative for ophthalmic compositions
WO2012073856A1 (ja) * 2010-11-29 2012-06-07 千寿製薬株式会社 ジフルプレドナートおよびトブラマイシンを含有する水中油型エマルジョン組成物
WO2013065028A1 (en) * 2011-11-04 2013-05-10 Micro Labs Limited Fixed dose combination containing azithromycin and loteprednol for treatment of ocular infections
US11596599B2 (en) 2012-05-03 2023-03-07 The Johns Hopkins University Compositions and methods for ophthalmic and/or other applications
US9827191B2 (en) * 2012-05-03 2017-11-28 The Johns Hopkins University Compositions and methods for ophthalmic and/or other applications
CA2871745C (en) 2012-05-03 2023-01-24 Kala Pharmaceuticals, Inc. Pharmaceutical nanoparticles showing improved mucosal transport
JP6360039B2 (ja) 2012-05-03 2018-07-18 カラ ファーマシューティカルズ インコーポレイテッド 複数の被覆された粒子を含む組成物、医薬組成物、医薬製剤、及び当該粒子の形成方法
WO2017193060A1 (en) * 2016-05-05 2017-11-09 Veloce Biopharma, Llc Compositions and methods for treatment of inflammation or infection of the eye
CN110996904A (zh) * 2017-05-19 2020-04-10 奥古根有限公司 眼用组合物及使用方法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4710495A (en) * 1980-07-10 1987-12-01 Otsuka Pharmaceutical Co., Ltd. Soft steroids having anti-inflammatory activity
US4996335A (en) * 1980-07-10 1991-02-26 Nicholas S. Bodor Soft steroids having anti-inflammatory activity
US6610675B1 (en) * 1980-07-10 2003-08-26 Nicholas S. Bodor Inactive metabolite approach to soft drug design
US5192535A (en) * 1988-02-08 1993-03-09 Insite Vision Incorporated Ophthalmic suspensions
US5149693A (en) * 1988-03-09 1992-09-22 Alcon Laboratories, Inc. Combination of tobramycin and fluorometholone for topical ophthalmic use
US5340572A (en) * 1993-02-08 1994-08-23 Insite Vision Incorporated Alkaline ophthalmic suspensions
US5540930A (en) * 1993-10-25 1996-07-30 Pharmos Corporation Suspension of loteprednol etabonate for ear, eye, or nose treatment
TW503113B (en) * 1997-01-16 2002-09-21 Senju Pharma Co Aqueous suspension for nasal administration
JP3147076B2 (ja) * 1997-03-14 2001-03-19 千寿製薬株式会社 ロテプレドノール エタボネート水性懸濁液
KR100508227B1 (ko) * 1997-03-14 2006-03-23 센주 세이야꾸 가부시키가이샤 로테프레드놀에타보네이트수성현탁액
US6239113B1 (en) * 1999-03-31 2001-05-29 Insite Vision, Incorporated Topical treatment or prevention of ocular infections
US20010049366A1 (en) * 2000-02-09 2001-12-06 Alcon Universal Ltd. Topical solution formulations containing an antibiotic and a corticosteroid
US20020098154A1 (en) * 2001-01-20 2002-07-25 Dyer Gordon Wayne Methods and apparatus for medicating the nasal sinuses
JP4893305B2 (ja) * 2003-06-19 2012-03-07 ボーダー、ニコラス・エス 局所又は他の局部投与用のソフト抗炎症性ステロイドの活性及び／又は作用持続性の増強
US20050095205A1 (en) * 2003-10-31 2005-05-05 Ramesh Krishnamoorthy Combination of loteprednol etabonate and tobramycin for topical ophthalmic use

Also Published As

Publication number Publication date
ES2303967T3 (es) 2008-09-01
EP1677761B1 (en) 2008-04-09
JP5726774B2 (ja) 2015-06-03
KR20060110312A (ko) 2006-10-24
HK1092354A1 (en) 2007-02-09
CA2544139A1 (en) 2005-05-19
BRPI0416123B1 (pt) 2018-11-21
US20100003334A1 (en) 2010-01-07
DE602004013035D1 (de) 2008-05-21
AU2004287443A1 (en) 2005-05-19
TW200526235A (en) 2005-08-16
WO2005044231A1 (en) 2005-05-19
KR101086990B1 (ko) 2011-11-29
JP2012087151A (ja) 2012-05-10
BRPI0416123A (pt) 2007-01-02
CN1897917A (zh) 2007-01-17
CA2544139C (en) 2012-10-09
JP2007509952A (ja) 2007-04-19
DE602004013035T2 (de) 2009-05-07
TWI359022B (en) 2012-03-01
US20050095205A1 (en) 2005-05-05
AU2004287443B2 (en) 2011-01-27
EP1677761A1 (en) 2006-07-12
ATE391493T1 (de) 2008-04-15

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B15K Others concerning applications: alteration of classification

Free format text: PARA:INT.CI. A61K 9/10, A61K 31/56, A61K 31/7036, A61P 27/02

Ipc: A61K 9/10 (2011.01), A61K 31/56 (2011.01), A61K 31

B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI

B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: INDEFIRO O PEDIDO DE ACORDO COM O(S) ARTIGO(S) 8, 13 E 25 DA LPI

B12B Appeal against refusal [chapter 12.2 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 21/11/2018, OBSERVADAS AS CONDICOES LEGAIS.

B16C Correction of notification of the grant [chapter 16.3 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 27/10/2004 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF