BRPI0415319A - derivado de azol útil como agentes antifúngicos com reduzida interação com citocromos metabólicos - Google Patents

derivado de azol útil como agentes antifúngicos com reduzida interação com citocromos metabólicos

Info

Publication number
BRPI0415319A
BRPI0415319A BRPI0415319-7A BRPI0415319A BRPI0415319A BR PI0415319 A BRPI0415319 A BR PI0415319A BR PI0415319 A BRPI0415319 A BR PI0415319A BR PI0415319 A BRPI0415319 A BR PI0415319A
Authority
BR
Brazil
Prior art keywords
antifungal agents
cytochromes
metabolic
azole derivative
derivative useful
Prior art date
Application number
BRPI0415319-7A
Other languages
English (en)
Inventor
Massimo Pinori
Maria Lattanzio
Daniela Modena
Paolo Mascagni
Original Assignee
Italfarmaco Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Italfarmaco Spa filed Critical Italfarmaco Spa
Publication of BRPI0415319A publication Critical patent/BRPI0415319A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Steroid Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

"DERIVADO DE AZOL úTIL COMO AGENTES ANTIFúNGICOS COM REDUZIDA INTERAçãO COM CITOCROMOS METABóLICOS". A presente invenção refere-se a novos compostos da fórmula geral (I) , suas formas de óxido de N, seus sais com ácidos farmaceuticamente aceitáveis e seus isómeros estereoquímicos, que são úteis como agentes antifúngicos; refere-se a composições farmacêuticas contendo esses compostos como o princípio ativo; refere-se a métodos para a produção dos referidos compostos e das composições farmacêuticas associadas.
BRPI0415319-7A 2003-10-17 2004-10-14 derivado de azol útil como agentes antifúngicos com reduzida interação com citocromos metabólicos BRPI0415319A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT002020A ITMI20032020A1 (it) 2003-10-17 2003-10-17 Nuovi agenti antifungini azolici con diminuita interazione con i citocromi metabolici
PCT/EP2004/011667 WO2005040156A1 (en) 2003-10-17 2004-10-14 Azole derivative useful as antifungal agents with reduced interaction with metabolic cytochromes

Publications (1)

Publication Number Publication Date
BRPI0415319A true BRPI0415319A (pt) 2006-12-05

Family

ID=34509451

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0415319-7A BRPI0415319A (pt) 2003-10-17 2004-10-14 derivado de azol útil como agentes antifúngicos com reduzida interação com citocromos metabólicos

Country Status (17)

Country Link
US (1) US7427620B2 (pt)
EP (1) EP1673368B1 (pt)
JP (1) JP4744446B2 (pt)
KR (1) KR101182740B1 (pt)
CN (1) CN1867565B (pt)
AT (1) ATE463493T1 (pt)
BR (1) BRPI0415319A (pt)
CA (1) CA2542361C (pt)
CY (1) CY1112166T1 (pt)
DE (1) DE602004026457D1 (pt)
DK (1) DK1673368T3 (pt)
ES (1) ES2344703T3 (pt)
IT (1) ITMI20032020A1 (pt)
PL (1) PL1673368T3 (pt)
PT (1) PT1673368E (pt)
SI (1) SI1673368T1 (pt)
WO (1) WO2005040156A1 (pt)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10738324B2 (en) 2010-09-30 2020-08-11 Kagoshima University Growth-regulated viral vector containing the aurora kinase promoter

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3609596A1 (de) * 1986-03-21 1987-10-01 Hoechst Ag 2-azolylmethyl-2-aryl-1,3-dioxolane und deren salze, verfahren zu ihrer herstellung, sie enthaltende mittel und ihre verwendung
EP0237693A1 (fr) 1986-03-21 1987-09-23 Ambrogio Catracchia Gicleur pour le nettoyage des dents et des appareils dentaires
US4788190A (en) * 1986-12-24 1988-11-29 Schering Corporation 2,4,4-tri- and 2,2,4,4-tetra substituted-1,3-dioxolane antifungal, antiallergy compounds
CO4520281A1 (es) * 1993-12-21 1997-10-15 Schering Corp Antifungicos de tetrahidrofurano
AU3483497A (en) * 1996-06-28 1998-01-21 Schering Corporation Solid solution of an antifungal agent with enhanced bioavailability
ES2224364T3 (es) 1997-02-11 2005-03-01 Janssen Pharmaceutica N.V. Azoles antifungicos que contienen esteres de aminoacidos.
EP0957101A1 (en) 1998-05-14 1999-11-17 Janssen Pharmaceutica N.V. Water soluble azoles as broad-spectrum antifungals
FR2807434B1 (fr) 2000-04-05 2002-10-18 Hoechst Marion Roussel Inc Nouveaux derives de la 1,2,3,4-tetrahydroisoquinoleine, leur procede de preparation et leur application comme fongicides

Also Published As

Publication number Publication date
PL1673368T3 (pl) 2010-09-30
CN1867565B (zh) 2011-06-22
CN1867565A (zh) 2006-11-22
DK1673368T3 (da) 2010-06-07
ITMI20032020A1 (it) 2005-04-18
EP1673368A1 (en) 2006-06-28
JP4744446B2 (ja) 2011-08-10
CY1112166T1 (el) 2015-12-09
CA2542361A1 (en) 2005-05-06
WO2005040156A1 (en) 2005-05-06
ES2344703T3 (es) 2010-09-03
KR20060130554A (ko) 2006-12-19
DE602004026457D1 (de) 2010-05-20
CA2542361C (en) 2012-04-24
PT1673368E (pt) 2010-07-09
JP2007533638A (ja) 2007-11-22
KR101182740B1 (ko) 2012-09-13
US20070129376A1 (en) 2007-06-07
US7427620B2 (en) 2008-09-23
ATE463493T1 (de) 2010-04-15
WO2005040156A8 (en) 2005-06-23
SI1673368T1 (sl) 2010-08-31
EP1673368B1 (en) 2010-04-07

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI

B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]