BRPI0412059A - método para a preparação de formulação de liberação controlada - Google Patents

método para a preparação de formulação de liberação controlada

Info

Publication number
BRPI0412059A
BRPI0412059A BRPI0412059-0A BRPI0412059A BRPI0412059A BR PI0412059 A BRPI0412059 A BR PI0412059A BR PI0412059 A BRPI0412059 A BR PI0412059A BR PI0412059 A BRPI0412059 A BR PI0412059A
Authority
BR
Brazil
Prior art keywords
controlled release
release compositions
bioactive agent
present
production
Prior art date
Application number
BRPI0412059-0A
Other languages
English (en)
Portuguese (pt)
Inventor
Gary P Cook
Original Assignee
Pr Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pr Pharmaceuticals Inc filed Critical Pr Pharmaceuticals Inc
Publication of BRPI0412059A publication Critical patent/BRPI0412059A/pt

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605Excipients; Inactive ingredients
    • A61K9/1629Organic macromolecular compounds
    • A61K9/1641Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647Polyesters, e.g. poly(lactide-co-glycolide)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682Processes
    • A61K9/1694Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51Nanocapsules; Nanoparticles
    • A61K9/5107Excipients; Inactive ingredients
    • A61K9/513Organic macromolecular compounds; Dendrimers
    • A61K9/5146Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
    • A61K9/5153Polyesters, e.g. poly(lactide-co-glycolide)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51Nanocapsules; Nanoparticles
    • A61K9/5192Processes
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00Nanotechnology
    • Y10S977/902Specified use of nanostructure
    • Y10S977/904Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/906Drug delivery

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Nanotechnology (AREA)
  • Biomedical Technology (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
BRPI0412059-0A 2003-07-15 2004-07-15 método para a preparação de formulação de liberação controlada BRPI0412059A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US48766303P 2003-07-15 2003-07-15
PCT/US2004/022816 WO2005009356A2 (en) 2003-07-15 2004-07-15 Method for the preparation of controlled release formulations

Publications (1)

Publication Number Publication Date
BRPI0412059A true BRPI0412059A (pt) 2006-09-05

Family

ID=34102710

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0412059-0A BRPI0412059A (pt) 2003-07-15 2004-07-15 método para a preparação de formulação de liberação controlada

Country Status (9)

Country Link
US (1) US8871269B2 (https=)
EP (2) EP1651136B1 (https=)
JP (2) JP5165239B2 (https=)
CN (2) CN1852687B (https=)
AU (1) AU2004259208B2 (https=)
BR (1) BRPI0412059A (https=)
CA (1) CA2532302C (https=)
ES (1) ES2625343T3 (https=)
WO (1) WO2005009356A2 (https=)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070207211A1 (en) * 2003-04-10 2007-09-06 Pr Pharmaceuticals, Inc. Emulsion-based microparticles and methods for the production thereof
EP2548550A1 (en) 2003-04-10 2013-01-23 Surmodics Pharmaceuticals, Inc. Emulsion-based micro particles
JP5165239B2 (ja) 2003-07-15 2013-03-21 ピーアール ファーマシューティカルズ, インコーポレイテッド 制御放出処方物の調製のための方法
WO2005007122A2 (en) * 2003-07-18 2005-01-27 Oakwood Laboratories, L.L.C. Polymer stabilization
WO2005009357A2 (en) 2003-07-23 2005-02-03 Pr Pharmaceuticals, Inc. Controlled release compositions
JP2007517042A (ja) * 2003-12-30 2007-06-28 デュレクト コーポレーション 活性物質、好ましくはgnrhの制御放出のための、好ましくはpegおよびplgの混合物を含有するポリマーインプラント
EP1679065A1 (en) * 2005-01-07 2006-07-12 OctoPlus Sciences B.V. Controlled release compositions for interferon based on PEGT/PBT block copolymers
US20100290982A1 (en) * 2007-04-13 2010-11-18 University Of North Texas Health Science Center At Fort Worth Solid in oil/water emulsion-diffusion-evaporation formulation for preparing curcumin-loaded plga nanoparticles
BRPI0810899A2 (pt) * 2007-04-13 2014-10-29 Univ North Texas Formulação de nanopartículas de plga ativadas carregadas com agente ativo para substâncias nano-terapêuticas anticâncer direcionais.
NZ580700A (en) * 2007-04-19 2012-01-12 Dong A Pharm Co Ltd A biodegradable microsphere composition suitable for the controlled release of glucose controlling peptide and formulation thereof
GB0709322D0 (en) * 2007-05-15 2007-06-20 Nordic Bioscience As Exposure agent for detection of vitamin d
WO2008145183A1 (en) * 2007-05-30 2008-12-04 Nestec S.A. Oil-in-water emulsion and its use for the delayed release of active elements
ES2667945T3 (es) 2007-10-08 2018-05-16 Aurinia Pharmaceuticals Inc. Composiciones oftálmicas que comprenden inhibidores de calcineurina o Inhibidores de mTOR
ES2324009B1 (es) * 2007-11-23 2010-05-21 Gp Pharm S.A. Composicion farmaceutica de liberacion sostenida de somatostatina o un analogo suyo.
US8071914B2 (en) * 2007-12-26 2011-12-06 Noboru Oshima Heating apparatus
JP5222550B2 (ja) * 2007-12-27 2013-06-26 財團法人工業技術研究院 徐放性組成物およびその製造方法
US9161943B2 (en) * 2007-12-31 2015-10-20 Industrial Technology Research Institute Sustained release composition and manufacturing method thereof
WO2009100222A1 (en) * 2008-02-08 2009-08-13 Qps Llc Non-polymeric compositions for controlled drug delivery
CA2730760A1 (en) 2008-07-16 2010-01-21 Surmodics Pharmaceuticals, Inc. Process for preparing microparticles containing bioactive peptides
EP2440185B1 (en) 2009-06-09 2015-04-08 Aurinia Pharmaceuticals Inc. Topical drug delivery systems for ophthalmic use
JP2013501033A (ja) * 2009-08-05 2013-01-10 ピエリス アーゲー リポカリン突然変異タンパク質の制御放出製剤
US20110151028A1 (en) * 2009-12-19 2011-06-23 Filiberto Zadini Topical vaginal preparation
ES2362604B1 (es) * 2009-12-22 2012-06-28 Bcn Peptides, S.A. Formulación tópica oftálmica de péptidos.
UA123856C2 (uk) * 2010-03-11 2021-06-16 Уайт Елелсі Фармацевтичні композиції метилналтрексону та натрію додецилсульфату для перорального введення
JP5222917B2 (ja) * 2010-09-21 2013-06-26 財團法人工業技術研究院 徐放性組成物およびその製造方法
TWI501781B (zh) * 2010-12-10 2015-10-01 Ind Tech Res Inst 可控制釋放的組合物及其製造方法
US10046058B2 (en) 2014-12-02 2018-08-14 Rezolute, Inc. Use of hydrophobic organic acids to increase hydrophobicity of proteins and protein conjugates
US20190224275A1 (en) 2017-05-12 2019-07-25 Aurinia Pharmaceuticals Inc. Protocol for treatment of lupus nephritis
US20190117573A1 (en) * 2017-10-19 2019-04-25 Hyalo Technologies, LLC Composition and method of preparation of risperidone extended release preparation
US20230062487A1 (en) * 2020-01-24 2023-03-02 W. L. Gore & Associates, Inc. Sustained-release matrices for adventitial or periadventitial neural ablation and uses thereof
CN111643483B (zh) * 2020-07-06 2022-03-29 济南大学 一种用于制备加兰他敏缓释微球的方法
US11992559B2 (en) 2021-02-24 2024-05-28 Oakwood Laboratories, Llc Microsphere formulations comprising lurasidone and methods for making and using the same
WO2022226534A2 (en) * 2021-04-23 2022-10-27 Oakwood Laboratories, Llc Microsphere formulations comprising multiple non-identical peptides and methods for making the same
CA3236685A1 (en) * 2021-11-18 2023-05-25 Inventage Lab Inc. Method for preparing microparticles containing poorly soluble drugs
US20250009644A1 (en) * 2021-12-02 2025-01-09 University Of Connecticut Long-acting injectable in situ forming biodegradable implants comprising non-steroidal anti-inflammatory drugs
CN116421578A (zh) * 2023-03-31 2023-07-14 辉粒药业(苏州)有限公司 生长抑素类似物缓释微球及其制备方法
AU2024253395A1 (en) * 2023-04-03 2025-10-02 Ferring B.V. Methods of manufacturing peptide salts

Family Cites Families (59)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3664963A (en) 1969-10-22 1972-05-23 Balchem Corp Encapsulation process
US3780195A (en) 1969-10-22 1973-12-18 Balchem Corp Encapsulation process
DE2059494B2 (de) 1970-12-03 1972-03-16 Licentia Gmbh Biegsamer hohlleiter
JPS523342B2 (https=) 1972-01-26 1977-01-27
US3865352A (en) 1973-11-16 1975-02-11 Minnesota Mining & Mfg Static mixing device
DE2604832A1 (de) 1976-02-07 1977-08-11 Basf Ag Verfahren zur analyse von loesungen
US4171981A (en) 1977-04-29 1979-10-23 The Mead Corporation Process for the production of hot melt coating compositions containing microcapsules
US4183681A (en) 1978-05-19 1980-01-15 Exxon Research & Engineering Co. Emulsion preparation method using a packed tube emulsifier
US4299501A (en) 1979-08-10 1981-11-10 Ortho Pharmaceutical Corporation Continuous process for the preparation of semisolid dispersions
US4384975A (en) * 1980-06-13 1983-05-24 Sandoz, Inc. Process for preparation of microspheres
US4933105A (en) 1980-06-13 1990-06-12 Sandoz Pharm. Corp. Process for preparation of microspheres
US4389330A (en) 1980-10-06 1983-06-21 Stolle Research And Development Corporation Microencapsulation process
US4897268A (en) 1987-08-03 1990-01-30 Southern Research Institute Drug delivery system and method of making the same
GB2209937B (en) 1987-09-21 1991-07-03 Depiopharm S A Water insoluble polypeptides
DE3732370A1 (de) 1987-09-25 1989-04-06 Hoechst Ag Verfahren zur vermischung von lebenden zellen oder mikroorganismen mit einer viskosen fluessigkeit und mischungen, die nach diesem verfahren hergestellt wurden
WO1990013361A1 (en) 1989-05-04 1990-11-15 Southern Research Institute Improved encapsulation process and products therefrom
PH30995A (en) 1989-07-07 1997-12-23 Novartis Inc Sustained release formulations of water soluble peptides.
US5112604A (en) * 1989-09-01 1992-05-12 Riker Laboratories, Inc. Oral suspension formulation
MY107937A (en) * 1990-02-13 1996-06-29 Takeda Chemical Industries Ltd Prolonged release microcapsules.
US6120805A (en) * 1990-04-06 2000-09-19 Rhone-Poulenc Rorer Sa Microspheres, process for their preparation and their use
FR2660556B1 (fr) 1990-04-06 1994-09-16 Rhone Poulenc Sante Microspheres, leur procede de preparation et leur utilisation.
US5733566A (en) 1990-05-15 1998-03-31 Alkermes Controlled Therapeutics Inc. Ii Controlled release of antiparasitic agents in animals
NZ260909A (en) 1993-07-05 1995-04-27 Takeda Chemical Industries Ltd Production of sustained release preparation by allowing a water-soluble polypeptide to permeate into a biodegradable matrix in an aqueous solution
CA2474701C (en) 1993-11-19 2009-01-27 Alkermes Controlled Therapeutics Inc. Ii Preparation of biodegradeable microparticles containing a biologically active agent
JP2832143B2 (ja) 1993-12-28 1998-12-02 信越化学工業株式会社 シリコーン微粒子およびその製造方法
WO1997004747A1 (en) 1995-07-27 1997-02-13 Dunn James M Drug delivery systems for macromolecular drugs
US5629277A (en) * 1995-10-04 1997-05-13 William L. Brown Paint removing composition
US6140040A (en) 1995-10-06 2000-10-31 Advanced Minerals Corporation Method of mechanically separating microparticles suspended in fluids using particulate media
EP0799616A1 (en) 1996-04-01 1997-10-08 Takeda Chemical Industries, Ltd. Oral composition comprising a fumagillol derivative
AU5678398A (en) * 1997-01-29 1998-08-18 Takeda Chemical Industries Ltd. Sustained-release microspheres, their production and use
JPH10273447A (ja) 1997-01-29 1998-10-13 Takeda Chem Ind Ltd 徐放性マイクロスフィア、その製造法および用途
SE9701161D0 (sv) * 1997-03-27 1997-03-27 Karolinska Innovations Ab New use I
AR012448A1 (es) 1997-04-18 2000-10-18 Ipsen Pharma Biotech Composicion en forma de microcapsulas o de implantes que comprende un excipiente biodegradable, polimero o co-polimero, o una mezcla de talesexcipientes, y una sustancia activa o una mezcla de sustancias activas, procedimiento para la preparacion de una sustancia soluble en agua de elevada
ES2175668T3 (es) 1997-12-16 2002-11-16 Chiron Corp Uso de microparticulas combinadas con emulsiones de aceite en agua submicronicas.
CA2316273A1 (en) 1998-01-16 1999-07-22 Takeda Chemical Industries, Ltd. Sustained-release composition, method of its production and use thereof
US6270700B1 (en) * 1998-07-23 2001-08-07 Societe De Conseils De Recherches Et D'applications Scientifiques, Sas Encapsulation of water soluble peptides
JP3012608B1 (ja) 1998-09-17 2000-02-28 農林水産省食品総合研究所長 マイクロチャネル装置及び同装置を用いたエマルションの製造方法
US6194006B1 (en) * 1998-12-30 2001-02-27 Alkermes Controlled Therapeutics Inc. Ii Preparation of microparticles having a selected release profile
EP1044683A1 (en) * 1999-04-15 2000-10-18 Debio Recherche Pharmaceutique S.A. One-step dispersion method for the microencapsulation of water soluble substances
US6291013B1 (en) 1999-05-03 2001-09-18 Southern Biosystems, Inc. Emulsion-based processes for making microparticles
US7919119B2 (en) 1999-05-27 2011-04-05 Acusphere, Inc. Porous drug matrices and methods of manufacture thereof
AU7853500A (en) 1999-10-08 2001-04-23 Procter & Gamble Company, The Apparatus and process for in-line preparation of hipes
AUPQ529000A0 (en) * 2000-01-28 2000-02-17 Research Laboratories Of Australia Pty Ltd Toner characterization cell
US6953593B2 (en) 2000-02-01 2005-10-11 Lipoprotein Technologies, Inc. Sustained-release microencapsulated delivery system
US6264987B1 (en) 2000-05-19 2001-07-24 Alkermes Controlled Therapeutics Inc. Ii Method for preparing microparticles having a selected polymer molecular weight
US6306423B1 (en) 2000-06-02 2001-10-23 Allergan Sales, Inc. Neurotoxin implant
JP2002126043A (ja) * 2000-07-17 2002-05-08 Takeda Chem Ind Ltd 凍結乾燥物の製造法
US6565873B1 (en) 2000-10-25 2003-05-20 Salvona Llc Biodegradable bioadhesive controlled release system of nano-particles for oral care products
ES2382636T3 (es) * 2000-10-31 2012-06-12 Surmodics Pharmaceuticals, Inc. Método para producir composiciones para la administración mejorada de moléculas bioactivas
EP1352269A2 (en) 2001-01-15 2003-10-15 3M Innovative Properties Company Multilayer infrared reflecting film with high and smooth transmission in visible wavelength region and laminate articles made therefrom
WO2002058672A2 (en) 2001-01-26 2002-08-01 Debio Recherche Pharmaceutique S.A. Microparticles of biodegradable polymer encapsulating a biologically active substance
AR034641A1 (es) 2001-06-29 2004-03-03 Takeda Pharmaceutical Composicion de liberacion controlada y metodo para producirla
US20060083778A1 (en) 2002-05-03 2006-04-20 Dean Allison Controlled release compositions of estradiol metabolites
US20100143485A1 (en) * 2003-03-05 2010-06-10 Hudnut Paul S Oxycontin controlled release formulations and methods of using same
EP2548550A1 (en) 2003-04-10 2013-01-23 Surmodics Pharmaceuticals, Inc. Emulsion-based micro particles
US20070207211A1 (en) 2003-04-10 2007-09-06 Pr Pharmaceuticals, Inc. Emulsion-based microparticles and methods for the production thereof
CA2521381C (en) 2003-04-11 2020-05-26 Rezolute, Inc. Method for preparation of site-specific protein conjugates
JP5165239B2 (ja) 2003-07-15 2013-03-21 ピーアール ファーマシューティカルズ, インコーポレイテッド 制御放出処方物の調製のための方法
WO2005009357A2 (en) 2003-07-23 2005-02-03 Pr Pharmaceuticals, Inc. Controlled release compositions

Also Published As

Publication number Publication date
CN1852687A (zh) 2006-10-25
CA2532302C (en) 2016-12-20
EP2462896A1 (en) 2012-06-13
CA2532302A1 (en) 2005-02-03
EP1651136A2 (en) 2006-05-03
US8871269B2 (en) 2014-10-28
AU2004259208B2 (en) 2011-04-28
ES2625343T3 (es) 2017-07-19
AU2004259208A1 (en) 2005-02-03
JP2011144207A (ja) 2011-07-28
EP1651136A4 (en) 2009-07-08
WO2005009356A2 (en) 2005-02-03
WO2005009356A3 (en) 2005-06-09
EP1651136B1 (en) 2017-03-08
JP5165239B2 (ja) 2013-03-21
CN1852687B (zh) 2014-01-22
JP2007524645A (ja) 2007-08-30
CN102935069A (zh) 2013-02-20
US20060228414A1 (en) 2006-10-12

Similar Documents

Publication Publication Date Title
BRPI0412059A (pt) método para a preparação de formulação de liberação controlada
AR037490A1 (es) Composiciones farmaceuticas solidas, proceso para su preparacion, kit para el tratamiento de la obesidad y uso de dichas composiciones en la elaboracion de medicamentos
AR088381A1 (es) Formulaciones de etanercept estabilizadas con meglumina
ES2178268T3 (es) Formulaciones de liberacion controlada.
AR063471A1 (es) Formulaciones para administracion parenteral de compuestos y sus usos
AR029462A1 (es) Derivados del acido picolinico, procedimiento para prepararlos y composiciones formuladas con dichos derivados como agente activo, procedimientos preventivos o curativos contra hongos fitopatogenos, metodos preventivos o de tratamiento de la madera para la construccion utilizando dichos compuestos y
AR084285A1 (es) Composiciones inmunogenicas
BR0107535A (pt) Uso de carotenóides e forma de dosagem unitária destes
BRPI0507473A (pt) cápsula de gelatina mole, uso de pelo menos um ácido graxo polinsaturado Èmega-3, processo para a manufatura de uma cápsula de gelatina mole, uso de gelatina extraìda por um processo de extração, e, método de tratamento ou de profilaxia de uma condição
BR0316310A (pt) Composições farmacêuticas tendo um veìculo modificado
BRPI0509062A (pt) composição para preparação farmacêutica sólida de solifenacina ou seu sal
SV2002000250A (es) Formula de dosis de droga accionada por hidrogel ref. pc10818ajtb/bb
AR043863A1 (es) Composiciones que contienen piperacilina y tazobactam, utiles para inyeccioines
BR112018074352A2 (pt) partículas de nanoalume contendo um agente de dimensionamento
BRPI0508933A (pt) composições para entrega tópica
CL2018001420A1 (es) Tratamiento de trastornos cognitivos con (r)-7-cloro-n-(quinuclidin-3-il)benzo[b]tiofeno-2-carboxamida y sales farmacéuticamente aceptables de la misma. (divisional solicitud 201701853)
AR060063A1 (es) Material cementicio, formulacion de material cementicio y articulo obtenido
BR0311460A (pt) Composição farmacêutica de liberação modificada, uso de uma formulação, e, método para tratar um distúrbio cardiovascular em um paciente
BR112015021124A2 (pt) solução para acne
PE20050822A1 (es) Derivados de florfenicol con mejor solubilidad en agua
AR109263A2 (es) Composición que comprende moxidectina
BR112022026699A2 (pt) Mecanismo de liberação de fragrâncias, método e usos do mesmo
BR0109672A (pt) Uso de zd6126 ou de um seu sal farmaceuticamente aceitável e um de: um agente antitumoral de plantina e um taxano, composição farmacêutica, produto de combinação, kit, e, método para a produção de um efeito de danificação vascular em um animal de sangue quente
BRPI0412063A (pt) um método para produzir ácido orgánico
BRPI0707488B8 (pt) método para a produção de uma composição de epoprostenol, composição farmacêutica e solução estável

Legal Events

Date Code Title Description
B08F Application fees: dismissal - article 86 of industrial property law

Free format text: REFERENTE A 7A ANUIDADE.

B08K Lapse as no evidence of payment of the annual fee has been furnished to inpi (acc. art. 87)

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2159 DE 22/05/2012.