BRPI0411679A - agente para inibição da reprodução de vìrus na membrana, método para a produção da mesma, composição farmacêutica e método para inibição da infecção viral - Google Patents
agente para inibição da reprodução de vìrus na membrana, método para a produção da mesma, composição farmacêutica e método para inibição da infecção viralInfo
- Publication number
- BRPI0411679A BRPI0411679A BRPI0411679-8A BRPI0411679A BRPI0411679A BR PI0411679 A BRPI0411679 A BR PI0411679A BR PI0411679 A BRPI0411679 A BR PI0411679A BR PI0411679 A BRPI0411679 A BR PI0411679A
- Authority
- BR
- Brazil
- Prior art keywords
- virus
- inhibiting
- membrane
- agent
- viral infection
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 7
- 241000700605 Viruses Species 0.000 title abstract 5
- 230000002401 inhibitory effect Effects 0.000 title abstract 5
- 239000012528 membrane Substances 0.000 title abstract 5
- 238000004519 manufacturing process Methods 0.000 title abstract 3
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 3
- 208000036142 Viral infection Diseases 0.000 title abstract 2
- 230000009385 viral infection Effects 0.000 title abstract 2
- 239000003795 chemical substances by application Substances 0.000 abstract 3
- XMWRBQBLMFGWIX-UHFFFAOYSA-N C60 fullerene Chemical compound C12=C3C(C4=C56)=C7C8=C5C5=C9C%10=C6C6=C4C1=C1C4=C6C6=C%10C%10=C9C9=C%11C5=C8C5=C8C7=C3C3=C7C2=C1C1=C2C4=C6C4=C%10C6=C9C9=C%11C5=C5C8=C3C3=C7C1=C1C2=C4C6=C2C9=C5C3=C12 XMWRBQBLMFGWIX-UHFFFAOYSA-N 0.000 abstract 2
- 241000711549 Hepacivirus C Species 0.000 abstract 2
- 241000725303 Human immunodeficiency virus Species 0.000 abstract 2
- 229910003472 fullerene Inorganic materials 0.000 abstract 2
- 208000035473 Communicable disease Diseases 0.000 abstract 1
- 241000700584 Simplexvirus Species 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 150000001450 anions Chemical class 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 231100000053 low toxicity Toxicity 0.000 abstract 1
- 230000007246 mechanism Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
- 230000029812 viral genome replication Effects 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/785—Polymers containing nitrogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/55—Protease inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Communicable Diseases (AREA)
- Gastroenterology & Hepatology (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Biotechnology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
"AGENTE PARA INIBIçãO DA REPRODUçãO DE VìRUS NA MEMBRANA, MéTODO PARA A PRODUçãO DA MESMA, COMPOSIçãO FARMACêUTICA E MéTODO PARA INIBIçãO DA INFECçãO VIRAL". A presente invenção se refere à indústria farmacêutica e mais especificamente ao fornecimento de um agente para a inibição da replicação de vírus na membrana, o objeto da invenção é fornecer um agente com base nos anions policarboxílicos de fulereno para a supressão da atividade dos vírus nas membranas no tratamento de doenças causadas por esses vírus; para realizar o referido objetivo, foi proposto um grupo de invenções reunidas por um conceito inventivo em comum, o referido grupo compreende um método para preparar compostos, estudando os mecanismos de ação, provisão de composições farmacêuticas e desenvolvimento de métodos de tratamento com seu uso; o referido objeto é obtido através da seleção de razões quantitativas dos componentes e das condições de reação, as quais garantem o preparado dos produtos de poliadição; estabeleceu-se que ao conduzir a síntese, a quantia de aminoácidos deve exceder a quantia de fulereno em mais de 50 vezes; o produto preparado pelo método proposto possui uma solubilidade ilimitada na água, biodisponibilidade necessária, alta eficácia de ação nas células não-infectadas, baixa toxicidade; o conteúdo da principal substância no produto alvo é de pelo menos 90%; o processo é adaptável à produção em linha de fluxo e pode ser utilizado na indústria farmacêutica; composições de drogas e métodos de tratamento de doenças infecciosas causadas pelo vírus da imunodeficiência humana (HIV), vírus do herpes simplex (HSC) e vírus da hepatite C (HCV) foram desenvolvidos
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RU2003118500/15A RU2236852C1 (ru) | 2003-06-23 | 2003-06-23 | Средство для ингибирования репродукции оболоченных вирусов, способ его получения, фармацевтическая композиция и способ ингибирования вирусных инфекций |
| PCT/RU2004/000208 WO2004112804A1 (fr) | 2003-06-23 | 2004-05-31 | Agent d'inhibition de la reproduction de virus a membrane, procede de production dudit agent, composition pharmaceutique et methode d'inhibition des infections virales |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0411679A true BRPI0411679A (pt) | 2006-08-29 |
Family
ID=33434013
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0411679-8A BRPI0411679A (pt) | 2003-06-23 | 2004-05-31 | agente para inibição da reprodução de vìrus na membrana, método para a produção da mesma, composição farmacêutica e método para inibição da infecção viral |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US20060122276A1 (pt) |
| EP (1) | EP1645279A4 (pt) |
| JP (1) | JP2007522082A (pt) |
| KR (1) | KR20060017887A (pt) |
| CN (1) | CN1819834A (pt) |
| AP (1) | AP2006003495A0 (pt) |
| AU (1) | AU2004249090A1 (pt) |
| BR (1) | BRPI0411679A (pt) |
| CA (1) | CA2530004A1 (pt) |
| EA (1) | EA010483B1 (pt) |
| GE (1) | GEP20084377B (pt) |
| IL (1) | IL172634A0 (pt) |
| RU (1) | RU2236852C1 (pt) |
| UA (1) | UA82528C2 (pt) |
| WO (1) | WO2004112804A1 (pt) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2006160664A (ja) * | 2004-12-07 | 2006-06-22 | Vitamin C60 Bioresearch Kk | フリーラジカル疾患予防治療用組成物 |
| CA2687557A1 (en) * | 2007-06-19 | 2008-12-31 | Institute Of Problems Of Chemical Physics Ras (Ipcp Ras) | Polyfunctional fullerene c60 amino acid derivatives |
| RU2462473C2 (ru) * | 2007-06-19 | 2012-09-27 | Учреждение Российской Академии Наук Институт Проблем Химической Физики Ран (Ипхф Ран) | Полифункциональные аминокислотные производные фуллерена c60 |
| AU2008320642A1 (en) * | 2007-10-29 | 2009-05-07 | Cipla Limited | Novel antiretroviral combination |
| RU2458914C1 (ru) * | 2011-02-01 | 2012-08-20 | Лев Давидович Раснецов | Гомо- и гетеро-полиаминокислотные производные фуллерена c60, способ их получения и фармацевтические композиции на их основе |
| RU2458046C1 (ru) * | 2011-02-01 | 2012-08-10 | Лев Давидович Раснецов | Гидратированные n-фуллерен-аминокислоты, способ их получения и фармацевтические композиции на их основе |
| RU2477273C2 (ru) | 2011-03-30 | 2013-03-10 | Учреждение Российской Академии Наук Институт Проблем Химической Физики Ран (Ипхф Ран) | Серосодержащие производные фуллеренов и способ их получения |
| RU2501785C2 (ru) * | 2011-08-30 | 2013-12-20 | Федеральное государственное бюджетное учреждение науки Институт проблем химической физики Российской академии наук | Применение пентааминофуллеренов в качестве противомикробных средств и противомикробная композиция на их основе |
| CN103347848B (zh) * | 2012-02-06 | 2016-09-21 | 列夫·达维多维奇·拉斯涅特索夫 | 水合n-富勒烯氨基酸、其制备方法和以它为基础的药物组合物 |
| CN103347849B (zh) * | 2012-02-06 | 2016-05-11 | 列夫·达维多维奇·拉斯涅特索夫 | 富勒烯с60的均聚氨基酸和杂多氨基酸衍生物、其制备方法和基于该衍生物的药物组合物 |
| RU2533232C2 (ru) * | 2012-07-20 | 2014-11-20 | Федеральное государственное бюджетное учреждение "Научно-исследовательский институт вирусологии им. Д.И. Ивановского" Министерства здравоохранения и социального развития Российской Федерации (ФГБУ "НИИ вирусологии им. Д.И. Ивановского" Минздравсоцразвития России | Применение поликарбоксильного производного фуллерена в качестве микробицидного противовирусного средства |
| CN103705388A (zh) * | 2013-12-19 | 2014-04-09 | 深圳市通产丽星股份有限公司 | 一种富勒烯胶囊及其应用 |
| CN111135188A (zh) * | 2018-11-06 | 2020-05-12 | 海南森溪海科技有限公司 | 富勒烯和/或其水溶性衍生物在预防和治疗女性生殖道疾病药物中的应用 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW406020B (en) * | 1993-09-29 | 2000-09-21 | Bristol Myers Squibb Co | Stabilized pharmaceutical composition and its method for preparation and stabilizing solvent |
| US5811460A (en) * | 1994-01-24 | 1998-09-22 | The Regents Of The University Of California | Water soluble fullerenes with antiviral activity |
| US5648523A (en) * | 1995-10-26 | 1997-07-15 | Chiang Long Y | Fullerene derivatives as free-radical scavengers |
| RU2124022C1 (ru) * | 1997-04-10 | 1998-12-27 | Институт биоорганической химии им.М.М.Шемякина и Ю.А.Овчинникова РАН | Фуллереновое производное гликопептида, обладающее адъювантной активностью |
| US20030027870A1 (en) * | 2001-05-15 | 2003-02-06 | Wilson Stephen R. | Fullerene derivatives that modulate nitric oxide synthase and clamodulin activity |
| RU2196602C1 (ru) * | 2002-01-22 | 2003-01-20 | Закрытое акционерное общество "ДЕСКО" | Средство для ингибирования вич и цмв-инфекций и способ их ингибирования |
-
2003
- 2003-06-23 RU RU2003118500/15A patent/RU2236852C1/ru active
-
2004
- 2004-05-31 CA CA002530004A patent/CA2530004A1/en not_active Abandoned
- 2004-05-31 KR KR1020057024813A patent/KR20060017887A/ko not_active Application Discontinuation
- 2004-05-31 WO PCT/RU2004/000208 patent/WO2004112804A1/ru active Application Filing
- 2004-05-31 UA UAA200600635A patent/UA82528C2/uk unknown
- 2004-05-31 CN CNA2004800171673A patent/CN1819834A/zh active Pending
- 2004-05-31 BR BRPI0411679-8A patent/BRPI0411679A/pt not_active IP Right Cessation
- 2004-05-31 EA EA200600010A patent/EA010483B1/ru not_active IP Right Cessation
- 2004-05-31 US US10/559,681 patent/US20060122276A1/en not_active Abandoned
- 2004-05-31 EP EP04748919A patent/EP1645279A4/en not_active Withdrawn
- 2004-05-31 JP JP2006517009A patent/JP2007522082A/ja not_active Withdrawn
- 2004-05-31 AU AU2004249090A patent/AU2004249090A1/en not_active Abandoned
- 2004-05-31 AP AP2006003495A patent/AP2006003495A0/xx unknown
- 2004-05-31 GE GEAP20049178A patent/GEP20084377B/en unknown
-
2005
- 2005-12-15 IL IL172634A patent/IL172634A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2530004A1 (en) | 2004-12-29 |
| IL172634A0 (en) | 2006-04-10 |
| AP2006003495A0 (en) | 2006-02-28 |
| RU2236852C1 (ru) | 2004-09-27 |
| CN1819834A (zh) | 2006-08-16 |
| AU2004249090A1 (en) | 2004-12-29 |
| UA82528C2 (uk) | 2008-04-25 |
| KR20060017887A (ko) | 2006-02-27 |
| WO2004112804A1 (fr) | 2004-12-29 |
| EP1645279A4 (en) | 2009-10-21 |
| GEP20084377B (en) | 2008-05-27 |
| EA200600010A1 (ru) | 2006-06-30 |
| JP2007522082A (ja) | 2007-08-09 |
| EA010483B1 (ru) | 2008-10-30 |
| US20060122276A1 (en) | 2006-06-08 |
| EP1645279A1 (en) | 2006-04-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE AS 7A E 8A ANUIDADES. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2159 DE 22/05/2012. |