BRPI0408618A - espirolactonização de esteróide - Google Patents

espirolactonização de esteróide

Info

Publication number
BRPI0408618A
BRPI0408618A BRPI0408618-0A BRPI0408618A BRPI0408618A BR PI0408618 A BRPI0408618 A BR PI0408618A BR PI0408618 A BRPI0408618 A BR PI0408618A BR PI0408618 A BRPI0408618 A BR PI0408618A
Authority
BR
Brazil
Prior art keywords
steroid
semihydrogenation
spirolactone
disclosed
intermediates
Prior art date
Application number
BRPI0408618-0A
Other languages
English (en)
Inventor
Thaddeus S Ii Franczyk
Grace M Wagner
Bruce Allen Pearlman
Amphlett Greg Padilla
Sonja S Mackey
Jeffrey L Havens
Haifeng Wu
Original Assignee
Pharmacia Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia Corp filed Critical Pharmacia Corp
Publication of BRPI0408618A publication Critical patent/BRPI0408618A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J19/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 by a lactone ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/94—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom spiro-condensed with carbocyclic rings or ring systems, e.g. griseofulvins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

"ESPIROLACTONIZAçãO DE ESTERóIDE". Um esteróide compreendendo uma 17-espirolactona ou estrutura de lactona aberta correspondente é obtido por carbonilação de um substrato de 17-alquenila ou 17-alquinila. Um intermediário de 17-alquenila pode ser preparado por semi-hidrogenação de um grupo 17-alquinila. Múltiplos esquemas de reação são revelados para preparação de um esteróide de 3-ceto-9,11-epóxi-17-espirolactona como eplerenona. Intermediários novos são também revelados, como também etapas para formar tais intermediários novos, ou os convertendo em outros intermediários ou produtos, por semi-hidrogenação, carbonilação, 6,7-desidrogenação, furilação ou outras transformações ou combinações destas.
BRPI0408618-0A 2003-03-21 2004-03-22 espirolactonização de esteróide BRPI0408618A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US45671603P 2003-03-21 2003-03-21
PCT/US2004/008629 WO2004085458A2 (en) 2003-03-21 2004-03-22 Steroid spirolactonization

Publications (1)

Publication Number Publication Date
BRPI0408618A true BRPI0408618A (pt) 2006-03-07

Family

ID=33098145

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0408618-0A BRPI0408618A (pt) 2003-03-21 2004-03-22 espirolactonização de esteróide

Country Status (15)

Country Link
US (2) US20060264412A1 (pt)
EP (1) EP1606306A2 (pt)
JP (1) JP2006520802A (pt)
KR (1) KR20050114254A (pt)
CN (1) CN1839145A (pt)
AR (1) AR043744A1 (pt)
AU (1) AU2004223881A1 (pt)
BR (1) BRPI0408618A (pt)
CA (1) CA2519770A1 (pt)
CL (1) CL2004000574A1 (pt)
MX (1) MXPA05010011A (pt)
RU (1) RU2005132467A (pt)
TW (1) TW200505459A (pt)
WO (1) WO2004085458A2 (pt)
ZA (1) ZA200507351B (pt)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1321128C (zh) * 2005-07-15 2007-06-13 浙江医药股份有限公司新昌制药厂 孕甾－4－烯－7，21－二甲酸，9，11－环氧－17－羟基－3－氧代，γ－内酯，甲酯，(7α,11α,17α)－的制备方法
WO2008137050A2 (en) * 2007-05-01 2008-11-13 Sicor Inc. A process for preparing drospirenone and intermediate thereof
WO2009111574A2 (en) * 2008-03-05 2009-09-11 Evestra, Inc. BISMETHYLENE-17α CARBOLACTONES AND RELATED USES
US8222237B2 (en) * 2008-11-25 2012-07-17 Evestra, Inc. Progestational 3-(6,6-ethylene-17B-hydroxy-3-oxo-17A-pregna-4-ene-17A-yl)propionic acid G-lactones
US8334375B2 (en) * 2009-04-10 2012-12-18 Evestra, Inc. Methods for the preparation of drospirenone
ES2419663T3 (es) * 2010-08-03 2013-08-21 Newchem S.P.A. Métodos para la preparación de Drospirenona y productos intermedios de la misma
BR112014010590A2 (pt) * 2011-11-04 2017-05-02 Bayer Ip Gmbh 18-metil-6,7-metilen-3-oxo-17-pregn-4-eno-21,17?-carbolactonas, preparações farmacêuticas contendo os compostos mencionados e seu uso na terapia da endometriose
CN104262450A (zh) * 2014-09-19 2015-01-07 江苏嘉逸医药有限公司 依普利酮的制备及精制方法
WO2016141182A1 (en) 2015-03-03 2016-09-09 Yee Richard W Compositions and methods for treating ocular diseases
CN105753930A (zh) * 2016-03-30 2016-07-13 北京万全德众医药生物技术有限公司 依普利酮的一种合成方法
CN107312060B (zh) * 2017-06-26 2019-04-23 淮海工学院 一种制备螺内酯的方法
CN114409726B (zh) * 2022-01-24 2023-07-04 东华大学 桦木醇环烯烃衍生物及其用途和制备方法
CN117624274B (zh) * 2023-10-19 2024-08-27 浙江晟创制药有限公司 一种依普利酮中间体δ9,11-坎利酮的制备方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2888471A (en) * 1955-03-25 1959-05-26 Syntex Sa Process for preparing 17alpha-ethinyl-delta1, 4-androstadiene-17 beta-ol-3-one
SE7801152L (sv) * 1977-02-22 1978-08-23 Roussel Uclaf Sett att framstella 17alfa-acetylen-derivat av androst-4-en
US4270994A (en) * 1980-02-20 1981-06-02 G. D. Searle & Co. Electrochemical dehydrogenation of steroidal Δ3,5 enol ethers under basic conditions to provide steroidal Δ4,6 dienones
FI77669C (fi) * 1983-04-13 1989-04-10 Ciba Geigy Ag 20-spiroxaner och analoger, som innehaoller en oeppen ring e, foerfarande foer deras framstaellning samt dessa innehaollande farmaceutiska preparat.
US5236913A (en) * 1985-07-24 1993-08-17 Akzo N.V. 11-methylene-oestr-15-enes, processes for their preparation, and pharmaceutical compositions
US5276023A (en) * 1989-08-08 1994-01-04 Roussel Uclaf 19-nor-steroid esters
US5981744A (en) * 1995-12-11 1999-11-09 G. D. Searle And Co. Processes for preparation of 9,11-epoxy steroids and intermediates useful therein
DE19633685C1 (de) * 1996-08-12 1997-10-09 Schering Ag Verfahren zur Herstellung von Drospirenon (6beta,7beta;15 beta,16beta-Dimethyl-en-3-oxo-17alpha-pregn-4-en-21,17-carbolacton, DRSP) sowie 7alpha-(3-Hydroxy-1-propyl)-6beta,7beta;15beta, 16beta-dimethylen-5beta-androstan-3beta,5,17beta-triol (ZK 92836) und 6beta,7beta;15beta,16beta-dimethylen-5beta-hydroxy-3-oxo-17alpha-androstan-21,17-carbolacton (90965) als Zwischenprodukte des Verfahrens
PT944644E (pt) * 1996-12-11 2003-02-28 Searle & Co Processos para a preparacao de esteroides 9,11-epoxi e intermediarios uteis para esse efeito
AU2003220251A1 (en) * 2002-03-22 2003-10-13 Pharmacia Corporation C-17 spirolactonization and 6,7 oxidation of steroids
US7235655B2 (en) * 2002-03-22 2007-06-26 Pharmacia & Upjohn Company Processes to prepare eplerenone

Also Published As

Publication number Publication date
MXPA05010011A (es) 2006-05-25
TW200505459A (en) 2005-02-16
CA2519770A1 (en) 2004-10-07
KR20050114254A (ko) 2005-12-05
AU2004223881A1 (en) 2004-10-07
US20050090663A1 (en) 2005-04-28
CL2004000574A1 (es) 2005-02-11
WO2004085458A9 (en) 2006-06-08
WO2004085458A2 (en) 2004-10-07
AR043744A1 (es) 2005-08-10
CN1839145A (zh) 2006-09-27
WO2004085458A3 (en) 2006-03-16
JP2006520802A (ja) 2006-09-14
EP1606306A2 (en) 2005-12-21
US20060264412A1 (en) 2006-11-23
ZA200507351B (en) 2008-04-30
RU2005132467A (ru) 2007-04-27

Similar Documents

Publication Publication Date Title
BRPI0408618A (pt) espirolactonização de esteróide
Song et al. A convenient synthesis of coumarin-3-carboxylic acids via Knoevenagel condensation of Meldrum's acid with ortho-hydroxyaryl aldehydes or ketones
Das et al. A rapid and high-yielding synthesis of thiazoles and aminothiazoles using ammonium-12-molybdophosphate
Krohn et al. Total synthesis of (+)-xyloketal D, a secondary metabolite from the mangrove fungus Xylaria sp.
WO2007140917A3 (de) KRISTALLINE FORMEN VON 11 ß-(4-ACETYLPHENYL)-20, 20, 21,21, 21-PENTAFLUOR-17- HYDROXY-19-NOR-17α-PREGNA-4,9-DIEN-3-ON
BR112012015503A2 (pt) produção de hidrocarbonetos a partir de matérias-primas contendo ácido graxo superior livre.
BR0114649A (pt) Processos para prepapar um composto e fulvestrant, e, composto
Yuan et al. Copper-catalysed difluoroalkylation of aromatic aldehydes via a decarboxylation/aldol reaction
Ayad et al. Asymmetric syntheses of (−)-lentiginosine and an original pyrrolizidinic analogue thereof from a versatile epoxyamine intermediate
FI20011889A0 (fi) Menetelmä ksylitolin valmistamiseksi
Loh et al. A concise synthesis of (±)-methylenolactocin and the formal synthesis of (±)-phaseolinic acid
Sellès et al. Convergent stereospecific synthesis of LL-Z1640-2 (or C292), hypothemycin and related macrolides. Part 2
AR027559A1 (es) Metodo para la preparacion de citalopram
Redon et al. A new oxa-Michael reaction and a gold-catalysed cyclisation en route to C-glycosides
Zhang et al. A general asymmetric route to enantio-enriched isoflavanes via an organocatalytic annulation of o-quinone methides and aldehydes
Clarke et al. A Maitland–Japp inspired synthesis of dihydropyran-4-ones and their stereoselective conversion to functionalised tetrahydropyran-4-ones
Das et al. Sulfonic acid functionalized silica: an efficient heterogeneous catalyst for a three-component synthesis of 1, 4-dihydropyridines under solvent-free conditions
Samanta et al. Thiol-mediated tandem Michael–aldol reaction: a convenient method for the synthesis of fused cyclopentenones
Liu et al. Synthetic studies towards Chlorahololides A: practical synthesis of a lindenane-type sesquiterpenoid core framework with a 5, 6-double bond
Das et al. A simple and facile synthesis of homoallylic amines using silica supported sodium hydrogen sulfate
Rao et al. Total synthesis of AI-77-B
Thorsheim et al. Hydroxylated oxanes as xyloside analogs for determination of the minimal binding requirements of β4GalT7
Ellis et al. Synthesis of a trans-fused perhydroindan analog of hispidospermidin
Anaç et al. Synthesis of Highly Functionalized γ‐Lactones via 1, 5‐Electrocyclic Ring Closure
Altendorfer et al. Design, synthesis and biological evaluation of simplified side chains of the macrolide antibiotic etnangien

Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 5A , 6A E 7A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2129 DE 25/10/2011.