BRPI0408274B8 - compostos de ligação de amiloide e composição farmacêutica - Google Patents

compostos de ligação de amiloide e composição farmacêutica

Info

Publication number
BRPI0408274B8
BRPI0408274B8 BRPI0408274A BRPI0408274A BRPI0408274B8 BR PI0408274 B8 BRPI0408274 B8 BR PI0408274B8 BR PI0408274 A BRPI0408274 A BR PI0408274A BR PI0408274 A BRPI0408274 A BR PI0408274A BR PI0408274 B8 BRPI0408274 B8 BR PI0408274B8
Authority
BR
Brazil
Prior art keywords
compounds
disease
pharmaceutical composition
deposit
amyloid
Prior art date
Application number
BRPI0408274A
Other languages
English (en)
Portuguese (pt)
Inventor
A Mathis Chester Jr
E Klunk William
Wang Yanming
Original Assignee
Univ Pittsburgh
Univ Pittsburgh Commonwealth Sys Higher Education
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/388,173 external-priority patent/US7270800B2/en
Priority claimed from US10/645,847 external-priority patent/US20050043523A1/en
Application filed by Univ Pittsburgh, Univ Pittsburgh Commonwealth Sys Higher Education filed Critical Univ Pittsburgh
Priority claimed from PCT/US2004/007797 external-priority patent/WO2004083195A1/en
Publication of BRPI0408274A publication Critical patent/BRPI0408274A/pt
Publication of BRPI0408274B1 publication Critical patent/BRPI0408274B1/pt
Publication of BRPI0408274B8 publication Critical patent/BRPI0408274B8/pt

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/64—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2
    • C07D277/66—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2 with aromatic rings or ring systems directly attached in position 2
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/60—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances involving radioactive labelled substances

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
BRPI0408274A 2003-03-14 2004-03-15 compostos de ligação de amiloide e composição farmacêutica BRPI0408274B8 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US10/388,173 2003-03-14
US10/388,173 US7270800B2 (en) 2000-08-24 2003-03-14 Thioflavin derivatives for use in antemortem diagnosis of Alzheimer's disease and in vivo imaging and prevention of amyloid deposition
US10/645,847 US20050043523A1 (en) 2003-08-22 2003-08-22 Benzothiazole derivative compounds, compositions and uses
US10/645,847 2003-08-22
PCT/US2004/007797 WO2004083195A1 (en) 2003-03-14 2004-03-15 Benzothiazole derivative compounds, compositions and uses

Publications (3)

Publication Number Publication Date
BRPI0408274A BRPI0408274A (pt) 2006-03-21
BRPI0408274B1 BRPI0408274B1 (pt) 2019-02-26
BRPI0408274B8 true BRPI0408274B8 (pt) 2021-05-25

Family

ID=35057877

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0408274A BRPI0408274B8 (pt) 2003-03-14 2004-03-15 compostos de ligação de amiloide e composição farmacêutica

Country Status (16)

Country Link
EP (1) EP1611115B1 (https=)
JP (1) JP4875487B2 (https=)
CN (2) CN102532055B (https=)
AU (2) AU2004221897B2 (https=)
BE (1) BE2015C005I2 (https=)
BR (1) BRPI0408274B8 (https=)
CY (2) CY1113334T1 (https=)
DK (1) DK1611115T3 (https=)
ES (1) ES2393921T3 (https=)
FR (1) FR15C0005I2 (https=)
HU (1) HUS1500006I1 (https=)
NO (3) NO330861B1 (https=)
PL (1) PL1611115T3 (https=)
PT (1) PT1611115E (https=)
RU (1) RU2440995C2 (https=)
SI (1) SI1611115T1 (https=)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT1334091E (pt) * 2000-08-24 2013-01-07 Univ Pittsburgh Derivados de tioflavina e seu uso no diagnóstico e terapia da doença de alzheimer
US7270800B2 (en) 2000-08-24 2007-09-18 University Of Pittsburgh Thioflavin derivatives for use in antemortem diagnosis of Alzheimer's disease and in vivo imaging and prevention of amyloid deposition
KR20070032700A (ko) * 2004-05-20 2007-03-22 폴드알엑스 파마슈티칼스, 인크. 트랜스티레틴을 안정화하고 트랜스티레틴 미스폴딩을억제하기 위한, ２-((헤테로)아릴)-벤즈옥사졸 화합물 및유도체, 그리고 조성물 및 방법
GB0516564D0 (en) * 2005-08-12 2005-09-21 Ge Healthcare Ltd Fluorination process
ES2414614T3 (es) * 2007-01-30 2013-07-22 Ge Healthcare Limited Herramientas para ayudar en el diagnóstico de enfermedades neurodegenerativas
CN101293878B (zh) * 2007-04-25 2010-12-15 中国科学院上海应用物理研究所 苯并噻唑苯胺类化合物及其制备方法和应用
CA2731738A1 (en) * 2008-07-24 2010-01-28 Siemens Medical Solutions Usa, Inc. Imaging agents useful for identifying ad pathology
CN102224423B (zh) * 2008-09-23 2014-10-22 维斯塔实验室有限公司 聚集的τ分子的配体
JP6182668B2 (ja) 2013-09-26 2017-08-16 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ 画像化ツールとしてのイミダゾ［１，２−ａ］ピリジン−７−アミン
JP6260967B2 (ja) * 2013-11-06 2018-01-17 国立大学法人京都大学 放射性ヨウ素標識化合物、及び、これを含む放射性医薬
CN103613589B (zh) * 2013-11-29 2016-03-30 江苏华益科技有限公司 一种用于神经退行性疾病领域的新型pet显像剂前体及标准品的合成方法
AU2015308709B2 (en) * 2014-08-29 2020-01-02 Chdi Foundation, Inc. Probes for imaging huntingtin protein
CN109400615B (zh) * 2017-08-18 2021-07-16 上海交通大学医学院附属新华医院 一种靶向β-淀粉样蛋白的香豆素类化合物及其制备与应用
GR1009516B (el) * 2018-03-22 2019-05-02 Εκεφε Δημοκριτος Τρικαρβονυλο-συμπλοκα μεταλλων μεταπτωσεως με βενζο-ετεροκυκλικο παραγωγο του κυκλοπενταδιενυλικου ανιοντος με υψηλη διαπερατοτητα του αιματοεγκεφαλικου φραγμου για εφαρμογες στη διαγνωση και θεραπεια νοσων του κνς
CN119462558B (zh) * 2024-10-18 2025-09-19 河南中医药大学 一种布美他尼衍生物及其制备方法和用途

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998022493A2 (en) * 1996-11-22 1998-05-28 Elan Pharmaceuticals, Inc. N-(ARYL/HETEROARYL) AMINO ACID DERIVATIVES, PHARMACEUTICAL COMPOSITIONS COMPRISING SAME, AND METHODS FOR INHIBITING β-AMYLOID PEPTIDE RELEASE AND/OR ITS SYNTHESIS BY USE OF SUCH COMPOUNDS
GB9919673D0 (en) * 1999-08-20 1999-10-20 Cancer Res Campaign Tech 2-Arlybenzazole compounds
PT1334091E (pt) * 2000-08-24 2013-01-07 Univ Pittsburgh Derivados de tioflavina e seu uso no diagnóstico e terapia da doença de alzheimer
EP1345914A1 (en) * 2000-12-22 2003-09-24 AstraZeneca AB Therapeutic compounds
WO2002085903A2 (en) * 2001-04-23 2002-10-31 The Trustees Of The University Of Pennsylvania Amyloid plaque aggregation inhibitors and diagnostic imaging agents
GB0229686D0 (en) * 2002-12-20 2003-01-29 Amersham Plc Solid-phase fluorination of benzothiazoles

Also Published As

Publication number Publication date
AU2011200667A1 (en) 2011-03-10
NO20054674D0 (no) 2005-10-11
FR15C0005I2 (fr) 2015-07-24
SI1611115T1 (sl) 2012-12-31
RU2440995C2 (ru) 2012-01-27
AU2004221897B2 (en) 2010-11-18
BE2015C005I2 (https=) 2023-03-07
AU2004221897A1 (en) 2004-09-30
CN1784392A (zh) 2006-06-07
AU2011200667B2 (en) 2011-12-22
JP2006522104A (ja) 2006-09-28
JP4875487B2 (ja) 2012-02-15
NO20110980L (no) 2005-12-13
AU2004221897A9 (en) 2009-08-20
ES2393921T3 (es) 2013-01-02
NO2015005I2 (no) 2015-02-18
NO20054674L (no) 2005-12-13
NO2015005I1 (no) 2015-03-02
AU2004221897A2 (en) 2004-09-30
CN102532055A (zh) 2012-07-04
NO330861B1 (no) 2011-08-01
BRPI0408274B1 (pt) 2019-02-26
HK1086270A1 (en) 2006-09-15
HUS1500006I1 (hu) 2015-02-18
CY1113334T1 (el) 2015-12-09
PL1611115T3 (pl) 2013-01-31
EP1611115A1 (en) 2006-01-04
DK1611115T3 (da) 2012-11-26
BRPI0408274A (pt) 2006-03-21
RU2005131872A (ru) 2006-02-27
CY2015007I1 (el) 2015-12-09
PT1611115E (pt) 2012-12-07
CN102532055B (zh) 2016-05-11
EP1611115B1 (en) 2012-08-22

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B25D Requested change of name of applicant approved

Owner name: UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYS

B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 26/02/2019, OBSERVADAS AS CONDICOES LEGAIS.

B25G Requested change of headquarter approved

Owner name: UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYS

B16C Correction of notification of the grant [chapter 16.3 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 15/03/2004 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF

B21F Lapse acc. art. 78, item iv - on non-payment of the annual fees in time

Free format text: REFERENTE A 22A ANUIDADE.

B21H Decision of lapse of a patent or of a certificate of addition of invention cancelled [chapter 21.8 patent gazette]

Free format text: ANULADA A PUBLICACAO CODIGO 21.6 NA RPI NO 2871 DE 13/01/2026 POR TER SIDO INDEVIDA.