BRPI0309594A8 - Piperazina benzothiazóis como agentes para o tratamento de distúrbios isquêmicos cerebrais ou distúrbios do snc - Google Patents
Piperazina benzothiazóis como agentes para o tratamento de distúrbios isquêmicos cerebrais ou distúrbios do sncInfo
- Publication number
- BRPI0309594A8 BRPI0309594A8 BRPI0309594A BR0309594A BRPI0309594A8 BR PI0309594 A8 BRPI0309594 A8 BR PI0309594A8 BR PI0309594 A BRPI0309594 A BR PI0309594A BR 0309594 A BR0309594 A BR 0309594A BR PI0309594 A8 BRPI0309594 A8 BR PI0309594A8
- Authority
- BR
- Brazil
- Prior art keywords
- disorders
- piperazine
- treatment
- benzothiazoles
- agents
- Prior art date
Links
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 title abstract 4
- 230000000302 ischemic effect Effects 0.000 title abstract 2
- 238000011282 treatment Methods 0.000 title abstract 2
- 210000004556 brain Anatomy 0.000 title 1
- 210000003169 central nervous system Anatomy 0.000 title 1
- 208000015114 central nervous system disease Diseases 0.000 abstract 1
- 230000002490 cerebral effect Effects 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP02100417 | 2002-04-25 | ||
| PCT/EP2003/004323 WO2003091249A1 (en) | 2002-04-25 | 2003-04-25 | Piperazine benzothiazoles as agents for the treatment of cerebral ischemic disorders or cns disorders |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BRPI0309594A2 BRPI0309594A2 (pt) | 2016-11-16 |
| BRPI0309594A8 true BRPI0309594A8 (pt) | 2017-04-11 |
Family
ID=29265991
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0309594A BRPI0309594A8 (pt) | 2002-04-25 | 2003-04-25 | Piperazina benzothiazóis como agentes para o tratamento de distúrbios isquêmicos cerebrais ou distúrbios do snc |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US7314878B2 (enExample) |
| EP (1) | EP1501828B1 (enExample) |
| JP (1) | JP4523289B2 (enExample) |
| KR (1) | KR100948469B1 (enExample) |
| CN (1) | CN1310911C (enExample) |
| AT (1) | ATE383356T1 (enExample) |
| AU (1) | AU2003233067B2 (enExample) |
| BR (1) | BRPI0309594A8 (enExample) |
| CA (1) | CA2481763C (enExample) |
| CY (1) | CY1107204T1 (enExample) |
| DE (1) | DE60318567T2 (enExample) |
| DK (1) | DK1501828T3 (enExample) |
| EA (1) | EA009682B1 (enExample) |
| ES (1) | ES2297165T3 (enExample) |
| IL (2) | IL164796A0 (enExample) |
| MX (1) | MXPA04010474A (enExample) |
| PT (1) | PT1501828E (enExample) |
| RS (1) | RS51407B (enExample) |
| SI (1) | SI1501828T1 (enExample) |
| UA (1) | UA78035C2 (enExample) |
| WO (1) | WO2003091249A1 (enExample) |
| ZA (1) | ZA200408023B (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE60318567T2 (de) | 2002-04-25 | 2009-02-19 | Laboratoires Serono S.A., Coinsins | Piperazinbenzothiazole als wirkstoffe in der behandlung von ischämien und krankheiten des zns-systems |
| HRP20070527T3 (en) * | 2003-09-12 | 2007-12-31 | Laboratoires Serono Sa | Benzothiazole derivatives for the treatment of diabetes |
| WO2005118543A1 (ja) * | 2004-06-03 | 2005-12-15 | Ono Pharmaceutical Co., Ltd. | キナーゼ阻害薬およびその用途 |
| JP5144271B2 (ja) * | 2004-11-17 | 2013-02-13 | アレス トレーディング ソシエテ アノニム | ベンゾチアゾ−ル製剤、及びそれらの使用 |
| US7838522B2 (en) | 2004-11-17 | 2010-11-23 | Ares Trading S.A. | Benzothiazole formulations and use thereof |
| BRPI0613042A2 (pt) * | 2005-07-15 | 2010-12-14 | Serono Lab | inibidores de jnk para o tratamento de endometriose |
| KR20080044836A (ko) | 2005-07-15 | 2008-05-21 | 라보라뚜와르 세로노 에스. 에이. | 자궁내막증 치료용 ｊｎｋ 억제제 |
| WO2008125518A2 (en) * | 2007-04-17 | 2008-10-23 | Merck Serono S.A. | Process for the preparation of piperazine benzothiazoles |
| KR101368079B1 (ko) * | 2008-05-16 | 2014-03-14 | 에프. 호프만-라 로슈 아게 | Ｊｎｋ 의 억제제 |
| CA2799328C (en) * | 2010-06-04 | 2018-02-20 | Humberto Bartolome Arzeno | 2 -amino- pyrimidine derivatives useful as inhibitors of jnk |
| US8471027B2 (en) * | 2011-04-06 | 2013-06-25 | Hoffmann-La Roche Inc. | Adamantyl compounds |
| WO2014114186A1 (zh) * | 2013-01-24 | 2014-07-31 | 山东亨利医药科技有限责任公司 | Jnk抑制剂 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4153574B2 (ja) * | 1997-09-10 | 2008-09-24 | トーアエイヨー株式会社 | 新規なピペリジン誘導体、その製造法およびそれを含有する循環器官用剤 |
| EP1110957A1 (en) * | 1999-12-24 | 2001-06-27 | Applied Research Systems ARS Holding N.V. | Benzazole derivatives and their use as JNK modulators |
| EP1193256A1 (en) * | 2000-09-27 | 2002-04-03 | Applied Research Systems ARS Holding N.V. | Pharmaceutically active benzsulfonamide derivatives as inhibitors of JNK proteins |
| DE60318567T2 (de) | 2002-04-25 | 2009-02-19 | Laboratoires Serono S.A., Coinsins | Piperazinbenzothiazole als wirkstoffe in der behandlung von ischämien und krankheiten des zns-systems |
-
2003
- 2003-04-25 DE DE60318567T patent/DE60318567T2/de not_active Expired - Lifetime
- 2003-04-25 WO PCT/EP2003/004323 patent/WO2003091249A1/en not_active Ceased
- 2003-04-25 CN CNB03814493XA patent/CN1310911C/zh not_active Expired - Fee Related
- 2003-04-25 EP EP03727365A patent/EP1501828B1/en not_active Expired - Lifetime
- 2003-04-25 SI SI200331114T patent/SI1501828T1/sl unknown
- 2003-04-25 BR BRPI0309594A patent/BRPI0309594A8/pt not_active IP Right Cessation
- 2003-04-25 AU AU2003233067A patent/AU2003233067B2/en not_active Ceased
- 2003-04-25 DK DK03727365T patent/DK1501828T3/da active
- 2003-04-25 CA CA2481763A patent/CA2481763C/en not_active Expired - Fee Related
- 2003-04-25 MX MXPA04010474A patent/MXPA04010474A/es active IP Right Grant
- 2003-04-25 AT AT03727365T patent/ATE383356T1/de active
- 2003-04-25 IL IL16479603A patent/IL164796A0/xx unknown
- 2003-04-25 KR KR1020047016871A patent/KR100948469B1/ko not_active Expired - Fee Related
- 2003-04-25 IL IL164796A patent/IL164796A/en not_active IP Right Cessation
- 2003-04-25 EA EA200401423A patent/EA009682B1/ru not_active IP Right Cessation
- 2003-04-25 UA UA20041008647A patent/UA78035C2/uk unknown
- 2003-04-25 JP JP2003587807A patent/JP4523289B2/ja not_active Expired - Fee Related
- 2003-04-25 RS YUP-928/04A patent/RS51407B/sr unknown
- 2003-04-25 US US10/511,438 patent/US7314878B2/en not_active Expired - Lifetime
- 2003-04-25 PT PT03727365T patent/PT1501828E/pt unknown
- 2003-04-25 ES ES03727365T patent/ES2297165T3/es not_active Expired - Lifetime
-
2004
- 2004-10-05 ZA ZA2004/08023A patent/ZA200408023B/en unknown
-
2008
- 2008-02-18 CY CY20081100199T patent/CY1107204T1/el unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CY1107204T1 (el) | Πιπεραζινοβενζοθειαζολια ως ουσιες για την θεραπευτικη αντιμετωπιση εγκεφαλικων ισχαιμικων διαταραχων ή διαταραχων του κνς | |
| ATE524169T1 (de) | Therapeutische strategien für die prävention und behandlung der alzeheimer-krankheit | |
| BR0317020A (pt) | Derivados de hidroxietilamina para o tratamento de doença de alzheimer | |
| DK1242415T3 (da) | 3-thiazol-4-yl-pyrolidinderivater som AMP-specifikke phosphodiesteraseinhibitorer | |
| BR0314059A (pt) | Compostos heterocìclicos | |
| IS6436A (is) | Pýrrólidín afleiður sem hringlaga AMP-sértækir fosfódíesterasa hindrarar | |
| ATE325612T1 (de) | Verwendung von hydroxyethylrutosiden zur behandlung von erkältungssymptomen, symptomen der allergischen rhinitis und atemwegsinfektionen | |
| DE602004024572D1 (de) | Zusammensetzungen, die sich als inhibitoren von proteinkinasen eignen | |
| CY1113306T1 (el) | Παραγωγα της κινολινης και η χρηση τους ως προσδεματων 5-ht6 | |
| CY1112238T1 (el) | Αναστολεις μιτωτικης κινεσινης και μεθοδοι χρησης αυτων | |
| DE602004014117D1 (de) | Thiazole zur verwendung als inhibitoren von protein-kinasen | |
| BR0117009A (pt) | Composiçoes para utilização no tratamento de distúrbios associados a ige | |
| NO20080967L (no) | Benzimidazoler nyttige som inhibitorer av proteinkinaser | |
| ATE388708T1 (de) | Piperazinderivate und anwendungsverfahren | |
| DE602004012578D1 (de) | Als inhibitoren von c-met geeignete pyrrolzusammensetzungen | |
| ATE439363T1 (de) | Imidazo 2,1-b -1,3,4-thiadiazole sulfonamides | |
| BRPI0416500A (pt) | ferramenta de esmerilhar dividida | |
| GT200400231A (es) | Compuestos de sulfoniltetrahidro-3h-benzo(e)indol-8-amina como ligandos de la 5-hidroxitriptamina-6. | |
| BRPI0511124A (pt) | pró-drogas de inibidores de erk proteìna cinase de pirrolilpirimidina | |
| BRPI0608437A2 (pt) | derivados tiazol fundidos que possuem afinidade para o receptor histamina h3 | |
| DE60018470D1 (de) | Cyclische amp spezifische phosphodiesterase inhibitoren | |
| ATE345135T1 (de) | Tropan-derivate mit dopamin-wiederaufnahme-hemmer-wirkung für die behandlung von ischämischen erkrankungen | |
| ATE448779T1 (de) | Methode zur behandlung trockener augen und uveitis | |
| ATE394122T1 (de) | Hemmung des cd95 liganden/rezeptor-systems zur behandlung von neurologischen erkrankungen und verletzungen | |
| EA200200750A1 (ru) | Новое терапевтическое применение еноксапарина |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] | ||
| B25A | Requested transfer of rights approved |
Owner name: LABORATOIRES SERONO S.A. (CH) |
|
| B25D | Requested change of name of applicant approved |
Owner name: MERCK SERONO SA (CH) |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |