AU2003233067B2 - Piperazine benzothiazoles as agents for the treatment of cerebral ischemic disorders or CNS disorders - Google Patents

Piperazine benzothiazoles as agents for the treatment of cerebral ischemic disorders or CNS disorders Download PDF

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Publication number
AU2003233067B2
AU2003233067B2 AU2003233067A AU2003233067A AU2003233067B2 AU 2003233067 B2 AU2003233067 B2 AU 2003233067B2 AU 2003233067 A AU2003233067 A AU 2003233067A AU 2003233067 A AU2003233067 A AU 2003233067A AU 2003233067 B2 AU2003233067 B2 AU 2003233067B2
Authority
AU
Australia
Prior art keywords
alkyl
benzothiazol
piperazine
heteroaryl
aryl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2003233067A
Other languages
English (en)
Other versions
AU2003233067A1 (en
Inventor
Pascale Gaillard
Jean-Pierre Gotteland
Pierre-Alain Vitte
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Serono SA
Original Assignee
Merck Serono SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Serono SA filed Critical Merck Serono SA
Publication of AU2003233067A1 publication Critical patent/AU2003233067A1/en
Assigned to LABORATOIRES SERONO SA reassignment LABORATOIRES SERONO SA Request for Assignment Assignors: APPLIED RESEARCH SYSTEMS ARS HOLDING N.V.
Application granted granted Critical
Publication of AU2003233067B2 publication Critical patent/AU2003233067B2/en
Assigned to MERCK SERONO SA reassignment MERCK SERONO SA Alteration of Name(s) of Applicant(s) under S113 Assignors: LABORATOIRES SERONO SA
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
AU2003233067A 2002-04-25 2003-04-25 Piperazine benzothiazoles as agents for the treatment of cerebral ischemic disorders or CNS disorders Ceased AU2003233067B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP02100417 2002-04-25
EP02100417.1 2002-04-25
PCT/EP2003/004323 WO2003091249A1 (en) 2002-04-25 2003-04-25 Piperazine benzothiazoles as agents for the treatment of cerebral ischemic disorders or cns disorders

Publications (2)

Publication Number Publication Date
AU2003233067A1 AU2003233067A1 (en) 2003-11-10
AU2003233067B2 true AU2003233067B2 (en) 2009-01-08

Family

ID=29265991

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2003233067A Ceased AU2003233067B2 (en) 2002-04-25 2003-04-25 Piperazine benzothiazoles as agents for the treatment of cerebral ischemic disorders or CNS disorders

Country Status (22)

Country Link
US (1) US7314878B2 (enExample)
EP (1) EP1501828B1 (enExample)
JP (1) JP4523289B2 (enExample)
KR (1) KR100948469B1 (enExample)
CN (1) CN1310911C (enExample)
AT (1) ATE383356T1 (enExample)
AU (1) AU2003233067B2 (enExample)
BR (1) BRPI0309594A8 (enExample)
CA (1) CA2481763C (enExample)
CY (1) CY1107204T1 (enExample)
DE (1) DE60318567T2 (enExample)
DK (1) DK1501828T3 (enExample)
EA (1) EA009682B1 (enExample)
ES (1) ES2297165T3 (enExample)
IL (2) IL164796A0 (enExample)
MX (1) MXPA04010474A (enExample)
PT (1) PT1501828E (enExample)
RS (1) RS51407B (enExample)
SI (1) SI1501828T1 (enExample)
UA (1) UA78035C2 (enExample)
WO (1) WO2003091249A1 (enExample)
ZA (1) ZA200408023B (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60318567T2 (de) 2002-04-25 2009-02-19 Laboratoires Serono S.A., Coinsins Piperazinbenzothiazole als wirkstoffe in der behandlung von ischämien und krankheiten des zns-systems
HRP20070527T3 (en) * 2003-09-12 2007-12-31 Laboratoires Serono Sa Benzothiazole derivatives for the treatment of diabetes
WO2005118543A1 (ja) * 2004-06-03 2005-12-15 Ono Pharmaceutical Co., Ltd. キナーゼ阻害薬およびその用途
JP5144271B2 (ja) * 2004-11-17 2013-02-13 アレス トレーディング ソシエテ アノニム ベンゾチアゾ−ル製剤、及びそれらの使用
US7838522B2 (en) 2004-11-17 2010-11-23 Ares Trading S.A. Benzothiazole formulations and use thereof
BRPI0613042A2 (pt) * 2005-07-15 2010-12-14 Serono Lab inibidores de jnk para o tratamento de endometriose
KR20080044836A (ko) 2005-07-15 2008-05-21 라보라뚜와르 세로노 에스. 에이. 자궁내막증 치료용 ｊｎｋ 억제제
WO2008125518A2 (en) * 2007-04-17 2008-10-23 Merck Serono S.A. Process for the preparation of piperazine benzothiazoles
KR101368079B1 (ko) * 2008-05-16 2014-03-14 에프. 호프만-라 로슈 아게 Ｊｎｋ 의 억제제
CA2799328C (en) * 2010-06-04 2018-02-20 Humberto Bartolome Arzeno 2 -amino- pyrimidine derivatives useful as inhibitors of jnk
US8471027B2 (en) * 2011-04-06 2013-06-25 Hoffmann-La Roche Inc. Adamantyl compounds
WO2014114186A1 (zh) * 2013-01-24 2014-07-31 山东亨利医药科技有限责任公司 Jnk抑制剂

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001047920A1 (en) * 1999-12-24 2001-07-05 Applied Research Systems Ars Holding N.V. Benzazole derivatives and their use as jnk modulators

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4153574B2 (ja) * 1997-09-10 2008-09-24 トーアエイヨー株式会社 新規なピペリジン誘導体、その製造法およびそれを含有する循環器官用剤
EP1193256A1 (en) * 2000-09-27 2002-04-03 Applied Research Systems ARS Holding N.V. Pharmaceutically active benzsulfonamide derivatives as inhibitors of JNK proteins
DE60318567T2 (de) 2002-04-25 2009-02-19 Laboratoires Serono S.A., Coinsins Piperazinbenzothiazole als wirkstoffe in der behandlung von ischämien und krankheiten des zns-systems

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001047920A1 (en) * 1999-12-24 2001-07-05 Applied Research Systems Ars Holding N.V. Benzazole derivatives and their use as jnk modulators

Also Published As

Publication number Publication date
IL164796A (en) 2013-02-28
EP1501828B1 (en) 2008-01-09
US20050261304A1 (en) 2005-11-24
ZA200408023B (en) 2005-11-30
ES2297165T3 (es) 2008-05-01
SI1501828T1 (sl) 2008-04-30
DK1501828T3 (da) 2008-03-10
AU2003233067A1 (en) 2003-11-10
DE60318567D1 (de) 2008-02-21
CA2481763A1 (en) 2003-11-06
BRPI0309594A2 (pt) 2016-11-16
EA009682B1 (ru) 2008-02-28
RS92804A (sr) 2006-12-15
EP1501828A1 (en) 2005-02-02
CA2481763C (en) 2011-06-14
PT1501828E (pt) 2008-02-11
MXPA04010474A (es) 2004-12-13
KR100948469B1 (ko) 2010-03-17
EA200401423A1 (ru) 2005-04-28
WO2003091249A1 (en) 2003-11-06
KR20040104572A (ko) 2004-12-10
UA78035C2 (en) 2007-02-15
RS51407B (sr) 2011-02-28
CN1310911C (zh) 2007-04-18
BRPI0309594A8 (pt) 2017-04-11
ATE383356T1 (de) 2008-01-15
CY1107204T1 (el) 2012-11-21
JP2006504631A (ja) 2006-02-09
CN1662528A (zh) 2005-08-31
IL164796A0 (en) 2005-12-18
JP4523289B2 (ja) 2010-08-11
US7314878B2 (en) 2008-01-01
HK1075664A1 (en) 2005-12-23
DE60318567T2 (de) 2009-02-19

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Legal Events

Date Code Title Description
PC1 Assignment before grant (sect. 113)

Owner name: LABORATOIRES SERONO SA

Free format text: FORMER APPLICANT(S): APPLIED RESEARCH SYSTEMS ARS HOLDING N.V.

FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired