BRPI0209416A2 - Novos vetores de expressão e uso dos mesmos - Google Patents
Novos vetores de expressão e uso dos mesmosInfo
- Publication number
- BRPI0209416A2 BRPI0209416A2 BR0209416-9A BRPI0209416A BRPI0209416A2 BR PI0209416 A2 BRPI0209416 A2 BR PI0209416A2 BR PI0209416 A BRPI0209416 A BR PI0209416A BR PI0209416 A2 BRPI0209416 A2 BR PI0209416A2
- Authority
- BR
- Brazil
- Prior art keywords
- vectors
- dna
- relates
- expression
- nuclear
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/53—DNA (RNA) vaccination
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/10—Plasmid DNA
- C12N2800/108—Plasmid DNA episomal vectors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/42—Vector systems having a special element relevant for transcription being an intron or intervening sequence for splicing and/or stability of RNA
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2840/00—Vectors comprising a special translation-regulating system
- C12N2840/20—Vectors comprising a special translation-regulating system translation of more than one cistron
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2840/00—Vectors comprising a special translation-regulating system
- C12N2840/20—Vectors comprising a special translation-regulating system translation of more than one cistron
- C12N2840/203—Vectors comprising a special translation-regulating system translation of more than one cistron having an IRES
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Zoology (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Wood Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Virology (AREA)
- Molecular Biology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Abstract
"NOVOS VETORES DE EXPRESSãO E USO DOS MESMOS". A presente invenção refere-se a novos vetores, a vacinas de DNA e produtos para terapia gênica contendo tais vetores, a métodos para a preparação dos vetores e das vacinas de DNA e dos produtos para terapia gênica contendo os vetores, e aos usos terapêuticos dos ditos vetores. Mais especificamente, a presente invenção refere-se a novos vetores compreendendo (a) um cassete de expressão de um gene de uma proteína de ancoragem nuclear, o qual contém (i) um domínio de ligação de DNA capaz de ligar-se a uma seq³ência de DNA específica e (ii) um domínio funcional capaz de ligar-se a um componente nuclear, e (b) uma seq³ência de DNA multimerizada formando um sítio de ligação para a proteína de ancoragem, e opcionalmente (c) um ou mais cassetes de expressão de uma seq³ência de DNA de interesse. Em particular, a invenção refere-se a vetores carentes de uma origem de replicação do papilomavírus. A proteína de ancoragem nuclear deve ser a E2 do papilomavírus bovino tipo 1 ou antígeno nuclear do vírus de Epstein-Barr 1. A invenção também refere-se a vetores carentes de uma origem de replicação funcional em uma célula de mamífero. A invenção refere-se ainda a métodos para a expressão de uma seq³ência de DNA de interesse em um indivíduo.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FI20010922A FI116851B (fi) | 2001-05-03 | 2001-05-03 | Ilmentämisvektori, sen käyttöjä ja menetelmä sen valmistamiseksi sekä sitä sisältäviä tuotteita |
| US10/138,098 US7498314B2 (en) | 2001-05-03 | 2002-05-03 | Expression vectors and uses thereof |
| PCT/FI2002/000379 WO2002090558A1 (en) | 2001-05-03 | 2002-05-03 | Novel expression vectors and uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BRPI0209416A2 true BRPI0209416A2 (pt) | 2004-03-30 |
| BRPI0209416A8 BRPI0209416A8 (pt) | 2018-05-08 |
Family
ID=26161168
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0209416A BRPI0209416A8 (pt) | 2001-05-03 | 2002-05-03 | novos vetores de expressão e uso dos mesmos |
Country Status (23)
| Country | Link |
|---|---|
| EP (1) | EP1390516B1 (pt) |
| JP (1) | JP5016779B2 (pt) |
| CN (1) | CN100430482C (pt) |
| AP (1) | AP2368A (pt) |
| AT (1) | ATE426035T1 (pt) |
| AU (1) | AU2002253198B2 (pt) |
| BR (1) | BRPI0209416A8 (pt) |
| CA (1) | CA2446260C (pt) |
| CZ (1) | CZ301691B6 (pt) |
| DE (1) | DE60231613D1 (pt) |
| DK (1) | DK1390516T3 (pt) |
| EA (1) | EA009388B1 (pt) |
| EE (1) | EE05691B1 (pt) |
| ES (1) | ES2324095T3 (pt) |
| HK (1) | HK1063486A1 (pt) |
| HU (1) | HU227667B1 (pt) |
| IL (2) | IL158730A0 (pt) |
| MX (1) | MXPA03009978A (pt) |
| NZ (1) | NZ529327A (pt) |
| PL (1) | PL206097B1 (pt) |
| SI (1) | SI1390516T1 (pt) |
| SK (1) | SK287471B6 (pt) |
| WO (1) | WO2002090558A1 (pt) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2003292280A1 (en) * | 2002-12-20 | 2004-07-14 | Strom & Gulliksson Ip Ab | Vectors lacking an origin of replication functioning in mammalian cells and expressing growth factors |
| FI116068B (fi) * | 2003-09-15 | 2005-09-15 | Fit Biotech Oyj Plc | Uusi selektiojärjestelmä, siinä käyttökelpoinen vektori, bakteerisolukantoja sekä menetelmä solujen valikoimiseksi |
| US8445431B2 (en) * | 2004-06-01 | 2013-05-21 | The Ohio State University | Ligands having metal binding ability and targeting properties |
| EP2185192B1 (en) | 2007-08-03 | 2018-10-31 | Institut Pasteur | Lentiviral gene transfer vectors and their medicinal applications |
| EP2047861B1 (en) * | 2007-10-12 | 2019-07-31 | Institut Pasteur | Lentiviral gene transfer vectors suitable for iterative administration and their medicinal applications |
| ES2646320T3 (es) * | 2009-03-27 | 2017-12-13 | Eidgenössische Technische Hochschule Zürich | Salmonella enterica que presenta un N-glicano de C. Jejuni o derivados del mismo |
| WO2014089480A1 (en) | 2012-12-06 | 2014-06-12 | Pin Pharma, Inc. | Treatment of inflammation, autoimmune, and neurodegenerative disorders with immunosuppressive tat derivative polypeptides |
| CN107344962B (zh) * | 2016-05-04 | 2021-03-02 | 中国科学院微生物研究所 | 阻遏蛋白、调控元件组和基因表达调控系统及其构建方法 |
| WO2018185110A1 (en) | 2017-04-03 | 2018-10-11 | Fit Biotech Oy | Novel expression vectors and uses thereof |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4987071A (en) | 1986-12-03 | 1991-01-22 | University Patents, Inc. | RNA ribozyme polymerases, dephosphorylases, restriction endoribonucleases and methods |
| DE69704206T2 (de) * | 1996-08-16 | 2001-08-30 | Medical Res Council London | Selbst-replizierende episomale expressionsvektoren, welche gewebespezifische expression vermitteln |
-
2002
- 2002-05-03 BR BRPI0209416A patent/BRPI0209416A8/pt not_active IP Right Cessation
- 2002-05-03 EA EA200301207A patent/EA009388B1/ru not_active IP Right Cessation
- 2002-05-03 MX MXPA03009978A patent/MXPA03009978A/es active IP Right Grant
- 2002-05-03 CZ CZ20033201A patent/CZ301691B6/cs not_active IP Right Cessation
- 2002-05-03 NZ NZ529327A patent/NZ529327A/en not_active IP Right Cessation
- 2002-05-03 SI SI200230827T patent/SI1390516T1/sl unknown
- 2002-05-03 CA CA2446260A patent/CA2446260C/en not_active Expired - Lifetime
- 2002-05-03 AU AU2002253198A patent/AU2002253198B2/en not_active Ceased
- 2002-05-03 IL IL15873002A patent/IL158730A0/xx unknown
- 2002-05-03 HU HU0304053A patent/HU227667B1/hu not_active IP Right Cessation
- 2002-05-03 SK SK1469-2003A patent/SK287471B6/sk not_active IP Right Cessation
- 2002-05-03 DE DE60231613T patent/DE60231613D1/de not_active Expired - Lifetime
- 2002-05-03 EE EEP200300483A patent/EE05691B1/xx unknown
- 2002-05-03 AP APAP/P/2003/002914A patent/AP2368A/en active
- 2002-05-03 DK DK02722308T patent/DK1390516T3/da active
- 2002-05-03 JP JP2002587618A patent/JP5016779B2/ja not_active Expired - Fee Related
- 2002-05-03 AT AT02722308T patent/ATE426035T1/de active
- 2002-05-03 CN CNB028133048A patent/CN100430482C/zh not_active Expired - Fee Related
- 2002-05-03 ES ES02722308T patent/ES2324095T3/es not_active Expired - Lifetime
- 2002-05-03 WO PCT/FI2002/000379 patent/WO2002090558A1/en active Application Filing
- 2002-05-03 PL PL367126A patent/PL206097B1/pl unknown
- 2002-05-03 EP EP02722308A patent/EP1390516B1/en not_active Expired - Lifetime
-
2003
- 2003-11-03 IL IL158730A patent/IL158730A/en active IP Right Grant
-
2004
- 2004-08-19 HK HK04106222.3A patent/HK1063486A1/xx not_active IP Right Cessation
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Legal Events
| Date | Code | Title | Description |
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| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
| B07F | Notification of approval that there is no relation to art. 229 of lpi (pipeline patents) [chapter 7.6 patent gazette] | ||
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] | ||
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |