BR9916515A - Polinucleotìdeo, vetor de expressão, células de e. coli e de agrobacterium tumefaciens transformadas com o vetor de expressão, célula de planta transgênica, semente de planta transgênica, célula eucariótica transgênica, composição imunogênica, método de evocar uma resposta imune em um animal ou ser humano, planta transgênica, e, adjuvante - Google Patents

Polinucleotìdeo, vetor de expressão, células de e. coli e de agrobacterium tumefaciens transformadas com o vetor de expressão, célula de planta transgênica, semente de planta transgênica, célula eucariótica transgênica, composição imunogênica, método de evocar uma resposta imune em um animal ou ser humano, planta transgênica, e, adjuvante

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Publication number
BR9916515A
BR9916515A BR9916515-5A BR9916515A BR9916515A BR 9916515 A BR9916515 A BR 9916515A BR 9916515 A BR9916515 A BR 9916515A BR 9916515 A BR9916515 A BR 9916515A
Authority
BR
Brazil
Prior art keywords
transgenic plant
expression vector
transgenic
coli
adjuvant
Prior art date
Application number
BR9916515-5A
Other languages
English (en)
Inventor
Hugh S Mason
Charles J Arntzen
Original Assignee
Thompson Boyce Plant Res
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Thompson Boyce Plant Res filed Critical Thompson Boyce Plant Res
Publication of BR9916515A publication Critical patent/BR9916515A/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
    • C07K14/245—Escherichia (G)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/28—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Vibrionaceae (F)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/515—Animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A61K2039/541—Mucosal route
    • A61K2039/542—Mucosal route oral/gastrointestinal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Oncology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

"POLINUCLEOTìDEO,VETOR DE EXPRESSãO, CéLULAS DE COLI E DE AGROBACTERIUM TUMEFACIENS TRANSFORMADAS COM O VETOR DE EXPRESSãO, CéLULA DE PLANTA TRANSGêNICA, SEMENTE DE PLANTA TRANSGêNICA CéLULA EUCARIóTICA TRANSGêNICA, COMPOSIçãO IMUNOGêNICA, MéTODO DE EVOCAR UMA RESPOSTA IMUNE EM UM ANIMAL OU SER HUMANO, PLANTA TRANSGêNICA, E, ADJUVANTE". A invenção fornece polipeptídeos mutantes de Escherichia coli instáveis ao calor (LT) e da toxina Vibrio cholerae (CT) e os polinucleotídeos que os codificam. Os polipeptídeos mutantes LT e CT podem ser facilmente produzidos em plantas e podem ser usados para tratar ou impedir doenças causadas pelo E. coli e pelo V. cholera. Os polipeptídeos também são utilizáveis como adjuvantes.
BR9916515-5A 1998-12-22 1999-12-22 Polinucleotìdeo, vetor de expressão, células de e. coli e de agrobacterium tumefaciens transformadas com o vetor de expressão, célula de planta transgênica, semente de planta transgênica, célula eucariótica transgênica, composição imunogênica, método de evocar uma resposta imune em um animal ou ser humano, planta transgênica, e, adjuvante BR9916515A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11350798P 1998-12-22 1998-12-22
PCT/US1999/030747 WO2000037609A2 (en) 1998-12-22 1999-12-22 Orally immunogenic bacterial enterotoxins expressed in transgenic plants

Publications (1)

Publication Number Publication Date
BR9916515A true BR9916515A (pt) 2001-11-06

Family

ID=22349850

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9916515-5A BR9916515A (pt) 1998-12-22 1999-12-22 Polinucleotìdeo, vetor de expressão, células de e. coli e de agrobacterium tumefaciens transformadas com o vetor de expressão, célula de planta transgênica, semente de planta transgênica, célula eucariótica transgênica, composição imunogênica, método de evocar uma resposta imune em um animal ou ser humano, planta transgênica, e, adjuvante

Country Status (9)

Country Link
US (1) US20030176653A1 (pt)
EP (1) EP1175144A4 (pt)
JP (1) JP2002533068A (pt)
CN (1) CN1191357C (pt)
AU (1) AU773953B2 (pt)
BR (1) BR9916515A (pt)
CA (1) CA2359586A1 (pt)
MX (1) MXPA01006294A (pt)
WO (1) WO2000037609A2 (pt)

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GB9513371D0 (en) * 1995-06-30 1995-09-06 Biocine Spa Immunogenic detoxified mutant toxins
GB9326174D0 (en) * 1993-12-22 1994-02-23 Biocine Sclavo Mucosal adjuvant
CN100410268C (zh) * 1998-12-23 2008-08-13 博伊斯汤普生植物研究所 免疫原性的乙型肝炎表面抗原在转基因植物中的表达
ATE451386T1 (de) * 2001-06-07 2009-12-15 Wyeth Corp Mutantenformen von cholera holotoxin als adjuvans
WO2002098369A2 (en) * 2001-06-07 2002-12-12 Wyeth Holdings Corporation Mutant forms of cholera holotoxin as an adjuvant
CN1533438A (zh) * 2001-06-08 2004-09-29 �����Ŵ��Ƽ���˾ 在植物生产蛋白质的方法
WO2003068912A2 (en) * 2002-02-12 2003-08-21 Cornell Research Foundation, Inc. PSEUDOMONAS SYRINGAE HARPINS, HopPtoP AND HopPmaHPTO, AND THEIR USES
DE60326369D1 (de) * 2002-08-27 2009-04-09 Dow Agrosciences Llc Verwendung von hitzelabilem escherichia-coli-toxin als adjuvans bei geflügel
CA2567952C (en) 2004-05-31 2016-02-02 The Kitasato Institute Oral anti-protozoiasis vaccines based on transgenic plants
US20090304733A1 (en) * 2004-07-28 2009-12-10 Jacob Pitcovski Vaccine comprising recombinant ct or lt toxin
CN100387719C (zh) * 2005-05-09 2008-05-14 中国农业科学院生物技术研究所 编码大肠杆菌热敏毒素基因及其表达载体和用途
CN1324138C (zh) * 2005-07-21 2007-07-04 华东理工大学 大肠杆菌热敏毒素b亚单位的真核表达方法
JP2009514547A (ja) 2005-11-04 2009-04-09 ダウ・アグロサイエンス・エル・エル・シー 組み換え植物懸濁培養物を使用するワクチンマスター細胞系統の調製
CN100500842C (zh) * 2006-03-09 2009-06-17 昆明理工大学 一种大肠杆菌热不稳定肠毒素的制备方法
WO2008042026A2 (en) * 2006-06-06 2008-04-10 The University Of Nebraska-Lincoln Uses of the pseudomonas syringae effector protein hopu1 related to its ability to adp-ribosylate eukaryotic rna binding proteins
CN103626876B (zh) 2008-05-02 2016-09-14 出光兴产株式会社 细菌毒素疫苗
KR101233018B1 (ko) 2010-02-05 2013-02-13 전북대학교산학협력단 대장균 장독소 ｂ 서브유닛 유전자로 형질전환된 식물배양체, 및 이를 포함하는 백신
CN107261129A (zh) * 2010-05-03 2017-10-20 财团法人生物技术开发中心 用作疫苗的多糖与去毒大肠杆菌(e. coli)不耐热肠毒素(lt)的偶联
JP6014666B2 (ja) 2012-06-20 2016-10-25 国立大学法人 東京大学 粘膜免疫賦活化剤及びｈｐｖ感染症治療用経口医薬組成物

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IL101715A (en) * 1991-05-02 2005-06-19 Amgen Inc Recombinant dna-derived cholera toxin subunit analogs
IT1253009B (it) * 1991-12-31 1995-07-10 Sclavo Ricerca S R L Mutanti immunogenici detossificati della tossina colerica e della tossina lt, loro preparazione ed uso per la preparazione di vaccini
GB9513371D0 (en) * 1995-06-30 1995-09-06 Biocine Spa Immunogenic detoxified mutant toxins
DE69533964T2 (de) * 1994-10-24 2006-03-30 The Texas A & M University System, College Station Orale immunisierung durch verwendung von transgenen pflanzen
GB9622660D0 (en) * 1996-10-31 1997-01-08 Biocine Spa Immunogenic detoxified mutant toxin
US5980898A (en) * 1996-11-14 1999-11-09 The United States Of America As Represented By The U.S. Army Medical Research & Material Command Adjuvant for transcutaneous immunization
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FI110323B (fi) * 1997-06-02 2002-12-31 Timo Korpela Rekombinanttikonstrukti geenin ilmentämisen lisäämiseksi kasveissa

Also Published As

Publication number Publication date
CA2359586A1 (en) 2000-06-29
CN1191357C (zh) 2005-03-02
WO2000037609A2 (en) 2000-06-29
AU773953B2 (en) 2004-06-10
AU2381800A (en) 2000-07-12
EP1175144A2 (en) 2002-01-30
JP2002533068A (ja) 2002-10-08
US20030176653A1 (en) 2003-09-18
CN1331558A (zh) 2002-01-16
MXPA01006294A (es) 2002-06-04
EP1175144A4 (en) 2002-10-30
WO2000037609A3 (en) 2000-09-14

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