BR9916515A - Polinucleotìdeo, vetor de expressão, células de e. coli e de agrobacterium tumefaciens transformadas com o vetor de expressão, célula de planta transgênica, semente de planta transgênica, célula eucariótica transgênica, composição imunogênica, método de evocar uma resposta imune em um animal ou ser humano, planta transgênica, e, adjuvante - Google Patents

Polinucleotìdeo, vetor de expressão, células de e. coli e de agrobacterium tumefaciens transformadas com o vetor de expressão, célula de planta transgênica, semente de planta transgênica, célula eucariótica transgênica, composição imunogênica, método de evocar uma resposta imune em um animal ou ser humano, planta transgênica, e, adjuvante

Info

Publication number
BR9916515A
BR9916515A BR9916515-5A BR9916515A BR9916515A BR 9916515 A BR9916515 A BR 9916515A BR 9916515 A BR9916515 A BR 9916515A BR 9916515 A BR9916515 A BR 9916515A
Authority
BR
Brazil
Prior art keywords
transgenic plant
expression vector
transgenic
coli
adjuvant
Prior art date
Application number
BR9916515-5A
Other languages
English (en)
Inventor
Hugh S Mason
Charles J Arntzen
Original Assignee
Thompson Boyce Plant Res
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Thompson Boyce Plant Res filed Critical Thompson Boyce Plant Res
Publication of BR9916515A publication Critical patent/BR9916515A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
    • C07K14/245—Escherichia (G)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/28—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Vibrionaceae (F)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/515—Animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A61K2039/541—Mucosal route
    • A61K2039/542—Mucosal route oral/gastrointestinal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

"POLINUCLEOTìDEO,VETOR DE EXPRESSãO, CéLULAS DE COLI E DE AGROBACTERIUM TUMEFACIENS TRANSFORMADAS COM O VETOR DE EXPRESSãO, CéLULA DE PLANTA TRANSGêNICA, SEMENTE DE PLANTA TRANSGêNICA CéLULA EUCARIóTICA TRANSGêNICA, COMPOSIçãO IMUNOGêNICA, MéTODO DE EVOCAR UMA RESPOSTA IMUNE EM UM ANIMAL OU SER HUMANO, PLANTA TRANSGêNICA, E, ADJUVANTE". A invenção fornece polipeptídeos mutantes de Escherichia coli instáveis ao calor (LT) e da toxina Vibrio cholerae (CT) e os polinucleotídeos que os codificam. Os polipeptídeos mutantes LT e CT podem ser facilmente produzidos em plantas e podem ser usados para tratar ou impedir doenças causadas pelo E. coli e pelo V. cholera. Os polipeptídeos também são utilizáveis como adjuvantes.
BR9916515-5A 1998-12-22 1999-12-22 Polinucleotìdeo, vetor de expressão, células de e. coli e de agrobacterium tumefaciens transformadas com o vetor de expressão, célula de planta transgênica, semente de planta transgênica, célula eucariótica transgênica, composição imunogênica, método de evocar uma resposta imune em um animal ou ser humano, planta transgênica, e, adjuvante BR9916515A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11350798P 1998-12-22 1998-12-22
PCT/US1999/030747 WO2000037609A2 (en) 1998-12-22 1999-12-22 Orally immunogenic bacterial enterotoxins expressed in transgenic plants

Publications (1)

Publication Number Publication Date
BR9916515A true BR9916515A (pt) 2001-11-06

Family

ID=22349850

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9916515-5A BR9916515A (pt) 1998-12-22 1999-12-22 Polinucleotìdeo, vetor de expressão, células de e. coli e de agrobacterium tumefaciens transformadas com o vetor de expressão, célula de planta transgênica, semente de planta transgênica, célula eucariótica transgênica, composição imunogênica, método de evocar uma resposta imune em um animal ou ser humano, planta transgênica, e, adjuvante

Country Status (9)

Country Link
US (1) US20030176653A1 (pt)
EP (1) EP1175144A4 (pt)
JP (1) JP2002533068A (pt)
CN (1) CN1191357C (pt)
AU (1) AU773953B2 (pt)
BR (1) BR9916515A (pt)
CA (1) CA2359586A1 (pt)
MX (1) MXPA01006294A (pt)
WO (1) WO2000037609A2 (pt)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9513371D0 (en) * 1995-06-30 1995-09-06 Biocine Spa Immunogenic detoxified mutant toxins
GB9326174D0 (en) * 1993-12-22 1994-02-23 Biocine Sclavo Mucosal adjuvant
CN100410268C (zh) * 1998-12-23 2008-08-13 博伊斯汤普生植物研究所 免疫原性的乙型肝炎表面抗原在转基因植物中的表达
DE60234695D1 (de) * 2001-06-07 2010-01-21 Univ Colorado Mutantenformen von cholera holotoxin als adjuvans
CA2449670A1 (en) * 2001-06-07 2002-12-12 Wyeth Holdings Corporation Mutant forms of cholera holotoxin as an adjuvant
JP2004535192A (ja) * 2001-06-08 2004-11-25 イコン ジェネティクス インコーポレイティッド 植物中におけるタンパク質の産生
US7109397B2 (en) * 2002-02-12 2006-09-19 Cornell Research Foundation, Inc. Pseudomonas syringae harpins, HopPtoP and HopPmaHPto, and their uses
US20040146533A1 (en) * 2002-08-27 2004-07-29 Miller Timothy J. Use of escherichia coli heat labile toxin as an adjuvant in birds and poultry
DK1767639T3 (da) * 2004-05-31 2012-06-11 Kitasato Daiichi Sankyo Vaccine Co Ltd Orale anti-leucocytozoonose-vacciner på basis af transgeniske planter
US20090304733A1 (en) * 2004-07-28 2009-12-10 Jacob Pitcovski Vaccine comprising recombinant ct or lt toxin
CN100387719C (zh) * 2005-05-09 2008-05-14 中国农业科学院生物技术研究所 编码大肠杆菌热敏毒素基因及其表达载体和用途
CN1324138C (zh) * 2005-07-21 2007-07-04 华东理工大学 大肠杆菌热敏毒素b亚单位的真核表达方法
AU2006312126A1 (en) 2005-11-04 2007-05-18 Dow Agrosciences Llc Preparation of vaccine master cell lines using recombinant plant suspension cultures
CN100500842C (zh) * 2006-03-09 2009-06-17 昆明理工大学 一种大肠杆菌热不稳定肠毒素的制备方法
US20080028487A1 (en) * 2006-06-06 2008-01-31 The University Of Nebraska-Lincoln USES OF THE PSEUDOMONAS SYRINGAE EFFECTOR PROTEIN HopU1 RELATED TO ITS ABILITY TO ADP-RIBOSYLATE EUKARYOTIC RNA BINDING PROTEINS
EP2287300B1 (en) 2008-05-02 2018-06-27 Idemitsu Kosan Co., Ltd. Bacterial toxin vaccine
KR101233018B1 (ko) 2010-02-05 2013-02-13 전북대학교산학협력단 대장균 장독소 ｂ 서브유닛 유전자로 형질전환된 식물배양체, 및 이를 포함하는 백신
TWI451874B (zh) * 2010-05-03 2014-09-11 Dev Center Biotechnology 多醣體與大腸桿菌熱不穩定腸毒素之共軛物，其用途及製法
WO2013191225A1 (ja) 2012-06-20 2013-12-27 国立大学法人 東京大学 粘膜免疫賦活化剤及びｈｐｖ感染症治療用経口医薬組成物

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL101715A (en) * 1991-05-02 2005-06-19 Amgen Inc Recombinant dna-derived cholera toxin subunit analogs
GB9513371D0 (en) * 1995-06-30 1995-09-06 Biocine Spa Immunogenic detoxified mutant toxins
IT1253009B (it) * 1991-12-31 1995-07-10 Sclavo Ricerca S R L Mutanti immunogenici detossificati della tossina colerica e della tossina lt, loro preparazione ed uso per la preparazione di vaccini
JPH10507916A (ja) * 1994-10-24 1998-08-04 ザ テキサス エーアンドエム ユニバーシティ システム トランスジェニック植物による経口免疫
GB9622660D0 (en) * 1996-10-31 1997-01-08 Biocine Spa Immunogenic detoxified mutant toxin
US5980898A (en) * 1996-11-14 1999-11-09 The United States Of America As Represented By The U.S. Army Medical Research & Material Command Adjuvant for transcutaneous immunization
US6818222B1 (en) * 1997-03-21 2004-11-16 Chiron Corporation Detoxified mutants of bacterial ADP-ribosylating toxins as parenteral adjuvants
FI110323B (fi) * 1997-06-02 2002-12-31 Timo Korpela Rekombinanttikonstrukti geenin ilmentämisen lisäämiseksi kasveissa

Also Published As

Publication number Publication date
AU773953B2 (en) 2004-06-10
EP1175144A4 (en) 2002-10-30
WO2000037609A3 (en) 2000-09-14
MXPA01006294A (es) 2002-06-04
WO2000037609A2 (en) 2000-06-29
CN1191357C (zh) 2005-03-02
EP1175144A2 (en) 2002-01-30
CA2359586A1 (en) 2000-06-29
JP2002533068A (ja) 2002-10-08
CN1331558A (zh) 2002-01-16
US20030176653A1 (en) 2003-09-18
AU2381800A (en) 2000-07-12

Similar Documents

Publication Publication Date Title
BR9916515A (pt) Polinucleotìdeo, vetor de expressão, células de e. coli e de agrobacterium tumefaciens transformadas com o vetor de expressão, célula de planta transgênica, semente de planta transgênica, célula eucariótica transgênica, composição imunogênica, método de evocar uma resposta imune em um animal ou ser humano, planta transgênica, e, adjuvante
Batschauer A plant gene for photolyase: an enzyme catalyzing the repair of UV‐light‐induced DNA damage
MY108154A (en) Immunogenic detoxified mutants, of cholera toxin and of the toxin lt, their preparation and their use for the preparation of vaccines.
BR0208203A (pt) Polipeptìdeo do fator vii, derivado do fator vii, composição, composição farmacêutica, construção de polinucleotìdeo, célula hospedeira eucariótica, animal transgênico, planta transgênica, e, métodos para produzir o polipeptìdeo do fator vii e um derivado do fator vii, uso de um derivado do fator vii, métodos para o tratamento de episódios de hemorragia ou distúrbios de hemorragia em um paciente ou para a intensificação do sistema hemostático normal e para inibir a formação de trobo em um paciente
Reichman et al. Human leukocyte interferon and the antiviral factor (AVF) from virus-infected plants stimulate plant tissues to produce nucleotides with antiviral activity
Alderton et al. Heat adaptation and ion exchange in Bacillus megaterium spores
DE3873672D1 (de) Stilbensynthase-gen.
BR9508633A (pt) Composição preparação de vacina estojo e processos para criar ou sustentar uma resposta imune protetora ou adaptadora a um antígeno em um hospedeiro e para induzir uma resposta imune protetora contra um organismo bacteriano enterotóxico
FI820467L (fi) Farmaceutiska kompositioner som frigoers kontinuerligt
ES2147551T3 (es) Procedimiento para transformar plantas monocotiledoneas.
DK1029023T3 (da) Brandhæmmende og biocidt præparat og fremgangsmåde til fremstilling deraf
DE69636735D1 (de) Immunogene, ungiftige choleratoxinmutante
ES2164636T3 (es) Plasmidos para la produccion de plantas transgenicas que se modifican en su constitucion fisica y rendimiento.
ES2196293T3 (es) Procedimiento e instalacion para la inactivacion enzimatica subsiguiente a la extraccion de pure de productos alimenticios.
BR9808430A (pt) Método para melhorar a especificidade da regulação de gens em um organismo transformado
ES8206447A1 (es) Procedimiento para preparar derivados de enterotoxina termoestable (st) de e. coli.
Karpova et al. Lectins of Sambucus nigra as biologically active and DNA-protective substances
AR036178A1 (es) Genes de la desaturasa del acido graso de la granada y procedimiento para la preparacion de acidos grasos insaturados
PT824548E (pt) Moleculas hibridas entre a enterotoxina labil ao calor e a subunidade b da toxina da colera
MX9206806A (es) Pudines listos para tomar que contienen polifosfato
NZ332973A (en) 1-Galactose derivatives which inhibit binding of toxins such as heat labile enterotoxin or cholera toxin
Welsh et al. Heat-shock treatment of mouse pancreatic islets results in a partial loss of islet cells but no remaining functional impairment among the surviving β cells
AR002648A1 (es) Procedimiento para preparar un producto de carne en trozos.
CO4870727A1 (es) Inhibicion pre y post cosecha de la transformacion de pro- ductos almacenados
NO952601L (no) Oligonukleotider for inhibering av ekspresjon av isoprenylprotein-transferaser

Legal Events

Date Code Title Description
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: INDEFIRO O PEDIDO DE ACORDO COM O(S) ARTIGO(S) 8, 13 E 37 DA LPI

B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL.