BR9915390A - Tratamento de tumores através de administração de compostos que liberam harmÈnio de crescimento e seus antagonistas - Google Patents
Tratamento de tumores através de administração de compostos que liberam harmÈnio de crescimento e seus antagonistasInfo
- Publication number
- BR9915390A BR9915390A BR9915390-4A BR9915390A BR9915390A BR 9915390 A BR9915390 A BR 9915390A BR 9915390 A BR9915390 A BR 9915390A BR 9915390 A BR9915390 A BR 9915390A
- Authority
- BR
- Brazil
- Prior art keywords
- tumors
- growth hormone
- compounds
- antagonists
- administration
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 5
- 206010028980 Neoplasm Diseases 0.000 title abstract 4
- 102000018997 Growth Hormone Human genes 0.000 title abstract 3
- 108010051696 Growth Hormone Proteins 0.000 title abstract 3
- 239000005557 antagonist Substances 0.000 title abstract 3
- 239000000122 growth hormone Substances 0.000 title abstract 3
- 241000124008 Mammalia Species 0.000 abstract 2
- 208000026310 Breast neoplasm Diseases 0.000 abstract 1
- CZCIKBSVHDNIDH-UHFFFAOYSA-N Nalpha-methyl-DL-tryptophan Natural products C1=CC=C2C(CC(NC)C(O)=O)=CNC2=C1 CZCIKBSVHDNIDH-UHFFFAOYSA-N 0.000 abstract 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 abstract 1
- 208000024770 Thyroid neoplasm Diseases 0.000 abstract 1
- 210000000481 breast Anatomy 0.000 abstract 1
- 210000004072 lung Anatomy 0.000 abstract 1
- 208000037841 lung tumor Diseases 0.000 abstract 1
- 125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 230000035755 proliferation Effects 0.000 abstract 1
- 210000001685 thyroid gland Anatomy 0.000 abstract 1
- 208000013076 thyroid tumor Diseases 0.000 abstract 1
- 231100000588 tumorigenic Toxicity 0.000 abstract 1
- 230000000381 tumorigenic effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/29—Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
- A61P5/12—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH for decreasing, blocking or antagonising the activity of the posterior pituitary hormones
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Endocrinology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Reproductive Health (AREA)
- Diabetes (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Pulmonology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
Patente de Invenção: <B>"TRATAMENTO DE TUMORES ATRAVéS DE ADMINISTRAçãO DE COMPOSTOS QUE LIBERAM HORMÈNIO DE CRESCIMENTO E SEUS ANTAGONISTAS"<D>. Esta invenção refere-se a um método para tratar tumor em mamífero mediante administração de um composto que libera hormónio de crescimento ou um antagonista desse composto, em uma quantidade eficaz para reduzir ou inibir proliferação de células tumorigênicas no mamífero. Em particular, os tumores a serem tratados incluem tumores de pulmão, mamários, de tireóide ou de pâncreas. Os compostos preferidos são certos peptídeos que contêm unidades de metil triptofano e de lisina.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/192,406 US6124263A (en) | 1998-11-16 | 1998-11-16 | Treatment of tumors by administration of growth hormone releasing compounds and their antagonists |
PCT/EP1999/008662 WO2000029011A1 (en) | 1998-11-16 | 1999-11-11 | Treatment of tumors by administration of growth hormone releasing compounds and their antagonists |
Publications (1)
Publication Number | Publication Date |
---|---|
BR9915390A true BR9915390A (pt) | 2001-08-07 |
Family
ID=22709509
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR9915390-4A BR9915390A (pt) | 1998-11-16 | 1999-11-11 | Tratamento de tumores através de administração de compostos que liberam harmÈnio de crescimento e seus antagonistas |
Country Status (30)
Country | Link |
---|---|
US (1) | US6124263A (pt) |
EP (1) | EP1131083B1 (pt) |
JP (1) | JP2002529512A (pt) |
KR (1) | KR100704138B1 (pt) |
CN (3) | CN100368014C (pt) |
AR (1) | AR021286A1 (pt) |
AT (1) | ATE258062T1 (pt) |
BG (1) | BG105572A (pt) |
BR (1) | BR9915390A (pt) |
CA (1) | CA2350914A1 (pt) |
CO (1) | CO5140111A1 (pt) |
CZ (1) | CZ20011577A3 (pt) |
DE (1) | DE69914365T2 (pt) |
DK (1) | DK1131083T3 (pt) |
ES (1) | ES2212650T3 (pt) |
HK (1) | HK1040934A1 (pt) |
HU (1) | HUP0104374A3 (pt) |
IL (1) | IL142858A0 (pt) |
MX (1) | MXPA01004689A (pt) |
NO (1) | NO20012367L (pt) |
NZ (1) | NZ511280A (pt) |
PL (1) | PL347659A1 (pt) |
PT (1) | PT1131083E (pt) |
RU (1) | RU2240133C2 (pt) |
SK (1) | SK6352001A3 (pt) |
TR (1) | TR200101350T2 (pt) |
TW (2) | TWI237565B (pt) |
UA (1) | UA73100C2 (pt) |
WO (1) | WO2000029011A1 (pt) |
ZA (1) | ZA200103182B (pt) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6211156B1 (en) * | 1999-11-10 | 2001-04-03 | Asta Medica A.G. | Peptides for treatment of erectile dysfunction |
CU23157A1 (es) * | 2001-01-03 | 2006-07-18 | Ct Ingenieria Genetica Biotech | COMPOSICION FARMACéUTICA PARA EL TRATAMIENTO DEL DANO TISULAR DEBIDO A FALTA DE IRRIGACION SANGUINEA ARTERIAL |
DE10112882A1 (de) * | 2001-03-15 | 2002-09-19 | Max Delbrueck Centrum | Verwendung von Tryptophan-Derivaten zur spezifischen zytostatischen Behandlung von Serotonin-produzierenden Tumoren |
AU2002254800B2 (en) * | 2001-05-10 | 2006-09-28 | Queensland University Of Technology | Reproductive cancer diagnosis and therapy |
EP1312363A1 (en) * | 2001-09-28 | 2003-05-21 | Pfizer Products Inc. | Methods of treatment and kits comprising a growth hormone secretagogue |
TWI331922B (en) * | 2002-08-09 | 2010-10-21 | Ipsen Pharma Sas | Growth hormone releasing peptides |
WO2005027913A1 (en) * | 2003-09-19 | 2005-03-31 | Pfizer Products Inc. | Pharmaceutical compositions and methods comprising combinations of 2-alkylidene-19-nor-vitamin d derivatives and a growth hormone secretagogue |
US20050164952A1 (en) * | 2004-01-23 | 2005-07-28 | Vital Pharmaceuticals, Inc. | Delivery system for growth hormone releasing peptides |
EP2021015A2 (en) * | 2006-04-28 | 2009-02-11 | The Administrators Of The Tulane Educational Fund | Ghrelin/growth hormone releasing peptide/growth hormone secretatogue receptor antagonists and uses thereof |
CN101541341B (zh) | 2006-09-27 | 2013-06-05 | 益普生制药两合公司 | N末端取代的生长素释放肽类似物 |
JP2010518158A (ja) * | 2007-02-13 | 2010-05-27 | ヘルシン セラピューティクス(ユー.エス.),インコーポレイティド | 成長ホルモン分泌促進物質を用いた細胞増殖性障害の治療方法 |
WO2010118309A2 (en) * | 2009-04-10 | 2010-10-14 | Board Of Regents, The University Of Texas System | Inhibitors of stat3 and uses thereof |
US9724381B2 (en) | 2009-05-12 | 2017-08-08 | The Administrators Of The Tulane Educational Fund | Methods of inhibiting the ghrelin/growth hormone secretatogue receptor pathway and uses thereof |
IT1399610B1 (it) * | 2010-01-28 | 2013-04-26 | Univ Milano Bicocca | Uso di agonisti e antagonisti dei recettori per i growth hormone secretagogues per la prevenzione e il trattamento di convulsioni ed epilessia |
EP3920961A4 (en) | 2019-02-08 | 2022-12-14 | United States Government as represented by the Department of Veterans Affairs | GROWTH HORMONE RELEASING HORMONE ANTAGONISTS AND THEIR USES |
WO2021011874A1 (en) * | 2019-07-18 | 2021-01-21 | University Of Miami | Ghrh antagonists for use in a method of treating sarcoidosis |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2053250A1 (en) * | 1989-04-26 | 1990-10-27 | David H. Coy | Linear somatostatin analogs |
IT1240643B (it) * | 1990-05-11 | 1993-12-17 | Mediolanum Farmaceutici Spa | Peptidi biologicamente attivi contenenti in catena 2-alchiltriptofano |
US5385682A (en) * | 1990-05-15 | 1995-01-31 | Exxon Research & Engineering Co. | Grease composition |
SK15096A3 (en) * | 1993-08-09 | 1996-07-03 | Biomeasure Inc | Therapeutic peptide derivatives and a method of their application |
US5550212A (en) * | 1993-12-17 | 1996-08-27 | The Administrators Of The Tulane Educational Fund | Analogues of hGH-RH(1-29)NH2 having antagonistic activity |
US5807985A (en) * | 1996-06-11 | 1998-09-15 | Deghenghi; Romano | Oligopeptide compounds containing D-2-alkyltryptophan capable of promoting the release of growth hormone |
US6063796A (en) * | 1997-04-04 | 2000-05-16 | Merck & Co., Inc. | Somatostatin agonists |
-
1998
- 1998-11-16 US US09/192,406 patent/US6124263A/en not_active Expired - Fee Related
-
1999
- 1999-10-28 CO CO99068206A patent/CO5140111A1/es unknown
- 1999-11-11 CN CNB2006100998244A patent/CN100368014C/zh not_active Expired - Fee Related
- 1999-11-11 CN CNB200410045995XA patent/CN1277840C/zh not_active Expired - Fee Related
- 1999-11-11 ES ES99955974T patent/ES2212650T3/es not_active Expired - Lifetime
- 1999-11-11 CA CA002350914A patent/CA2350914A1/en not_active Abandoned
- 1999-11-11 BR BR9915390-4A patent/BR9915390A/pt not_active IP Right Cessation
- 1999-11-11 JP JP2000582057A patent/JP2002529512A/ja active Pending
- 1999-11-11 CN CNB998133612A patent/CN1200726C/zh not_active Expired - Fee Related
- 1999-11-11 IL IL14285899A patent/IL142858A0/xx unknown
- 1999-11-11 PT PT99955974T patent/PT1131083E/pt unknown
- 1999-11-11 HU HU0104374A patent/HUP0104374A3/hu unknown
- 1999-11-11 MX MXPA01004689A patent/MXPA01004689A/es not_active IP Right Cessation
- 1999-11-11 SK SK635-2001A patent/SK6352001A3/sk unknown
- 1999-11-11 KR KR1020017006163A patent/KR100704138B1/ko not_active IP Right Cessation
- 1999-11-11 TR TR2001/01350T patent/TR200101350T2/xx unknown
- 1999-11-11 EP EP99955974A patent/EP1131083B1/en not_active Expired - Lifetime
- 1999-11-11 CZ CZ20011577A patent/CZ20011577A3/cs unknown
- 1999-11-11 AT AT99955974T patent/ATE258062T1/de not_active IP Right Cessation
- 1999-11-11 RU RU2001116722/14A patent/RU2240133C2/ru not_active IP Right Cessation
- 1999-11-11 DK DK99955974T patent/DK1131083T3/da active
- 1999-11-11 UA UA2001064044A patent/UA73100C2/uk unknown
- 1999-11-11 WO PCT/EP1999/008662 patent/WO2000029011A1/en active IP Right Grant
- 1999-11-11 PL PL99347659A patent/PL347659A1/xx unknown
- 1999-11-11 DE DE69914365T patent/DE69914365T2/de not_active Expired - Fee Related
- 1999-11-11 NZ NZ511280A patent/NZ511280A/xx unknown
- 1999-11-16 AR ARP990105814A patent/AR021286A1/es unknown
- 1999-11-30 TW TW088117984A patent/TWI237565B/zh not_active IP Right Cessation
- 1999-11-30 TW TW094111886A patent/TWI263642B/zh not_active IP Right Cessation
-
2001
- 2001-04-19 ZA ZA200103182A patent/ZA200103182B/en unknown
- 2001-05-14 NO NO20012367A patent/NO20012367L/no not_active Application Discontinuation
- 2001-06-07 BG BG105572A patent/BG105572A/xx unknown
-
2002
- 2002-04-12 HK HK02102769.3A patent/HK1040934A1/zh unknown
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE 10A. E 11A. ANUIDADES. |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2073 DE 28/09/2010. |