BR9915134A - Co-terapia e terapia combinada para o tratamento de distúrbio cardiovascular em um indivìduo, e, composição - Google Patents
Co-terapia e terapia combinada para o tratamento de distúrbio cardiovascular em um indivìduo, e, composiçãoInfo
- Publication number
- BR9915134A BR9915134A BR9915134-0A BR9915134A BR9915134A BR 9915134 A BR9915134 A BR 9915134A BR 9915134 A BR9915134 A BR 9915134A BR 9915134 A BR9915134 A BR 9915134A
- Authority
- BR
- Brazil
- Prior art keywords
- therapy
- treatment
- individual
- composition
- cardiovascular disorders
- Prior art date
Links
- 208000024172 Cardiovascular disease Diseases 0.000 title abstract 3
- 238000011262 co‐therapy Methods 0.000 title abstract 3
- 238000002648 combination therapy Methods 0.000 title abstract 2
- 239000005541 ACE inhibitor Substances 0.000 abstract 1
- 206010007559 Cardiac failure congestive Diseases 0.000 abstract 1
- 108010061435 Enalapril Proteins 0.000 abstract 1
- 206010019280 Heart failures Diseases 0.000 abstract 1
- 108010007859 Lisinopril Proteins 0.000 abstract 1
- 239000002170 aldosterone antagonist Substances 0.000 abstract 1
- 229940083712 aldosterone antagonist Drugs 0.000 abstract 1
- 229940044094 angiotensin-converting-enzyme inhibitor Drugs 0.000 abstract 1
- 229960000830 captopril Drugs 0.000 abstract 1
- FAKRSMQSSFJEIM-RQJHMYQMSA-N captopril Chemical compound SC[C@@H](C)C(=O)N1CCC[C@H]1C(O)=O FAKRSMQSSFJEIM-RQJHMYQMSA-N 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 229960000873 enalapril Drugs 0.000 abstract 1
- GBXSMTUPTTWBMN-XIRDDKMYSA-N enalapril Chemical compound C([C@@H](C(=O)OCC)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(O)=O)CC1=CC=CC=C1 GBXSMTUPTTWBMN-XIRDDKMYSA-N 0.000 abstract 1
- 229960002394 lisinopril Drugs 0.000 abstract 1
- RLAWWYSOJDYHDC-BZSNNMDCSA-N lisinopril Chemical compound C([C@H](N[C@@H](CCCCN)C(=O)N1[C@@H](CCC1)C(O)=O)C(O)=O)CC1=CC=CC=C1 RLAWWYSOJDYHDC-BZSNNMDCSA-N 0.000 abstract 1
- 239000002171 loop diuretic Substances 0.000 abstract 1
- 229960002256 spironolactone Drugs 0.000 abstract 1
- LXMSZDCAJNLERA-ZHYRCANASA-N spironolactone Chemical compound C([C@@H]1[C@]2(C)CC[C@@H]3[C@@]4(C)CCC(=O)C=C4C[C@H]([C@@H]13)SC(=O)C)C[C@@]21CCC(=O)O1 LXMSZDCAJNLERA-ZHYRCANASA-N 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/401—Proline; Derivatives thereof, e.g. captopril
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
- A61K31/585—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin containing lactone rings, e.g. oxandrolone, bufalin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/05—Dipeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/55—Protease inhibitors
- A61K38/556—Angiotensin converting enzyme inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cardiology (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Heart & Thoracic Surgery (AREA)
- Molecular Biology (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
"CO-TERAPIA E TERAPIA COMBINADA PARA O TRATAMENTO DE DISTúRBIO CARDIOVASCULAR EM UM INDIVìDUO, E, COMPOSIçãO" Combinações de um inibidor de ACE, um antagonista de aldosterona, e um diurético de alça são descritos para o uso no tratamento de distúrbios circulatórios. De interesse particular são as terapias que utilizam captopril, enalapril ou lisinopril co-administrados com espironolactona. Esta co-terapia será particularmente útil para reduzir o índice de mortalidade ou o número de hospitalizações não-fatais ou para prevenir a progressão de insuficiência cardíaca congestiva em pacientes com doença cardiovascular.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10739898P | 1998-11-06 | 1998-11-06 | |
US12297799P | 1999-03-05 | 1999-03-05 | |
US12297899P | 1999-03-05 | 1999-03-05 | |
PCT/US1999/026206 WO2000027380A2 (en) | 1998-11-06 | 1999-11-05 | Combination therapy of angiotensin converting enzyme inhibitor and aldosterone antagonist for reducing morbidity and mortality from cardiovascular disease |
Publications (1)
Publication Number | Publication Date |
---|---|
BR9915134A true BR9915134A (pt) | 2001-08-07 |
Family
ID=27380294
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR9915134-0A BR9915134A (pt) | 1998-11-06 | 1999-11-05 | Co-terapia e terapia combinada para o tratamento de distúrbio cardiovascular em um indivìduo, e, composição |
Country Status (17)
Country | Link |
---|---|
US (3) | US6410524B1 (pt) |
EP (1) | EP1126880A2 (pt) |
JP (1) | JP2002529405A (pt) |
KR (1) | KR20010100986A (pt) |
CN (1) | CN1330556A (pt) |
AU (1) | AU1714000A (pt) |
BR (1) | BR9915134A (pt) |
CA (1) | CA2348885A1 (pt) |
CZ (1) | CZ20011590A3 (pt) |
EA (1) | EA003782B1 (pt) |
HK (1) | HK1040056A1 (pt) |
HU (1) | HUP0104249A3 (pt) |
ID (1) | ID29778A (pt) |
IL (1) | IL142911A0 (pt) |
NO (1) | NO20012229L (pt) |
PL (1) | PL348198A1 (pt) |
WO (1) | WO2000027380A2 (pt) |
Families Citing this family (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20050250748A1 (en) * | 1999-03-05 | 2005-11-10 | G. D. Searle & Co. | Combination therapy of angiotensin converting enzyme inhibitor and eplerenone for treatment of cardiovascular disease |
AU2001255730A1 (en) * | 2000-04-26 | 2001-11-07 | First Horizon Pharmaceutical Corporation | Methods and compositions for the treatment of cardiac indications |
AU1604001A (en) * | 2000-06-13 | 2001-12-24 | Pharmacia Corp | Use of an aldosterone antagonist for the treatment or prohpylaxis of aldosterone-mediated pathogenic effects |
DE60122898T2 (de) * | 2000-07-27 | 2007-04-12 | Pharmacia Corp. | Aldosteronantagonist und cyclooxygenase-2 hemmer-kombinationstherapie zur verhinderung oder behandlung von kardiovaskulären krankheiten mit entzündunsbezug |
WO2002009761A2 (en) * | 2000-07-27 | 2002-02-07 | Pharmacia Corporation | Epoxy-steroidal aldosterone antagonist and calcium channel blocker combination therapy for treatment of congestive heart failure |
US20020111337A1 (en) * | 2000-08-28 | 2002-08-15 | Fedde Kenton N. | Use of an aldosterone receptor antagonist to improve cognitive function |
US7534768B2 (en) * | 2000-12-13 | 2009-05-19 | Henderson Morely Research And Development Ltd. | Treatment of DNA viral infections |
US20030225123A1 (en) * | 2001-03-22 | 2003-12-04 | Auerbach Bruce Jeffrey | Antihypertensive agents and use |
US20040156903A1 (en) * | 2002-05-22 | 2004-08-12 | Abrams Andrew L.. | Metering and packaging of controlled release medication |
AU2003235579A1 (en) * | 2002-01-15 | 2003-07-30 | Delta Hf. | Formulations of quinapril and related ace inhibitors |
CL2004000366A1 (es) * | 2003-02-26 | 2005-01-07 | Pharmacia Corp Sa Organizada B | USO DE UNA COMBINACION DE UN COMPUESTO DERIVADO DE PIRAZOL INHIBIDOR DE QUINASA p38, Y UN INHIBIDOR DE ACE PARA TRATAR DISFUNCION RENAL, ENFERMEDAD CARDIOVASCULAR Y VASCULAR, RETINOPATIA, NEUROPATIA, EDEMA, DISFUNCION ENDOTELIAL O INSULINOPATIA. |
US20040214804A1 (en) * | 2003-04-25 | 2004-10-28 | Pharmacia Corporation | Combination of an aldosterone receptor antagonist and an anti-obesity agent |
US20050131028A1 (en) * | 2003-09-11 | 2005-06-16 | Pharmacia Corporation | Methods and compositions for the extended duration treatment of pain, inflammation and inflammation-related disorders |
US20050153885A1 (en) * | 2003-10-08 | 2005-07-14 | Yun Anthony J. | Treatment of conditions through modulation of the autonomic nervous system |
GB0329288D0 (en) | 2003-12-18 | 2004-01-21 | Inverness Medical Switzerland | Monitoring method and apparatus |
EP1698058A4 (en) * | 2003-12-18 | 2009-09-23 | Inverness Medical Switzerland | METHOD AND DEVICE FOR MONITORING |
KR101228233B1 (ko) | 2004-03-30 | 2013-01-31 | 리립사, 인크. | 이온 결합 중합체 및 이의 용도 |
GB2413282B (en) * | 2004-04-23 | 2009-01-14 | Henderson Morley Plc | DNA Viral Infections |
US8569277B2 (en) * | 2004-08-11 | 2013-10-29 | Palo Alto Investors | Methods of treating a subject for a condition |
US20060135497A1 (en) * | 2004-12-17 | 2006-06-22 | Ajay Gupta | Combination therapy for treating heart disease |
US20100028439A1 (en) * | 2005-05-23 | 2010-02-04 | Elan Pharma International Limited | Nanoparticulate stabilized anti-hypertensive compositions |
US20070112593A1 (en) * | 2005-11-14 | 2007-05-17 | Rxcera Pharmaceutical, Inc. | Selection system, dispensing system and treatment with a one-a-day combination pill for hypertension, hypercholesterolemia, hypertriglyceridemia and anti-platelet treatment |
US9884024B2 (en) * | 2005-12-27 | 2018-02-06 | Hemant N Joshi | Physically dispersed, molecularly dissolved and/or chemically bound drug(s) in an empty, hard capsule shell composition |
EP2051696A2 (en) * | 2006-08-18 | 2009-04-29 | Morton Grove Pharmaceuticals, Inc. | Stable liquid levetiracetam compositions and methods |
CN100367956C (zh) * | 2006-08-29 | 2008-02-13 | 陈俊云 | 用于治疗高血压的药物 |
US20090076119A1 (en) * | 2007-09-19 | 2009-03-19 | Protia, Llc | Deuterium-enriched ramipril |
NZ588623A (en) | 2008-04-17 | 2012-11-30 | Sanofi Aventis | Use of a medicament containing dronedarone with food for preventing cardiovascular hospitalization |
EP2116239A1 (en) * | 2008-04-29 | 2009-11-11 | Sanofi-Aventis | Method for managing the risks associated with an increase in serum creatinine during dronedarone treatment |
GB0819635D0 (en) * | 2008-10-27 | 2008-12-03 | Auron Invest Ltd | A composition for the treatment of hypertension |
US20100249081A1 (en) * | 2009-03-26 | 2010-09-30 | Ajay Gupta | Compositions and methods for treatment of renal disease |
US20110054033A1 (en) * | 2009-08-26 | 2011-03-03 | Virginia Tech Intellectual Properties, Inc. | Methods of using abscisic acid for ameliorating hypertension and vascular inflammation |
US8602215B2 (en) | 2010-06-30 | 2013-12-10 | Sanofi | Methods for reducing the risk of an adverse dronedarone/beta-blockers interaction in a patient suffering from atrial fibrillation |
KR20150088243A (ko) | 2012-10-08 | 2015-07-31 | 리립사, 인크. | 고혈압 및 고칼륨혈증을 치료하기 위한 칼륨-결합제 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3257390A (en) | 1963-06-12 | 1966-06-21 | Merck & Co Inc | Ring a unsaturated 21-hydroxy-3-oxo-17alpha-pregnane-17-carboxylic acid lactone diuretic agents |
DE2652761C2 (de) * | 1976-11-16 | 1985-11-21 | Schering AG, 1000 Berlin und 4709 Bergkamen | 15,16-Methylen-Spirolactone, Verfahren zu deren Herstellung und diese enthaltende Arzneimittel |
US4559332A (en) * | 1983-04-13 | 1985-12-17 | Ciba Geigy Corporation | 20-Spiroxanes and analogues having an open ring E, processes for their manufacture, and pharmaceutical preparations thereof |
DE3506100A1 (de) | 1985-02-18 | 1986-08-21 | Schering AG, 1000 Berlin und 4709 Bergkamen | 1(alpha).7(alpha)-dithiosubstituierte spirolactone, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
CA2212713A1 (en) * | 1995-02-10 | 1996-08-15 | G.D. Searle & Co. | Combination of angiotensin converting enzyme inhibitor and side-effect-reduced amount of aldosterone antagonist |
NZ302578A (en) | 1995-02-10 | 2001-05-25 | G | A combination of a diuretic, aldosterone antagonist and an angiotensin converting enzyme inhibitor for treating cardiovascular diseases |
AU4777896A (en) * | 1995-02-10 | 1996-08-27 | G.D. Searle & Co. | Use of low dose amount of spironolactone for treatment of cardiovascular disease |
WO1996040255A2 (en) * | 1995-06-07 | 1996-12-19 | G.D. Searle & Co. | Method to treat cardiofibrosis with a combination therapy of an angiotensin ii antagonist and an epoxy-steroidal aldosterone antagonist |
WO1996040256A1 (en) | 1995-06-07 | 1996-12-19 | G.D. Searle & Co. | Method to treat cardiofibrosis with a combination of an angiotensin ii antagonist and spironolactone |
-
1999
- 1999-11-05 EP EP99960221A patent/EP1126880A2/en not_active Withdrawn
- 1999-11-05 HU HU0104249A patent/HUP0104249A3/hu unknown
- 1999-11-05 AU AU17140/00A patent/AU1714000A/en not_active Abandoned
- 1999-11-05 CA CA002348885A patent/CA2348885A1/en not_active Abandoned
- 1999-11-05 ID IDW00200100977A patent/ID29778A/id unknown
- 1999-11-05 BR BR9915134-0A patent/BR9915134A/pt not_active Application Discontinuation
- 1999-11-05 CN CN99814366A patent/CN1330556A/zh active Pending
- 1999-11-05 US US09/434,685 patent/US6410524B1/en not_active Expired - Lifetime
- 1999-11-05 IL IL14291199A patent/IL142911A0/xx unknown
- 1999-11-05 EA EA200100418A patent/EA003782B1/ru unknown
- 1999-11-05 WO PCT/US1999/026206 patent/WO2000027380A2/en not_active Application Discontinuation
- 1999-11-05 CZ CZ20011590A patent/CZ20011590A3/cs unknown
- 1999-11-05 KR KR1020017005639A patent/KR20010100986A/ko not_active Application Discontinuation
- 1999-11-05 JP JP2000580609A patent/JP2002529405A/ja not_active Withdrawn
- 1999-11-05 PL PL99348198A patent/PL348198A1/xx not_active Application Discontinuation
-
2001
- 2001-05-04 NO NO20012229A patent/NO20012229L/no not_active Application Discontinuation
-
2002
- 2002-02-15 US US10/077,134 patent/US6747020B2/en not_active Expired - Lifetime
- 2002-02-28 HK HK02101565.1A patent/HK1040056A1/zh unknown
-
2004
- 2004-01-08 US US10/753,610 patent/US20040167108A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
CA2348885A1 (en) | 2000-05-18 |
US6410524B1 (en) | 2002-06-25 |
US20040167108A1 (en) | 2004-08-26 |
KR20010100986A (ko) | 2001-11-14 |
IL142911A0 (en) | 2002-04-21 |
ID29778A (id) | 2001-10-11 |
JP2002529405A (ja) | 2002-09-10 |
EA200100418A1 (ru) | 2001-12-24 |
EA003782B1 (ru) | 2003-08-28 |
AU1714000A (en) | 2000-05-29 |
US6747020B2 (en) | 2004-06-08 |
WO2000027380A2 (en) | 2000-05-18 |
US20030040484A1 (en) | 2003-02-27 |
NO20012229L (no) | 2001-07-03 |
HUP0104249A2 (hu) | 2002-04-29 |
WO2000027380A3 (en) | 2000-08-24 |
NO20012229D0 (no) | 2001-05-04 |
CN1330556A (zh) | 2002-01-09 |
HUP0104249A3 (en) | 2002-06-28 |
PL348198A1 (en) | 2002-05-06 |
HK1040056A1 (zh) | 2002-05-24 |
CZ20011590A3 (cs) | 2003-01-15 |
EP1126880A2 (en) | 2001-08-29 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
B15K | Others concerning applications: alteration of classification |
Free format text: ALTERADA DA INT.CL: A61K 31/401, A61K 31/341, A61P 9/00 Ipc: A61K 31/401 (2009.01), A61K 31/341 (2009.01), A61P |
|
B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
B09B | Patent application refused [chapter 9.2 patent gazette] |
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