BR9912437A - ácidos nucléicos codificando um receptor ligado à proteìna g envolvido na transdução sensória - Google Patents
ácidos nucléicos codificando um receptor ligado à proteìna g envolvido na transdução sensóriaInfo
- Publication number
- BR9912437A BR9912437A BR9912437-8A BR9912437A BR9912437A BR 9912437 A BR9912437 A BR 9912437A BR 9912437 A BR9912437 A BR 9912437A BR 9912437 A BR9912437 A BR 9912437A
- Authority
- BR
- Brazil
- Prior art keywords
- nucleic acids
- acids encoding
- protein involved
- receptor linked
- sensory transduction
- Prior art date
Links
- 102000039446 nucleic acids Human genes 0.000 title abstract 3
- 108020004707 nucleic acids Proteins 0.000 title abstract 3
- 150000007523 nucleic acids Chemical class 0.000 title abstract 3
- 230000015155 detection of stimulus involved in sensory perception Effects 0.000 title 1
- 102000004169 proteins and genes Human genes 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 title 1
- 102000003688 G-Protein-Coupled Receptors Human genes 0.000 abstract 2
- 108090000045 G-Protein-Coupled Receptors Proteins 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 102000005962 receptors Human genes 0.000 abstract 2
- 108020003175 receptors Proteins 0.000 abstract 2
- 230000001953 sensory effect Effects 0.000 abstract 2
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 1
- 238000012216 screening Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
- G01N33/5041—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects involving analysis of members of signalling pathways
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
- C07K14/723—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH receptor
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Medicinal Chemistry (AREA)
- Toxicology (AREA)
- Cell Biology (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Endocrinology (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- General Physics & Mathematics (AREA)
- Tropical Medicine & Parasitology (AREA)
- Food Science & Technology (AREA)
- Analytical Chemistry (AREA)
- Pathology (AREA)
- Plant Pathology (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US9546498P | 1998-07-28 | 1998-07-28 | |
| US11274798P | 1998-12-17 | 1998-12-17 | |
| PCT/US1999/017104 WO2000006593A1 (en) | 1998-07-28 | 1999-07-27 | Nucleic acids encoding a g-protein coupled receptor involved in sensory transduction |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR9912437A true BR9912437A (pt) | 2001-09-25 |
Family
ID=26790259
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR9912437-8A BR9912437A (pt) | 1998-07-28 | 1999-07-27 | ácidos nucléicos codificando um receptor ligado à proteìna g envolvido na transdução sensória |
Country Status (15)
| Country | Link |
|---|---|
| US (8) | US6383778B1 (cg-RX-API-DMAC7.html) |
| EP (1) | EP1100811B1 (cg-RX-API-DMAC7.html) |
| JP (2) | JP4657450B2 (cg-RX-API-DMAC7.html) |
| KR (1) | KR100643622B1 (cg-RX-API-DMAC7.html) |
| CN (1) | CN1178952C (cg-RX-API-DMAC7.html) |
| AT (2) | ATE366256T1 (cg-RX-API-DMAC7.html) |
| AU (2) | AU764180B2 (cg-RX-API-DMAC7.html) |
| BR (1) | BR9912437A (cg-RX-API-DMAC7.html) |
| CA (1) | CA2335376C (cg-RX-API-DMAC7.html) |
| DE (2) | DE69942622D1 (cg-RX-API-DMAC7.html) |
| DK (1) | DK1100811T3 (cg-RX-API-DMAC7.html) |
| ES (1) | ES2289817T3 (cg-RX-API-DMAC7.html) |
| IL (3) | IL140980A0 (cg-RX-API-DMAC7.html) |
| NO (1) | NO20010320L (cg-RX-API-DMAC7.html) |
| WO (1) | WO2000006593A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (99)
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|---|---|---|---|---|
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| US7402400B2 (en) * | 2001-07-03 | 2008-07-22 | Regents Of The University Of California | Mammalian sweet taste receptors |
| US6875574B1 (en) * | 1999-01-27 | 2005-04-05 | The Regents Of The University Of California | Assays for sensory modulators using a sensory cell specific G-protein alpha subunit |
| GB9923146D0 (en) * | 1999-09-30 | 1999-12-01 | Imperial College | Detector array |
| TW201006846A (en) * | 2000-03-07 | 2010-02-16 | Senomyx Inc | T1R taste receptor and genes encidung same |
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| US7678539B2 (en) | 2000-08-10 | 2010-03-16 | Corning Incorporated | Arrays of biological membranes and methods and use thereof |
| EP1319015A2 (en) * | 2000-09-22 | 2003-06-18 | ChemCom S.A. | Olfactory and pheromones g-protein coupled receptors |
| TW201022287A (en) * | 2001-01-03 | 2010-06-16 | Senomyx Inc | T1R taste receptors and genes encoding same |
| US6955887B2 (en) * | 2001-03-30 | 2005-10-18 | Senomyx, Inc. | Use of T1R hetero-oligomeric taste receptor to screen for compounds that modulate taste signaling |
| US7309577B2 (en) * | 2001-03-07 | 2007-12-18 | Senomyx, Inc. | Binding assays that use the T1R1/T1R3 (umami) taste receptor to identify compounds that elicit or modulate umami taste |
| US7368285B2 (en) * | 2001-03-07 | 2008-05-06 | Senomyx, Inc. | Heteromeric umami T1R1/T1R3 taste receptors and isolated cells that express same |
| US7763431B1 (en) | 2001-03-07 | 2010-07-27 | Senomyx, Inc. | Binding assays that use the T1R2/T1R3 (sweet) taste receptor to identify compounds that elicit or modulate sweet taste |
| US7301009B2 (en) * | 2001-06-26 | 2007-11-27 | Senomyx, Inc. | Isolated (T1R1/T1R3) umami taste receptors that respond to umami taste stimuli |
| US20080244761A1 (en) * | 2001-03-07 | 2008-10-02 | Senomyx, Inc. | T1r hetero-oligomeric taste receptors and cell lines that express said receptors and use thereof for identification of taste compounds |
| US7338771B2 (en) | 2001-07-10 | 2008-03-04 | Alexey Pronin | Use of specific T2R taste receptors to identify compounds that block bitter taste |
| US7883856B2 (en) | 2001-04-05 | 2011-02-08 | Senomyx Inc. | Identification of bitter ligands that specifically activate human T2R receptors and related assays for identifying human bitter taste modulators |
| US7803982B2 (en) | 2001-04-20 | 2010-09-28 | The Mount Sinai School Of Medicine Of New York University | T1R3 transgenic animals, cells and related methods |
| MXPA03009580A (es) * | 2001-04-20 | 2004-12-06 | Sinai School Medicine | Tir3, un receptor de sabor novedoso. |
| JP5001512B2 (ja) * | 2001-06-26 | 2012-08-15 | セノミックス インコーポレイテッド | T1rヘテロオリゴマー味覚受容体及び前記受容体を発現する細胞系並びに味覚化合物の特定のためのその使用 |
| DK2327985T3 (en) * | 2001-06-26 | 2016-09-05 | Senomyx Inc | H1 Oligomeric T1R Taste Receptors and Cell Lines Expressing the Receptors, and Their Use to Identify Taste Compounds |
| EP1412750B1 (en) * | 2001-06-26 | 2012-05-23 | Senomyx, Inc. | T1r2-t1r3 hetero-oligomeric sweet taste receptors and cell lines that express said receptors and use thereof for identification of sweet taste compounds |
| CA2452716C (en) | 2001-07-03 | 2012-06-26 | The Regents Of The University Of California | Mammalian sweet and amino acid heterodimeric taste receptors |
| CA2452315A1 (en) | 2001-07-06 | 2003-01-16 | Senomyx, Inc. | Expression of functional human olfactory cyclic nucleotide gated (cng) channel in recombinant host cells and use thereof in cell based assays to identify smell modulators |
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| EP1644528A2 (en) * | 2003-06-19 | 2006-04-12 | THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, the Department of Health and Human Services, | Variants of human taste receptor genes |
| WO2005005480A2 (en) | 2003-06-27 | 2005-01-20 | Monell Chemical Senses Center | Taste receptors of the t1r family from domestic cat |
| US7517968B2 (en) * | 2003-07-07 | 2009-04-14 | Syracuse University | Rapid and inexpensive method for the purification of proteorhodopsin |
| SG153714A1 (en) | 2003-08-06 | 2009-07-29 | Senomyx Inc | T1r hetero-oligomeric taste receptors, cell lines that express said receptors, and taste compounds |
| US20050106571A1 (en) | 2003-10-02 | 2005-05-19 | The Regents Of The University Of California | Mammalian T1R3 sweet taste receptors |
| US20060045953A1 (en) * | 2004-08-06 | 2006-03-02 | Catherine Tachdjian | Aromatic amides and ureas and their uses as sweet and/or umami flavor modifiers, tastants and taste enhancers |
| US20060257543A1 (en) * | 2005-02-04 | 2006-11-16 | Catherine Tachdjian | Molecules comprising linked organic moieties as flavor modifiers for comestible compositions |
| EP1850681B1 (en) * | 2005-02-04 | 2019-12-18 | Firmenich Incorporated | Compounds comprising linked hetero aryl moieties and their use as novel umami flavor modifiers, tastants and taste enhancers for comestible compositions |
| WO2006113422A2 (en) * | 2005-04-13 | 2006-10-26 | The Government Of The Usa As Represented By The Secretary Of The Dept. Of Health And Human Services | Human sweet and umami taste receptor variants |
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| JP5342878B2 (ja) | 2005-10-20 | 2013-11-13 | セノミクス・インコーポレーテッド | キメラヒト甘味‐旨味および旨味‐甘味味覚受容体 |
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| US20110097741A1 (en) * | 2006-04-20 | 2011-04-28 | Jay Patrick Slack | Partial t1r2 nucleic acid sequence, receptor protein and its use in screening assays |
| EP2995950B1 (en) * | 2006-04-20 | 2024-01-17 | Givaudan SA | Method relating to sweetness enhancement |
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| US7777877B2 (en) * | 2006-10-20 | 2010-08-17 | California Institute Of Technology | High efficiency coupling optics for pumping and detection of fluorescence |
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| US8784898B2 (en) | 2006-10-25 | 2014-07-22 | Revalesio Corporation | Methods of wound care and treatment |
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| US8445546B2 (en) | 2006-10-25 | 2013-05-21 | Revalesio Corporation | Electrokinetically-altered fluids comprising charge-stabilized gas-containing nanostructures |
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| US10745467B2 (en) | 2010-03-26 | 2020-08-18 | The Trustees Of Dartmouth College | VISTA-Ig for treatment of autoimmune, allergic and inflammatory disorders |
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| US9128079B2 (en) | 2011-08-08 | 2015-09-08 | The Coca-Cola Company | Methods of using lung or bronchial epithelial cells to identify bitter taste modulators |
| JP6285923B2 (ja) | 2012-06-22 | 2018-02-28 | トラスティーズ・オブ・ダートマス・カレッジ | 新規VISTA−Igコンストラクト及び自己免疫、アレルギー性及び炎症性障害の処置のためのVISTA−Igの使用 |
| US9890215B2 (en) | 2012-06-22 | 2018-02-13 | King's College London | Vista modulators for diagnosis and treatment of cancer |
| EP3552628A1 (en) | 2012-09-07 | 2019-10-16 | The Trustees Of Dartmouth College | Vista modulators for diagnosis and treatment of cancer |
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| WO2015089073A2 (en) | 2013-12-09 | 2015-06-18 | New York University | Compositions and methods for phagocyte delivery of anti-staphylococcal agents |
| US11014987B2 (en) | 2013-12-24 | 2021-05-25 | Janssen Pharmaceutics Nv | Anti-vista antibodies and fragments, uses thereof, and methods of identifying same |
| US10273301B2 (en) | 2013-12-24 | 2019-04-30 | Janssen Pharmaceutica Nv | Anti-vista antibodies and fragments |
| JP6755640B2 (ja) | 2014-03-28 | 2020-09-16 | 味の素株式会社 | 甘味受容体キメラタンパク質及びその利用 |
| US11123426B2 (en) | 2014-06-11 | 2021-09-21 | The Trustees Of Dartmouth College | Use of vista agonists and antagonists to suppress or enhance humoral immunity |
| MX2017007136A (es) | 2014-12-05 | 2017-12-04 | Immunext Inc | Identificacion de vsig8 como el receptor vista putativo y su uso para producir moduladores vista/vsig8. |
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Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4146501A (en) | 1975-12-12 | 1979-03-27 | Henkin Robert I | Process for isolating and purifying taste bud receptors for screening and evaluating tastants |
| US5688662A (en) | 1992-04-09 | 1997-11-18 | Linguagen Corporation | Gustducin polynucleotides, vectors, host cells and recombinant methods |
| ATE366256T1 (de) * | 1998-07-28 | 2007-07-15 | Univ California | Für einen g-protein gekoppelten rezeptor, der an der empfindungstransduktion beteiligt ist, kodierende nukleinsäuren |
| TW201006846A (en) | 2000-03-07 | 2010-02-16 | Senomyx Inc | T1R taste receptor and genes encidung same |
| US20010037364A1 (en) | 2000-05-10 | 2001-11-01 | Michalek Nancy R. | Management of enterprise communications |
| CA2452716C (en) | 2001-07-03 | 2012-06-26 | The Regents Of The University Of California | Mammalian sweet and amino acid heterodimeric taste receptors |
-
1999
- 1999-07-27 AT AT99938846T patent/ATE366256T1/de active
- 1999-07-27 EP EP99938846A patent/EP1100811B1/en not_active Expired - Lifetime
- 1999-07-27 US US09/361,631 patent/US6383778B1/en not_active Expired - Lifetime
- 1999-07-27 JP JP2000562390A patent/JP4657450B2/ja not_active Expired - Lifetime
- 1999-07-27 AT AT07008610T patent/ATE474852T1/de not_active IP Right Cessation
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- 1999-07-27 WO PCT/US1999/017104 patent/WO2000006593A1/en not_active Ceased
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2002
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2003
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2007
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2009
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2010
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2011
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2013
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