BR9912318A - Compostos de 1- (4-arilpiperazin-1-il) -w- [n- (ol, w -dicarboximido) ] alcanos de utilidade como bloqueadores uro-seletivos de 1 - adrenoceptor. - Google Patents
Compostos de 1- (4-arilpiperazin-1-il) -w- [n- (ol, w -dicarboximido) ] alcanos de utilidade como bloqueadores uro-seletivos de 1 - adrenoceptor.Info
- Publication number
- BR9912318A BR9912318A BR9912318-5A BR9912318A BR9912318A BR 9912318 A BR9912318 A BR 9912318A BR 9912318 A BR9912318 A BR 9912318A BR 9912318 A BR9912318 A BR 9912318A
- Authority
- BR
- Brazil
- Prior art keywords
- compounds
- alkanes
- uro
- adrenoceptor
- utility
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 4
- 150000001335 aliphatic alkanes Chemical class 0.000 title abstract 3
- 108060003345 Adrenergic Receptor Proteins 0.000 title abstract 2
- 102000017910 Adrenergic receptor Human genes 0.000 title abstract 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 4
- 229910052757 nitrogen Inorganic materials 0.000 abstract 2
- -1 2,6 - dioxopiperidin -1-yl Chemical group 0.000 abstract 1
- 206010004446 Benign prostatic hyperplasia Diseases 0.000 abstract 1
- 206010020772 Hypertension Diseases 0.000 abstract 1
- 208000018262 Peripheral vascular disease Diseases 0.000 abstract 1
- 208000004403 Prostatic Hyperplasia Diseases 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 230000007812 deficiency Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 125000004193 piperazinyl group Chemical group 0.000 abstract 1
- KZNICNPSHKQLFF-UHFFFAOYSA-N succinimide Chemical compound O=C1CCC(=O)N1 KZNICNPSHKQLFF-UHFFFAOYSA-N 0.000 abstract 1
- 229940066771 systemic antihistamines piperazine derivative Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/36—Oxygen or sulfur atoms
- C07D207/40—2,5-Pyrrolidine-diones
- C07D207/404—2,5-Pyrrolidine-diones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms, e.g. succinimide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/36—Oxygen or sulfur atoms
- C07D207/40—2,5-Pyrrolidine-diones
- C07D207/404—2,5-Pyrrolidine-diones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms, e.g. succinimide
- C07D207/408—Radicals containing only hydrogen and carbon atoms attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/86—Oxygen atoms
- C07D211/88—Oxygen atoms attached in positions 2 and 6, e.g. glutarimide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
<B>"COMPOSTOS DE 1- (4- ARILPIPERAZIN-1-IL) - <sym>-[N -(<244>, <sym> - DICARBOXIMIDO) ]ALCANOS DE UTILIDADE COMO BLOQUEADORES URO-SELETIVOS DE <244>1- ADRENOCEPTOR"<D>. A presente invenção se refere a novos derivados de piperazina substituídos em um nitrogênio por um sistema aromático e no outro nitrogênio por (2,5 - dioxopirrolidin) - 1 -il) alcanos ou (2,6 - dioxopiperidin -1-il) alcanos, tendo sido encontrado que tais compostos exibem uma atividade <244>~ 1A~ -adrenérgica seletiva. Os compostos da invenção são de utilidade no tratamento de condições doentias, tais como doença vascular periférica, deficiência congestiva do coração, hipertensão e, especialmente, hipertrofia prostática benigna.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/120,265 US6083950A (en) | 1997-11-13 | 1998-07-21 | 1-(4-arylpiperazin-1-yl)-ω-[n-(α,ω-dicarboximido)]-alka nes useful as uro-selective α1-adrenoceptor blockers |
PCT/IB1999/000140 WO2000005206A1 (en) | 1998-07-21 | 1999-01-26 | Arylpiperazine derivatives useful as uro-selective alpha-1-adrenoceptor blockers |
PCT/IB1999/001296 WO2000005205A1 (en) | 1998-07-21 | 1999-07-16 | Arylpiperazine derivatives useful as uroselective alpha1-adrenoceptor blockers |
Publications (1)
Publication Number | Publication Date |
---|---|
BR9912318A true BR9912318A (pt) | 2001-05-02 |
Family
ID=26318738
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR9912318-5A BR9912318A (pt) | 1998-07-21 | 1999-07-16 | Compostos de 1- (4-arilpiperazin-1-il) -w- [n- (ol, w -dicarboximido) ] alcanos de utilidade como bloqueadores uro-seletivos de 1 - adrenoceptor. |
Country Status (10)
Country | Link |
---|---|
EP (1) | EP1097134A1 (pt) |
AU (1) | AU763541B2 (pt) |
BR (1) | BR9912318A (pt) |
CA (1) | CA2338317A1 (pt) |
HU (1) | HUP0102980A3 (pt) |
MX (1) | MXPA01000637A (pt) |
NZ (1) | NZ509388A (pt) |
PL (1) | PL345562A1 (pt) |
SK (1) | SK932001A3 (pt) |
WO (1) | WO2000005205A1 (pt) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR100906102B1 (ko) | 2001-03-27 | 2009-07-07 | 사무엘 보고치 | 레플리킨 펩타이드 및 그의 이용 |
WO2005113498A1 (en) * | 2004-05-19 | 2005-12-01 | Ranbaxy Laboratories Limited | Adrenergic receptor antagonists |
US20090312344A1 (en) * | 2004-05-31 | 2009-12-17 | Mohammad Salman | Arylpiperazine derivatives as adrenergic receptor antagonists |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BE788280A (fr) * | 1971-09-04 | 1973-02-28 | Pfizer | Nouvelles 1-(3-trifluoro-methyl-phenyl)-4-((amido cyclique)- alkyl) piperazines et composition pharmaceutique les contenant |
DE2727469A1 (de) * | 1977-06-18 | 1978-12-21 | Hoechst Ag | Neue hexahydropyrimidine, verfahren zu ihrer herstellung und arzneimittel, die diese verbindungen enthalten |
JPS57197265A (en) * | 1981-05-29 | 1982-12-03 | Eisai Co Ltd | Carboxylic acid imide derivative, its preparation and medicament containing the same |
US4452798A (en) * | 1982-06-22 | 1984-06-05 | Warner-Lambert Company | 1-Substituted phenyl-4-alkyl hydantoin piperazine compounds as antihypertensive agents |
US4675403A (en) * | 1985-10-16 | 1987-06-23 | American Home Products Corporation | 3-Aminoalkyl derivatives of 5,5-disubstituted hydantoins with psychotropic activity |
ES2094690B1 (es) * | 1994-11-22 | 1997-08-01 | Univ Madrid Complutense | Nuevos derivados de imida-piperazinas. |
ES2157366T3 (es) * | 1995-06-09 | 2001-08-16 | Hoffmann La Roche | Derivados de pirimidindiona, pirimidintriona, triacindiona como antagonistas de receptores alfa-1-adrenergicos. |
-
1999
- 1999-07-16 CA CA002338317A patent/CA2338317A1/en not_active Abandoned
- 1999-07-16 PL PL99345562A patent/PL345562A1/xx not_active Application Discontinuation
- 1999-07-16 WO PCT/IB1999/001296 patent/WO2000005205A1/en not_active Application Discontinuation
- 1999-07-16 AU AU46410/99A patent/AU763541B2/en not_active Ceased
- 1999-07-16 NZ NZ509388A patent/NZ509388A/en unknown
- 1999-07-16 EP EP99929633A patent/EP1097134A1/en not_active Withdrawn
- 1999-07-16 BR BR9912318-5A patent/BR9912318A/pt not_active IP Right Cessation
- 1999-07-16 HU HU0102980A patent/HUP0102980A3/hu unknown
- 1999-07-16 SK SK93-2001A patent/SK932001A3/sk unknown
- 1999-07-16 MX MXPA01000637A patent/MXPA01000637A/es unknown
Also Published As
Publication number | Publication date |
---|---|
PL345562A1 (en) | 2001-12-17 |
NZ509388A (en) | 2003-12-19 |
WO2000005205A1 (en) | 2000-02-03 |
HUP0102980A2 (hu) | 2001-12-28 |
HUP0102980A3 (en) | 2003-02-28 |
SK932001A3 (en) | 2001-08-06 |
AU4641099A (en) | 2000-02-14 |
EP1097134A1 (en) | 2001-05-09 |
CA2338317A1 (en) | 2000-02-03 |
AU763541B2 (en) | 2003-07-24 |
MXPA01000637A (es) | 2002-04-08 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE AO NAO RECOLHIMENTO DA(S) 8A E 9A ANUIDADE(S). |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 DA RPI 1986 DE 27/03/2009. |