BR9912279A - Uso de uteroglobina humana recombinante no tratamento de condições inflamatórias e fibróticas - Google Patents
Uso de uteroglobina humana recombinante no tratamento de condições inflamatórias e fibróticasInfo
- Publication number
- BR9912279A BR9912279A BR9912279-0A BR9912279A BR9912279A BR 9912279 A BR9912279 A BR 9912279A BR 9912279 A BR9912279 A BR 9912279A BR 9912279 A BR9912279 A BR 9912279A
- Authority
- BR
- Brazil
- Prior art keywords
- uteroglobin
- recombinant human
- inflammatory
- treatment
- receptor
- Prior art date
Links
- 101000777301 Homo sapiens Uteroglobin Proteins 0.000 title abstract 3
- 230000003176 fibrotic effect Effects 0.000 title abstract 2
- 230000002757 inflammatory effect Effects 0.000 title abstract 2
- 101000966253 Mus musculus Protein LMBR1L Proteins 0.000 abstract 3
- 206010028980 Neoplasm Diseases 0.000 abstract 2
- 201000011510 cancer Diseases 0.000 abstract 2
- 206010027476 Metastases Diseases 0.000 abstract 1
- 102000003848 Uteroglobin Human genes 0.000 abstract 1
- 108090000203 Uteroglobin Proteins 0.000 abstract 1
- 230000010261 cell growth Effects 0.000 abstract 1
- 230000011132 hemopoiesis Effects 0.000 abstract 1
- 239000003446 ligand Substances 0.000 abstract 1
- 230000009401 metastasis Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000000638 stimulation Effects 0.000 abstract 1
- 230000008685 targeting Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4721—Lipocortins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/07—Animals genetically altered by homologous recombination
- A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Epidemiology (AREA)
- Biophysics (AREA)
- Marine Sciences & Fisheries (AREA)
- Molecular Biology (AREA)
- Toxicology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Urology & Nephrology (AREA)
- Communicable Diseases (AREA)
- Pulmonology (AREA)
- Oncology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
"USO DE UTEROGLOBINA HUMANA RECOMBINANTE NO TRATAMENTO DE CONDIçõES INFLAMATóRIAS E FIBRóTICAS". A presente invenção refere-se e reivindica composições e a métodos para prevenir ou tratar crescimento de células cancerosas primárias e metástase de tumor, bem como estimulação de hematopoiese. A presente invenção também refere-se a métodos de tratamento de câncer e condições relacionadas a receptor de uteroglobina almejando-se um receptor de uteroglobina com uteroglobina humana recombinante (rhUG). São também descritos e reivindicados métodos de purificação de um receptor de uteroglobina e método para usar tais receptores na identificação de análogos estruturais de uteroglobina e ligandos de receptor de UG.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/120,264 US20020160948A1 (en) | 1998-07-21 | 1998-07-21 | Recombinant human uteroglobin in treatment of inflammatory and fibrotic conditions |
PCT/US1999/016312 WO2000004863A2 (en) | 1998-07-21 | 1999-07-19 | Use of recombinant human uteroglobin in treatment of inflammatory and fibrotic conditions |
Publications (1)
Publication Number | Publication Date |
---|---|
BR9912279A true BR9912279A (pt) | 2002-01-02 |
Family
ID=22389207
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR9912279-0A BR9912279A (pt) | 1998-07-21 | 1999-07-19 | Uso de uteroglobina humana recombinante no tratamento de condições inflamatórias e fibróticas |
Country Status (10)
Country | Link |
---|---|
US (1) | US20020160948A1 (pt) |
EP (1) | EP1100524A4 (pt) |
JP (1) | JP2002521316A (pt) |
KR (1) | KR20010085294A (pt) |
CN (1) | CN1323216A (pt) |
AU (1) | AU5112499A (pt) |
BR (1) | BR9912279A (pt) |
CA (1) | CA2338299A1 (pt) |
IL (1) | IL140926A0 (pt) |
WO (1) | WO2000004863A2 (pt) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7122344B2 (en) * | 1997-05-28 | 2006-10-17 | Claragen, Inc. | Methods for the production of purified recombinant human uteroglobin for the treatment of inflammatory and fibrotic conditions |
US20060025348A1 (en) * | 1997-05-28 | 2006-02-02 | Pilon Aprile L | Methods and compositions for the treatment of fibrotic conditions & impaired lung function & to enhance lymphocyte production |
US20060281681A1 (en) * | 1997-05-28 | 2006-12-14 | Pilon Aprile L | Methods and compositions for the reduction of neutrophil influx and for the treatment of bronchpulmonary dysplasia, respiratory distress syndrome, chronic lung disease, pulmonary fibrosis, asthma and chronic obstructive pulmonary disease |
AU5836700A (en) * | 1999-06-01 | 2000-12-18 | Patrick T. Prendergast | Peptides for therapeutic use |
US20040153073A1 (en) | 2000-02-01 | 2004-08-05 | Hand Innovations, Inc. | Orthopedic fixation system including plate element with threaded holes having divergent axes |
CN1315370A (zh) * | 2000-03-27 | 2001-10-03 | 上海博德基因开发有限公司 | 一种新的多肽——人子宫珠蛋白11和编码这种多肽的多核苷酸 |
WO2001080872A1 (en) * | 2000-04-21 | 2001-11-01 | George Washington University | Method of binding integrin for treatment of cancer |
CN1323824A (zh) * | 2000-05-16 | 2001-11-28 | 上海博德基因开发有限公司 | 一种新的多肽——人子宫珠蛋白9和编码这种多肽的多核苷酸 |
KR20110014199A (ko) * | 2008-05-13 | 2011-02-10 | 클라라산스, 인크. | 비강 비염 치료용 재조합 인간 cc10 및 이의 조성물 |
US8277651B2 (en) | 2009-03-13 | 2012-10-02 | Terrasep, Llc | Methods and apparatus for centrifugal liquid chromatography |
PL2459224T3 (pl) | 2009-07-27 | 2017-08-31 | Baxalta GmbH | Koniugaty białka związanego z krzepnięciem krwi |
US9168285B2 (en) | 2009-10-15 | 2015-10-27 | Therabron Therapeutics, Inc. | Recombinant human CC10 protein for treatment of influenza and ebola |
KR101597391B1 (ko) | 2009-10-15 | 2016-02-24 | 클라라산스, 인크. | 인플루엔자 치료용 재조합 사람 cc10 단백질 |
EP2531208A4 (en) * | 2010-02-03 | 2013-07-03 | Univ Rochester | TREATMENT OF FIBROSIS RELATED DISORDERS USING FIBRONECTIN BINDING PROTEINS AND POLYPEPTIDES |
JP7398677B2 (ja) * | 2018-03-12 | 2023-12-15 | 国立研究開発法人医薬基盤・健康・栄養研究所 | ウテログロビンを構造基盤とする二重特異性ポリペプチド |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5935860A (en) * | 1995-03-07 | 1999-08-10 | The George Washington University | Use of uteroglobin expression as a molecular marker for prostatic intraepithelial neoplasia |
US5696092A (en) * | 1995-03-07 | 1997-12-09 | George Washington University | Methods and compositions for inhibiting metastasis of epithelial cell-derived cancers |
WO1998007857A1 (en) * | 1996-08-19 | 1998-02-26 | Abbott Laboratories | Reagents and methods useful for detecting diseases of the breast |
-
1998
- 1998-07-21 US US09/120,264 patent/US20020160948A1/en not_active Abandoned
-
1999
- 1999-07-19 KR KR1020017000868A patent/KR20010085294A/ko not_active Application Discontinuation
- 1999-07-19 CA CA002338299A patent/CA2338299A1/en not_active Abandoned
- 1999-07-19 CN CN99811164A patent/CN1323216A/zh active Pending
- 1999-07-19 JP JP2000560856A patent/JP2002521316A/ja active Pending
- 1999-07-19 BR BR9912279-0A patent/BR9912279A/pt not_active IP Right Cessation
- 1999-07-19 IL IL14092699A patent/IL140926A0/xx unknown
- 1999-07-19 EP EP99935698A patent/EP1100524A4/en active Pending
- 1999-07-19 WO PCT/US1999/016312 patent/WO2000004863A2/en not_active Application Discontinuation
- 1999-07-19 AU AU51124/99A patent/AU5112499A/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
JP2002521316A (ja) | 2002-07-16 |
WO2000004863A3 (en) | 2000-11-23 |
AU5112499A (en) | 2000-02-14 |
US20020160948A1 (en) | 2002-10-31 |
IL140926A0 (en) | 2002-02-10 |
WO2000004863A2 (en) | 2000-02-03 |
KR20010085294A (ko) | 2001-09-07 |
EP1100524A4 (en) | 2003-08-27 |
CN1323216A (zh) | 2001-11-21 |
EP1100524A2 (en) | 2001-05-23 |
CA2338299A1 (en) | 2000-02-03 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 5O, 6O, 7O E 8O ANUIDADES. |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1913 DE 04/09/2007. |