BR9909660A - Caspase inhibitors - Google Patents
Caspase inhibitorsInfo
- Publication number
- BR9909660A BR9909660A BR9909660-9A BR9909660A BR9909660A BR 9909660 A BR9909660 A BR 9909660A BR 9909660 A BR9909660 A BR 9909660A BR 9909660 A BR9909660 A BR 9909660A
- Authority
- BR
- Brazil
- Prior art keywords
- sym
- compounds
- diseases
- relates
- methods
- Prior art date
Links
- 108010076667 Caspases Proteins 0.000 title abstract 5
- 102000011727 Caspases Human genes 0.000 title abstract 5
- 239000003112 inhibitor Substances 0.000 title abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 5
- 102000000589 Interleukin-1 Human genes 0.000 abstract 3
- 108010002352 Interleukin-1 Proteins 0.000 abstract 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 3
- 238000000034 method Methods 0.000 abstract 3
- 101000960954 Homo sapiens Interleukin-18 Proteins 0.000 abstract 2
- 102100039898 Interleukin-18 Human genes 0.000 abstract 2
- 230000006907 apoptotic process Effects 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 2
- 230000000694 effects Effects 0.000 abstract 2
- 230000001404 mediated effect Effects 0.000 abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 abstract 2
- 208000023275 Autoimmune disease Diseases 0.000 abstract 1
- 208000020084 Bone disease Diseases 0.000 abstract 1
- 108090000426 Caspase-1 Proteins 0.000 abstract 1
- 208000035473 Communicable disease Diseases 0.000 abstract 1
- 102000014150 Interferons Human genes 0.000 abstract 1
- 108010050904 Interferons Proteins 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 230000003247 decreasing effect Effects 0.000 abstract 1
- 230000001066 destructive effect Effects 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 230000001939 inductive effect Effects 0.000 abstract 1
- 208000027866 inflammatory disease Diseases 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 229940079322 interferon Drugs 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 208000015122 neurodegenerative disease Diseases 0.000 abstract 1
- 230000002062 proliferating effect Effects 0.000 abstract 1
Classifications
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
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Abstract
Patente de Invenção: <B>"INIBIDORES DE CASPASES"<D>. A presente invenção refere-se a novas classes de compostos que são inibidores de caspase, em particular inibidores de enzima de conversão de interleucina-1beta ("ICE"). Esta invenção também refere-se a composições farmacêuticas compreendendo estes compostos. Os compostos e as composições farmacêuticas desta invenção são particularmente bem adequados para a inibição de atividade de caspase e conseq³entemente, podem ser vantajosamente usados como agentes contra doenças mediadas por interleucina-1 ("IL-1"), apoptose, fator de indução de interferon-<sym> (IGIF), ou interferon-<sym> ("IFN-<sym>"), incluindo doenças inflamatórias, doenças auto-imunes, distúrbios de osso destrutivos, distúrbios proliferativos, doenças infecciosas, e doenças degenerativas. Esta invenção também refere-se a métodos para a inibição de atividade de caspase e diminuição de produção de IGIF e produção de IFN-<sym> e a métodos para o tratamento de doenças mediadas por interferon-<sym>, apoptose, e interleucina-1 usando-se os compostos e as composições desta invenção. Esta invenção também refere-se a métodos de preparação dos compostos desta invenção.Invention Patent: <B> "CASPASE INHIBITORS" <D>. The present invention relates to new classes of compounds that are caspase inhibitors, in particular interleukin-1beta converting enzyme ("ICE") inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for the inhibition of caspase activity and therefore can be advantageously used as agents against diseases mediated by interleukin-1 ("IL-1"), apoptosis, interferon inducing factor - <sym> (IGIF), or interferon- <sym> ("IFN- <sym>"), including inflammatory diseases, autoimmune diseases, destructive bone disorders, proliferative disorders, infectious diseases, and degenerative diseases. This invention also relates to methods for inhibiting caspase activity and decreasing IGIF production and IFN- <sym> production and methods for treating interferon- <sym> -mediated diseases, apoptosis, and interleukin- 1 using the compounds and compositions of this invention. This invention also relates to methods of preparing the compounds of this invention.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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US7877098P | 1998-03-19 | 1998-03-19 | |
PCT/US1999/005919 WO1999047545A2 (en) | 1998-03-19 | 1999-03-19 | Inhibitors of caspases |
Publications (1)
Publication Number | Publication Date |
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BR9909660A true BR9909660A (en) | 2000-11-21 |
Family
ID=22146109
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR9909660-9A BR9909660A (en) | 1998-03-19 | 1999-03-19 | Caspase inhibitors |
BRPI9909660A BRPI9909660B8 (en) | 1998-03-19 | 1999-03-19 | caspase inhibitor compounds, pharmaceutical composition and use of said compounds |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI9909660A BRPI9909660B8 (en) | 1998-03-19 | 1999-03-19 | caspase inhibitor compounds, pharmaceutical composition and use of said compounds |
Country Status (34)
Country | Link |
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US (3) | US6531474B1 (en) |
EP (6) | EP2261232A3 (en) |
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US6242422B1 (en) * | 1998-10-22 | 2001-06-05 | Idun Pharmacueticals, Inc. | (Substituted)Acyl dipeptidyl inhibitors of the ice/ced-3 family of cysteine proteases |
PE20011350A1 (en) | 2000-05-19 | 2002-01-15 | Vertex Pharma | PROPHARMAC OF AN INHIBITOR OF INTERLEUKIN-1ß CONVERTER ENZYME (ICE) |
WO2005047906A1 (en) * | 2003-11-10 | 2005-05-26 | Vertex Pharmaceuticals Incorporated | Methods for monitoring il-18 |
EP2270004A1 (en) * | 2004-02-27 | 2011-01-05 | Vertex Pharmceuticals Incorporated | Caspase inhibitors and uses thereof |
CN1980658A (en) * | 2004-05-27 | 2007-06-13 | 沃泰克斯药物股份有限公司 | Treatment of diseases using ICE inhibitors |
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1999
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