BR9908338A - Método, composição e dispositivo para a regulação do cio e da ovulação em matrizes - Google Patents
Método, composição e dispositivo para a regulação do cio e da ovulação em matrizesInfo
- Publication number
- BR9908338A BR9908338A BR9908338-8A BR9908338A BR9908338A BR 9908338 A BR9908338 A BR 9908338A BR 9908338 A BR9908338 A BR 9908338A BR 9908338 A BR9908338 A BR 9908338A
- Authority
- BR
- Brazil
- Prior art keywords
- sows
- estrus
- pseudopregnancy
- ovulation
- regulation
- Prior art date
Links
- 230000012173 estrus Effects 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 3
- 239000000203 mixture Substances 0.000 title abstract 3
- 230000033228 biological regulation Effects 0.000 title abstract 2
- 230000016087 ovulation Effects 0.000 title abstract 2
- 230000001939 inductive effect Effects 0.000 abstract 3
- PXGPLTODNUVGFL-BRIYLRKRSA-N (E,Z)-(1R,2R,3R,5S)-7-(3,5-Dihydroxy-2-((3S)-(3-hydroxy-1-octenyl))cyclopentyl)-5-heptenoic acid Chemical compound CCCCC[C@H](O)C=C[C@H]1[C@H](O)C[C@H](O)[C@@H]1CC=CCCCC(O)=O PXGPLTODNUVGFL-BRIYLRKRSA-N 0.000 abstract 1
- VOXZDWNPVJITMN-ZBRFXRBCSA-N 17β-estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 VOXZDWNPVJITMN-ZBRFXRBCSA-N 0.000 abstract 1
- 238000009395 breeding Methods 0.000 abstract 1
- 230000001488 breeding effect Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000013270 controlled release Methods 0.000 abstract 1
- 230000006698 induction Effects 0.000 abstract 1
- 239000004005 microsphere Substances 0.000 abstract 1
- 229920000747 poly(lactic acid) Polymers 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
- A61K31/515—Barbituric acids; Derivatives thereof, e.g. sodium pentobarbital
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A61K31/566—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol having an oxo group in position 17, e.g. estrone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
- A61K38/09—Luteinising hormone-releasing hormone [LHRH], i.e. Gonadotropin-releasing hormone [GnRH]; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/24—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g. HCG; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
- A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Dermatology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Zoology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Steroid Compounds (AREA)
Abstract
<B>"MéTODO, COMPOSIçãO E DISPOSITIVO PARA A REGULAçãO DO CIO E DA OVULAçãO EM MATRIZES"<D>. São reveladas composições de liberação controlada e métodos para induzir a pseudogravidez em matrizes e porcas. Na incorporação preferencial, a presente invenção inclui microesferas de polilactídeo liberando estradiol 17ß em níveis fisiologicamente utilizáveis ao longo de um período de tempo entre cinco e trinta dias. Após a indução da pseudogravidez, a pseudogravidez pode ser encerrada e o cio pode ser induzido por meio de compostos tais como O PGF2<244>. As vantagens da indução da pseudogravidez seguida da indução do cio são que os padrões de procriação de um grande número de matrizes e porcas podem ser controlados.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/026,463 US6028057A (en) | 1998-02-19 | 1998-02-19 | Regulation of estrus and ovulation in gilts |
PCT/US1999/003441 WO1999042110A1 (en) | 1998-02-19 | 1999-02-18 | Regulation of estrus and ovulation in gilts |
Publications (1)
Publication Number | Publication Date |
---|---|
BR9908338A true BR9908338A (pt) | 2000-10-10 |
Family
ID=21831965
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR9908338-8A BR9908338A (pt) | 1998-02-19 | 1999-02-18 | Método, composição e dispositivo para a regulação do cio e da ovulação em matrizes |
Country Status (10)
Country | Link |
---|---|
US (1) | US6028057A (pt) |
EP (1) | EP1054675A1 (pt) |
JP (1) | JP2002503696A (pt) |
KR (1) | KR20010034494A (pt) |
CN (1) | CN1291101A (pt) |
AU (1) | AU2685099A (pt) |
BR (1) | BR9908338A (pt) |
CA (1) | CA2321102A1 (pt) |
PL (1) | PL342402A1 (pt) |
WO (1) | WO1999042110A1 (pt) |
Families Citing this family (43)
Publication number | Priority date | Publication date | Assignee | Title |
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NZ330726A (en) * | 1998-06-18 | 2000-10-27 | Dec Res | Intra-vaginal delivery unit or composition containing a cyclodextrin which improves absorbtion of 17-beta oestradiol or oestradiol benzoate |
EP1478353A4 (en) * | 2002-01-24 | 2007-10-17 | Smart Drug Systems Inc | PHARMACEUTICAL COMPOSITION WITH DELAYED RELEASE |
GB0222522D0 (en) | 2002-09-27 | 2002-11-06 | Controlled Therapeutics Sct | Water-swellable polymers |
PT1684782E (pt) | 2003-10-03 | 2015-12-21 | Thorn Bioscience Llc | Processo para a sincronização da ovulação para reprodução regulada sem detecção do cio |
GB0417401D0 (en) | 2004-08-05 | 2004-09-08 | Controlled Therapeutics Sct | Stabilised prostaglandin composition |
JP4721752B2 (ja) * | 2005-04-06 | 2011-07-13 | 独立行政法人科学技術振興機構 | 妊娠状態における薬物代謝予測法 |
US20080286375A1 (en) * | 2005-11-15 | 2008-11-20 | Amorepacific Corporation | Method for Preparing Sustained-Release Microparticles Comprising Sucrose Acetate Isobutyrate |
US20070197435A1 (en) * | 2006-02-17 | 2007-08-23 | Webel Stephen K | Process for the synchronization of ovulation for timed breeding without heat detection |
GB0613333D0 (en) * | 2006-07-05 | 2006-08-16 | Controlled Therapeutics Sct | Hydrophilic polyurethane compositions |
GB0613638D0 (en) | 2006-07-08 | 2006-08-16 | Controlled Therapeutics Sct | Polyurethane elastomers |
US20080160065A1 (en) * | 2006-07-12 | 2008-07-03 | Janet Anne Halliday | Drug delivery polymer with hydrochloride salt of clindamycin |
US20080051381A1 (en) * | 2006-08-22 | 2008-02-28 | Burns Patrick J | Suppression of estrus in mares by a single injection method |
GB0620685D0 (en) * | 2006-10-18 | 2006-11-29 | Controlled Therapeutics Sct | Bioresorbable polymers |
ES2661240T3 (es) | 2009-04-23 | 2018-03-28 | Jbs United Animal Health Ii Llc | Método y composición para sincronizar el momento de inseminación |
CN101822636A (zh) * | 2010-05-24 | 2010-09-08 | 中国人民解放军军事医学科学院放射与辐射医学研究所 | 可注射雌三醇缓控释给药系统 |
KR101256300B1 (ko) * | 2011-01-25 | 2013-04-18 | 박영호 | 암퇘지에게 발정을 지속적으로 유도하여 인공수정하는 방법. |
PT2782584T (pt) | 2011-11-23 | 2021-09-02 | Therapeuticsmd Inc | Preparações e terapias de substituição para hormonoterapias naturais combinadas |
US9301920B2 (en) | 2012-06-18 | 2016-04-05 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
WO2013184919A1 (en) | 2012-06-06 | 2013-12-12 | Minitube Of America, Inc. | Multi-compartment container for biological liquids |
US10806697B2 (en) | 2012-12-21 | 2020-10-20 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US20130338122A1 (en) | 2012-06-18 | 2013-12-19 | Therapeuticsmd, Inc. | Transdermal hormone replacement therapies |
US20150196640A1 (en) | 2012-06-18 | 2015-07-16 | Therapeuticsmd, Inc. | Progesterone formulations having a desirable pk profile |
US10806740B2 (en) | 2012-06-18 | 2020-10-20 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
US9724380B2 (en) | 2012-11-28 | 2017-08-08 | Jbs United Animal Health Ii Llc | Method and compositions for synchronizing time of insemination in gilts |
US10471072B2 (en) | 2012-12-21 | 2019-11-12 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US9180091B2 (en) | 2012-12-21 | 2015-11-10 | Therapeuticsmd, Inc. | Soluble estradiol capsule for vaginal insertion |
US11246875B2 (en) | 2012-12-21 | 2022-02-15 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US10537581B2 (en) | 2012-12-21 | 2020-01-21 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US11266661B2 (en) | 2012-12-21 | 2022-03-08 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US10568891B2 (en) | 2012-12-21 | 2020-02-25 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
KR101360830B1 (ko) | 2013-11-21 | 2014-02-11 | (주)나비바이오텍 | 젖산을 함유한 동물의 난소 기능 불활 조성물 |
CN103918604B (zh) * | 2014-04-25 | 2016-03-30 | 安顺德康农牧有限公司 | 一种种猪养殖繁育方法 |
JP2017516768A (ja) | 2014-05-22 | 2017-06-22 | セラピューティックスエムディー インコーポレーテッドTherapeuticsmd, Inc. | 天然の併用ホルモン補充療法剤及び療法 |
US20170304260A1 (en) * | 2014-10-08 | 2017-10-26 | Maamar Achacha | Altrenogest formulation and uses thereof for estrus synchronisation in animals |
US10328087B2 (en) | 2015-07-23 | 2019-06-25 | Therapeuticsmd, Inc. | Formulations for solubilizing hormones |
WO2017105512A1 (en) | 2015-12-18 | 2017-06-22 | Proinvet Innovations S.A. | Formulations and methods for controlling the reproductive cycle and ovulation |
JP6692037B2 (ja) * | 2016-03-25 | 2020-05-13 | 学校法人麻布獣医学園 | ブタの初乳作出法 |
KR20180126582A (ko) | 2016-04-01 | 2018-11-27 | 쎄러퓨틱스엠디, 인코퍼레이티드 | 스테로이드 호르몬 약제학적 조성물 |
US10286077B2 (en) | 2016-04-01 | 2019-05-14 | Therapeuticsmd, Inc. | Steroid hormone compositions in medium chain oils |
US11376220B2 (en) | 2017-06-30 | 2022-07-05 | Therio, LLC | Single-injection methods and formulations to induce and control multiple ovarian follicles in bovine, caprine, ovine, camelid and other female animals |
US11633405B2 (en) | 2020-02-07 | 2023-04-25 | Therapeuticsmd, Inc. | Steroid hormone pharmaceutical formulations |
CN114145263A (zh) * | 2021-11-26 | 2022-03-08 | 佳和农牧股份有限公司 | 一种新型丹系后备母猪诱情方式 |
CN117981715B (zh) * | 2024-04-07 | 2024-07-09 | 中国农业大学 | 一种促进后备母猪初情期启动和改善发情障碍的后备母猪批次化养殖方法 |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3860701A (en) * | 1968-04-22 | 1975-01-14 | Searle & Co | Method for use and compositions of 11-lower alkyl steroids and drug delivery system for the controlled elution of 11-lower alkyl steroids |
SU549118A1 (ru) * | 1973-04-02 | 1977-03-05 | Способ синхронизации половой охоты у циклирующих свиноматок | |
US3991750A (en) * | 1975-04-28 | 1976-11-16 | Syntex Corporation | Dromostanolone propionate implant pellet useful for producing weight gains in animals and suppressing estrus in female animals |
US4732763A (en) * | 1978-10-17 | 1988-03-22 | Stolle Research And Development Corporation | Active/passive immunization of the internal female reproductive organs |
US4756907A (en) * | 1978-10-17 | 1988-07-12 | Stolle Research & Development Corp. | Active/passive immunization of the internal female reproductive organs |
GB8428201D0 (en) * | 1984-11-08 | 1984-12-19 | Glaxo Group Ltd | Biological preparations |
US5276022A (en) * | 1987-09-24 | 1994-01-04 | Jencap Research Ltd. | Hormone preparation and method |
US4975280A (en) * | 1989-01-23 | 1990-12-04 | Ethyl Corporation | Bioerodable sustained release implants |
FR2663223B1 (fr) * | 1990-06-14 | 1994-12-02 | Af Aplicaciones Far Lab | Forme galenique parenterale. |
IE62665B1 (en) * | 1990-12-17 | 1995-02-22 | Akzo Nv | Contraceptive regimen |
HU222501B1 (hu) * | 1991-06-28 | 2003-07-28 | Endorecherche Inc. | MPA-t vagy MGA-t tartalmazó nyújtott hatóanyag-felszabadulású gyógyászati készítmény és eljárás előállítására |
EP0721348B1 (en) * | 1993-09-29 | 1999-09-01 | Alza Corporation | Monoglyceride/lactate ester permeation enhancer |
US5650173A (en) * | 1993-11-19 | 1997-07-22 | Alkermes Controlled Therapeutics Inc. Ii | Preparation of biodegradable microparticles containing a biologically active agent |
FR2717688B1 (fr) * | 1994-03-28 | 1996-07-05 | Lhd Lab Hygiene Dietetique | Système matriciel transdermique d'administration d'un oestrogène et/ou un progestatif à base d'EVA. |
US5747058A (en) * | 1995-06-07 | 1998-05-05 | Southern Biosystems, Inc. | High viscosity liquid controlled delivery system |
FR2747042B1 (fr) * | 1996-04-05 | 1998-06-05 | Besins Iscovesco Lab | Medicament a base de progesterone et d'oestradiol |
US6051558A (en) * | 1997-05-28 | 2000-04-18 | Southern Biosystems, Inc. | Compositions suitable for controlled release of the hormone GnRH and its analogs |
-
1998
- 1998-02-19 US US09/026,463 patent/US6028057A/en not_active Expired - Fee Related
-
1999
- 1999-02-18 KR KR1020007008934A patent/KR20010034494A/ko not_active Application Discontinuation
- 1999-02-18 BR BR9908338-8A patent/BR9908338A/pt not_active IP Right Cessation
- 1999-02-18 CA CA002321102A patent/CA2321102A1/en not_active Abandoned
- 1999-02-18 AU AU26850/99A patent/AU2685099A/en not_active Abandoned
- 1999-02-18 WO PCT/US1999/003441 patent/WO1999042110A1/en not_active Application Discontinuation
- 1999-02-18 EP EP99907115A patent/EP1054675A1/en not_active Withdrawn
- 1999-02-18 JP JP2000532125A patent/JP2002503696A/ja not_active Withdrawn
- 1999-02-18 PL PL99342402A patent/PL342402A1/xx unknown
- 1999-02-18 CN CN99803109A patent/CN1291101A/zh active Pending
Also Published As
Publication number | Publication date |
---|---|
US6028057A (en) | 2000-02-22 |
EP1054675A1 (en) | 2000-11-29 |
JP2002503696A (ja) | 2002-02-05 |
CA2321102A1 (en) | 1999-08-26 |
KR20010034494A (ko) | 2001-04-25 |
CN1291101A (zh) | 2001-04-11 |
PL342402A1 (en) | 2001-06-04 |
WO1999042110A1 (en) | 1999-08-26 |
AU2685099A (en) | 1999-09-06 |
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