BR9901298A - Novos compostos de benzotiofeno, benzofurano e indol, um processo para sua preparação e composições farmacêuticas que os contêm - Google Patents
Novos compostos de benzotiofeno, benzofurano e indol, um processo para sua preparação e composições farmacêuticas que os contêmInfo
- Publication number
- BR9901298A BR9901298A BR9901298-7A BR9901298A BR9901298A BR 9901298 A BR9901298 A BR 9901298A BR 9901298 A BR9901298 A BR 9901298A BR 9901298 A BR9901298 A BR 9901298A
- Authority
- BR
- Brazil
- Prior art keywords
- group
- benzofuran
- atom
- pharmaceutical compositions
- preparation
- Prior art date
Links
- IANQTJSKSUMEQM-UHFFFAOYSA-N 1-benzofuran Chemical compound C1=CC=C2OC=CC2=C1 IANQTJSKSUMEQM-UHFFFAOYSA-N 0.000 title abstract 4
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- FCEHBMOGCRZNNI-UHFFFAOYSA-N 1-benzothiophene Chemical compound C1=CC=C2SC=CC2=C1 FCEHBMOGCRZNNI-UHFFFAOYSA-N 0.000 title 2
- 150000002475 indoles Chemical class 0.000 title 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000000623 heterocyclic group Chemical group 0.000 abstract 2
- 229910052717 sulfur Inorganic materials 0.000 abstract 2
- 125000004434 sulfur atom Chemical group 0.000 abstract 2
- SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical compound C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 125000002102 aryl alkyloxo group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000000732 arylene group Chemical group 0.000 abstract 1
- 125000004104 aryloxy group Chemical group 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 125000000000 cycloalkoxy group Chemical group 0.000 abstract 1
- 125000002993 cycloalkylene group Chemical group 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000002349 hydroxyamino group Chemical group [H]ON([H])[*] 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D333/64—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
Patente de Invenção: <B>"NOVOS COMPOSTOS DE BENZOTIOFENO, BENZOFURANO E INDOL, UM PROCESSO PARA SUA PREPARAçãO E COMPOSIçõES FARMACêUTICAS QUE OS CONTêM"<D>. Compostos de fórmula geral (I): em que: X representa um átomo de oxigênio, um átomo de enxofre ou um grupo NR3 em que R3 é como definido na descrição, Y representa um átomo de oxigênio, um átomo de enxofre ou um grupo NR3 ou pode representar uma ligação simples quando X representa um grupo NR3, Z representa um átomo de nitrogênio, um átomo de carbono ou um grupo CH, A representa uma ligação simples, um grupo alquileno (opcionalmente substituído), um grupo arileno, um grupo cicloalquileno, um grupo heterocíclico ou um grupo -SO2-R~ 4~-em que R~ 4~ é como definido na descrição, W representa um grupo hidroxila, um grupo alcóxi, um grupo arilóxi, um grupo arilalcóxi, um grupo cicloalcóxi, um heterociclo ligado a um átomo de oxigênio, um grupo amino ou um grupo hidroxiamino, Ra, Rb, Rc ou Rd que podem ser idênticos ou diferentes cada um, independentemente dos outros, são como definido na descrição, R1 representa um grupo arila substituído por de um a cinco substituintes idênticos ou diferentes, cada um independentemente dos outros, uma heteroarila opcionalmente substituída ou um grupo como definido para fórmula (I).
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9805239A FR2777886B1 (fr) | 1998-04-27 | 1998-04-27 | Nouveaux derives benzothiopheniques, benzofuraniques et indoliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR9901298A true BR9901298A (pt) | 2000-05-02 |
Family
ID=9525701
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR9901298-7A BR9901298A (pt) | 1998-04-27 | 1999-04-27 | Novos compostos de benzotiofeno, benzofurano e indol, um processo para sua preparação e composições farmacêuticas que os contêm |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US6048875A (pt) |
| EP (1) | EP0955299B1 (pt) |
| JP (1) | JP3957424B2 (pt) |
| CN (1) | CN1211362C (pt) |
| AT (1) | ATE214387T1 (pt) |
| AU (1) | AU744456B2 (pt) |
| BR (1) | BR9901298A (pt) |
| CA (1) | CA2270086C (pt) |
| DE (1) | DE69901006T2 (pt) |
| DK (1) | DK0955299T3 (pt) |
| ES (1) | ES2174579T3 (pt) |
| FR (1) | FR2777886B1 (pt) |
| HK (1) | HK1022694A1 (pt) |
| HU (1) | HUP9901403A1 (pt) |
| NO (1) | NO319101B1 (pt) |
| NZ (1) | NZ335388A (pt) |
| PT (1) | PT955299E (pt) |
| ZA (1) | ZA992941B (pt) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6162930A (en) * | 1998-03-06 | 2000-12-19 | Baylor University | Anti-mitotic agents which inhibit tubulin polymerization |
| FR2799756B1 (fr) * | 1999-10-15 | 2001-12-14 | Adir | Nouveaux derives benzothiopheniques, benzofuraniques et indoliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| EP1263763B1 (en) * | 2000-03-10 | 2007-07-25 | Baylor University | Tubulin binding ligands |
| WO2002096416A1 (en) * | 2001-05-31 | 2002-12-05 | Cellegy Pharmaceuticals, Inc. | Store operated calcium influx inhibitors and methods of use |
| WO2003000253A1 (en) | 2001-06-20 | 2003-01-03 | Wyeth | Substituted indole acid derivatives as inhibitors of plasminogen activator inhibitor-1 (pai-1) |
| TWI224101B (en) | 2001-06-20 | 2004-11-21 | Wyeth Corp | Substituted naphthyl indole derivatives as inhibitors of plasminogen activator inhibitor type-1 (PAI-1) |
| CA2509191A1 (en) * | 2002-12-10 | 2004-06-24 | Wyeth | Aryl, aryloxy, and alkyloxy substituted 1h-indol-3-yl glyoxylic acid derivatives as inhibitors of plasminogen activator inhibitor-1 (pai-1) |
| WO2004052853A2 (en) * | 2002-12-10 | 2004-06-24 | Wyeth | Substituted 3-alkyl and 3-arylalkyl 1h-indol-1-yl acetic acid derivatives as inhibitors of plasminogen activator inhibitor-1 (pai-1) |
| CN1726190A (zh) | 2002-12-10 | 2006-01-25 | 惠氏公司 | 作为纤溶酶原激活物抑制剂－1(pai－1)的抑制剂的取代3－羰基－1h－吲哚－1－基乙酸衍生物 |
| UA80453C2 (en) * | 2002-12-10 | 2007-09-25 | Derivatives of substituted dyhydropyranoindol-3,4-dion as inhibitors of plasminogen activator inhibitor-1 (pai-1) | |
| MXPA05006287A (es) | 2002-12-10 | 2005-09-08 | Wyeth Corp | Derivados de acido indoloxo-acetilaminoacetico sustituidos como inhibidores del inhibidor del activador de plasminogeno 1 (pai-1). |
| US7411083B2 (en) | 2003-09-25 | 2008-08-12 | Wyeth | Substituted acetic acid derivatives |
| US7265148B2 (en) | 2003-09-25 | 2007-09-04 | Wyeth | Substituted pyrrole-indoles |
| US7268159B2 (en) | 2003-09-25 | 2007-09-11 | Wyeth | Substituted indoles |
| US7163954B2 (en) | 2003-09-25 | 2007-01-16 | Wyeth | Substituted naphthyl benzothiophene acids |
| US7351726B2 (en) | 2003-09-25 | 2008-04-01 | Wyeth | Substituted oxadiazolidinediones |
| US7141592B2 (en) | 2003-09-25 | 2006-11-28 | Wyeth | Substituted oxadiazolidinediones |
| US7442805B2 (en) | 2003-09-25 | 2008-10-28 | Wyeth | Substituted sulfonamide-indoles |
| US7342039B2 (en) | 2003-09-25 | 2008-03-11 | Wyeth | Substituted indole oximes |
| US7534894B2 (en) | 2003-09-25 | 2009-05-19 | Wyeth | Biphenyloxy-acids |
| US7420083B2 (en) | 2003-09-25 | 2008-09-02 | Wyeth | Substituted aryloximes |
| US7446201B2 (en) | 2003-09-25 | 2008-11-04 | Wyeth | Substituted heteroaryl benzofuran acids |
| US7582773B2 (en) | 2003-09-25 | 2009-09-01 | Wyeth | Substituted phenyl indoles |
| US7332521B2 (en) | 2003-09-25 | 2008-02-19 | Wyeth | Substituted indoles |
| RU2007106868A (ru) | 2004-08-23 | 2008-09-27 | Вайет (Us) | Оксазол-нафтиловые кислоты и их применение в качестве модуляторов ингибитора активатора плазминогена-1 (pai) для лечения тромбоза и сердечно-сосудистых заболеваний |
| CN101044127A (zh) * | 2004-08-23 | 2007-09-26 | 惠氏公司 | 用作纤溶酶原激活剂抑制剂－1的噻唑基－萘基酸 |
| BRPI0514549A (pt) * | 2004-08-23 | 2008-06-17 | Wyeth Corp | ácidos de pirrol-naftila como inibidores de pai-1 |
| EP1919866A2 (en) * | 2005-08-17 | 2008-05-14 | Wyeth a Corporation of the State of Delaware | Substituted indoles and use thereof |
| CA2660546A1 (en) * | 2006-08-21 | 2008-02-28 | Genentech, Inc. | Aza-benzofuranyl compounds and methods of use |
| JP5349306B2 (ja) * | 2006-08-21 | 2013-11-20 | ジェネンテック， インコーポレイテッド | アザベンゾチオフェニル化合物および使用方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4663344A (en) * | 1985-03-11 | 1987-05-05 | Merck & Co., Inc. | Anti-inflammatory and analgesic 3-hydroxybenzo[b]thiophene derivatives, compositions, and method of use therefor |
| IT1227362B (it) * | 1988-11-18 | 1991-04-08 | Istituto Biochimico Italiano | Derivati indolici, processo per la loro preparazione e loro uso comefarmaci antitrombotici |
| US5356926A (en) * | 1992-02-24 | 1994-10-18 | Warner-Lambert Company | 3-alkyloxy-, aryloxy-, or arylalkyloxy-benzo [β]thiophene-2-carboxamides as inhibitors of cell adhesion |
-
1998
- 1998-04-27 FR FR9805239A patent/FR2777886B1/fr not_active Expired - Fee Related
-
1999
- 1999-04-23 NO NO19991957A patent/NO319101B1/no unknown
- 1999-04-26 CA CA002270086A patent/CA2270086C/fr not_active Expired - Fee Related
- 1999-04-26 DE DE69901006T patent/DE69901006T2/de not_active Expired - Fee Related
- 1999-04-26 ES ES99401010T patent/ES2174579T3/es not_active Expired - Lifetime
- 1999-04-26 US US09/299,271 patent/US6048875A/en not_active Expired - Fee Related
- 1999-04-26 DK DK99401010T patent/DK0955299T3/da active
- 1999-04-26 NZ NZ335388A patent/NZ335388A/xx unknown
- 1999-04-26 PT PT99401010T patent/PT955299E/pt unknown
- 1999-04-26 EP EP99401010A patent/EP0955299B1/fr not_active Expired - Lifetime
- 1999-04-26 AT AT99401010T patent/ATE214387T1/de not_active IP Right Cessation
- 1999-04-26 JP JP11736799A patent/JP3957424B2/ja not_active Expired - Fee Related
- 1999-04-26 ZA ZA9902941A patent/ZA992941B/xx unknown
- 1999-04-27 BR BR9901298-7A patent/BR9901298A/pt not_active Application Discontinuation
- 1999-04-27 AU AU24021/99A patent/AU744456B2/en not_active Ceased
- 1999-04-27 CN CNB991051815A patent/CN1211362C/zh not_active Expired - Fee Related
- 1999-04-27 HU HU9901403A patent/HUP9901403A1/hu unknown
-
2000
- 2000-03-21 HK HK00101709A patent/HK1022694A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| ATE214387T1 (de) | 2002-03-15 |
| HU9901403D0 (en) | 1999-06-28 |
| DK0955299T3 (da) | 2002-06-24 |
| NO991957L (no) | 1999-10-28 |
| CN1211362C (zh) | 2005-07-20 |
| DE69901006D1 (de) | 2002-04-18 |
| JPH11349586A (ja) | 1999-12-21 |
| HK1022694A1 (en) | 2000-08-18 |
| US6048875A (en) | 2000-04-11 |
| EP0955299A1 (fr) | 1999-11-10 |
| FR2777886B1 (fr) | 2002-05-31 |
| NZ335388A (en) | 2000-03-27 |
| AU2402199A (en) | 1999-11-04 |
| PT955299E (pt) | 2002-07-31 |
| CN1235156A (zh) | 1999-11-17 |
| NO319101B1 (no) | 2005-06-20 |
| AU744456B2 (en) | 2002-02-21 |
| EP0955299B1 (fr) | 2002-03-13 |
| CA2270086A1 (fr) | 1999-10-27 |
| ZA992941B (en) | 1999-10-26 |
| HUP9901403A1 (hu) | 2000-06-28 |
| CA2270086C (fr) | 2005-04-05 |
| JP3957424B2 (ja) | 2007-08-15 |
| DE69901006T2 (de) | 2002-11-07 |
| NO991957D0 (no) | 1999-04-23 |
| ES2174579T3 (es) | 2002-11-01 |
| FR2777886A1 (fr) | 1999-10-29 |
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| B11E | Dismissal acc. art. 34 of ipl - requirements for examination incomplete | ||
| B11T | Dismissal of application maintained [chapter 11.20 patent gazette] |