BR9814575A - Alcalóides monoméricos e diméricos do grupo das arilisoquinolinas e seus derivados - Google Patents
Alcalóides monoméricos e diméricos do grupo das arilisoquinolinas e seus derivadosInfo
- Publication number
- BR9814575A BR9814575A BR9814575-4A BR9814575A BR9814575A BR 9814575 A BR9814575 A BR 9814575A BR 9814575 A BR9814575 A BR 9814575A BR 9814575 A BR9814575 A BR 9814575A
- Authority
- BR
- Brazil
- Prior art keywords
- monomeric
- present
- dimeric
- arylisoquinoline
- compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
- C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/24—Oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Tropical Medicine & Parasitology (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
Abstract
<B>ALCALóIDES MONOMéRICOS E DIMéRICOS DO GRUPO DAS ARILISOQUINOLINAS E SEUS DERIVADOS A presente invenção proporciona novos derivados monoméricos do alcalóide dionocofilina D de naftilisoquinolina ligados em C-8' - 7. A presente invenção também proporciona novos derivados monoméricos com substituições em C-4 de alcalóides do grupo das arilisoquinolinas. a presente invenção proporciona, além disso, alcalóides diméricos inéditos do grupo das arilisoquinolinas constituídos de um primeiro e de um segundo monómero de arilisoquinolina acoplados, em que ou um dos monómeros é um composto monomérico da presente invenção ou ambos o são. Os compostos monoméricos e diméricos da presente invenção têm propriedades úteis do ponto de vista médico, tais como propriedades antimicrobianas, mais especificamente, tais como propriedades antimaláricas e antivirais. Os compostos monoméricos da presente invenção também são úteis como blocos componentes ou como intermediários para a síntese de alcalóides diméricos inéditos do grupo das arilisoquinolinas. Os compostos monoméricos e diméricos da presente invenção podem ser obtidos, numa forma substancialmente pura, por síntese total, parcial ou por derivação de compostos conhecidos sintéticos ou naturais e por isolamento e purificação de plantas das famílias Dioncophyllaceae e Ancistrocladaceae.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/001,801 US6140339A (en) | 1994-02-14 | 1997-12-31 | Monomeric and dimeric arylisoquinoline alkaloids and derivatives thereof |
PCT/US1998/027407 WO1999033811A1 (en) | 1997-12-31 | 1998-12-23 | Monomeric and dimeric arylisoquinoline alkaloids and derivatives thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
BR9814575A true BR9814575A (pt) | 2000-10-10 |
Family
ID=21697901
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR9814575-4A BR9814575A (pt) | 1997-12-31 | 1998-12-23 | Alcalóides monoméricos e diméricos do grupo das arilisoquinolinas e seus derivados |
Country Status (8)
Country | Link |
---|---|
US (2) | US6140339A (pt) |
EP (1) | EP1045837B1 (pt) |
AT (1) | ATE356809T1 (pt) |
AU (1) | AU751591B2 (pt) |
BR (1) | BR9814575A (pt) |
CA (1) | CA2313487A1 (pt) |
DE (1) | DE69837349D1 (pt) |
WO (1) | WO1999033811A1 (pt) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6140339A (en) | 1994-02-14 | 2000-10-31 | The United States Of America As Represented By The Department Of Health And Human Services | Monomeric and dimeric arylisoquinoline alkaloids and derivatives thereof |
US8449858B2 (en) * | 2009-06-10 | 2013-05-28 | Carbon Solutions, Inc. | Continuous extraction technique for the purification of carbon nanomaterials |
US8394159B2 (en) * | 2011-01-31 | 2013-03-12 | Honda Motor Co., Ltd. | Vehicle air cleaner housing |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CH541609A (de) * | 1970-02-03 | 1973-09-15 | Ciba Geigy Ag | Verfahren zur Herstellung von Bi-isochinolinonen und deren Verwendung als Fluoreszenzfarbstoffe in Kunststoffen |
US4096190A (en) * | 1976-11-26 | 1978-06-20 | Ici Americas Inc. | Oxidative coupling of alkylphenols catalyzed by metal ammonia complexes |
US5001115A (en) * | 1989-05-17 | 1991-03-19 | University Of Florida | Prodrugs of biologically active hydroxyaromatic compounds |
US5025020A (en) * | 1989-09-28 | 1991-06-18 | Cancer Biologics Of America, Inc. | Use of tetrandrine and its derivatives to treat malaria |
WO1992018125A1 (en) * | 1991-04-12 | 1992-10-29 | The United States Of America, As Represented By The Secretary, U.S. Department Of Commerce | Michellamines useful as antiviral agents, composition and method of treatment |
DE4117080A1 (de) * | 1991-05-25 | 1992-11-26 | Basf Ag | Anwendung von dioncophyllinen als fungizide |
EP0695294A1 (en) * | 1993-04-19 | 1996-02-07 | THE GOVERNMENT OF THE UNITED STATES OF AMERICA as represented by the SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES | Michellamines useful as antiviral agents |
US5571919A (en) * | 1994-07-22 | 1996-11-05 | The United States Of America As Represented By The Department Of Health And Human Services | Dimeric naphthylisoquinoline alkaloids and synthesis methods thereof |
US5578729A (en) * | 1994-07-22 | 1996-11-26 | The United States Of America As Represented By The Department Of Health And Human Services | Dimeric arylisoquinoline alkaloid compounds |
US5639761A (en) * | 1994-02-14 | 1997-06-17 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Antimalarial naphthylisoquinoline alkaloids and pharmaceutical compositions and medical uses thereof |
US5552550A (en) * | 1994-07-22 | 1996-09-03 | The United States Of America, As Represented By The Department Of Health And Human Services | Monomeric Naphthylisoquinoline alkaloids and synthesis methods thereof |
US5409938A (en) * | 1994-02-14 | 1995-04-25 | The United States Of America As Represented By The Secretary, Department Of Health And Human Services | Antimalarial korupensamines and pharmaceutical compositions and medical uses thereof |
US6140339A (en) | 1994-02-14 | 2000-10-31 | The United States Of America As Represented By The Department Of Health And Human Services | Monomeric and dimeric arylisoquinoline alkaloids and derivatives thereof |
ES2197205T3 (es) * | 1994-07-22 | 2004-01-01 | The United States Of America, As Represented By The Secretary, Departm. Of Health And Human Services | Alcaloides monomericos y dimericos de naftilisoquinoleina y procedimiento de sintesis de los mismos. |
US5543523A (en) * | 1994-11-15 | 1996-08-06 | Regents Of The University Of Minnesota | Method and intermediates for the synthesis of korupensamines |
-
1997
- 1997-12-31 US US09/001,801 patent/US6140339A/en not_active Expired - Fee Related
-
1998
- 1998-12-23 DE DE69837349T patent/DE69837349D1/de not_active Expired - Lifetime
- 1998-12-23 CA CA002313487A patent/CA2313487A1/en not_active Abandoned
- 1998-12-23 WO PCT/US1998/027407 patent/WO1999033811A1/en active IP Right Grant
- 1998-12-23 EP EP98966748A patent/EP1045837B1/en not_active Expired - Lifetime
- 1998-12-23 AU AU24496/99A patent/AU751591B2/en not_active Ceased
- 1998-12-23 BR BR9814575-4A patent/BR9814575A/pt not_active Application Discontinuation
- 1998-12-23 AT AT98966748T patent/ATE356809T1/de not_active IP Right Cessation
-
2000
- 2000-03-16 US US09/527,002 patent/US6331630B1/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
US6140339A (en) | 2000-10-31 |
ATE356809T1 (de) | 2007-04-15 |
DE69837349D1 (de) | 2007-04-26 |
US6331630B1 (en) | 2001-12-18 |
AU2449699A (en) | 1999-07-19 |
EP1045837B1 (en) | 2007-03-14 |
EP1045837A1 (en) | 2000-10-25 |
CA2313487A1 (en) | 1999-07-08 |
AU751591B2 (en) | 2002-08-22 |
WO1999033811A1 (en) | 1999-07-08 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
B09B | Patent application refused [chapter 9.2 patent gazette] |
Free format text: INDEFIRO O PRESENTE PEDIDO DE ACORDO COM OS ARTIGOS 10 (INCISO IX), 22 E 25 DA LPI. |
|
B09B | Patent application refused [chapter 9.2 patent gazette] |
Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL. |