BR9814575A - Alcalóides monoméricos e diméricos do grupo das arilisoquinolinas e seus derivados - Google Patents

Alcalóides monoméricos e diméricos do grupo das arilisoquinolinas e seus derivados

Info

Publication number
BR9814575A
BR9814575A BR9814575-4A BR9814575A BR9814575A BR 9814575 A BR9814575 A BR 9814575A BR 9814575 A BR9814575 A BR 9814575A BR 9814575 A BR9814575 A BR 9814575A
Authority
BR
Brazil
Prior art keywords
monomeric
present
dimeric
arylisoquinoline
compounds
Prior art date
Application number
BR9814575-4A
Other languages
English (en)
Inventor
Gerhard Bringmann
Matthias Wenzel
Michael R Boyd
Original Assignee
Us Health
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Us Health filed Critical Us Health
Publication of BR9814575A publication Critical patent/BR9814575A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/24—Oxygen atoms

Abstract

<B>ALCALóIDES MONOMéRICOS E DIMéRICOS DO GRUPO DAS ARILISOQUINOLINAS E SEUS DERIVADOS A presente invenção proporciona novos derivados monoméricos do alcalóide dionocofilina D de naftilisoquinolina ligados em C-8' - 7. A presente invenção também proporciona novos derivados monoméricos com substituições em C-4 de alcalóides do grupo das arilisoquinolinas. a presente invenção proporciona, além disso, alcalóides diméricos inéditos do grupo das arilisoquinolinas constituídos de um primeiro e de um segundo monómero de arilisoquinolina acoplados, em que ou um dos monómeros é um composto monomérico da presente invenção ou ambos o são. Os compostos monoméricos e diméricos da presente invenção têm propriedades úteis do ponto de vista médico, tais como propriedades antimicrobianas, mais especificamente, tais como propriedades antimaláricas e antivirais. Os compostos monoméricos da presente invenção também são úteis como blocos componentes ou como intermediários para a síntese de alcalóides diméricos inéditos do grupo das arilisoquinolinas. Os compostos monoméricos e diméricos da presente invenção podem ser obtidos, numa forma substancialmente pura, por síntese total, parcial ou por derivação de compostos conhecidos sintéticos ou naturais e por isolamento e purificação de plantas das famílias Dioncophyllaceae e Ancistrocladaceae.
BR9814575-4A 1997-12-31 1998-12-23 Alcalóides monoméricos e diméricos do grupo das arilisoquinolinas e seus derivados BR9814575A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/001,801 US6140339A (en) 1994-02-14 1997-12-31 Monomeric and dimeric arylisoquinoline alkaloids and derivatives thereof
PCT/US1998/027407 WO1999033811A1 (en) 1997-12-31 1998-12-23 Monomeric and dimeric arylisoquinoline alkaloids and derivatives thereof

Publications (1)

Publication Number Publication Date
BR9814575A true BR9814575A (pt) 2000-10-10

Family

ID=21697901

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9814575-4A BR9814575A (pt) 1997-12-31 1998-12-23 Alcalóides monoméricos e diméricos do grupo das arilisoquinolinas e seus derivados

Country Status (8)

Country Link
US (2) US6140339A (pt)
EP (1) EP1045837B1 (pt)
AT (1) ATE356809T1 (pt)
AU (1) AU751591B2 (pt)
BR (1) BR9814575A (pt)
CA (1) CA2313487A1 (pt)
DE (1) DE69837349D1 (pt)
WO (1) WO1999033811A1 (pt)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6140339A (en) 1994-02-14 2000-10-31 The United States Of America As Represented By The Department Of Health And Human Services Monomeric and dimeric arylisoquinoline alkaloids and derivatives thereof
US8449858B2 (en) * 2009-06-10 2013-05-28 Carbon Solutions, Inc. Continuous extraction technique for the purification of carbon nanomaterials
US8394159B2 (en) * 2011-01-31 2013-03-12 Honda Motor Co., Ltd. Vehicle air cleaner housing

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH541609A (de) * 1970-02-03 1973-09-15 Ciba Geigy Ag Verfahren zur Herstellung von Bi-isochinolinonen und deren Verwendung als Fluoreszenzfarbstoffe in Kunststoffen
US4096190A (en) * 1976-11-26 1978-06-20 Ici Americas Inc. Oxidative coupling of alkylphenols catalyzed by metal ammonia complexes
US5001115A (en) * 1989-05-17 1991-03-19 University Of Florida Prodrugs of biologically active hydroxyaromatic compounds
US5025020A (en) * 1989-09-28 1991-06-18 Cancer Biologics Of America, Inc. Use of tetrandrine and its derivatives to treat malaria
EP0594795B1 (en) * 1991-04-12 2002-02-13 THE UNITED STATES OF AMERICA as represented by the Secretary United States Department of Commerce Michellamines useful as antiviral agents, composition and method of treatment
DE4117080A1 (de) * 1991-05-25 1992-11-26 Basf Ag Anwendung von dioncophyllinen als fungizide
AU4290993A (en) * 1993-04-19 1994-11-08 United States Of America, Represented By The Secretary, Department Of Health And Human Services, The Michellamines useful as antiviral agents
US5409938A (en) * 1994-02-14 1995-04-25 The United States Of America As Represented By The Secretary, Department Of Health And Human Services Antimalarial korupensamines and pharmaceutical compositions and medical uses thereof
US5578729A (en) * 1994-07-22 1996-11-26 The United States Of America As Represented By The Department Of Health And Human Services Dimeric arylisoquinoline alkaloid compounds
US6140339A (en) 1994-02-14 2000-10-31 The United States Of America As Represented By The Department Of Health And Human Services Monomeric and dimeric arylisoquinoline alkaloids and derivatives thereof
US5571919A (en) * 1994-07-22 1996-11-05 The United States Of America As Represented By The Department Of Health And Human Services Dimeric naphthylisoquinoline alkaloids and synthesis methods thereof
US5552550A (en) * 1994-07-22 1996-09-03 The United States Of America, As Represented By The Department Of Health And Human Services Monomeric Naphthylisoquinoline alkaloids and synthesis methods thereof
US5639761A (en) * 1994-02-14 1997-06-17 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Antimalarial naphthylisoquinoline alkaloids and pharmaceutical compositions and medical uses thereof
JPH10506616A (ja) * 1994-07-22 1998-06-30 アメリカ合衆国 単量体および二量体ナフチルイソキノリンアルカロイド類およびその合成方法
US5543523A (en) * 1994-11-15 1996-08-06 Regents Of The University Of Minnesota Method and intermediates for the synthesis of korupensamines

Also Published As

Publication number Publication date
DE69837349D1 (de) 2007-04-26
US6140339A (en) 2000-10-31
ATE356809T1 (de) 2007-04-15
AU751591B2 (en) 2002-08-22
EP1045837B1 (en) 2007-03-14
EP1045837A1 (en) 2000-10-25
AU2449699A (en) 1999-07-19
US6331630B1 (en) 2001-12-18
WO1999033811A1 (en) 1999-07-08
CA2313487A1 (en) 1999-07-08

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Legal Events

Date Code Title Description
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: INDEFIRO O PRESENTE PEDIDO DE ACORDO COM OS ARTIGOS 10 (INCISO IX), 22 E 25 DA LPI.

B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL.