BR9809056A - Compostos de 4-aminopirido[2,3-d]pirimidina 5,6,7-trissubstituìda - Google Patents
Compostos de 4-aminopirido[2,3-d]pirimidina 5,6,7-trissubstituìdaInfo
- Publication number
- BR9809056A BR9809056A BR9809056-9A BR9809056A BR9809056A BR 9809056 A BR9809056 A BR 9809056A BR 9809056 A BR9809056 A BR 9809056A BR 9809056 A BR9809056 A BR 9809056A
- Authority
- BR
- Brazil
- Prior art keywords
- compound
- pyrimidine
- compounds
- aminopyride
- trisubstituted
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Diabetes (AREA)
- Rheumatology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Transplantation (AREA)
- Urology & Nephrology (AREA)
- Oncology (AREA)
- Psychiatry (AREA)
- Communicable Diseases (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
"COMPOSTOS DE 4-AMINOPIRIDO[2,3-D]PIRIMIDINA 5,6,7-TRISSUBSTITUìDA" Um composto tendo a fórmula (II), na qual R^ 1^, R^ 2^, R^ 3^, R^ 4^ e R^ 5^ são definidos, um método para a inibição de adenosina cinase por administração de um seu composto, uma composição farmacêutica compreendendo uma quantidade terapeuticamente efetiva de um seu composto acima descrito, em combinação com um carreador farmaceuticamente aceitável, um método de tratar isquemia cerebral, epilepsia, dor, nocipercepção, inflamação e sepse em um mamífero precisando de tal tratamento, compreendendo administrar ao mamífero uma quantidade terapeuticamente efetiva de um seu composto, e métodos para a preparação do mesmo.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US84348497A | 1997-04-16 | 1997-04-16 | |
| PCT/US1998/007201 WO1998046604A1 (en) | 1997-04-16 | 1998-04-13 | 5,6,7-trisubstituted-4-aminopyridol[2,3-d]pyrimidine compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR9809056A true BR9809056A (pt) | 2000-08-01 |
Family
ID=25290123
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR9809056-9A BR9809056A (pt) | 1997-04-16 | 1998-04-13 | Compostos de 4-aminopirido[2,3-d]pirimidina 5,6,7-trissubstituìda |
Country Status (19)
| Country | Link |
|---|---|
| EP (1) | EP0975633A1 (pt) |
| JP (1) | JP2001520654A (pt) |
| KR (1) | KR20010006462A (pt) |
| CN (1) | CN1252069A (pt) |
| AR (1) | AR012437A1 (pt) |
| AU (1) | AU741033B2 (pt) |
| BG (1) | BG103853A (pt) |
| BR (1) | BR9809056A (pt) |
| CA (1) | CA2286592A1 (pt) |
| CO (1) | CO4940470A1 (pt) |
| HU (1) | HUP0001443A3 (pt) |
| IL (1) | IL131617A0 (pt) |
| NO (1) | NO995035L (pt) |
| NZ (1) | NZ337125A (pt) |
| PL (1) | PL336265A1 (pt) |
| SK (1) | SK140099A3 (pt) |
| TR (1) | TR199902550T2 (pt) |
| WO (1) | WO1998046604A1 (pt) |
| ZA (1) | ZA983175B (pt) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001057040A1 (en) * | 2000-02-03 | 2001-08-09 | Abbott Laboratories | 6,7-disubstituted-4-aminopyrido[2,3-d]pyrimidine compounds |
| WO2002064594A2 (en) | 2001-02-12 | 2002-08-22 | F. Hoffmann-La Roche Ag | 6-substituted pyrido-pyrimidines |
| CN107744520A (zh) * | 2017-10-25 | 2018-03-02 | 南京多宝生物科技有限公司 | 嘧啶类化合物在制备促进小肠蠕动药物中的应用 |
| CN112209924B (zh) * | 2019-07-09 | 2022-04-05 | 中国科学院天津工业生物技术研究所 | 选择性腺苷a1受体拮抗剂 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB774094A (en) * | 1953-01-02 | 1957-05-08 | Wellcome Found | Improvements in or relating to pyrimidine compounds |
| IL112249A (en) * | 1994-01-25 | 2001-11-25 | Warner Lambert Co | Pharmaceutical compositions containing di and tricyclic pyrimidine derivatives for inhibiting tyrosine kinases of the epidermal growth factor receptor family and some new such compounds |
-
1998
- 1998-04-13 WO PCT/US1998/007201 patent/WO1998046604A1/en not_active Application Discontinuation
- 1998-04-13 JP JP54408398A patent/JP2001520654A/ja active Pending
- 1998-04-13 NZ NZ337125A patent/NZ337125A/en unknown
- 1998-04-13 EP EP98918091A patent/EP0975633A1/en not_active Withdrawn
- 1998-04-13 IL IL13161798A patent/IL131617A0/xx unknown
- 1998-04-13 KR KR1019997009552A patent/KR20010006462A/ko not_active Application Discontinuation
- 1998-04-13 PL PL98336265A patent/PL336265A1/xx unknown
- 1998-04-13 TR TR1999/02550T patent/TR199902550T2/xx unknown
- 1998-04-13 BR BR9809056-9A patent/BR9809056A/pt not_active IP Right Cessation
- 1998-04-13 SK SK1400-99A patent/SK140099A3/sk unknown
- 1998-04-13 AU AU71080/98A patent/AU741033B2/en not_active Ceased
- 1998-04-13 HU HU0001443A patent/HUP0001443A3/hu unknown
- 1998-04-13 CN CN98804117A patent/CN1252069A/zh active Pending
- 1998-04-13 CA CA002286592A patent/CA2286592A1/en not_active Abandoned
- 1998-04-15 ZA ZA983175A patent/ZA983175B/xx unknown
- 1998-04-15 AR ARP980101734A patent/AR012437A1/es unknown
- 1998-04-16 CO CO98020978A patent/CO4940470A1/es unknown
-
1999
- 1999-10-15 NO NO995035A patent/NO995035L/no not_active Application Discontinuation
- 1999-11-03 BG BG103853A patent/BG103853A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| BG103853A (en) | 2000-06-30 |
| KR20010006462A (ko) | 2001-01-26 |
| HUP0001443A3 (en) | 2001-01-29 |
| IL131617A0 (en) | 2001-01-28 |
| PL336265A1 (en) | 2000-06-19 |
| CN1252069A (zh) | 2000-05-03 |
| EP0975633A1 (en) | 2000-02-02 |
| AU741033B2 (en) | 2001-11-22 |
| HUP0001443A2 (hu) | 2000-10-28 |
| NO995035L (no) | 1999-12-15 |
| CO4940470A1 (es) | 2000-07-24 |
| WO1998046604A1 (en) | 1998-10-22 |
| SK140099A3 (en) | 2000-05-16 |
| JP2001520654A (ja) | 2001-10-30 |
| TR199902550T2 (xx) | 2000-04-21 |
| ZA983175B (en) | 1998-10-21 |
| NO995035D0 (no) | 1999-10-15 |
| AR012437A1 (es) | 2000-10-18 |
| NZ337125A (en) | 2001-06-29 |
| CA2286592A1 (en) | 1998-10-22 |
| AU7108098A (en) | 1998-11-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 5A,6A,7A,8A E 9AANUIDADES |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1890 DE 27/03/2007. |