BR9807528A - Oil-free pharmaceutical compositions containing cyclosporine a - Google Patents
Oil-free pharmaceutical compositions containing cyclosporine aInfo
- Publication number
- BR9807528A BR9807528A BR9807528-4A BR9807528A BR9807528A BR 9807528 A BR9807528 A BR 9807528A BR 9807528 A BR9807528 A BR 9807528A BR 9807528 A BR9807528 A BR 9807528A
- Authority
- BR
- Brazil
- Prior art keywords
- oil
- present
- pharmaceutical compositions
- compositions containing
- free pharmaceutical
- Prior art date
Links
- 229930105110 Cyclosporin A Natural products 0.000 title abstract 3
- PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 title abstract 3
- 108010036949 Cyclosporine Proteins 0.000 title abstract 3
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 3
- 229960001265 ciclosporin Drugs 0.000 abstract 2
- 239000007903 gelatin capsule Substances 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 239000002202 Polyethylene glycol Substances 0.000 abstract 1
- 229920001223 polyethylene glycol Polymers 0.000 abstract 1
- 239000004094 surface-active agent Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
- A61K38/13—Cyclosporins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Rheumatology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Dispersion Chemistry (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pain & Pain Management (AREA)
- Transplantation (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
Patente de Invenção: <B>"COMPOSIçõES FARMACêUTICAS ISENTAS DE óLEO CONTENDO CICLOSPORINA A"<D>. A presente invenção provê uma cápsula de gelatina dura contendo uma composição farmacêutica compreendendo ciclosporina A em uma mistura com um tensoativo de valor de HLB de pelo menos 10, substancialmente livre de qualquer óleo e quando uma fase hidrofílica está presente, a fase hidrofílica sendo um polietileno glicol e/ou um alcanol inferior contando que qualquer alcanol inferior presente está presente em menos que 12% do peso total da composição ausente a cápsula de gelatina dura.Invention Patent: <B> "OIL-FREE PHARMACEUTICAL COMPOSITIONS CONTAINING CYCLOSPORIN A" <D>. The present invention provides a hard gelatin capsule containing a pharmaceutical composition comprising cyclosporin A in a mixture with an HLB value surfactant of at least 10, substantially free of any oil and when a hydrophilic phase is present, the hydrophilic phase being a polyethylene glycol and / or a lower alkanol provided that any lower alkanol present is present in less than 12% of the total weight of the composition without the hard gelatin capsule.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9701881.6A GB9701881D0 (en) | 1997-01-30 | 1997-01-30 | Organic compounds |
GBGB9702594.4A GB9702594D0 (en) | 1997-02-07 | 1997-02-07 | Organic compounds |
PCT/EP1998/000453 WO1998033512A1 (en) | 1997-01-30 | 1998-01-28 | Oil-free pharmaceutical compositions containing cyclosporin a |
Publications (1)
Publication Number | Publication Date |
---|---|
BR9807528A true BR9807528A (en) | 2000-03-14 |
Family
ID=26310891
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR9807528-4A BR9807528A (en) | 1997-01-30 | 1998-01-28 | Oil-free pharmaceutical compositions containing cyclosporine a |
Country Status (26)
Country | Link |
---|---|
US (3) | US6475519B1 (en) |
EP (2) | EP0988046B1 (en) |
JP (2) | JP2000516256A (en) |
KR (3) | KR20050084502A (en) |
CN (2) | CN1679917A (en) |
AT (1) | ATE275963T1 (en) |
AU (1) | AU737053B2 (en) |
BR (1) | BR9807528A (en) |
CA (1) | CA2278675A1 (en) |
CY (1) | CY2548B1 (en) |
CZ (1) | CZ295207B6 (en) |
DE (3) | DE29824679U1 (en) |
ES (1) | ES2229473T3 (en) |
GB (2) | GB2335854B (en) |
HK (1) | HK1027745A1 (en) |
HU (1) | HUP0001013A3 (en) |
ID (1) | ID26696A (en) |
IL (2) | IL130797A0 (en) |
NZ (1) | NZ336900A (en) |
PL (1) | PL190420B1 (en) |
PT (1) | PT988046E (en) |
RU (1) | RU2211047C2 (en) |
SG (1) | SG115386A1 (en) |
SK (1) | SK285019B6 (en) |
TR (1) | TR199901686T2 (en) |
WO (1) | WO1998033512A1 (en) |
Families Citing this family (50)
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GB9903547D0 (en) * | 1999-02-16 | 1999-04-07 | Novartis Ag | Organic compounds |
GB9912476D0 (en) * | 1999-05-28 | 1999-07-28 | Novartis Ag | Organic compounds |
US7919113B2 (en) | 1999-12-30 | 2011-04-05 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Dispersible concentrate lipospheres for delivery of active agents |
AR033711A1 (en) * | 2001-05-09 | 2004-01-07 | Novartis Ag | PHARMACEUTICAL COMPOSITIONS |
AU2002333809C1 (en) * | 2001-09-10 | 2009-02-05 | Janssen Sciences Ireland Unlimited Company | Method for the preparation of hexahydro-furo[2,3-b]furan-3-ol |
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GB2391471B (en) * | 2002-08-02 | 2005-05-04 | Satishchandra Punambhai Patel | Pharmaceutical compositions |
WO2004082629A2 (en) * | 2003-03-17 | 2004-09-30 | Albany Molecular Research, Inc. | Novel cyclosporins |
EP1660047B1 (en) | 2003-08-13 | 2013-11-27 | Biocon Limited | Micro-particle fatty acid salt solid dosage formulations for therapeutic agents |
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EP1809656A4 (en) * | 2004-09-29 | 2009-03-25 | Amr Technology Inc | Cyclosporin alkyne analogues and their pharmaceutical uses |
US7511013B2 (en) * | 2004-09-29 | 2009-03-31 | Amr Technology, Inc. | Cyclosporin analogues and their pharmaceutical uses |
WO2006041631A2 (en) * | 2004-10-06 | 2006-04-20 | Amr Technology, Inc. | Novel cyclosporin alkynes and their utility as pharmaceutical agents |
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US7297679B2 (en) * | 2005-07-13 | 2007-11-20 | Allergan, Inc. | Cyclosporin compositions |
US7202209B2 (en) | 2005-07-13 | 2007-04-10 | Allergan, Inc. | Cyclosporin compositions |
US20070015691A1 (en) | 2005-07-13 | 2007-01-18 | Allergan, Inc. | Cyclosporin compositions |
US7276476B2 (en) * | 2005-07-13 | 2007-10-02 | Allergan, Inc. | Cyclosporin compositions |
US7288520B2 (en) * | 2005-07-13 | 2007-10-30 | Allergan, Inc. | Cyclosporin compositions |
US20070015693A1 (en) * | 2005-07-13 | 2007-01-18 | Allergan, Inc. | Cyclosporin compositions |
US7501393B2 (en) * | 2005-07-27 | 2009-03-10 | Allergan, Inc. | Pharmaceutical compositions comprising cyclosporins |
US9839667B2 (en) | 2005-10-14 | 2017-12-12 | Allergan, Inc. | Prevention and treatment of ocular side effects with a cyclosporin |
US7745400B2 (en) * | 2005-10-14 | 2010-06-29 | Gregg Feinerman | Prevention and treatment of ocular side effects with a cyclosporin |
US7696165B2 (en) * | 2006-03-28 | 2010-04-13 | Albany Molecular Research, Inc. | Use of cyclosporin alkyne analogues for preventing or treating viral-induced disorders |
US7696166B2 (en) * | 2006-03-28 | 2010-04-13 | Albany Molecular Research, Inc. | Use of cyclosporin alkyne/alkene analogues for preventing or treating viral-induced disorders |
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JP2011504871A (en) * | 2007-06-01 | 2011-02-17 | ノボ・ノルデイスク・エー/エス | Naturally dispersible preconcentrate containing peptide drug in solid or semi-solid carrier |
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EP2910571B1 (en) | 2008-03-18 | 2016-10-05 | Novo Nordisk A/S | Protease stabilized, acylated insulin analogues |
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US11304960B2 (en) | 2009-01-08 | 2022-04-19 | Chandrashekar Giliyar | Steroidal compositions |
US20180153904A1 (en) | 2010-11-30 | 2018-06-07 | Lipocine Inc. | High-strength testosterone undecanoate compositions |
US9358241B2 (en) | 2010-11-30 | 2016-06-07 | Lipocine Inc. | High-strength testosterone undecanoate compositions |
US9034858B2 (en) | 2010-11-30 | 2015-05-19 | Lipocine Inc. | High-strength testosterone undecanoate compositions |
US20120148675A1 (en) | 2010-12-10 | 2012-06-14 | Basawaraj Chickmath | Testosterone undecanoate compositions |
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1998
- 1998-01-28 DE DE29824679U patent/DE29824679U1/en not_active Expired - Lifetime
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- 1998-01-28 IL IL13079798A patent/IL130797A0/en active IP Right Grant
- 1998-01-28 TR TR1999/01686T patent/TR199901686T2/en unknown
- 1998-01-28 ES ES98904156T patent/ES2229473T3/en not_active Expired - Lifetime
- 1998-01-28 SK SK1020-99A patent/SK285019B6/en not_active IP Right Cessation
- 1998-01-28 CZ CZ19992663A patent/CZ295207B6/en not_active IP Right Cessation
- 1998-01-28 CN CNA2005100666723A patent/CN1679917A/en active Pending
- 1998-01-28 DE DE69826272T patent/DE69826272T2/en not_active Revoked
- 1998-01-28 EP EP98904156A patent/EP0988046B1/en not_active Revoked
- 1998-01-28 HU HU0001013A patent/HUP0001013A3/en unknown
- 1998-01-28 KR KR1020057012172A patent/KR20050084502A/en active Search and Examination
- 1998-01-28 US US09/284,391 patent/US6475519B1/en not_active Expired - Fee Related
- 1998-01-28 EP EP03007982A patent/EP1331002A3/en not_active Withdrawn
- 1998-01-28 BR BR9807528-4A patent/BR9807528A/en not_active Application Discontinuation
- 1998-01-28 CN CN98802163A patent/CN1246058A/en active Pending
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- 1998-01-28 KR KR1019997006094A patent/KR20000069900A/en active Search and Examination
- 1998-01-28 AU AU62141/98A patent/AU737053B2/en not_active Ceased
- 1998-01-28 SG SG200104053A patent/SG115386A1/en unknown
- 1998-01-28 JP JP10532524A patent/JP2000516256A/en not_active Withdrawn
- 1998-01-28 RU RU99118508/14A patent/RU2211047C2/en not_active IP Right Cessation
- 1998-01-28 KR KR10-2003-7005807A patent/KR20040004416A/en not_active Application Discontinuation
- 1998-01-28 CA CA002278675A patent/CA2278675A1/en not_active Abandoned
- 1998-01-28 AT AT98904156T patent/ATE275963T1/en not_active IP Right Cessation
- 1998-01-28 DE DE19882037T patent/DE19882037T1/en not_active Ceased
- 1998-01-28 WO PCT/EP1998/000453 patent/WO1998033512A1/en not_active Application Discontinuation
- 1998-01-28 GB GB9917521A patent/GB2335854B/en not_active Expired - Fee Related
- 1998-01-28 GB GB0024188A patent/GB2355195B/en not_active Expired - Fee Related
- 1998-01-29 ID IDW990766A patent/ID26696A/en unknown
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1999
- 1999-07-05 IL IL130797A patent/IL130797A/en not_active IP Right Cessation
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2000
- 2000-09-26 HK HK00106122A patent/HK1027745A1/en not_active IP Right Cessation
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2001
- 2001-11-06 US US09/992,584 patent/US6723339B2/en not_active Expired - Fee Related
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2004
- 2004-02-18 US US10/781,069 patent/US20040161458A1/en not_active Abandoned
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2005
- 2005-05-12 JP JP2005139910A patent/JP2005225897A/en active Pending
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2006
- 2006-02-13 CY CY0600002A patent/CY2548B1/en unknown
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