BR9800341A - Construto de ácido nucléico para expressar subst ncias ativas que podem ser ativadas por proteases preparação e uso - Google Patents
Construto de ácido nucléico para expressar subst ncias ativas que podem ser ativadas por proteases preparação e usoInfo
- Publication number
- BR9800341A BR9800341A BR9800341A BR9800341A BR9800341A BR 9800341 A BR9800341 A BR 9800341A BR 9800341 A BR9800341 A BR 9800341A BR 9800341 A BR9800341 A BR 9800341A BR 9800341 A BR9800341 A BR 9800341A
- Authority
- BR
- Brazil
- Prior art keywords
- proteases
- activated
- preparation
- nucleic acid
- active substances
- Prior art date
Links
- 102000035195 Peptidases Human genes 0.000 title 1
- 108091005804 Peptidases Proteins 0.000 title 1
- 239000004365 Protease Substances 0.000 title 1
- 239000013543 active substance Substances 0.000 title 1
- 150000007523 nucleic acids Chemical class 0.000 title 1
- 102000039446 nucleic acids Human genes 0.000 title 1
- 108020004707 nucleic acids Proteins 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6432—Coagulation factor Xa (3.4.21.6)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21006—Coagulation factor Xa (3.4.21.6)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/007—Vector systems having a special element relevant for transcription cell cycle specific enhancer/promoter combination
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/008—Vector systems having a special element relevant for transcription cell type or tissue specific enhancer/promoter combination
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2840/00—Vectors comprising a special translation-regulating system
- C12N2840/20—Vectors comprising a special translation-regulating system translation of more than one cistron
Landscapes
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19701141A DE19701141C1 (de) | 1997-01-16 | 1997-01-16 | Genkonstrukte für durch Proteasen aktivierbare Wirksubstanzen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR9800341A true BR9800341A (pt) | 1999-06-29 |
Family
ID=7817422
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR9800341A BR9800341A (pt) | 1997-01-16 | 1998-01-16 | Construto de ácido nucléico para expressar subst ncias ativas que podem ser ativadas por proteases preparação e uso |
Country Status (15)
| Country | Link |
|---|---|
| US (3) | US6080575A (pt) |
| EP (1) | EP0859058A3 (pt) |
| JP (1) | JPH10210973A (pt) |
| KR (1) | KR19980070549A (pt) |
| CN (1) | CN1192473A (pt) |
| AR (1) | AR008555A1 (pt) |
| AU (1) | AU738717B2 (pt) |
| BR (1) | BR9800341A (pt) |
| CA (1) | CA2227159A1 (pt) |
| CZ (1) | CZ13298A3 (pt) |
| DE (1) | DE19701141C1 (pt) |
| HU (1) | HUP9800075A3 (pt) |
| PL (1) | PL324328A1 (pt) |
| RU (1) | RU2204414C2 (pt) |
| TR (1) | TR199800046A3 (pt) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10039844A1 (de) * | 1999-08-10 | 2001-04-19 | Hepavec Ag Fuer Gentherapie | Kombinationsvektoren für den Gentransfer, Verfahren zu ihrer Herstellung und ihre Verwendung |
| US20030186384A1 (en) * | 2000-04-22 | 2003-10-02 | Stefan Barth | Apoptotic agents |
| US8314060B2 (en) | 2000-09-05 | 2012-11-20 | Biosight Ltd. | Peptide conjugated anti-cancer prodrugs |
| IL154696A (en) | 2000-09-05 | 2008-11-03 | Biosight Ltd | Peptide conjugated anti-cancer prodrugs |
| US7273722B2 (en) * | 2000-11-29 | 2007-09-25 | Allergan, Inc. | Neurotoxins with enhanced target specificity |
| US7041787B2 (en) * | 2000-12-29 | 2006-05-09 | Kimberly-Clark Worldwide, Inc. | Design and use of advanced zinc chelating peptides to regulate matrix metalloproteinases |
| US6600057B2 (en) | 2000-12-29 | 2003-07-29 | Kimberly-Clark Worldwide, Inc. | Matrix metalloproteinase inhibitors |
| US7141392B2 (en) | 2001-01-09 | 2006-11-28 | Queen Mary And Westfield College | Latent fusion protein |
| US6942853B2 (en) * | 2001-01-09 | 2005-09-13 | Queen Mary And Westfield College | Latent fusion protein |
| GB0105929D0 (en) * | 2001-03-09 | 2001-04-25 | Btg Int Ltd | Physiologically activated prodrugs |
| EP1385994A2 (de) * | 2001-04-02 | 2004-02-04 | Bayer HealthCare AG | Verfahren zur spezifischen detektion, isolation und charakterisierung von zellen aus körperproben durch transfektion von nukleinsäurekonstrukten |
| US7247618B2 (en) | 2001-04-30 | 2007-07-24 | Tripathi Rajavashisth | Methods for inhibiting macrophage colony stimulating factor and c-FMS-dependent cell signaling |
| US20030157641A1 (en) * | 2001-11-16 | 2003-08-21 | Idec Pharmaceuticals Corporation | Polycistronic expression of antibodies |
| JP4342314B2 (ja) * | 2001-12-17 | 2009-10-14 | ユニバーシティ カレッジ カーディフ コンサルタンツ リミテッド | 病変部位への特異的送達のための開裂薬剤 |
| US20030119073A1 (en) * | 2001-12-21 | 2003-06-26 | Stephen Quirk | Sensors and methods of detection for proteinase enzymes |
| WO2003068934A2 (en) * | 2002-02-14 | 2003-08-21 | Rutter William J | Chimeric molecules for cleavage in a treated host |
| AU2003241409A1 (en) * | 2003-05-12 | 2005-01-21 | Potomac Pharmaceuticals, Inc. | Gene expression suppression agents |
| EP1639097B1 (en) * | 2003-06-25 | 2013-08-07 | Ottawa Health Research Institute | Methods and compositions for modulating stem cell growth and differentiation |
| WO2005121316A1 (en) * | 2004-06-11 | 2005-12-22 | Bernard O'brien Institute Of Microsurgery | Tissue material and muscle derived matrix |
| KR100604976B1 (ko) * | 2004-09-03 | 2006-07-28 | 학교법인연세대학교 | 다작용기 리간드로 안정화된 수용성 나노입자 |
| WO2008013918A2 (en) * | 2006-07-26 | 2008-01-31 | Myelin Repair Foundation, Inc. | Cell cycle regulation and differentiation |
| JP2010525812A (ja) | 2007-05-02 | 2010-07-29 | メリアル リミテッド | 発現及び安定性が改善されたｄｎａプラスミド |
| US20100216659A1 (en) * | 2007-06-15 | 2010-08-26 | The Scipps Research Institute | Methods and compositions for indentifying binding partners from libraries of biomolecules |
| GB0800272D0 (en) * | 2008-01-08 | 2008-02-13 | Plant Bioscience Ltd | Protein expression systems |
| CN106995495A (zh) | 2009-01-12 | 2017-08-01 | 希托马克斯医疗有限责任公司 | 修饰抗体组合物及其制备和使用方法 |
| WO2011123683A2 (en) * | 2010-04-02 | 2011-10-06 | University Of Rochester | Protease activated cytokines |
| EP2628748A1 (en) | 2012-02-14 | 2013-08-21 | Szilak Laboratories Bioinformatics & Molecule-Design Ltd. | Angiostatin chimeras and uses thereof |
| MX365612B (es) | 2012-07-25 | 2019-06-07 | Catalyst Biosciences Inc | Polipeptidos de factor x modificados y usos de los mismos. |
| MA40094B1 (fr) * | 2014-08-06 | 2022-05-31 | Univ Miami | Protéines de fusion de l'interleukine-2/récepteur alpha de l'interleukine-2 et procédés d'utilisation |
| AU2019271148B2 (en) | 2018-05-14 | 2023-07-06 | Werewolf Therapeutics, Inc. | Activatable interleukin-2 polypeptides and methods of use thereof |
| KR20210021468A (ko) | 2018-05-14 | 2021-02-26 | 웨어울프 세라퓨틱스, 인크. | 활성화가능한 사이토카인 폴리펩타이드 및 이의 사용 방법 |
| WO2020232305A1 (en) * | 2019-05-14 | 2020-11-19 | Werewolf Therapeutics, Inc. | Separation moieties and methods and use thereof |
| WO2021097376A1 (en) | 2019-11-14 | 2021-05-20 | Werewolf Therapeutics, Inc. | Activatable cytokine polypeptides and methods of use thereof |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4228457A1 (de) * | 1992-08-27 | 1994-04-28 | Beiersdorf Ag | Herstellung von heterodimerem PDGF-AB mit Hilfe eines bicistronischen Vektorsystems in Säugerzellen |
| GB9506466D0 (en) | 1994-08-26 | 1995-05-17 | Prolifix Ltd | Cell cycle regulated repressor and dna element |
| DE19524720A1 (de) | 1995-07-12 | 1997-01-16 | Hoechst Ag | Zellspezifische Gentherapie mit Hilfe eines neuen Promotors für den "Tissue Inhibitor of Metalloproteinasn-3" |
| SE9403613D0 (sv) | 1994-10-21 | 1994-10-21 | Pharmacia Ab | Improvement of an expression vector for production of recombinant proteins |
| AU4608296A (en) * | 1994-12-30 | 1996-07-31 | Chiron Corporation | Methods and compositions for treatment of solid tumors in vivo |
| US5726050A (en) | 1995-06-20 | 1998-03-10 | Massachusetts Institute Of Technology | Z-DNA binding protein and applications |
| JPH11509088A (ja) | 1995-06-23 | 1999-08-17 | プレジデント アンド フェローズ オブ ハーバード カレッジ | 血管内皮増殖因子受容体をコードする遺伝子の転写調節 |
| DE19605279A1 (de) | 1996-02-13 | 1997-08-14 | Hoechst Ag | Zielzellspezifische Vektoren für die Einschleusung von Genen in Zellen, Arzneimittel enthaltend derartige Vektoren und deren Verwendung |
| DE19605274A1 (de) | 1996-02-13 | 1997-08-14 | Hoechst Ag | Nukleinsäurekonstrukte für die zellzyklusregulierte Expression von Genen, derartige Konstrukte enthaltende Zellen sowie deren Verwendung zur Herstellung von Heilmitteln |
| AU716564B2 (en) * | 1996-11-06 | 2000-03-02 | Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The | Protease-activatable pseudomonas exotoxin A-like proproteins |
-
1997
- 1997-01-16 DE DE19701141A patent/DE19701141C1/de not_active Expired - Fee Related
-
1998
- 1998-01-14 CZ CZ98132A patent/CZ13298A3/cs unknown
- 1998-01-14 TR TR1998/00046A patent/TR199800046A3/tr unknown
- 1998-01-14 AR ARP980100164A patent/AR008555A1/es unknown
- 1998-01-14 CN CN98103791A patent/CN1192473A/zh active Pending
- 1998-01-15 EP EP98100632A patent/EP0859058A3/de not_active Withdrawn
- 1998-01-15 RU RU98100678/14A patent/RU2204414C2/ru not_active IP Right Cessation
- 1998-01-15 HU HU9800075A patent/HUP9800075A3/hu unknown
- 1998-01-16 KR KR1019980001096A patent/KR19980070549A/ko not_active Application Discontinuation
- 1998-01-16 AU AU52107/98A patent/AU738717B2/en not_active Ceased
- 1998-01-16 JP JP10006589A patent/JPH10210973A/ja active Pending
- 1998-01-16 PL PL98324328A patent/PL324328A1/xx unknown
- 1998-01-16 BR BR9800341A patent/BR9800341A/pt not_active IP Right Cessation
- 1998-01-16 CA CA002227159A patent/CA2227159A1/en not_active Abandoned
- 1998-01-16 US US09/008,308 patent/US6080575A/en not_active Expired - Lifetime
-
1999
- 1999-02-24 US US09/256,237 patent/US6670147B1/en not_active Expired - Lifetime
-
2003
- 2003-08-12 US US10/638,537 patent/US20040110682A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| HU9800075D0 (en) | 1998-03-30 |
| KR19980070549A (ko) | 1998-10-26 |
| TR199800046A2 (xx) | 1998-10-21 |
| EP0859058A2 (de) | 1998-08-19 |
| PL324328A1 (en) | 1998-07-20 |
| HUP9800075A3 (en) | 2004-03-29 |
| US20040110682A1 (en) | 2004-06-10 |
| HUP9800075A2 (hu) | 1998-10-28 |
| CZ13298A3 (cs) | 1998-08-12 |
| CA2227159A1 (en) | 1998-07-16 |
| US6080575A (en) | 2000-06-27 |
| AR008555A1 (es) | 2000-01-19 |
| RU2204414C2 (ru) | 2003-05-20 |
| AU5210798A (en) | 1998-07-23 |
| US6670147B1 (en) | 2003-12-30 |
| AU738717B2 (en) | 2001-09-27 |
| CN1192473A (zh) | 1998-09-09 |
| EP0859058A3 (de) | 2003-05-28 |
| TR199800046A3 (tr) | 1998-10-21 |
| DE19701141C1 (de) | 1998-04-09 |
| JPH10210973A (ja) | 1998-08-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PC | Transfer |
Free format text: AVENTIS PHARMA DEUTSCHLAND GMBH (DE) |
|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 7A,8A E 9A ANUIDADES |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1892 DE 10/04/2007. |