BR9713346A - Inibidores de indenos de cox - 2 - Google Patents
Inibidores de indenos de cox - 2Info
- Publication number
- BR9713346A BR9713346A BR9713346-9A BR9713346A BR9713346A BR 9713346 A BR9713346 A BR 9713346A BR 9713346 A BR9713346 A BR 9713346A BR 9713346 A BR9713346 A BR 9713346A
- Authority
- BR
- Brazil
- Prior art keywords
- cox
- alkyl
- inhibitors
- fluoralkoxy
- scf3
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 230000001939 inductive effect Effects 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000004414 alkyl thio group Chemical group 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical group 0.000 abstract 2
- 150000002431 hydrogen Chemical group 0.000 abstract 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 2
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- 101150071146 COX2 gene Proteins 0.000 abstract 1
- 101100114534 Caenorhabditis elegans ctc-2 gene Proteins 0.000 abstract 1
- 206010009944 Colon cancer Diseases 0.000 abstract 1
- 208000001333 Colorectal Neoplasms Diseases 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 101150000187 PTGS2 gene Proteins 0.000 abstract 1
- 125000004644 alkyl sulfinyl group Chemical group 0.000 abstract 1
- 125000004390 alkyl sulfonyl group Chemical group 0.000 abstract 1
- 230000002917 arthritic effect Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- -1 fluoralkoxy Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/60—Two oxygen atoms, e.g. succinic anhydride
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Furan Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Indole Compounds (AREA)
Abstract
Patente de Invenção: <B>"INIBIDORES DE INDENOS DE COX - 2"<D>. Esta invenção proporciona compostos da fórmula (1) tendo estrutura (1) em que: R^ 1^ é hidrogênio, halogênio, alquila, alcóxi, fluoralcóxi, trifluormetila, alquiltio ou SCF3; R^ 2^ e R^ 3^ são cada qual independentemente hidrogênio ou alquila ou R^ 2^ e R^ 3^ podem ser tomados juntos para formar um anel de cicloalquila saturado: e R^ 4^, R^ 5^, R^ 7^ e R^ 8^ são cada qual independentemente hidrogênio, alquila, alcóxi, alquiltio, alquilsulfinila, alquilsulfonila, halogênio, fluoralcóxi, CF3 ou SCF3 que são úteis no tratamento de distúrbios artríticos, câncer colo-retal e doença de Alzheimer.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US74794896A | 1996-11-12 | 1996-11-12 | |
| PCT/US1997/020231 WO1998021195A1 (en) | 1996-11-12 | 1997-11-10 | Indene inhibitors of cox-2 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR9713346A true BR9713346A (pt) | 2000-05-09 |
Family
ID=25007366
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR9713346-9A BR9713346A (pt) | 1996-11-12 | 1997-11-10 | Inibidores de indenos de cox - 2 |
Country Status (9)
| Country | Link |
|---|---|
| EP (1) | EP0948493A1 (pt) |
| JP (1) | JP2001504118A (pt) |
| KR (1) | KR20000053227A (pt) |
| CN (1) | CN1237162A (pt) |
| AU (1) | AU5105598A (pt) |
| BR (1) | BR9713346A (pt) |
| CA (1) | CA2269035A1 (pt) |
| HU (1) | HUP9904696A2 (pt) |
| WO (1) | WO1998021195A1 (pt) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2003523958A (ja) | 1999-12-23 | 2003-08-12 | ニトロメド インコーポレーテッド | ニトロソ化およびニトロシル化されたシクロオキシゲナーゼ−２の阻害剤、組成物ならびに使用法 |
| PL1745791T3 (pl) | 2003-05-07 | 2013-11-29 | Osteologix As | Leczenie chorób chrząstki/kości za pomocą rozpuszczalnych w wodzie soli strontu |
| AU2007205208B2 (en) | 2006-01-04 | 2012-11-01 | Southern Research Institute | Derivatives of sulindac, use thereof and preparation thereof |
| CN104592091B (zh) * | 2015-01-27 | 2017-07-04 | 冉瑞琼 | 一种含吲哚乙酸核心结构的化合物及其应用 |
| CA3209491A1 (en) | 2021-03-15 | 2022-09-22 | Saul Yedgar | Hyaluronic acid-conjugated dipalmitoyl phosphatidyl ethanolamine in combination with non-steroidal anti-inflammatory drugs (nsaids) for treating or alleviating inflammatory disease |
| CN116635368A (zh) * | 2021-10-15 | 2023-08-22 | 北京安健熹医药科技有限公司 | 2,3-二甲氧基-5-甲基-1,4-苯醌烷基醇衍生物及其应用 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3647858A (en) * | 1970-05-01 | 1972-03-07 | Merck & Co Inc | Process for preparing 1-benzylidene-3-indenyl acetic acids |
| MX9302419A (es) * | 1992-04-28 | 1994-03-31 | American Home Prod | Derivados de acido tetronico, tiotetronico y tetramico. |
| GB9403857D0 (en) * | 1994-03-01 | 1994-04-20 | Scotia Holdings Plc | Fatty acid derivatives |
-
1997
- 1997-11-10 HU HU9904696A patent/HUP9904696A2/hu unknown
- 1997-11-10 AU AU51055/98A patent/AU5105598A/en not_active Abandoned
- 1997-11-10 EP EP97945622A patent/EP0948493A1/en not_active Withdrawn
- 1997-11-10 BR BR9713346-9A patent/BR9713346A/pt not_active Application Discontinuation
- 1997-11-10 WO PCT/US1997/020231 patent/WO1998021195A1/en not_active Application Discontinuation
- 1997-11-10 CA CA002269035A patent/CA2269035A1/en not_active Abandoned
- 1997-11-10 KR KR1019990704202A patent/KR20000053227A/ko not_active Application Discontinuation
- 1997-11-10 JP JP52266398A patent/JP2001504118A/ja active Pending
- 1997-11-10 CN CN97199655A patent/CN1237162A/zh active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| JP2001504118A (ja) | 2001-03-27 |
| WO1998021195A1 (en) | 1998-05-22 |
| CN1237162A (zh) | 1999-12-01 |
| CA2269035A1 (en) | 1998-05-22 |
| HUP9904696A2 (hu) | 2000-05-28 |
| EP0948493A1 (en) | 1999-10-13 |
| KR20000053227A (ko) | 2000-08-25 |
| AU5105598A (en) | 1998-06-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA10 | Dismissal: dismissal - article 33 of industrial property law | ||
| B11Y | Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette] |