BR9712720A - Derivados de piperazina como antagÈnicos de neurocinina - Google Patents
Derivados de piperazina como antagÈnicos de neurocininaInfo
- Publication number
- BR9712720A BR9712720A BR9712720-5A BR9712720A BR9712720A BR 9712720 A BR9712720 A BR 9712720A BR 9712720 A BR9712720 A BR 9712720A BR 9712720 A BR9712720 A BR 9712720A
- Authority
- BR
- Brazil
- Prior art keywords
- piperazine derivatives
- neurokinin antagonists
- compounds
- neurokinin
- antagonists
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
- C07D451/06—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/06—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing isoquinuclidine ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
Abstract
Patente de Invenção:<B>"DERIVADOS DE PIPERAZINA COMO ANTAGÈNICOS DE NEUROCININA"<D>. A invenção refere-se a compostos de Fórmula (I) onde Z, R~ c~, Y, m, u, Ar~ 1~, n, X, R'~ c~, I e Ar~ 2~ são como descritos aqui. Estes compostos são antagónicos de neurocinina. Estes compostos são úteis no tratamento de doenças das vias aéreas crónicas, tais como asma.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US74108396A | 1996-10-30 | 1996-10-30 | |
PCT/US1997/018986 WO1998018788A1 (en) | 1996-10-30 | 1997-10-28 | Piperazino derivatives as neurokinin antagonists |
Publications (1)
Publication Number | Publication Date |
---|---|
BR9712720A true BR9712720A (pt) | 1999-10-26 |
Family
ID=24979315
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR9712720-5A BR9712720A (pt) | 1996-10-30 | 1997-10-28 | Derivados de piperazina como antagÈnicos de neurocinina |
Country Status (24)
Country | Link |
---|---|
EP (1) | EP0937069B1 (pt) |
JP (1) | JP3292478B2 (pt) |
KR (1) | KR20000052921A (pt) |
AR (1) | AR008903A1 (pt) |
AT (1) | ATE325118T1 (pt) |
AU (1) | AU733454B2 (pt) |
BR (1) | BR9712720A (pt) |
CA (1) | CA2269128C (pt) |
CO (1) | CO5190719A1 (pt) |
CZ (1) | CZ146999A3 (pt) |
DE (1) | DE69735811T2 (pt) |
ES (1) | ES2263173T3 (pt) |
HU (1) | HUP9904594A2 (pt) |
ID (1) | ID23054A (pt) |
IL (1) | IL129660A0 (pt) |
NO (1) | NO992066L (pt) |
NZ (1) | NZ335052A (pt) |
PE (1) | PE10599A1 (pt) |
PL (1) | PL333079A1 (pt) |
SK (1) | SK54899A3 (pt) |
TR (1) | TR199901570T2 (pt) |
TW (1) | TW445264B (pt) |
WO (1) | WO1998018788A1 (pt) |
ZA (1) | ZA979670B (pt) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AUPO735997A0 (en) * | 1997-06-17 | 1997-07-10 | Fujisawa Pharmaceutical Co., Ltd. | Piperazine derivatives |
CA2317760A1 (en) * | 1998-01-14 | 1999-07-22 | Schering Corporation | Piperazino derivatives as neurokinin antagonists |
SE9904765D0 (sv) | 1999-12-23 | 1999-12-23 | Astra Ab | Pharmaceutically-useful compounds |
CA2423154A1 (en) | 2000-09-21 | 2002-03-28 | David Kenneth Dean | Imidazole derivatives as raf kinase inhibitors |
FR2873693B1 (fr) * | 2004-07-29 | 2006-09-15 | Sanofi Synthelabo | Derives d'amino-tropane, leur preparation et leur application en therapeutique |
EP2129381A1 (en) | 2007-01-24 | 2009-12-09 | Glaxo Group Limited | Pharmaceutical compositions comprising 3, 5-diamin0-6- (2, 3-dichl0phenyl) -l, 2, 4-triazine or r (-) -2, 4-diamino-5- (2, 3-dichlorophenyl) -6-fluoromethyl pyrimidine and an nk1 |
CN101910151A (zh) | 2007-10-22 | 2010-12-08 | 先灵公司 | 双环杂环衍生物及其作为gpr119活性调节剂的用途 |
AR076024A1 (es) | 2009-04-03 | 2011-05-11 | Schering Corp | Derivados de heterociclos biciclicos puenteados y metodos de uso de los mismos |
US11117852B2 (en) | 2017-04-05 | 2021-09-14 | University Of Mississippi | Isolation of pure cannabinoids from Cannabis |
CN111801251B (zh) | 2018-02-02 | 2022-06-24 | 奥托立夫开发公司 | 安全带装置 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL111730A (en) * | 1993-11-29 | 1998-12-06 | Fujisawa Pharmaceutical Co | Piperazine derivatives, processes for their preparation and pharmaceutical preparations containing them |
DE69629023T2 (de) * | 1995-05-02 | 2004-04-22 | Schering Corp. | Piperazino-derivative als neurokininantagonisten |
BR9610277A (pt) * | 1995-08-31 | 1999-07-06 | Schering Corp | Derivados de piperazino como antagonistas de neurowuinina |
US6087357A (en) * | 1995-12-18 | 2000-07-11 | Fujisawa Pharmaceutical Co., Ltd. | Piperazine derivatives as tachykinin antagonists |
-
1997
- 1997-10-28 BR BR9712720-5A patent/BR9712720A/pt unknown
- 1997-10-28 TW TW086115979A patent/TW445264B/zh active
- 1997-10-28 ES ES97912827T patent/ES2263173T3/es not_active Expired - Lifetime
- 1997-10-28 EP EP97912827A patent/EP0937069B1/en not_active Expired - Lifetime
- 1997-10-28 JP JP52056098A patent/JP3292478B2/ja not_active Expired - Fee Related
- 1997-10-28 SK SK548-99A patent/SK54899A3/sk unknown
- 1997-10-28 CA CA002269128A patent/CA2269128C/en not_active Expired - Fee Related
- 1997-10-28 HU HU9904594A patent/HUP9904594A2/hu unknown
- 1997-10-28 NZ NZ335052A patent/NZ335052A/xx unknown
- 1997-10-28 TR TR1999/01570T patent/TR199901570T2/xx unknown
- 1997-10-28 WO PCT/US1997/018986 patent/WO1998018788A1/en active IP Right Grant
- 1997-10-28 ID IDW990258A patent/ID23054A/id unknown
- 1997-10-28 AR ARP970104985A patent/AR008903A1/es unknown
- 1997-10-28 PE PE1997000960A patent/PE10599A1/es not_active Application Discontinuation
- 1997-10-28 KR KR1019990703789A patent/KR20000052921A/ko not_active Application Discontinuation
- 1997-10-28 AU AU49917/97A patent/AU733454B2/en not_active Ceased
- 1997-10-28 PL PL97333079A patent/PL333079A1/xx unknown
- 1997-10-28 CZ CZ991469A patent/CZ146999A3/cs unknown
- 1997-10-28 DE DE69735811T patent/DE69735811T2/de not_active Expired - Fee Related
- 1997-10-28 ZA ZA9709670A patent/ZA979670B/xx unknown
- 1997-10-28 IL IL12966097A patent/IL129660A0/xx unknown
- 1997-10-28 AT AT97912827T patent/ATE325118T1/de not_active IP Right Cessation
- 1997-10-29 CO CO97063643A patent/CO5190719A1/es not_active Application Discontinuation
-
1999
- 1999-04-29 NO NO992066A patent/NO992066L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
NZ335052A (en) | 2000-10-27 |
AU4991797A (en) | 1998-05-22 |
CO5190719A1 (es) | 2002-08-29 |
WO1998018788A1 (en) | 1998-05-07 |
CA2269128C (en) | 2005-01-11 |
KR20000052921A (ko) | 2000-08-25 |
NO992066D0 (no) | 1999-04-29 |
EP0937069A1 (en) | 1999-08-25 |
CA2269128A1 (en) | 1998-05-07 |
NO992066L (no) | 1999-06-29 |
ID23054A (id) | 2000-01-20 |
TR199901570T2 (xx) | 1999-09-21 |
TW445264B (en) | 2001-07-11 |
IL129660A0 (en) | 2000-02-29 |
DE69735811T2 (de) | 2006-12-28 |
SK54899A3 (en) | 2000-05-16 |
JP2000504342A (ja) | 2000-04-11 |
PE10599A1 (es) | 1999-02-10 |
AR008903A1 (es) | 2000-02-23 |
PL333079A1 (en) | 1999-11-08 |
EP0937069B1 (en) | 2006-05-03 |
JP3292478B2 (ja) | 2002-06-17 |
AU733454B2 (en) | 2001-05-17 |
ZA979670B (en) | 1998-04-28 |
DE69735811D1 (de) | 2006-06-08 |
ATE325118T1 (de) | 2006-06-15 |
HUP9904594A2 (hu) | 2000-09-28 |
CZ146999A3 (cs) | 1999-09-15 |
ES2263173T3 (es) | 2006-12-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |