BR9710501B1 - método para deformilação de uma proteìna recombinante produzida em uma célula hospedeira bacteriana, célula hospedeira de e. coli e seqüência de vetor. - Google Patents
método para deformilação de uma proteìna recombinante produzida em uma célula hospedeira bacteriana, célula hospedeira de e. coli e seqüência de vetor.Info
- Publication number
- BR9710501B1 BR9710501B1 BRPI9710501-5A BR9710501A BR9710501B1 BR 9710501 B1 BR9710501 B1 BR 9710501B1 BR 9710501 A BR9710501 A BR 9710501A BR 9710501 B1 BR9710501 B1 BR 9710501B1
- Authority
- BR
- Brazil
- Prior art keywords
- deforming
- coli
- host cell
- recombinant protein
- protein produced
- Prior art date
Links
- 230000001580 bacterial effect Effects 0.000 title abstract 2
- 239000013598 vector Substances 0.000 title abstract 2
- 102000007056 Recombinant Fusion Proteins Human genes 0.000 title 1
- 108010008281 Recombinant Fusion Proteins Proteins 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- 102000004169 proteins and genes Human genes 0.000 abstract 2
- PYUSHNKNPOHWEZ-YFKPBYRVSA-N N-formyl-L-methionine Chemical compound CSCC[C@@H](C(O)=O)NC=O PYUSHNKNPOHWEZ-YFKPBYRVSA-N 0.000 abstract 1
- 108010026809 Peptide deformylase Proteins 0.000 abstract 1
- 230000006198 deformylation Effects 0.000 abstract 1
- 238000006344 deformylation reaction Methods 0.000 abstract 1
- 230000003292 diminished effect Effects 0.000 abstract 1
- 230000014759 maintenance of location Effects 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/53—Colony-stimulating factor [CSF]
- C07K14/535—Granulocyte CSF; Granulocyte-macrophage CSF
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/5409—IL-5
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/555—Interferons [IFN]
- C07K14/57—IFN-gamma
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/61—Growth hormone [GH], i.e. somatotropin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
- C12N9/80—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in linear amides (3.5.1)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Endocrinology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2268796P | 1996-07-19 | 1996-07-19 | |
| PCT/US1997/012458 WO1998003664A1 (en) | 1996-07-19 | 1997-07-17 | DEFORMYLATION OF f-MET PEPTIDES IN BACTERIAL EXPRESSION SYSTEMS |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BR9710501A BR9710501A (pt) | 1999-08-17 |
| BR9710501B1 true BR9710501B1 (pt) | 2009-12-01 |
Family
ID=21810912
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI9710501-5A BR9710501B1 (pt) | 1996-07-19 | 1997-07-17 | método para deformilação de uma proteìna recombinante produzida em uma célula hospedeira bacteriana, célula hospedeira de e. coli e seqüência de vetor. |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US5834243A (pt) |
| EP (1) | EP0917580B1 (pt) |
| JP (1) | JP2000515017A (pt) |
| KR (1) | KR100484602B1 (pt) |
| CN (1) | CN1230994A (pt) |
| AT (1) | ATE256748T1 (pt) |
| AU (1) | AU731039B2 (pt) |
| BR (1) | BR9710501B1 (pt) |
| CA (1) | CA2261016A1 (pt) |
| DE (1) | DE69726868T2 (pt) |
| WO (1) | WO1998003664A1 (pt) |
| ZA (1) | ZA976353B (pt) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2261016A1 (en) * | 1996-07-19 | 1998-01-29 | Monsanto Company | Deformylation of f-met peptides in bacterial expression systems |
| US6284878B1 (en) * | 1996-08-16 | 2001-09-04 | Smithkline Beecham Corporation | def1 |
| US6586578B1 (en) * | 1997-05-21 | 2003-07-01 | Smithkline Beecham Corporation | Defl |
| US5962666A (en) * | 1997-09-16 | 1999-10-05 | Smithkline Beecham Corporation | Deformylase |
| GB9724627D0 (en) | 1997-11-20 | 1998-01-21 | Genencor Int Bv | Gram positive microorganism formate pathway |
| EP1013663A1 (en) * | 1998-12-22 | 2000-06-28 | Holland Sweetener Company V.O.F. | Synthesis and recovery of aspartame involving enzymatic deformylation step |
| US6617127B2 (en) * | 1998-12-22 | 2003-09-09 | Holland Sweetener Company, V.O.F. | Synthesis and recovery of aspartame involving enzymatic deformylation step |
| WO2000037486A1 (en) * | 1998-12-22 | 2000-06-29 | Holland Sweetener Company V.O.F. | Synthesis and recovery of aspartame involving enzymatic deformylation step |
| US6797820B2 (en) * | 1999-12-17 | 2004-09-28 | Vicuron Pharmaceuticals Inc. | Succinate compounds, compositions and methods of use and preparation |
| US20020137158A1 (en) * | 2000-05-25 | 2002-09-26 | Xiaotong Li | Novel human polypeptide deformylase (PDF) |
| DE60334912D1 (de) * | 2002-05-24 | 2010-12-23 | Medtronic Inc | Polypeptid-spaltungsprozess |
| AU2003243316A1 (en) | 2002-05-24 | 2003-12-12 | Nps Allelix Corp. | Method for enzymatic production of glp-2(1-33) and glp-2-(1-34) peptides |
| ME01366B (me) | 2003-11-21 | 2013-12-20 | Nps Allelix Corp | POSTUPAK ZA PROIZVODNJU PEPTIDA 2 NALIK NA GLUKAGON l NJIHOVIH ANALOGA |
| CN118389710B (zh) * | 2024-06-28 | 2024-09-06 | 南京农业大学 | 一种与鸡开产日龄性状相关的tdh基因分子标记及其应用 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3374070D1 (en) * | 1982-12-10 | 1987-11-19 | Nordisk Gentofte | A process for preparing ripe proteins from fusion proteins, synthetized in pro- or eukaryotic cells |
| CA2261016A1 (en) * | 1996-07-19 | 1998-01-29 | Monsanto Company | Deformylation of f-met peptides in bacterial expression systems |
-
1997
- 1997-07-17 CA CA002261016A patent/CA2261016A1/en not_active Abandoned
- 1997-07-17 ZA ZA9706353A patent/ZA976353B/xx unknown
- 1997-07-17 DE DE69726868T patent/DE69726868T2/de not_active Expired - Lifetime
- 1997-07-17 US US08/895,939 patent/US5834243A/en not_active Expired - Lifetime
- 1997-07-17 KR KR10-1999-7000391A patent/KR100484602B1/ko not_active IP Right Cessation
- 1997-07-17 AT AT97933523T patent/ATE256748T1/de not_active IP Right Cessation
- 1997-07-17 WO PCT/US1997/012458 patent/WO1998003664A1/en active IP Right Grant
- 1997-07-17 JP JP10507072A patent/JP2000515017A/ja active Pending
- 1997-07-17 AU AU36689/97A patent/AU731039B2/en not_active Ceased
- 1997-07-17 CN CN97198027A patent/CN1230994A/zh active Pending
- 1997-07-17 EP EP97933523A patent/EP0917580B1/en not_active Expired - Lifetime
- 1997-07-17 BR BRPI9710501-5A patent/BR9710501B1/pt not_active IP Right Cessation
-
1998
- 1998-11-09 US US09/188,820 patent/US6190902B1/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP0917580B1 (en) | 2003-12-17 |
| DE69726868D1 (de) | 2004-01-29 |
| US6190902B1 (en) | 2001-02-20 |
| DE69726868T2 (de) | 2004-10-28 |
| KR20000067927A (ko) | 2000-11-25 |
| JP2000515017A (ja) | 2000-11-14 |
| ATE256748T1 (de) | 2004-01-15 |
| CN1230994A (zh) | 1999-10-06 |
| AU731039B2 (en) | 2001-03-22 |
| CA2261016A1 (en) | 1998-01-29 |
| EP0917580A1 (en) | 1999-05-26 |
| KR100484602B1 (ko) | 2005-04-20 |
| BR9710501A (pt) | 1999-08-17 |
| ZA976353B (en) | 1998-02-03 |
| WO1998003664A1 (en) | 1998-01-29 |
| AU3668997A (en) | 1998-02-10 |
| US5834243A (en) | 1998-11-10 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| BR9710501B1 (pt) | método para deformilação de uma proteìna recombinante produzida em uma célula hospedeira bacteriana, célula hospedeira de e. coli e seqüência de vetor. | |
| BG102554A (en) | Vectors and methods for gene transfer into cells | |
| MY120693A (en) | Human bikunin | |
| HUP0001650A2 (hu) | Javított expressziós vektorok | |
| CA2089094A1 (en) | Expression of recombinant polypeptides with improved purification | |
| DK1090129T4 (da) | Overekspression af phytase-gener i gærsystemer | |
| DE69730592D1 (de) | Expressionssteigernde sequenzelemente (ease) für eukaryontische expressionssysteme | |
| EP0737747A3 (de) | Cytoplasmatische Expression von Antikörpern, Antikörperfragmenten und Antikörperfragment-Fusionsmolekülen in E. coli | |
| AU6435394A (en) | Fusion proteins between antigenic amino acid sequences and beta-2-microglobulin | |
| CA2157975A1 (en) | Recombinant mersacidin and a method for production | |
| Taguchi et al. | Efficient extracellular expression of a foreign protein in Streptomyces using secretory protease inhibitor (SSI) gene fusions | |
| CA2273196A1 (en) | Isolated mammalian monocyte cell genes; related reagents | |
| PT1025245E (pt) | Criacao rapida de linhas celulares estaveis de mamifero produzindo elevados iiveis de proteinas recombinantes | |
| AU8258591A (en) | Human mk gene and protein sequence | |
| IE852681L (en) | Monoclonal antibodies for cancer | |
| AU2001231881A1 (en) | Oligomers of nonpeptide restricted mimetics of dipeptides or tripeptides and theuse thereof in the synthesis of synthetic proteins and polypeptides | |
| EP0331356A3 (en) | Expression of hiv binding proteins | |
| BR9714133A (pt) | ácido nucleico isolado, molécula do mesmo, sonda, vetor de expressão recombinante, célula, polipeptìdeo, proteìna de fusão formulação de vacina e processos para produzir um polipeptìdeo de h. pylori, para detctar a presença de um ácido nucleico de helicobacter em uma amostra, para tratar ou reduzir um risco de infecção por h. pylori em um indivìduo e para produzir uma formulação de vacina | |
| AU5776799A (en) | Modified hcv peptide vaccines | |
| CA2159079A1 (en) | Methods and DNA Expression Systems for Over-Expression of Proteins in Host Cells | |
| BR9507473A (pt) | Sequéncia de dna isolada vetor célula hospedeira processo para produzir uma proteina gp350 homogénea proteína gp350 homogénea composição farmacéutica e uso na proteina gp350 homogénea | |
| EP1065214A4 (en) | NOVEL PEPTIDES WITH PHYSIOLOGICAL ACTIVITY AND THEIR USE | |
| Bietlot et al. | Isolation of carboxyl-terminal peptides from proteins by diagonal electrophoresis: application to the entomocidal toxin from Bacillus thuringiensis | |
| DK0805204T3 (da) | Bitestikel - specifikt receptorprotein og anvendelse heraf | |
| CA2176236A1 (en) | Tyrosinase-activator protein fusion enzyme |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B25D | Requested change of name of applicant approved |
Owner name: PHARMACIA CORPORATION (US) Free format text: ALTERADO DE: MONSANTO COMPANY |
|
| B25A | Requested transfer of rights approved |
Owner name: MONSANTO TECHNOLOGY LLC (US) Free format text: TRANSFERIDO DE: PHARMACIA CORPORATION |
|
| B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
| B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
| B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
| B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 29/12/2009, OBSERVADAS AS CONDICOES LEGAIS. |
|
| B24C | Patent annual fee: request for for restoration |
Free format text: REFERENTE A 15A ANUIDADE. |
|
| B24H | Lapse because of non-payment of annual fees (definitively: art 78 iv lpi) | ||
| B24F | Patent annual fee: publication cancelled |
Free format text: ANULADA A PUBLICACAO CODIGO 24.8 NA RPI NO 2259 DE 22/04/2014 POR TER SIDO INDEVIDA. |
|
| B21F | Lapse acc. art. 78, item iv - on non-payment of the annual fees in time |
Free format text: REFERENTE A 15A ANUIDADE. |
|
| B24J | Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12) |
Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2607 DE 22-12-2020 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |