BR9506540A - Polinucleotídeo purificado e isolado polipeptídeos mutante de deleção de calcineurina processos para identificar um composto inibidor putativo para melhorar a expressão de interleucina 2 por um linfócito t para isolar calcineurina de uma fração celular contendo a mesma e para determinar se uma célula contém uma proteina de ancoragem ligando pka e ligando calcineurina - Google Patents

Polinucleotídeo purificado e isolado polipeptídeos mutante de deleção de calcineurina processos para identificar um composto inibidor putativo para melhorar a expressão de interleucina 2 por um linfócito t para isolar calcineurina de uma fração celular contendo a mesma e para determinar se uma célula contém uma proteina de ancoragem ligando pka e ligando calcineurina

Info

Publication number
BR9506540A
BR9506540A BR9506540A BR9506540A BR9506540A BR 9506540 A BR9506540 A BR 9506540A BR 9506540 A BR9506540 A BR 9506540A BR 9506540 A BR9506540 A BR 9506540A BR 9506540 A BR9506540 A BR 9506540A
Authority
BR
Brazil
Prior art keywords
calcineurin
ligating
pka
lymphocyte
interleukin
Prior art date
Application number
BR9506540A
Other languages
English (en)
Inventor
Robert Owen Lockerbie
Vincent M Coghlan
Monique L Howard
William M Gallatin
John D Scott
Original Assignee
Icos Corp
Oregon State
Univ Oregon Health Sciences
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/344,227 external-priority patent/US5807693A/en
Application filed by Icos Corp, Oregon State, Univ Oregon Health Sciences filed Critical Icos Corp
Publication of BR9506540A publication Critical patent/BR9506540A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Toxicology (AREA)
  • General Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Bipolar Transistors (AREA)
BR9506540A 1994-11-23 1995-11-22 Polinucleotídeo purificado e isolado polipeptídeos mutante de deleção de calcineurina processos para identificar um composto inibidor putativo para melhorar a expressão de interleucina 2 por um linfócito t para isolar calcineurina de uma fração celular contendo a mesma e para determinar se uma célula contém uma proteina de ancoragem ligando pka e ligando calcineurina BR9506540A (pt)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US08/344,227 US5807693A (en) 1994-11-23 1994-11-23 Calcineurin inhibitory compounds and anchoring protein
US08/404,731 US5744354A (en) 1994-11-23 1995-03-15 Calcineurin inhibitory compounds and anchoring protein to induce IL-2 gene expression
US08/503,226 US5871945A (en) 1994-11-23 1995-07-17 Modulators of anchoring protein function
PCT/US1995/016039 WO1996016172A2 (en) 1994-11-23 1995-11-22 Modulators of anchoring protein function

Publications (1)

Publication Number Publication Date
BR9506540A true BR9506540A (pt) 1997-10-07

Family

ID=27407605

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9506540A BR9506540A (pt) 1994-11-23 1995-11-22 Polinucleotídeo purificado e isolado polipeptídeos mutante de deleção de calcineurina processos para identificar um composto inibidor putativo para melhorar a expressão de interleucina 2 por um linfócito t para isolar calcineurina de uma fração celular contendo a mesma e para determinar se uma célula contém uma proteina de ancoragem ligando pka e ligando calcineurina

Country Status (14)

Country Link
US (2) US5871945A (pt)
EP (1) EP0748379A1 (pt)
JP (1) JPH09509849A (pt)
CN (1) CN1153830C (pt)
AU (1) AU712168B2 (pt)
BR (1) BR9506540A (pt)
CA (1) CA2181826A1 (pt)
CZ (1) CZ213696A3 (pt)
FI (1) FI962932A (pt)
HU (1) HU221881B1 (pt)
NO (1) NO963049L (pt)
PL (1) PL184659B1 (pt)
SK (1) SK284105B6 (pt)
WO (1) WO1996016172A2 (pt)

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WO1998022122A1 (en) * 1996-11-21 1998-05-28 Promega Corporation Alkyl peptide amides and applications
EP0976823A1 (de) * 1998-07-22 2000-02-02 Helge Dr. Völkel Rekombinantes Expressions System und Hoch-Durchsatz BioAssay für die therapeutische Anwendung von Calcineurin-A-Alpha, Calcineurin-A-Beta, Calcineurin-A-Gamma, Calcineurin-B und Copper/Zinc-Superoxide Dismutase bzw. zur Identifizierung von Pharmazeutika
US7109317B1 (en) 1998-11-06 2006-09-19 President And Fellows Of Harvard College FK506-based regulation of biological events
JP2002529081A (ja) * 1998-11-06 2002-09-10 プレジデント アンド フェローズ オブ ハーバード カレッジ 生物学的事象のｆｋ５０６に基づく調節
US7550143B2 (en) 2005-04-06 2009-06-23 Ibc Pharmaceuticals, Inc. Methods for generating stably linked complexes composed of homodimers, homotetramers or dimers of dimers and uses
US7666400B2 (en) 2005-04-06 2010-02-23 Ibc Pharmaceuticals, Inc. PEGylation by the dock and lock (DNL) technique
US7332275B2 (en) * 1999-10-13 2008-02-19 Sequenom, Inc. Methods for detecting methylated nucleotides
EP1281756A1 (en) * 2001-07-31 2003-02-05 GENOPIA Biomedical GmbH Regulator of calcineurin
EP1501863A4 (en) * 2002-05-03 2007-01-24 Sequenom Inc KINASE ANCHOR PROTEIN, PEPTIDES AND RELATED METHODS THEREOF
US7906118B2 (en) 2005-04-06 2011-03-15 Ibc Pharmaceuticals, Inc. Modular method to prepare tetrameric cytokines with improved pharmacokinetics by the dock-and-lock (DNL) technology
JP3767632B2 (ja) 2003-05-29 2006-04-19 アステラス製薬株式会社 イヌｃｙｐ１ａ２遺伝子多型
WO2005076886A2 (en) * 2004-02-05 2005-08-25 Irm Llc Prostasin substrates and inhibitors
US8034352B2 (en) 2005-04-06 2011-10-11 Ibc Pharmaceuticals, Inc. Tetrameric cytokines with improved biological activity
US8491914B2 (en) 2004-02-13 2013-07-23 Ibc Pharmaceuticals, Inc. Dock-and-lock (DNL) complexes for delivery of interference RNA
WO2006107617A2 (en) 2005-04-06 2006-10-12 Ibc Pharmaceuticals, Inc. Methods for generating stably linked complexes composed of homodimers, homotetramers or dimers of dimers and uses
US8349332B2 (en) 2005-04-06 2013-01-08 Ibc Pharmaceuticals, Inc. Multiple signaling pathways induced by hexavalent, monospecific and bispecific antibodies for enhanced toxicity to B-cell lymphomas and other diseases
US9931413B2 (en) 2005-04-06 2018-04-03 Ibc Pharmaceuticals, Inc. Tetrameric cytokines with improved biological activity
US8481041B2 (en) 2005-04-06 2013-07-09 Ibc Pharmaceuticals, Inc. Dock-and-lock (DNL) constructs for human immunodeficiency virus (HIV) therapy
US9623115B2 (en) 2005-04-06 2017-04-18 Ibc Pharmaceuticals, Inc. Dock-and-Lock (DNL) Complexes for Disease Therapy
US20080242599A1 (en) * 2005-05-03 2008-10-02 Majd Zayzafoon Compositions and Methods for Increasing Osteoblast Cell Differentiation and Bone Generation
US9862770B2 (en) * 2005-10-19 2018-01-09 Ibc Pharmaceuticals, Inc. Multivalent antibody complexes targeting IGF-1R show potent toxicity against solid tumors
CA2734265C (en) 2008-08-20 2017-12-19 Ibc Pharmaceuticals, Inc. Dock-and-lock (dnl) vaccines for cancer therapy
GB201208775D0 (en) 2012-05-18 2012-07-04 Uni I Oslo Chemical compounds
CA2874541A1 (en) 2012-06-01 2013-12-05 Ibc Pharmaceuticals, Inc. Multimeric complexes with improved in vivo stability, pharmacokinetics and efficacy
US9382329B2 (en) 2012-08-14 2016-07-05 Ibc Pharmaceuticals, Inc. Disease therapy by inducing immune response to Trop-2 expressing cells
AU2013302696B9 (en) 2012-08-14 2018-08-09 Ibc Pharmaceuticals, Inc. T-cell redirecting bispecific antibodies for treatment of disease
US20150231241A1 (en) 2012-08-14 2015-08-20 Ibc Pharmaceuticals, Inc. Combination therapy for inducing immune response to disease
US9682143B2 (en) 2012-08-14 2017-06-20 Ibc Pharmaceuticals, Inc. Combination therapy for inducing immune response to disease
EP3062818B1 (en) 2013-11-01 2019-09-11 IBC Pharmaceuticals, Inc. Bispecific antibodies that neutralize both tnf-alpha and il-6: novel therapeutic agent for autoimmune disease
GB201320506D0 (en) 2013-11-26 2014-01-01 Uni I Oslo Cyclic amino compounds for the use in the treatment of cardiac disorders
CN107828815A (zh) * 2017-10-09 2018-03-23 中国农业科学院烟草研究所 一种用于批量转化的酿酒酵母转化方法及其应用

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US5180713A (en) * 1985-09-27 1993-01-19 Liposome Technology, Inc. Stabilized liposome/amphotercin B composition and method
US5252263A (en) * 1986-06-16 1993-10-12 The Liposome Company, Inc. Induction of asymmetry in vesicles
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US5283173A (en) * 1990-01-24 1994-02-01 The Research Foundation Of State University Of New York System to detect protein-protein interactions
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US5807693A (en) * 1994-11-23 1998-09-15 Icos Corporation Calcineurin inhibitory compounds and anchoring protein

Also Published As

Publication number Publication date
NO963049L (no) 1996-09-23
US5871945A (en) 1999-02-16
NO963049D0 (no) 1996-07-22
CA2181826A1 (en) 1996-05-30
CN1153830C (zh) 2004-06-16
JPH09509849A (ja) 1997-10-07
CN1148407A (zh) 1997-04-23
FI962932A (fi) 1996-09-20
EP0748379A1 (en) 1996-12-18
WO1996016172A3 (en) 1996-08-29
HU9602311D0 (en) 1996-10-28
PL315627A1 (en) 1996-11-25
HUT75826A (en) 1997-05-28
HU221881B1 (hu) 2003-02-28
AU712168B2 (en) 1999-10-28
FI962932A0 (fi) 1996-07-22
US6107104A (en) 2000-08-22
MX9602798A (es) 1997-12-31
SK95096A3 (en) 1997-07-09
SK284105B6 (sk) 2004-09-08
CZ213696A3 (en) 1997-05-14
WO1996016172A2 (en) 1996-05-30
PL184659B1 (pl) 2002-11-29
AU4513396A (en) 1996-06-17

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Legal Events

Date Code Title Description
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]