BR9407144A - Processo para a expressão de alto nível da proteina de membrana externa P2 de haemophilus influenzae tipo B (HIB-P2) em E.coli; processo de purifição da proteina de membrana externa P2 ou proteina de fusão da mesma;processo de reduplicação da proteina de membrana externa P2 ou proteina de fusão obtida; proteina de membrana externa P2 reduplicada, substancialmente pura, a partir de haemophilus influenzae tipo B (HIB-P2) ou proteina de fusão da mesma; vacina compreendendo a proteina de membrana externa P2 de hamophilus influenzae tipo B (HIB-P2) ou uma proteina de fusão da mesma; processo para obter uma proteina P2 ou conjugado proteina de fusão P2-polissacarídeo; processo para evitar a meningite bacteriana em um animal; vetor pNV-3; vetor pNV-2, e vetor pNV-6 - Google Patents
Processo para a expressão de alto nível da proteina de membrana externa P2 de haemophilus influenzae tipo B (HIB-P2) em E.coli; processo de purifição da proteina de membrana externa P2 ou proteina de fusão da mesma;processo de reduplicação da proteina de membrana externa P2 ou proteina de fusão obtida; proteina de membrana externa P2 reduplicada, substancialmente pura, a partir de haemophilus influenzae tipo B (HIB-P2) ou proteina de fusão da mesma; vacina compreendendo a proteina de membrana externa P2 de hamophilus influenzae tipo B (HIB-P2) ou uma proteina de fusão da mesma; processo para obter uma proteina P2 ou conjugado proteina de fusão P2-polissacarídeo; processo para evitar a meningite bacteriana em um animal; vetor pNV-3; vetor pNV-2, e vetor pNV-6Info
- Publication number
- BR9407144A BR9407144A BR9407144A BR9407144A BR9407144A BR 9407144 A BR9407144 A BR 9407144A BR 9407144 A BR9407144 A BR 9407144A BR 9407144 A BR9407144 A BR 9407144A BR 9407144 A BR9407144 A BR 9407144A
- Authority
- BR
- Brazil
- Prior art keywords
- outer membrane
- protein
- fusion protein
- membrane protein
- pnv
- Prior art date
Links
- 108020001507 fusion proteins Proteins 0.000 title 5
- 102000037865 fusion proteins Human genes 0.000 title 5
- 101710167677 Outer membrane protein P2 Proteins 0.000 title 4
- 238000000034 method Methods 0.000 title 4
- 241000606768 Haemophilus influenzae Species 0.000 title 2
- 229940045808 haemophilus influenzae type b Drugs 0.000 title 2
- 241000588724 Escherichia coli Species 0.000 title 1
- 206010027202 Meningitis bacterial Diseases 0.000 title 1
- 101710116435 Outer membrane protein Proteins 0.000 title 1
- 201000009904 bacterial meningitis Diseases 0.000 title 1
- 229920001282 polysaccharide Polymers 0.000 title 1
- 239000005017 polysaccharide Substances 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 title 1
- 102000004169 proteins and genes Human genes 0.000 title 1
- 238000000746 purification Methods 0.000 title 1
- 229960005486 vaccine Drugs 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/16—Central respiratory analeptics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/285—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Pasteurellaceae (F), e.g. Haemophilus influenza
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2795/00—Bacteriophages
- C12N2795/00011—Details
- C12N2795/10011—Details dsDNA Bacteriophages
- C12N2795/10211—Podoviridae
- C12N2795/10222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Communicable Diseases (AREA)
- Veterinary Medicine (AREA)
- Virology (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Engineering & Computer Science (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/096,181 US6153406A (en) | 1993-07-23 | 1993-07-23 | Method for the high level expression, purification and refolding of the outer membrane protein P2 from Haemophilus influenzae type B |
| PCT/US1994/008326 WO1995003069A1 (en) | 1993-07-23 | 1994-07-22 | Method for expression and purification of p2 protein from haemophilus influenzae type b |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR9407144A true BR9407144A (pt) | 1996-09-17 |
Family
ID=22256123
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR9407144A BR9407144A (pt) | 1993-07-23 | 1994-07-22 | Processo para a expressão de alto nível da proteina de membrana externa P2 de haemophilus influenzae tipo B (HIB-P2) em E.coli; processo de purifição da proteina de membrana externa P2 ou proteina de fusão da mesma;processo de reduplicação da proteina de membrana externa P2 ou proteina de fusão obtida; proteina de membrana externa P2 reduplicada, substancialmente pura, a partir de haemophilus influenzae tipo B (HIB-P2) ou proteina de fusão da mesma; vacina compreendendo a proteina de membrana externa P2 de hamophilus influenzae tipo B (HIB-P2) ou uma proteina de fusão da mesma; processo para obter uma proteina P2 ou conjugado proteina de fusão P2-polissacarídeo; processo para evitar a meningite bacteriana em um animal; vetor pNV-3; vetor pNV-2, e vetor pNV-6 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US6153406A (pt) |
| EP (1) | EP0724455A4 (pt) |
| JP (1) | JPH09500537A (pt) |
| AU (1) | AU698458B2 (pt) |
| BR (1) | BR9407144A (pt) |
| CA (1) | CA2167808A1 (pt) |
| FI (1) | FI960308A (pt) |
| NO (1) | NO960255L (pt) |
| NZ (1) | NZ271500A (pt) |
| PL (1) | PL181695B1 (pt) |
| WO (1) | WO1995003069A1 (pt) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9202219D0 (en) * | 1992-02-03 | 1992-03-18 | Connaught Lab | A synthetic heamophilus influenzae conjugate vaccine |
| US6033877A (en) * | 1995-11-02 | 2000-03-07 | Research Foundation Of State University Of New York | Peptide expression and delivery system |
| FR2748476B1 (fr) * | 1996-05-07 | 1998-08-14 | Pf Medicament | Complexe immunogene, son utilisation, son procede de preparation et vaccin le contenant |
| JP2001510169A (ja) | 1997-07-17 | 2001-07-31 | ノース アメリカン ワクチン， インコーポレイテッド | Ｂ型髄膜炎菌性ポーリンおよびＨ．ｉｎｆｌｕｅｎｚａｅ多糖体を含む免疫原性結合体 |
| US7785609B1 (en) | 1999-03-16 | 2010-08-31 | Sanofi Pasteur Limited | Recombinant Haemophilus influenzae adhesin proteins |
| DE19939246A1 (de) * | 1999-08-19 | 2001-02-22 | Phasys Gmbh M | Rückfaltung von Membranproteinen |
| ATE347557T1 (de) * | 2000-03-23 | 2006-12-15 | Takeda Pharmaceutical | Fluorisochinolinderivate, verfahren zu ihrer herstellung und ihre anwendung |
| FR2801219A1 (fr) * | 2000-09-18 | 2001-05-25 | Pf Medicament | Procede de preparation de proteine recombinante renaturee en presence de detergent |
| KR101652060B1 (ko) * | 2008-12-25 | 2016-08-29 | 잇빤 자이단호진 가가쿠오요비겟세이료호겐쿠쇼 | 재조합 닭 전염성 코라이자 백신 및 그 제조방법 |
| GB201009861D0 (en) * | 2010-06-11 | 2010-07-21 | Novartis Ag | OMV vaccines |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4356170A (en) * | 1981-05-27 | 1982-10-26 | Canadian Patents & Development Ltd. | Immunogenic polysaccharide-protein conjugates |
| US4902506A (en) * | 1983-07-05 | 1990-02-20 | The University Of Rochester | Immunogenic conjugates |
| US4455296A (en) * | 1982-02-02 | 1984-06-19 | Board Of Regents, The University Of Texas System | Hybrid cell lines producing monoclonal antibodies directed against Haemophilus influenzae |
| US4459286A (en) * | 1983-01-31 | 1984-07-10 | Merck & Co., Inc. | Coupled H. influenzae type B vaccine |
| US4695624A (en) * | 1984-05-10 | 1987-09-22 | Merck & Co., Inc. | Covalently-modified polyanionic bacterial polysaccharides, stable covalent conjugates of such polysaccharides and immunogenic proteins with bigeneric spacers, and methods of preparing such polysaccharides and conjugates and of confirming covalency |
| US4656255A (en) * | 1985-09-09 | 1987-04-07 | International Minerals & Chemical Corp. | Protein recovery |
| US5173294A (en) * | 1986-11-18 | 1992-12-22 | Research Foundation Of State University Of New York | Dna probe for the identification of haemophilus influenzae |
| US5196338A (en) * | 1986-12-31 | 1993-03-23 | Praxis Biologics, Inc. | Recombinant vectors for Haemophilus influenzae peptides and proteins |
| AU623353B2 (en) * | 1987-12-10 | 1992-05-14 | Board Of Regents, The University Of Texas System | Methods and compositions for the production of haemophilus influenzae type b major outer membrane protein antigens |
| US5192540A (en) * | 1988-04-19 | 1993-03-09 | American Cyanamid Company | Haemophilus influenzae type b oxidized polysaccharide-outer membrane protein conjugate vaccine |
| ATE120093T1 (de) * | 1988-12-19 | 1995-04-15 | Praxis Biolog Inc | Meningococcales klasse i-aussenmembranprotein- vakzin. |
| GB8830124D0 (en) * | 1988-12-23 | 1989-02-22 | Connaught Lab | Membrane proteins and peptides of haemophilus influenzae b |
| EP0378929A3 (en) * | 1988-12-23 | 1990-08-01 | Connaught Laboratories Limited | Membrane proteins and peptides of haemophilus influenzae type b |
| GB8912330D0 (en) * | 1989-05-30 | 1989-07-12 | Wellcome Found | Live vaccines |
| EP0504202B1 (en) * | 1989-12-14 | 1995-05-03 | National Research Council Of Canada | Improved meningococcal polysaccharide conjugate vaccine |
| SE466259B (sv) * | 1990-05-31 | 1992-01-20 | Arne Forsgren | Protein d - ett igd-bindande protein fraan haemophilus influenzae, samt anvaendning av detta foer analys, vacciner och uppreningsaendamaal |
| FI903414A (fi) * | 1990-07-06 | 1992-01-07 | Kansanterveyslaitos | Produktion av proteiner i grampositiva bakterier. |
| US5439808A (en) * | 1993-07-23 | 1995-08-08 | North American Vaccine, Inc. | Method for the high level expression, purification and refolding of the outer membrane group B porin proteins from Neisseria meningitidis |
| US5503992A (en) * | 1993-09-07 | 1996-04-02 | Washington University | DNA encoding the 15kD outer membrane protein of Haemophilus influenzae |
| US5866135A (en) * | 1994-04-21 | 1999-02-02 | North American Vaccine, Inc. | Group A streptococcal polysaccharide immunogenic compositions and methods |
| US5747287A (en) * | 1995-04-28 | 1998-05-05 | North American Vaccine, Inc. | Method for the high level expression, purification and refolding of the outer membrane group B porin proteins from Neisseria meningitidis |
-
1993
- 1993-07-23 US US08/096,181 patent/US6153406A/en not_active Expired - Fee Related
-
1994
- 1994-07-22 EP EP94925106A patent/EP0724455A4/en not_active Withdrawn
- 1994-07-22 CA CA002167808A patent/CA2167808A1/en not_active Abandoned
- 1994-07-22 PL PL94312700A patent/PL181695B1/pl unknown
- 1994-07-22 AU AU75144/94A patent/AU698458B2/en not_active Ceased
- 1994-07-22 BR BR9407144A patent/BR9407144A/pt not_active Application Discontinuation
- 1994-07-22 JP JP7505353A patent/JPH09500537A/ja not_active Ceased
- 1994-07-22 NZ NZ271500A patent/NZ271500A/en unknown
- 1994-07-22 WO PCT/US1994/008326 patent/WO1995003069A1/en not_active Application Discontinuation
-
1996
- 1996-01-22 NO NO960255A patent/NO960255L/no not_active Application Discontinuation
- 1996-01-23 FI FI960308A patent/FI960308A/fi not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| WO1995003069A1 (en) | 1995-02-02 |
| EP0724455A1 (en) | 1996-08-07 |
| FI960308A (fi) | 1996-03-22 |
| NO960255D0 (no) | 1996-01-22 |
| NO960255L (no) | 1996-03-22 |
| PL181695B1 (pl) | 2001-09-28 |
| AU698458B2 (en) | 1998-10-29 |
| EP0724455A4 (en) | 1998-02-04 |
| US6153406A (en) | 2000-11-28 |
| JPH09500537A (ja) | 1997-01-21 |
| PL312700A1 (en) | 1996-05-13 |
| CA2167808A1 (en) | 1995-02-02 |
| NZ271500A (en) | 1997-11-24 |
| AU7514494A (en) | 1995-02-20 |
| FI960308A0 (fi) | 1996-01-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EG | Technical examination (opinion): publication of technical examination (opinion) | ||
| FC | Decision: refusal | ||
| CKFC | Appeal: appeal against refusal | ||
| B15K | Others concerning applications: alteration of classification |
Ipc: C07K 14/005 (2006.01), C07K 14/285 (2006.0 |