BR9400021A - Uso de um composto, compostos, processo para a produção de um éter e composição farmacêutica - Google Patents
Uso de um composto, compostos, processo para a produção de um éter e composição farmacêuticaInfo
- Publication number
- BR9400021A BR9400021A BR9400021A BR9400021A BR9400021A BR 9400021 A BR9400021 A BR 9400021A BR 9400021 A BR9400021 A BR 9400021A BR 9400021 A BR9400021 A BR 9400021A BR 9400021 A BR9400021 A BR 9400021A
- Authority
- BR
- Brazil
- Prior art keywords
- alkyl
- formula
- hydrogen
- group
- compound
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 4
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 title 2
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 7
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 150000002431 hydrogen Chemical class 0.000 abstract 2
- CBOIHMRHGLHBPB-UHFFFAOYSA-N hydroxymethyl Chemical compound O[CH2] CBOIHMRHGLHBPB-UHFFFAOYSA-N 0.000 abstract 2
- 210000002569 neuron Anatomy 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 125000004076 pyridyl group Chemical group 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 abstract 1
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- 206010010904 Convulsion Diseases 0.000 abstract 1
- 208000023105 Huntington disease Diseases 0.000 abstract 1
- 208000013016 Hypoglycemia Diseases 0.000 abstract 1
- 206010021143 Hypoxia Diseases 0.000 abstract 1
- 231100000644 Toxic injury Toxicity 0.000 abstract 1
- 208000027418 Wounds and injury Diseases 0.000 abstract 1
- 230000002411 adverse Effects 0.000 abstract 1
- 230000036461 convulsion Effects 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 230000006378 damage Effects 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 206010015037 epilepsy Diseases 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 230000002218 hypoglycaemic effect Effects 0.000 abstract 1
- 230000007954 hypoxia Effects 0.000 abstract 1
- 208000014674 injury Diseases 0.000 abstract 1
- 208000028867 ischemia Diseases 0.000 abstract 1
- 125000000335 thiazolyl group Chemical group 0.000 abstract 1
- 125000001544 thienyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/22—Bridged ring systems
- C07D221/28—Morphinans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Psychiatry (AREA)
- Emergency Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Saccharide Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US113593A | 1993-01-06 | 1993-01-06 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR9400021A true BR9400021A (pt) | 1994-07-26 |
Family
ID=21694554
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR9400021A BR9400021A (pt) | 1993-01-06 | 1994-01-05 | Uso de um composto, compostos, processo para a produção de um éter e composição farmacêutica |
Country Status (23)
| Country | Link |
|---|---|
| EP (1) | EP0612730B1 (enExample) |
| JP (1) | JP2501298B2 (enExample) |
| KR (1) | KR940018094A (enExample) |
| CN (1) | CN1097006A (enExample) |
| AT (1) | ATE154931T1 (enExample) |
| AU (1) | AU681601B2 (enExample) |
| BR (1) | BR9400021A (enExample) |
| CA (1) | CA2110337A1 (enExample) |
| CZ (1) | CZ2294A3 (enExample) |
| DE (1) | DE69311887T2 (enExample) |
| DK (1) | DK0612730T3 (enExample) |
| ES (1) | ES2105061T3 (enExample) |
| FI (1) | FI940041L (enExample) |
| GR (1) | GR3024891T3 (enExample) |
| HU (2) | HUT66061A (enExample) |
| IL (1) | IL108247A (enExample) |
| MX (1) | MX9400177A (enExample) |
| NO (1) | NO940028D0 (enExample) |
| NZ (1) | NZ250580A (enExample) |
| PL (1) | PL175365B1 (enExample) |
| TW (1) | TW264473B (enExample) |
| UY (1) | UY23706A1 (enExample) |
| ZA (1) | ZA939806B (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9522176D0 (en) * | 1995-10-30 | 1996-01-03 | Iaf Biochem Int | Morphinan derivatives having neuroprotective activity |
| EP1384720A1 (en) * | 1996-06-13 | 2004-01-28 | SUMIKA FINE CHEMICALS Co., Ltd. | Process for drying paroxetine hydrochloride |
| FR2752163B1 (fr) * | 1996-08-12 | 1998-10-30 | Pf Medicament | Utilisation de l'efaroxan pour la fabricaton de medicament destine au traitement de la maladie de huntington |
| GB9706753D0 (en) * | 1997-04-03 | 1997-05-21 | Pharmacia & Upjohn Spa | Aralkoxy-morphinan derivatives |
| KR100425881B1 (ko) * | 2001-03-14 | 2004-04-03 | 고광호 | 신규한 몰피난 유도체 |
| CN103405431B (zh) * | 2002-05-17 | 2016-04-13 | 台湾J药品有限公司 | 阿片和阿片样化合物及其用途 |
| DE10229842A1 (de) * | 2002-07-03 | 2004-02-05 | Helmut Prof. Dr. Schmidhammer | Morphinanderivate und deren quartäre Ammoniumsalze substituiert in Position 14, Herstellungsverfahren und Verwendung |
| US20040204862A1 (en) | 2003-04-11 | 2004-10-14 | Wainer Irving W. | Computer-based model for identification and characterization for non-competitive inhibitors of nicotinic acetylcholine receptors and related ligand-gated ion channel receptors |
| US8017622B2 (en) | 2003-05-16 | 2011-09-13 | Jenken Biosciences, Inc. | Opioid and opioid-like compounds and uses thereof |
| CN102325776A (zh) * | 2009-02-23 | 2012-01-18 | 马林克罗特公司 | (+)-吗啡喃*季盐及其制备方法 |
| CN103044327B (zh) * | 2013-01-07 | 2014-12-17 | 苏州立新制药有限公司 | 一种右美沙芬的制备方法 |
| KR20170052684A (ko) * | 2014-09-14 | 2017-05-12 | 아바니르 파마슈티컬스, 인코포레이티드 | 치매에서의 초조함을 치료하기 위한 덱스트로메토르판 화합물 및 퀴니딘을 포함하는 약제학적 조성물 |
| US20160243112A1 (en) * | 2015-02-25 | 2016-08-25 | Alkermes, Inc. | Treatments for alzheimer's related diseases and disorders |
| WO2022045301A1 (ja) * | 2020-08-28 | 2022-03-03 | 日本ケミファ株式会社 | 新規銅触媒を用いたジアリールエーテル骨格を有するモルヒナン誘導体の製造方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FI773636A7 (fi) * | 1976-12-06 | 1978-06-07 | Hoffmann La Roche | Nya fenylderivat |
| US4113729A (en) * | 1976-12-06 | 1978-09-12 | Hoffmann-La Roche Inc. | 3-Phenoxymorphinans and derivatives thereof |
| US4806543A (en) * | 1986-11-25 | 1989-02-21 | Board Of Trustees Of The Leland Stanford Junior University | Method and compositions for reducing neurotoxic injury |
-
1993
- 1993-11-25 TW TW082109942A patent/TW264473B/zh active
- 1993-11-30 CA CA002110337A patent/CA2110337A1/en not_active Abandoned
- 1993-12-20 DK DK93120498.6T patent/DK0612730T3/da active
- 1993-12-20 ES ES93120498T patent/ES2105061T3/es not_active Expired - Lifetime
- 1993-12-20 AT AT93120498T patent/ATE154931T1/de not_active IP Right Cessation
- 1993-12-20 DE DE69311887T patent/DE69311887T2/de not_active Expired - Fee Related
- 1993-12-20 EP EP93120498A patent/EP0612730B1/en not_active Expired - Lifetime
- 1993-12-23 NZ NZ250580A patent/NZ250580A/en unknown
- 1993-12-30 ZA ZA939806A patent/ZA939806B/xx unknown
- 1993-12-30 JP JP5354172A patent/JP2501298B2/ja not_active Expired - Lifetime
- 1993-12-31 UY UY23706A patent/UY23706A1/es unknown
- 1993-12-31 IL IL108247A patent/IL108247A/en not_active IP Right Cessation
- 1993-12-31 AU AU52807/93A patent/AU681601B2/en not_active Ceased
-
1994
- 1994-01-03 MX MX9400177A patent/MX9400177A/es not_active IP Right Cessation
- 1994-01-03 HU HU9400002A patent/HUT66061A/hu unknown
- 1994-01-04 NO NO940028A patent/NO940028D0/no unknown
- 1994-01-04 KR KR1019940000067A patent/KR940018094A/ko not_active Ceased
- 1994-01-05 CZ CZ9422A patent/CZ2294A3/cs unknown
- 1994-01-05 FI FI940041A patent/FI940041L/fi unknown
- 1994-01-05 BR BR9400021A patent/BR9400021A/pt not_active Application Discontinuation
- 1994-01-05 PL PL94301784A patent/PL175365B1/pl unknown
- 1994-01-05 CN CN94100181A patent/CN1097006A/zh active Pending
-
1995
- 1995-06-19 HU HU95P/P00253P patent/HU211290A9/hu unknown
-
1997
- 1997-09-30 GR GR970402538T patent/GR3024891T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN1097006A (zh) | 1995-01-04 |
| AU5280793A (en) | 1994-07-14 |
| FI940041A7 (fi) | 1994-07-07 |
| DK0612730T3 (da) | 1998-02-02 |
| CZ2294A3 (en) | 1994-07-13 |
| HU9400002D0 (en) | 1994-05-30 |
| KR940018094A (ko) | 1994-08-16 |
| ES2105061T3 (es) | 1997-10-16 |
| NO940028L (enExample) | 1994-07-07 |
| UY23706A1 (es) | 1994-06-05 |
| TW264473B (enExample) | 1995-12-01 |
| HUT66061A (en) | 1994-09-28 |
| IL108247A (en) | 1998-02-22 |
| CA2110337A1 (en) | 1994-07-07 |
| NZ250580A (en) | 1996-07-26 |
| EP0612730A1 (en) | 1994-08-31 |
| EP0612730B1 (en) | 1997-07-02 |
| FI940041L (fi) | 1994-07-07 |
| AU681601B2 (en) | 1997-09-04 |
| NO940028D0 (no) | 1994-01-04 |
| JP2501298B2 (ja) | 1996-05-29 |
| FI940041A0 (fi) | 1994-01-05 |
| DE69311887D1 (de) | 1997-08-07 |
| MX9400177A (es) | 1994-07-29 |
| HU211290A9 (en) | 1995-11-28 |
| GR3024891T3 (en) | 1998-01-30 |
| IL108247A0 (en) | 1994-04-12 |
| DE69311887T2 (de) | 1998-01-15 |
| ZA939806B (en) | 1994-07-06 |
| ATE154931T1 (de) | 1997-07-15 |
| PL301784A1 (en) | 1994-07-11 |
| PL175365B1 (pl) | 1998-12-31 |
| JPH06316564A (ja) | 1994-11-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EE | Request for examination | ||
| EG | Technical examination (opinion): publication of technical examination (opinion) | ||
| FC | Decision: refusal | ||
| FC | Decision: refusal |