BR8201589A - Composto,composicao farmaceutica,processo para tratar e/ou evitar a hipertensao,insuficiencia cardiaca congestiva,arritmia,enxaqueca pertubacoes vasospasticas e asma num mamifero e processo para a preparacao de tal composto - Google Patents
Composto,composicao farmaceutica,processo para tratar e/ou evitar a hipertensao,insuficiencia cardiaca congestiva,arritmia,enxaqueca pertubacoes vasospasticas e asma num mamifero e processo para a preparacao de tal compostoInfo
- Publication number
- BR8201589A BR8201589A BR8201589A BR8201589A BR8201589A BR 8201589 A BR8201589 A BR 8201589A BR 8201589 A BR8201589 A BR 8201589A BR 8201589 A BR8201589 A BR 8201589A BR 8201589 A BR8201589 A BR 8201589A
- Authority
- BR
- Brazil
- Prior art keywords
- paste
- arrhythmia
- migraine
- heart failure
- congestive heart
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/48—Oxygen atoms attached in position 4 having an acyclic carbon atom attached in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Saccharide Compounds (AREA)
- Photoreceptors In Electrophotography (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/246,459 US4332804A (en) | 1981-03-23 | 1981-03-23 | 9-[2-(3-Indolyl)ethyl]-1oxa-4,9-diazaspiro[5.5]undecan-3-ones |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR8201589A true BR8201589A (pt) | 1983-02-08 |
Family
ID=22930776
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR8201589A BR8201589A (pt) | 1981-03-23 | 1982-02-22 | Composto,composicao farmaceutica,processo para tratar e/ou evitar a hipertensao,insuficiencia cardiaca congestiva,arritmia,enxaqueca pertubacoes vasospasticas e asma num mamifero e processo para a preparacao de tal composto |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US4332804A (enExample) |
| EP (1) | EP0061333B1 (enExample) |
| JP (1) | JPS57169485A (enExample) |
| KR (1) | KR830009094A (enExample) |
| AT (1) | ATE17249T1 (enExample) |
| AU (1) | AU557094B2 (enExample) |
| BR (1) | BR8201589A (enExample) |
| DE (1) | DE3268225D1 (enExample) |
| DK (1) | DK129282A (enExample) |
| ES (1) | ES8306373A1 (enExample) |
| FI (1) | FI820998A7 (enExample) |
| IE (1) | IE52652B1 (enExample) |
| IL (1) | IL65310A (enExample) |
| NO (1) | NO820937L (enExample) |
| NZ (1) | NZ200085A (enExample) |
| PH (1) | PH17233A (enExample) |
| PL (1) | PL235561A1 (enExample) |
| PT (1) | PT74626B (enExample) |
| ZA (1) | ZA821929B (enExample) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4861880A (en) * | 1982-09-20 | 1989-08-29 | Pfizer Inc. | 1-phenyl-2(1H,3H)-indolone psycho-therapeutic agents |
| US4977178A (en) * | 1982-09-20 | 1990-12-11 | Pfizer Inc. | Method of treating anxiety and depression with 1-phenyl-2(1H,3H)-indolone psycho-therapeutic agents |
| US4879391A (en) * | 1982-09-20 | 1989-11-07 | Pfizer Inc. | 1-Phenyl-2(1H,3H)-indolone psychotherapeutic agents |
| GB8808433D0 (en) * | 1988-04-11 | 1988-05-11 | Merck Sharp & Dohme | Therapeutic agents |
| CN101230034A (zh) * | 2000-03-06 | 2008-07-30 | 阿卡蒂亚药品公司 | 用于治疗5-羟色胺相关性疾病的氮杂环化合物 |
| NZ571695A (en) * | 2001-12-28 | 2010-02-26 | Acadia Pharm Inc | Spiroazacyclic compounds as monoamine receptor for modulating 5-HT2A receptor-mediated events |
| US7538222B2 (en) * | 2002-06-24 | 2009-05-26 | Acadia Pharmaceuticals, Inc. | N-substituted piperidine derivatives as serotonin receptor agents |
| US7253186B2 (en) * | 2002-06-24 | 2007-08-07 | Carl-Magnus Andersson | N-substituted piperidine derivatives as serotonin receptor agents |
| CA2490397A1 (en) * | 2002-06-24 | 2003-12-31 | Acadia Pharmaceuticals Inc. | N-substituted piperidine derivatives as serotonin receptor agents |
| US7601740B2 (en) | 2003-01-16 | 2009-10-13 | Acadia Pharmaceuticals, Inc. | Selective serotonin 2A/2C receptor inverse agonists as therapeutics for neurodegenerative diseases |
| US7820695B2 (en) * | 2004-05-21 | 2010-10-26 | Acadia Pharmaceuticals, Inc. | Selective serotonin receptor inverse agonists as therapeutics for disease |
| US20050261278A1 (en) * | 2004-05-21 | 2005-11-24 | Weiner David M | Selective serotonin receptor inverse agonists as therapeutics for disease |
| BRPI0516063A (pt) * | 2004-09-27 | 2008-08-19 | Acadia Pharm Inc | sìntese de n-(4-fluorbenzil)-n-(1-metilpiperidin-4-il)-n'-(4-(2-metilp ropi-loxi)fenilmetil)carbamida e seu sal tartarato e formas cristalinas |
| US7790899B2 (en) * | 2004-09-27 | 2010-09-07 | Acadia Pharmaceuticals, Inc. | Synthesis of N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N′-(4-(2-methylpropyloxy)phenylmethyl)carbamide and its tartrate salt and crystalline forms |
| EP2134330B1 (en) | 2007-03-19 | 2013-05-08 | Acadia Pharmaceuticals Inc. | Combinations of 5-ht2a inverse agonists and antagonists with antipsychotics |
| SI2200610T1 (en) * | 2007-09-21 | 2018-06-29 | Acadia Pharmaceuticals Inc. | Co-administration of pimavanserin with other agents |
| TWI685497B (zh) * | 2014-06-02 | 2020-02-21 | 西班牙商伊史帝夫製藥公司 | 具有多重模式抗疼痛活性的１-氧雜-４,９-二氮雜螺十一烷化合物之烷基衍生物 |
| SI3325444T1 (sl) | 2015-07-20 | 2021-11-30 | Acadia Pharmaceuticals Inc. | Postopki za pripravo N-(4-fluorobenzil)-N-(1-metilpiperidin-4-il)-N'- (4-(2-metilpropiloksi)fenilmetil)karbamida in njegove tartratne soli in polimorfne oblike C |
| US10927128B2 (en) | 2015-11-16 | 2021-02-23 | Esteve Pharmaceuticals. S.A. | Oxadiazaspiro compounds for the treatment of drug abuse and addiction |
| US10953000B2 (en) | 2016-03-25 | 2021-03-23 | Acadia Pharmaceuticals Inc. | Combination of pimavanserin and cytochrome P450 modulators |
| WO2017165635A1 (en) | 2016-03-25 | 2017-09-28 | Acadia Pharmaceuticals Inc. | Combination of pimavanserin and cytochrome p450 modulators |
| US11464768B2 (en) | 2016-12-20 | 2022-10-11 | Acadia Pharmaceuticals Inc. | Pimavanserin alone or in combination for use in the treatment of Alzheimer's disease psychosis |
| US11135211B2 (en) | 2017-04-28 | 2021-10-05 | Acadia Pharmaceuticals Inc. | Pimavanserin for treating impulse control disorder |
| EP3675827A1 (en) | 2017-08-30 | 2020-07-08 | Acadia Pharmaceuticals Inc. | Formulations of pimavanserin |
| PT3697795T (pt) | 2017-10-17 | 2024-02-29 | Acondicionamiento Tarrasense | Sais de (r)-9-(2,5-difluorofenetil)-4-etil-2-metil-1-oxa-4,9-diazaespiro[5.5]undecan-3-ona |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3481942A (en) * | 1968-09-06 | 1969-12-02 | Smithkline Corp | Oxa-diazaspiro(4.5)decane compounds |
| US3574204A (en) * | 1969-07-03 | 1971-04-06 | Yoshitomi Pharmaceutical | Piperidine spiro compounds |
| CA952908A (en) * | 1970-02-27 | 1974-08-13 | Yoshitomi Pharmaceutical Industries | Benzodioxane derivatives |
| US3723442A (en) * | 1970-12-31 | 1973-03-27 | Yoshitomi Pharmaceutical | 3-oxo-1-oxa-4,8-diazaspiro(4.5)decanes |
| US4255432A (en) * | 1979-09-06 | 1981-03-10 | Syntex (U.S.A.) Inc. | 8-[2-3-Indolyl)ethyl]-1-oxa-3-,8-diazaspiro[4.5]decan-2-ones, pharmaceutical compositions thereof and methods of use thereof |
-
1981
- 1981-03-23 US US06/246,459 patent/US4332804A/en not_active Expired - Fee Related
-
1982
- 1982-02-22 BR BR8201589A patent/BR8201589A/pt unknown
- 1982-03-22 NZ NZ200085A patent/NZ200085A/en unknown
- 1982-03-22 PL PL23556182A patent/PL235561A1/xx unknown
- 1982-03-22 AT AT82301460T patent/ATE17249T1/de not_active IP Right Cessation
- 1982-03-22 IE IE648/82A patent/IE52652B1/en unknown
- 1982-03-22 PH PH27035A patent/PH17233A/en unknown
- 1982-03-22 EP EP82301460A patent/EP0061333B1/en not_active Expired
- 1982-03-22 DK DK129282A patent/DK129282A/da not_active Application Discontinuation
- 1982-03-22 DE DE8282301460T patent/DE3268225D1/de not_active Expired
- 1982-03-22 ES ES510649A patent/ES8306373A1/es not_active Expired
- 1982-03-22 AU AU81769/82A patent/AU557094B2/en not_active Expired - Fee Related
- 1982-03-22 PT PT74626A patent/PT74626B/pt unknown
- 1982-03-22 NO NO820937A patent/NO820937L/no unknown
- 1982-03-22 KR KR1019820001218A patent/KR830009094A/ko not_active Withdrawn
- 1982-03-22 FI FI820998A patent/FI820998A7/fi not_active Application Discontinuation
- 1982-03-22 IL IL65310A patent/IL65310A/xx unknown
- 1982-03-22 ZA ZA821929A patent/ZA821929B/xx unknown
- 1982-03-23 JP JP57044755A patent/JPS57169485A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| PT74626A (en) | 1982-04-01 |
| AU8176982A (en) | 1982-09-30 |
| ATE17249T1 (de) | 1986-01-15 |
| IE52652B1 (en) | 1988-01-06 |
| EP0061333B1 (en) | 1986-01-02 |
| PL235561A1 (enExample) | 1982-10-25 |
| ZA821929B (en) | 1983-11-30 |
| IE820648L (en) | 1982-09-23 |
| JPS57169485A (en) | 1982-10-19 |
| PH17233A (en) | 1984-07-03 |
| ES510649A0 (es) | 1983-06-01 |
| NO820937L (no) | 1982-09-24 |
| FI820998L (fi) | 1982-09-24 |
| PT74626B (en) | 1983-12-19 |
| ES8306373A1 (es) | 1983-06-01 |
| EP0061333A1 (en) | 1982-09-29 |
| AU557094B2 (en) | 1986-12-04 |
| NZ200085A (en) | 1985-07-12 |
| IL65310A (en) | 1985-03-31 |
| KR830009094A (ko) | 1983-12-17 |
| FI820998A7 (fi) | 1982-09-24 |
| DK129282A (da) | 1982-09-24 |
| DE3268225D1 (de) | 1986-02-13 |
| US4332804A (en) | 1982-06-01 |
| IL65310A0 (en) | 1982-05-31 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| BR8201589A (pt) | Composto,composicao farmaceutica,processo para tratar e/ou evitar a hipertensao,insuficiencia cardiaca congestiva,arritmia,enxaqueca pertubacoes vasospasticas e asma num mamifero e processo para a preparacao de tal composto | |
| AU538494B2 (en) | Substituted piperidines and pyrrolidines | |
| NO810684L (no) | Fremgangsmaate ved fremstilling av indanderivater. | |
| DK163144C (da) | Diethylaminoalkoxybenzhydrolderivater og farmaceutisk acceptable syreadditionssalte og kvaternaere ammoniumsalte deraf, fremgangsmaade til fremstilling heraf, farmaceutisk praeparat og fremgangsmaade til fremstilling heraf | |
| KR910002835A (ko) | 인돌 유도체 | |
| AU558261B2 (en) | Dialkylaminoalkyoxybenzylalcohol derivatives | |
| ES8501763A1 (es) | "procedimiento para la fabricacion de derivados de la tetrahidro-5.6.7.7. 4h-tieno (3, 2-c) piridinona-2 | |
| ES8504180A1 (es) | Procedimiento para preparar nuevos derivados de piperidina | |
| AU566359B2 (en) | 5-oxo-3/beta (un/substituted phenyl) -2- pyrrolidine propanoic acid | |
| DE3160821D1 (en) | Alkyl and cycloalkyl substituted 2-(2-(2-hydroxy-3-tert.-butylamino-propoxy)-5-acylaminophenyl)-1,3,4-oxadiazoles, their preparation and pharmaceutical preparations containing them | |
| DE3469527D1 (en) | Nortropine derivative, process for its preparation and its use | |
| EG16489A (en) | Process for the preparation of accridanone derivatives |