ZA821929B - 9-(2-(3-indolyl)ethyl)-1-oxa-4,9-diazaspiro(5.5.)undecan-3-ones - Google Patents
9-(2-(3-indolyl)ethyl)-1-oxa-4,9-diazaspiro(5.5.)undecan-3-onesInfo
- Publication number
- ZA821929B ZA821929B ZA821929A ZA821929A ZA821929B ZA 821929 B ZA821929 B ZA 821929B ZA 821929 A ZA821929 A ZA 821929A ZA 821929 A ZA821929 A ZA 821929A ZA 821929 B ZA821929 B ZA 821929B
- Authority
- ZA
- South Africa
- Prior art keywords
- carbon atoms
- undecan
- diazaspiro
- oxa
- indolyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/48—Oxygen atoms attached in position 4 having an acyclic carbon atom attached in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Photoreceptors In Electrophotography (AREA)
- Saccharide Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/246,459 US4332804A (en) | 1981-03-23 | 1981-03-23 | 9-[2-(3-Indolyl)ethyl]-1oxa-4,9-diazaspiro[5.5]undecan-3-ones |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA821929B true ZA821929B (en) | 1983-11-30 |
Family
ID=22930776
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA821929A ZA821929B (en) | 1981-03-23 | 1982-03-22 | 9-(2-(3-indolyl)ethyl)-1-oxa-4,9-diazaspiro(5.5.)undecan-3-ones |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US4332804A (enExample) |
| EP (1) | EP0061333B1 (enExample) |
| JP (1) | JPS57169485A (enExample) |
| KR (1) | KR830009094A (enExample) |
| AT (1) | ATE17249T1 (enExample) |
| AU (1) | AU557094B2 (enExample) |
| BR (1) | BR8201589A (enExample) |
| DE (1) | DE3268225D1 (enExample) |
| DK (1) | DK129282A (enExample) |
| ES (1) | ES510649A0 (enExample) |
| FI (1) | FI820998A7 (enExample) |
| IE (1) | IE52652B1 (enExample) |
| IL (1) | IL65310A (enExample) |
| NO (1) | NO820937L (enExample) |
| NZ (1) | NZ200085A (enExample) |
| PH (1) | PH17233A (enExample) |
| PL (1) | PL235561A1 (enExample) |
| PT (1) | PT74626B (enExample) |
| ZA (1) | ZA821929B (enExample) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4879391A (en) * | 1982-09-20 | 1989-11-07 | Pfizer Inc. | 1-Phenyl-2(1H,3H)-indolone psychotherapeutic agents |
| US4977178A (en) * | 1982-09-20 | 1990-12-11 | Pfizer Inc. | Method of treating anxiety and depression with 1-phenyl-2(1H,3H)-indolone psycho-therapeutic agents |
| US4861880A (en) * | 1982-09-20 | 1989-08-29 | Pfizer Inc. | 1-phenyl-2(1H,3H)-indolone psycho-therapeutic agents |
| GB8808433D0 (en) * | 1988-04-11 | 1988-05-11 | Merck Sharp & Dohme | Therapeutic agents |
| NZ520240A (en) * | 2000-03-06 | 2005-04-29 | Acadia Pharm Inc | Azacyclic compounds for use in the treatment of serotonin related diseases |
| ATE466014T1 (de) * | 2001-12-28 | 2010-05-15 | Acadia Pharm Inc | Spiroazacyclische verbindungen als monoaminrezeptormodulatoren |
| US7538222B2 (en) * | 2002-06-24 | 2009-05-26 | Acadia Pharmaceuticals, Inc. | N-substituted piperidine derivatives as serotonin receptor agents |
| US7253186B2 (en) * | 2002-06-24 | 2007-08-07 | Carl-Magnus Andersson | N-substituted piperidine derivatives as serotonin receptor agents |
| BR0312217A (pt) * | 2002-06-24 | 2005-05-10 | Acadia Pharm Inc | Compostos, métodos de inibição da atividade/ativação de um receptor monoaminérgico e método de tratamento de condição doentia associada a um receptor de monoaminergético |
| WO2004064738A2 (en) | 2003-01-16 | 2004-08-05 | Acadia Pharmaceuticals Inc. | Selective serotonin 2a/2c receptor inverse agonists as therapeutics for neurodegenerative diseases |
| US7820695B2 (en) * | 2004-05-21 | 2010-10-26 | Acadia Pharmaceuticals, Inc. | Selective serotonin receptor inverse agonists as therapeutics for disease |
| US20050261278A1 (en) | 2004-05-21 | 2005-11-24 | Weiner David M | Selective serotonin receptor inverse agonists as therapeutics for disease |
| US7790899B2 (en) * | 2004-09-27 | 2010-09-07 | Acadia Pharmaceuticals, Inc. | Synthesis of N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N′-(4-(2-methylpropyloxy)phenylmethyl)carbamide and its tartrate salt and crystalline forms |
| PL2289879T3 (pl) * | 2004-09-27 | 2015-05-29 | Acadia Pharm Inc | Synteza formy krystalicznej soli winianowej n-(4-fluorobenzylo)-n-(1-metylopiperydyn-4-ylo)-n'-(4-(2-metylopropyloksy)fenylometylo)karbamidu |
| ES2423485T3 (es) | 2007-03-19 | 2013-09-20 | Acadia Pharmaceuticals Inc. | Asociaciones de agonistas y antagonistas inversos 5-HT2A con antipsicóticos |
| WO2009039460A2 (en) * | 2007-09-21 | 2009-03-26 | Acadia Pharmaceuticals, Inc. | Co-administration of pimavanserin with other agents |
| TWI685497B (zh) * | 2014-06-02 | 2020-02-21 | 西班牙商伊史帝夫製藥公司 | 具有多重模式抗疼痛活性的１-氧雜-４,９-二氮雜螺十一烷化合物之烷基衍生物 |
| SI3325444T1 (sl) | 2015-07-20 | 2021-11-30 | Acadia Pharmaceuticals Inc. | Postopki za pripravo N-(4-fluorobenzil)-N-(1-metilpiperidin-4-il)-N'- (4-(2-metilpropiloksi)fenilmetil)karbamida in njegove tartratne soli in polimorfne oblike C |
| SG11201803153RA (en) | 2015-11-16 | 2018-06-28 | Esteve Labor Dr | Oxadiazaspiro compounds for the treatment of drug abuse and addiction |
| US10953000B2 (en) | 2016-03-25 | 2021-03-23 | Acadia Pharmaceuticals Inc. | Combination of pimavanserin and cytochrome P450 modulators |
| WO2017165635A1 (en) | 2016-03-25 | 2017-09-28 | Acadia Pharmaceuticals Inc. | Combination of pimavanserin and cytochrome p450 modulators |
| EP3558311A1 (en) | 2016-12-20 | 2019-10-30 | Acadia Pharmaceuticals Inc. | Pimavanserin alone or in combination for use in the treatment of alzheimer's disease psychosis |
| US11135211B2 (en) | 2017-04-28 | 2021-10-05 | Acadia Pharmaceuticals Inc. | Pimavanserin for treating impulse control disorder |
| EP3675827A1 (en) | 2017-08-30 | 2020-07-08 | Acadia Pharmaceuticals Inc. | Formulations of pimavanserin |
| BR112020007359A2 (pt) | 2017-10-17 | 2020-09-29 | Esteve Pharmaceuticals, S.A. | sais de (r)-9-(2,5-difluorofenetil)-4-etil-2-metil-1-oxa-4,9-diazaespiro[5.5]undecan-3-ona |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3481942A (en) * | 1968-09-06 | 1969-12-02 | Smithkline Corp | Oxa-diazaspiro(4.5)decane compounds |
| US3574204A (en) * | 1969-07-03 | 1971-04-06 | Yoshitomi Pharmaceutical | Piperidine spiro compounds |
| CA952908A (en) * | 1970-02-27 | 1974-08-13 | Yoshitomi Pharmaceutical Industries | Benzodioxane derivatives |
| US3723442A (en) * | 1970-12-31 | 1973-03-27 | Yoshitomi Pharmaceutical | 3-oxo-1-oxa-4,8-diazaspiro(4.5)decanes |
| US4255432A (en) * | 1979-09-06 | 1981-03-10 | Syntex (U.S.A.) Inc. | 8-[2-3-Indolyl)ethyl]-1-oxa-3-,8-diazaspiro[4.5]decan-2-ones, pharmaceutical compositions thereof and methods of use thereof |
-
1981
- 1981-03-23 US US06/246,459 patent/US4332804A/en not_active Expired - Fee Related
-
1982
- 1982-02-22 BR BR8201589A patent/BR8201589A/pt unknown
- 1982-03-22 PT PT74626A patent/PT74626B/pt unknown
- 1982-03-22 AT AT82301460T patent/ATE17249T1/de not_active IP Right Cessation
- 1982-03-22 DE DE8282301460T patent/DE3268225D1/de not_active Expired
- 1982-03-22 IL IL65310A patent/IL65310A/xx unknown
- 1982-03-22 ES ES510649A patent/ES510649A0/es active Granted
- 1982-03-22 NZ NZ200085A patent/NZ200085A/en unknown
- 1982-03-22 EP EP82301460A patent/EP0061333B1/en not_active Expired
- 1982-03-22 PH PH27035A patent/PH17233A/en unknown
- 1982-03-22 NO NO820937A patent/NO820937L/no unknown
- 1982-03-22 ZA ZA821929A patent/ZA821929B/xx unknown
- 1982-03-22 KR KR1019820001218A patent/KR830009094A/ko not_active Withdrawn
- 1982-03-22 AU AU81769/82A patent/AU557094B2/en not_active Expired - Fee Related
- 1982-03-22 FI FI820998A patent/FI820998A7/fi not_active Application Discontinuation
- 1982-03-22 PL PL23556182A patent/PL235561A1/xx unknown
- 1982-03-22 IE IE648/82A patent/IE52652B1/en unknown
- 1982-03-22 DK DK129282A patent/DK129282A/da not_active Application Discontinuation
- 1982-03-23 JP JP57044755A patent/JPS57169485A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| NZ200085A (en) | 1985-07-12 |
| ATE17249T1 (de) | 1986-01-15 |
| IL65310A (en) | 1985-03-31 |
| EP0061333A1 (en) | 1982-09-29 |
| IE820648L (en) | 1982-09-23 |
| AU8176982A (en) | 1982-09-30 |
| JPS57169485A (en) | 1982-10-19 |
| IL65310A0 (en) | 1982-05-31 |
| EP0061333B1 (en) | 1986-01-02 |
| PL235561A1 (enExample) | 1982-10-25 |
| FI820998L (fi) | 1982-09-24 |
| ES8306373A1 (es) | 1983-06-01 |
| ES510649A0 (es) | 1983-06-01 |
| IE52652B1 (en) | 1988-01-06 |
| NO820937L (no) | 1982-09-24 |
| BR8201589A (pt) | 1983-02-08 |
| FI820998A7 (fi) | 1982-09-24 |
| KR830009094A (ko) | 1983-12-17 |
| DE3268225D1 (de) | 1986-02-13 |
| PT74626B (en) | 1983-12-19 |
| US4332804A (en) | 1982-06-01 |
| PH17233A (en) | 1984-07-03 |
| PT74626A (en) | 1982-04-01 |
| DK129282A (da) | 1982-09-24 |
| AU557094B2 (en) | 1986-12-04 |
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