BR112024001031A2 - Processo de obtenção de biocurativo tridimensional, biocurativo tridimensional obtido e seu uso - Google Patents

Processo de obtenção de biocurativo tridimensional, biocurativo tridimensional obtido e seu uso

Info

Publication number
BR112024001031A2
BR112024001031A2 BR112024001031A BR112024001031A BR112024001031A2 BR 112024001031 A2 BR112024001031 A2 BR 112024001031A2 BR 112024001031 A BR112024001031 A BR 112024001031A BR 112024001031 A BR112024001031 A BR 112024001031A BR 112024001031 A2 BR112024001031 A2 BR 112024001031A2
Authority
BR
Brazil
Prior art keywords
dimensional
biodressing
obtaining
biocurement
present
Prior art date
Application number
BR112024001031A
Other languages
English (en)
Inventor
Oliveira Manfiolli Adriana
Caliari Oliveira Carolina
Original Assignee
In Situ Terapia Celular Ltda
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by In Situ Terapia Celular Ltda filed Critical In Situ Terapia Celular Ltda
Publication of BR112024001031A2 publication Critical patent/BR112024001031A2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
    • A61L26/0028—Polypeptides; Proteins; Degradation products thereof
    • A61L26/0033—Collagen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
    • A61L15/28—Polysaccharides or their derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
    • A61L15/32—Proteins, polypeptides; Degradation products or derivatives thereof, e.g. albumin, collagen, fibrin, gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A61L15/44—Medicaments
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
    • A61L26/0023—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
    • A61L26/0028—Polypeptides; Proteins; Degradation products thereof
    • A61L26/0038—Gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0061—Use of materials characterised by their function or physical properties
    • A61L26/0066—Medicaments; Biocides
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B33—ADDITIVE MANUFACTURING TECHNOLOGY
    • B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
    • B33Y10/00—Processes of additive manufacturing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B33—ADDITIVE MANUFACTURING TECHNOLOGY
    • B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
    • B33Y80/00—Products made by additive manufacturing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/64—Animal cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • Manufacturing & Machinery (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

processo de obtenção de biocurativo tridimensional, biocurativo tridimensional obtido e seu uso. a presente invenção se refere a um processo de obtenção de um biocurativo tridimensional (3d) que compreende as etapas de (a) isolar e cultivar células mesenquimais com soro ab humano; (b) realizar bioimpressão tridimensional (3d) utilizando um biomaterial, tal como alginato de sódio, e células obtidas na etapa a; (c) colocar em repouso o biocurativo 3d obtido após a bioimpressão; (d) recobrir o biocurativo 3d com uma solução de cloreto de cálcio 100 mm; (e) lavar o biocurativo 3d; (f) adicionar meio de cultura de eagle modificado por dulbeccos (dmem); e (g) manter o biocurativo em incubadora por até 15 dias. adicionalmente, a presente invenção se refere ao biocurativo 3d obtido compreendendo, preferencialmente alginato de sódio 4% e células mesenquimais derivadas do cordão umbilical humano (mcus), o qual possui efeito cicatrizante, anti-inflamatório e analgésico. ainda, a presente invenção se refere ao uso do biocurativo 3d no tratamento de pacientes portadores de feridas crônicas e queimaduras graves.
BR112024001031A 2021-07-30 2022-06-23 Processo de obtenção de biocurativo tridimensional, biocurativo tridimensional obtido e seu uso BR112024001031A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
BR102021015108-0A BR102021015108A2 (pt) 2021-07-30 2021-07-30 Processo de obtenção de biocurativo tridimensional, biocurativo tridimensional obtido e seu uso
PCT/BR2022/050235 WO2023004480A1 (en) 2021-07-30 2022-06-23 Process to obtain three-dimensional biodressing, three- dimensional biodressing obtained and its use

Publications (1)

Publication Number Publication Date
BR112024001031A2 true BR112024001031A2 (pt) 2024-04-30

Family

ID=82942312

Family Applications (2)

Application Number Title Priority Date Filing Date
BR102021015108-0A BR102021015108A2 (pt) 2021-07-30 2021-07-30 Processo de obtenção de biocurativo tridimensional, biocurativo tridimensional obtido e seu uso
BR112024001031A BR112024001031A2 (pt) 2021-07-30 2022-06-23 Processo de obtenção de biocurativo tridimensional, biocurativo tridimensional obtido e seu uso

Family Applications Before (1)

Application Number Title Priority Date Filing Date
BR102021015108-0A BR102021015108A2 (pt) 2021-07-30 2021-07-30 Processo de obtenção de biocurativo tridimensional, biocurativo tridimensional obtido e seu uso

Country Status (4)

Country Link
EP (1) EP4376903A1 (pt)
BR (2) BR102021015108A2 (pt)
CA (1) CA3227390A1 (pt)
WO (1) WO2023004480A1 (pt)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUE055344T2 (hu) 2015-04-07 2021-11-29 Revotek Co Ltd Készítmények sejtalapú háromdimenziós nyomtatáshoz
WO2019122351A1 (en) 2017-12-22 2019-06-27 Cellink Ab Tissue-specific human bioinks for the physiological 3d-bioprinting of human tissues for in vitro culture and transplantation

Also Published As

Publication number Publication date
WO2023004480A1 (en) 2023-02-02
CA3227390A1 (en) 2023-02-02
BR102021015108A2 (pt) 2023-02-14
EP4376903A1 (en) 2024-06-05

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