BR112023024146A2 - Métodos de tratamento de distúrbios relacionados às mitocôndrias - Google Patents
Métodos de tratamento de distúrbios relacionados às mitocôndriasInfo
- Publication number
- BR112023024146A2 BR112023024146A2 BR112023024146A BR112023024146A BR112023024146A2 BR 112023024146 A2 BR112023024146 A2 BR 112023024146A2 BR 112023024146 A BR112023024146 A BR 112023024146A BR 112023024146 A BR112023024146 A BR 112023024146A BR 112023024146 A2 BR112023024146 A2 BR 112023024146A2
- Authority
- BR
- Brazil
- Prior art keywords
- mitochondria
- treatment
- methods
- methyl
- disorders related
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 210000003470 mitochondria Anatomy 0.000 title abstract 3
- LRJQZGXEGNOHBH-UHFFFAOYSA-N 5-[(2,4-dinitrophenoxy)methyl]-1-methyl-2-nitroimidazole Chemical compound [N+](=O)([O-])C1=C(OCC2=CN=C(N2C)[N+](=O)[O-])C=CC(=C1)[N+](=O)[O-] LRJQZGXEGNOHBH-UHFFFAOYSA-N 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 208000035475 disorder Diseases 0.000 abstract 2
- 208000024172 Cardiovascular disease Diseases 0.000 abstract 1
- 206010020772 Hypertension Diseases 0.000 abstract 1
- 208000008589 Obesity Diseases 0.000 abstract 1
- 206010012601 diabetes mellitus Diseases 0.000 abstract 1
- 208000019423 liver disease Diseases 0.000 abstract 1
- 235000020824 obesity Nutrition 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4168—1,3-Diazoles having a nitrogen attached in position 2, e.g. clonidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Heart & Thoracic Surgery (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Child & Adolescent Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Compounds Of Unknown Constitution (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
métodos de tratamento de distúrbios relacionados às mitocôndrias. trata-se de métodos de tratamento que compreendem a administração de uma quantidade terapeuticamente eficaz de 5-[(2,4-dinitrofenoxi)metil]-1-metil-2-nitro-1h-imidazol ou um sal farmaceuticamente aceitável do mesmo a um sujeito que necessita do mesmo. 5-[(2,4-dinitrofenoxi)metil]-1-metil-2-nitro-1h-imidazol é útil no tratamento de distúrbios ou afecções relacionadas às mitocôndrias, incluindo obesidade, diabetes, hipertensão, doenças cardiovasculares e doenças hepáticas.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US202163191321P | 2021-05-20 | 2021-05-20 | |
US202163222841P | 2021-07-16 | 2021-07-16 | |
US202263307515P | 2022-02-07 | 2022-02-07 | |
PCT/US2022/029992 WO2022246039A1 (en) | 2021-05-20 | 2022-05-19 | Methods of treating mitochondria-related disorders |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112023024146A2 true BR112023024146A2 (pt) | 2024-01-30 |
Family
ID=82020295
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112023024146A BR112023024146A2 (pt) | 2021-05-20 | 2022-05-19 | Métodos de tratamento de distúrbios relacionados às mitocôndrias |
Country Status (10)
Country | Link |
---|---|
EP (1) | EP4340829A1 (pt) |
JP (1) | JP2024521709A (pt) |
KR (1) | KR20240021827A (pt) |
AU (1) | AU2022275935A1 (pt) |
BR (1) | BR112023024146A2 (pt) |
CA (1) | CA3219548A1 (pt) |
CL (1) | CL2023003441A1 (pt) |
IL (1) | IL308669A (pt) |
TW (1) | TW202313010A (pt) |
WO (1) | WO2022246039A1 (pt) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2023150759A1 (en) * | 2022-02-07 | 2023-08-10 | Rivus Pharmaceuticals, Inc. | Methods of weight loss in a subject with elevated hba1c |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1098641B1 (en) | 1998-07-27 | 2016-04-27 | St. Jude Pharmaceuticals, Inc. | Chemically induced intracellular hyperthermia |
GEP20217227B (en) | 2017-01-06 | 2021-02-25 | Pharmaceuticals Inc Rivus | Novel phenyl derivatives |
-
2022
- 2022-05-19 IL IL308669A patent/IL308669A/en unknown
- 2022-05-19 AU AU2022275935A patent/AU2022275935A1/en active Pending
- 2022-05-19 BR BR112023024146A patent/BR112023024146A2/pt unknown
- 2022-05-19 CA CA3219548A patent/CA3219548A1/en active Pending
- 2022-05-19 KR KR1020237043901A patent/KR20240021827A/ko unknown
- 2022-05-19 WO PCT/US2022/029992 patent/WO2022246039A1/en active Application Filing
- 2022-05-19 JP JP2023571818A patent/JP2024521709A/ja active Pending
- 2022-05-19 EP EP22729956.7A patent/EP4340829A1/en active Pending
- 2022-05-20 TW TW111118998A patent/TW202313010A/zh unknown
-
2023
- 2023-11-20 CL CL2023003441A patent/CL2023003441A1/es unknown
Also Published As
Publication number | Publication date |
---|---|
KR20240021827A (ko) | 2024-02-19 |
CL2023003441A1 (es) | 2024-05-10 |
IL308669A (en) | 2024-01-01 |
CA3219548A1 (en) | 2022-11-24 |
JP2024521709A (ja) | 2024-06-04 |
TW202313010A (zh) | 2023-04-01 |
EP4340829A1 (en) | 2024-03-27 |
AU2022275935A1 (en) | 2023-12-07 |
WO2022246039A1 (en) | 2022-11-24 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
Serebrovskaya et al. | Intermittent hypoxia: cause of or therapy for systemic hypertension? | |
NO20053678L (no) | Kombinasjonsterapi for behandling av immuninflammatoriske forstyrrelser | |
RU2018110647A (ru) | Арильные, гетероарильные и гетероциклические соединения для лечения заболеваний | |
EA200800007A1 (ru) | Фармацевтические композиции на основе нейроактивного стероида и их применение | |
HUP0301146A2 (hu) | 2-Klór-5-nitrofenil karboxamidszármazékok, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk | |
BR112023024146A2 (pt) | Métodos de tratamento de distúrbios relacionados às mitocôndrias | |
CY1107930T1 (el) | Συνθεση κυνορροδου και ιχθυελαιου για την ανακουφιση των πονων στις αρθρωσεις και της δυσκαμψιας | |
EA201490163A1 (ru) | Ингибиторы кинуренин-3-монооксигеназы, фармацевтические композиции и способы их применения | |
AR114392A1 (es) | Tratamiento de pacientes con enfermedad de fabry clásica | |
ATE516366T1 (de) | Regulierte aptamer-therapeutika | |
CY1111783T1 (el) | Θεραπεια συνδυασμου διαταραχων κατωτερης ουροποιητικης οδου με 2 προσδεματα και μη στεροειδες αντιφλεγμονωδες φαρμακο | |
ATE414522T1 (de) | Verfahren zur behandlung von akuter und durch übermässige beanspruchung verursachter zerrung und verstauchung mit hyaluronsäure | |
Sukhov et al. | Long-term intranasal insulin administration improves spatial memory in male rats with prolonged type 1 diabetes mellitus and in healthy rats | |
BR112012020185A2 (pt) | uso de preparações de heparina oral para tratar doenças e afecções do trato urinário. | |
BR0005797A (pt) | Métodos para o tratamento de disfunção sexual com apomorfina em nìveis de concentração plasmática especificados | |
JP2019529569A5 (pt) | ||
AR117861A1 (es) | Métodos de reducción de eventos cerebrovasculares en pacientes con enfermedad de fabry | |
BR0012408A (pt) | Métodos para induzir ou aumentar a migração celular, para reduzir ou inibir a migração celular, para induzir ou aumentar a cura de ferimento em um paciente, e para regular a expressão de pelo menos um gene de uma célula, e, uso de um agonista de fator de tecido | |
EA202193190A1 (ru) | Композиция, включающая придопидин и его аналог, для лечения болезни гентингтона и ее симптомов | |
BR112023017999A2 (pt) | Obicetrapibe para tratamento de demências | |
BR112022008095A2 (pt) | Métodos e composições para o tratamento da síndrome de rett | |
ATE495750T1 (de) | Sulfatide zur behandlung von autoimmunkrankheiten | |
EA202000298A1 (ru) | ПРОТИВОКОРОНАВИРУСНОЕ СРЕДСТВО ДЛЯ КОМБИНИРОВАННОЙ ТЕРАПИИ COVID-19 (SARS-CoV-2) И СПОСОБ ЛЕЧЕНИЯ | |
EA200702534A1 (ru) | Применение бензоильного производного 3-аминокарбазола для лечения расстройства, связанного с продукцией простагландина e2(pge2) | |
Choi et al. | A case of Traditional Korean Medicine for a patient with fibromyalgia experiencing whole body pain and sleep and digestive disorders |