BR112023023486A2 - Composição farmacêutica, e, método de tratamento de uma doença ou condição na qual um efeito clínico benéfico é obtido pela redução na atividade de sintase de óxido nítrico neuronal - Google Patents

Composição farmacêutica, e, método de tratamento de uma doença ou condição na qual um efeito clínico benéfico é obtido pela redução na atividade de sintase de óxido nítrico neuronal

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Publication number
BR112023023486A2
BR112023023486A2 BR112023023486A BR112023023486A BR112023023486A2 BR 112023023486 A2 BR112023023486 A2 BR 112023023486A2 BR 112023023486 A BR112023023486 A BR 112023023486A BR 112023023486 A BR112023023486 A BR 112023023486A BR 112023023486 A2 BR112023023486 A2 BR 112023023486A2
Authority
BR
Brazil
Prior art keywords
disease
condition
nitric oxide
oxide synthase
pharmaceutical composition
Prior art date
Application number
BR112023023486A
Other languages
English (en)
Portuguese (pt)
Inventor
Jacob Domb Abraham
Haitham Amal
Original Assignee
Yissum Res Dev Co Of Hebrew Univ Jerusalem Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yissum Res Dev Co Of Hebrew Univ Jerusalem Ltd filed Critical Yissum Res Dev Co Of Hebrew Univ Jerusalem Ltd
Publication of BR112023023486A2 publication Critical patent/BR112023023486A2/pt

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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
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    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
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    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
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    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
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BR112023023486A 2021-05-10 2022-05-10 Composição farmacêutica, e, método de tratamento de uma doença ou condição na qual um efeito clínico benéfico é obtido pela redução na atividade de sintase de óxido nítrico neuronal BR112023023486A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202163186389P 2021-05-10 2021-05-10
PCT/IL2022/050486 WO2022239001A1 (en) 2021-05-10 2022-05-10 Pharmaceutical compositions for treating neurological conditions

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BR112023023486A2 true BR112023023486A2 (pt) 2024-01-30

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US (2) US20240316006A1 (enExample)
EP (1) EP4337197A1 (enExample)
JP (1) JP2024517903A (enExample)
KR (1) KR20240017813A (enExample)
AU (1) AU2022272489A1 (enExample)
BR (1) BR112023023486A2 (enExample)
CA (1) CA3217972A1 (enExample)
IL (1) IL308282A (enExample)
MX (1) MX2023013202A (enExample)
WO (1) WO2022239001A1 (enExample)

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Publication number Priority date Publication date Assignee Title
WO2024224296A2 (en) * 2023-04-24 2024-10-31 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Targeted pharmaceutical compositions to treat neurological conditions
WO2024231899A1 (en) * 2023-05-10 2024-11-14 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Compounds for nos-related cancers and methods of use
WO2025096244A1 (en) * 2023-10-30 2025-05-08 Olfera Corporation Olfactory delivery scaffolds and methods for making and using same

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