JP2024517903A - 神経学的状態を治療するための薬学的組成物 - Google Patents

神経学的状態を治療するための薬学的組成物 Download PDF

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JP2024517903A
JP2024517903A JP2023568675A JP2023568675A JP2024517903A JP 2024517903 A JP2024517903 A JP 2024517903A JP 2023568675 A JP2023568675 A JP 2023568675A JP 2023568675 A JP2023568675 A JP 2023568675A JP 2024517903 A JP2024517903 A JP 2024517903A
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pharmaceutical composition
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JP2024517903A5 (enExample
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アマル、ハイサム
ヤコブ ドム、アブラハム
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Yissum Research Development Co of Hebrew University of Jerusalem
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    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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JP2023568675A 2021-05-10 2022-05-10 神経学的状態を治療するための薬学的組成物 Pending JP2024517903A (ja)

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US202163186389P 2021-05-10 2021-05-10
US63/186,389 2021-05-10
PCT/IL2022/050486 WO2022239001A1 (en) 2021-05-10 2022-05-10 Pharmaceutical compositions for treating neurological conditions

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JP2024517903A true JP2024517903A (ja) 2024-04-23
JP2024517903A5 JP2024517903A5 (enExample) 2025-05-20

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US (2) US20240316006A1 (enExample)
EP (1) EP4337197A1 (enExample)
JP (1) JP2024517903A (enExample)
KR (1) KR20240017813A (enExample)
AU (1) AU2022272489A1 (enExample)
BR (1) BR112023023486A2 (enExample)
CA (1) CA3217972A1 (enExample)
IL (1) IL308282A (enExample)
MX (1) MX2023013202A (enExample)
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Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2024224296A2 (en) * 2023-04-24 2024-10-31 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Targeted pharmaceutical compositions to treat neurological conditions
WO2024231899A1 (en) * 2023-05-10 2024-11-14 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Compounds for nos-related cancers and methods of use
WO2025096244A1 (en) * 2023-10-30 2025-05-08 Olfera Corporation Olfactory delivery scaffolds and methods for making and using same

Family Cites Families (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4596556A (en) 1985-03-25 1986-06-24 Bioject, Inc. Hypodermic injection apparatus
US4790824A (en) 1987-06-19 1988-12-13 Bioject, Inc. Non-invasive hypodermic injection device
US4941880A (en) 1987-06-19 1990-07-17 Bioject, Inc. Pre-filled ampule and non-invasive hypodermic injection device assembly
US5549910A (en) 1989-03-31 1996-08-27 The Regents Of The University Of California Preparation of liposome and lipid complex compositions
US5252334A (en) 1989-09-08 1993-10-12 Cygnus Therapeutic Systems Solid matrix system for transdermal drug delivery
US5312335A (en) 1989-11-09 1994-05-17 Bioject Inc. Needleless hypodermic injection device
US5064413A (en) 1989-11-09 1991-11-12 Bioject, Inc. Needleless hypodermic injection device
JP3218637B2 (ja) 1990-07-26 2001-10-15 大正製薬株式会社 安定なリポソーム水懸濁液
JP2958076B2 (ja) 1990-08-27 1999-10-06 株式会社ビタミン研究所 遺伝子導入用多重膜リポソーム及び遺伝子捕捉多重膜リポソーム製剤並びにその製法
US5383851A (en) 1992-07-24 1995-01-24 Bioject Inc. Needleless hypodermic injection device
US5741516A (en) 1994-06-20 1998-04-21 Inex Pharmaceuticals Corporation Sphingosomes for enhanced drug delivery
WO1996021445A1 (en) * 1995-01-13 1996-07-18 The General Hospital Corporation Methods of inhibiting neurodegenerative diseases
US5795587A (en) 1995-01-23 1998-08-18 University Of Pittsburgh Stable lipid-comprising drug delivery complexes and methods for their production
US5697899A (en) 1995-02-07 1997-12-16 Gensia Feedback controlled drug delivery system
US5738868A (en) 1995-07-18 1998-04-14 Lipogenics Ltd. Liposome compositions and kits therefor
US5656016A (en) 1996-03-18 1997-08-12 Abbott Laboratories Sonophoretic drug delivery system
US5797898A (en) 1996-07-02 1998-08-25 Massachusetts Institute Of Technology Microchip drug delivery devices
US5783208A (en) 1996-07-19 1998-07-21 Theratech, Inc. Transdermal drug delivery matrix for coadministering estradiol and another steroid
US5779708A (en) 1996-08-15 1998-07-14 Cyberdent, Inc. Intraosseous drug delivery device and method
US6774279B2 (en) 1997-05-30 2004-08-10 Carnegie Institution Of Washington Use of FLP recombinase in mice
GB9818110D0 (en) 1998-08-19 1998-10-14 Weston Medical Ltd Needleless injectors and other devices
US6096002A (en) 1998-11-18 2000-08-01 Bioject, Inc. NGAS powered self-resetting needle-less hypodermic jet injection apparatus and method
US7749539B2 (en) 2000-11-30 2010-07-06 Efrat Biopolymers Ltd. Polymeric formulations for drug delivery
WO2003080809A2 (en) 2002-03-21 2003-10-02 Sangamo Biosciences, Inc. Methods and compositions for using zinc finger endonucleases to enhance homologous recombination
EP2806025B1 (en) 2002-09-05 2019-04-03 California Institute of Technology Use of zinc finger nucleases to stimulate gene targeting
WO2004064737A2 (en) 2003-01-17 2004-08-05 Alnylam Pharmaceuticals Therapeutics compositions
ES2702942T3 (es) 2003-04-17 2019-03-06 Alnylam Pharmaceuticals Inc Agentes de ARNi modificados
JP4991288B2 (ja) 2003-04-17 2012-08-01 アルナイラム ファーマシューティカルズ, インコーポレイテッド 二本鎖iRNA剤、および二本鎖iRNA剤の対合の安定性を調節する方法。
US20060014264A1 (en) 2004-07-13 2006-01-19 Stowers Institute For Medical Research Cre/lox system with lox sites having an extended spacer region
ES2582091T3 (es) 2005-10-18 2016-09-09 Precision Biosciences Meganucleasas diseñadas racionalmente con especificidad de secuencia y afinidad de unión a ADN alteradas
EP2067402A1 (en) 2007-12-07 2009-06-10 Max Delbrück Centrum für Molekulare Medizin (MDC) Berlin-Buch; Transponson-mediated mutagenesis in spermatogonial stem cells
UA105182C2 (ru) * 2008-07-03 2014-04-25 Ньюрексон, Інк. Бензоксазины, бензотиазины и родственные соединения, которые имеют ингибирующую nos активность
US8586526B2 (en) 2010-05-17 2013-11-19 Sangamo Biosciences, Inc. DNA-binding proteins and uses thereof
US20150030576A1 (en) 2012-01-10 2015-01-29 Moderna Therapeutics, Inc. Methods and compositions for targeting agents into and across the blood-brain barrier
WO2013126963A1 (en) 2012-02-29 2013-09-06 Benitec Biopharma Limited Pain treatment
CN109554350B (zh) 2012-11-27 2022-09-23 儿童医疗中心有限公司 用于胎儿血红蛋白再诱导的靶向bcl11a远端调控元件
US8697359B1 (en) 2012-12-12 2014-04-15 The Broad Institute, Inc. CRISPR-Cas systems and methods for altering expression of gene products
KR20150103280A (ko) 2013-01-08 2015-09-09 베니텍 바이오파마 리미티드 연령-관련 황반 변성 치료
US10569097B2 (en) 2015-07-28 2020-02-25 Photonmd, Inc. Systems and methods for phototherapeutic modulation of nitric oxide
FI130359B (fi) 2018-05-21 2023-07-20 Valmet Technologies Oy Leijupetikattilaksi soveltuva koaksiaalinen lämmönsiirtoputki ja menetelmä sen valmistamiseksi

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
AMANDA J. SALES ET.AL.: "Participation of hippocampal nitric oxide synthase and soluble guanylate cyclase in the modulation o", BEHAVIOURAL PHARMACOLOGY, vol. 28, no. 1, JPN6025042373, 2017, ISSN: 0005712250 *
DANA BARCHEL ET. AL.: "Oral Cannabidiol Use in Children With Autism Spectrum Disorder to Treat Related Symptoms and Co-morb", FRONTIERS IN PHARMACOLOGY, vol. 9, JPN6025042370, 9 January 2019 (2019-01-09), ISSN: 0005712253 *
DEBORA L. NICKLA ET. AL.: "Inhibiting the neuronal isoform of nitric oxide synthase has similar effects on the compensatory cho", EXP EYE RES., vol. 88 (6), JPN6025042372, June 2009 (2009-06-01), pages 1092 - 1099, ISSN: 0005712251 *
MANISH KUMAR TRIPATHI ET. AL.: "The role of nitric oxide in brain disorders: Autism spectrum disorder and oher psychiatric, neurolog", REDOX BIOLOGY, vol. 34, JPN6025042374, 2020, pages 101567, ISSN: 0005712249 *
NITIN B. GAWALI ET.AL.: "Involvement of nitric oxide in anticompulsive-like effect of agmatine on marble-burying behaviour in", EUROPEAN JOURNAL OF PHARMACOLOGY, vol. 770, JPN6025042371, 2016, pages 165 - 171, ISSN: 0005712252 *

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