BR112023022882A2 - Estabilização de rna para aplicações e formulações agrícolas de rnai exógeno - Google Patents
Estabilização de rna para aplicações e formulações agrícolas de rnai exógenoInfo
- Publication number
- BR112023022882A2 BR112023022882A2 BR112023022882A BR112023022882A BR112023022882A2 BR 112023022882 A2 BR112023022882 A2 BR 112023022882A2 BR 112023022882 A BR112023022882 A BR 112023022882A BR 112023022882 A BR112023022882 A BR 112023022882A BR 112023022882 A2 BR112023022882 A2 BR 112023022882A2
- Authority
- BR
- Brazil
- Prior art keywords
- rna
- formulations
- agricultural applications
- exogenous
- rna stabilization
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 6
- 230000021839 RNA stabilization Effects 0.000 title abstract 2
- 108091030071 RNAI Proteins 0.000 title abstract 2
- 108091032973 (ribonucleotides)n+m Proteins 0.000 abstract 4
- 239000004094 surface-active agent Substances 0.000 abstract 3
- 229910021645 metal ion Inorganic materials 0.000 abstract 2
- 239000002516 radical scavenger Substances 0.000 abstract 2
- 241000607479 Yersinia pestis Species 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
- 230000009368 gene silencing by RNA Effects 0.000 abstract 1
- 235000014666 liquid concentrate Nutrition 0.000 abstract 1
- 239000002736 nonionic surfactant Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/111—General methods applicable to biologically active non-coding nucleic acids
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/02—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing liquids as carriers, diluents or solvents
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/22—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing ingredients stabilising the active ingredients
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/30—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests characterised by the surfactants
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N63/00—Biocides, pest repellants or attractants, or plant growth regulators containing microorganisms, viruses, microbial fungi, animals or substances produced by, or obtained from, microorganisms, viruses, microbial fungi or animals, e.g. enzymes or fermentates
- A01N63/60—Isolated nucleic acids
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- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D1/00—Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
- C11D1/88—Ampholytes; Electroneutral compounds
- C11D1/94—Mixtures with anionic, cationic or non-ionic compounds
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering N.A.
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2320/00—Applications; Uses
- C12N2320/30—Special therapeutic applications
- C12N2320/32—Special delivery means, e.g. tissue-specific
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2320/00—Applications; Uses
- C12N2320/50—Methods for regulating/modulating their activity
- C12N2320/51—Methods for regulating/modulating their activity modulating the chemical stability, e.g. nuclease-resistance
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Plant Pathology (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Dentistry (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Environmental Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Toxicology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Virology (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
estabilização de rna para aplicações e formulações agrícolas de rnai exógeno. a presente invenção refere-se a composições para proporcionar estabilidade a rna podem incluir um tensoativo primário e um sequestrante de íon de metal. o tensoativo primário pode ser um tensoativo não iônico. a composição pode estar em uma forma de concentrado líquido solúvel e pode ser suficiente para proporcionar estabilidade de prateleira a rna por um ano à temperatura ambiente. composições para distribuir rna a uma praga por meio de aplicação foliar exógena da composição a uma planta podem compreender rna; um tensoativo primário; e um sequestrante de íon de metal.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US202163184508P | 2021-05-05 | 2021-05-05 | |
PCT/US2022/027816 WO2022235895A1 (en) | 2021-05-05 | 2022-05-05 | Stabilization of rna for exogenous rnai agricultural applications and formulations |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112023022882A2 true BR112023022882A2 (pt) | 2024-01-23 |
Family
ID=83932478
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112023022882A BR112023022882A2 (pt) | 2021-05-05 | 2022-05-05 | Estabilização de rna para aplicações e formulações agrícolas de rnai exógeno |
Country Status (5)
Country | Link |
---|---|
US (2) | US20220372478A1 (pt) |
EP (1) | EP4333623A1 (pt) |
JP (1) | JP2024517238A (pt) |
BR (1) | BR112023022882A2 (pt) |
WO (1) | WO2022235895A1 (pt) |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2011516061A (ja) * | 2008-04-04 | 2011-05-26 | グッドジーン インク. | 核酸を安定的に保管する新規皮膚遺伝子カードとこれを用いた遺伝子分析方法、並びにこの応用方法 |
CN102424821B (zh) * | 2011-12-22 | 2014-06-11 | 东北林业大学 | 饲料型四倍体刺槐叶片总rna的提取方法 |
CN103109800B (zh) * | 2013-02-26 | 2015-04-08 | 广州市锐博生物科技有限公司 | 壳聚糖纳米粒、防治小菜蛾的生物农药制剂及其制备方法 |
RU2754955C2 (ru) * | 2014-07-29 | 2021-09-08 | Монсанто Текнолоджи Ллс | Композиции и способы борьбы с насекомыми-вредителями |
US20180237790A1 (en) * | 2015-08-13 | 2018-08-23 | Forrest Innovation Ltd. | Formulations and compositions for delivery of nucleic acids to plant cells |
EP3389673B1 (en) * | 2015-12-14 | 2021-02-17 | Monsanto Technology LLC | Methods and compositions for delivery of polynucleotides |
US20210254085A1 (en) * | 2018-08-24 | 2021-08-19 | Flagship Pioneering Innovations Vi, Llc | Methods and compositions for the modification of plants |
-
2022
- 2022-05-05 WO PCT/US2022/027816 patent/WO2022235895A1/en active Application Filing
- 2022-05-05 EP EP22799571.9A patent/EP4333623A1/en active Pending
- 2022-05-05 US US17/737,426 patent/US20220372478A1/en active Pending
- 2022-05-05 BR BR112023022882A patent/BR112023022882A2/pt unknown
- 2022-05-05 JP JP2023567927A patent/JP2024517238A/ja active Pending
- 2022-10-06 US US17/961,205 patent/US20230106660A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
US20220372478A1 (en) | 2022-11-24 |
EP4333623A1 (en) | 2024-03-13 |
WO2022235895A1 (en) | 2022-11-10 |
JP2024517238A (ja) | 2024-04-19 |
US20230106660A1 (en) | 2023-04-06 |
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