BR112023021381A2 - Composto e seu processo de preparação, e composição farmacêutica - Google Patents

Composto e seu processo de preparação, e composição farmacêutica

Info

Publication number
BR112023021381A2
BR112023021381A2 BR112023021381A BR112023021381A BR112023021381A2 BR 112023021381 A2 BR112023021381 A2 BR 112023021381A2 BR 112023021381 A BR112023021381 A BR 112023021381A BR 112023021381 A BR112023021381 A BR 112023021381A BR 112023021381 A2 BR112023021381 A2 BR 112023021381A2
Authority
BR
Brazil
Prior art keywords
compound
pharmaceutical composition
preparation process
sigma
receptor
Prior art date
Application number
BR112023021381A
Other languages
English (en)
Inventor
Adriana Lorente-Crivillé
Carmen Almansa-Rosales
Original Assignee
Acondicionamiento Tarrasense
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Acondicionamiento Tarrasense filed Critical Acondicionamiento Tarrasense
Publication of BR112023021381A2 publication Critical patent/BR112023021381A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

composto e seu processo de preparação, e composição farmacêutica. a presente invenção se refere a novos compostos de fórmula (i´), como ligantes sigma que têm uma grande afinidade com receptores sigma, receptor sigma-1 (sigma1) e/ou receptor sigma-2 (sigma2). a presente invenção também se refere ao processo para a preparação dos mesmos, às composições que os compreendem e ao seu uso como medicamentos.
BR112023021381A 2021-04-16 2022-04-08 Composto e seu processo de preparação, e composição farmacêutica BR112023021381A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP21382324 2021-04-16
PCT/EP2022/059439 WO2022218856A1 (en) 2021-04-16 2022-04-08 NEW PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES AS SIGMA LIGANDS

Publications (1)

Publication Number Publication Date
BR112023021381A2 true BR112023021381A2 (pt) 2023-12-19

Family

ID=75581480

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112023021381A BR112023021381A2 (pt) 2021-04-16 2022-04-08 Composto e seu processo de preparação, e composição farmacêutica

Country Status (11)

Country Link
EP (1) EP4323363A1 (pt)
JP (1) JP2024514200A (pt)
KR (1) KR20240021758A (pt)
CN (1) CN117561261A (pt)
AR (1) AR125363A1 (pt)
AU (1) AU2022256725A1 (pt)
BR (1) BR112023021381A2 (pt)
CA (1) CA3215521A1 (pt)
IL (1) IL307766A (pt)
TW (1) TW202304453A (pt)
WO (1) WO2022218856A1 (pt)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010055126A1 (en) * 2008-11-14 2010-05-20 Neurosearch A/S Benzimidazole derivatives and their use for modulating the gabaa receptor complex
EP2733143A1 (en) * 2012-11-14 2014-05-21 Laboratorios Del Dr. Esteve, S.A. Substituted pyrazolo[3,4-d]pyrimidine compounds, their preparation and use as sigma receptors ligands

Also Published As

Publication number Publication date
AR125363A1 (es) 2023-07-12
JP2024514200A (ja) 2024-03-28
AU2022256725A1 (en) 2023-11-02
TW202304453A (zh) 2023-02-01
CA3215521A1 (en) 2022-10-20
EP4323363A1 (en) 2024-02-21
IL307766A (en) 2023-12-01
CN117561261A (zh) 2024-02-13
WO2022218856A1 (en) 2022-10-20
KR20240021758A (ko) 2024-02-19

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